A Quick Guide to Navigating Your Munchies

Ever felt a craving for fatty, sweet or salty food after a good toke or edible? Welcome to a classic case of the munchies. But have you ever wondered why we get the munchies after a good old-fashioned sesh? And, why do some smokers get paradoxically nauseated rather than hungry? Lastly, if you’re wondering whether to munch […]

The post A Quick Guide to Navigating Your Munchies appeared first on Latest Cannabis News Today – Headlines, Videos & Stocks.

New ReCreate Products Highlight Minor Cannabinoids

ReCreate is redefining the cannabis experience with their new product line, which features the addition of minor cannabinoids for a highly targeted, more effective experience. Founded in 2020, The brand is focused on unlocking the cannabis plant’s many wellness properties—a goal that remains clear with their newly reformulated products. With six main effects to choose from (Boost, Immunity, Relax, Relief, Sleep and Microdose), the new gummies and tinctures are intended to help consumers enhance their wellness goals while easily fitting into existing daily routines. 

While ReCreate products are designed for the health-conscious consumer, there’s no need to sacrifice flavor. Boost mind and body while having a little fun with their colorful and delicious gummies, available in flavors like Watermelon Lemonade, Strawberry Kiwi, and Tart Cherry. Cannabis wellness doesn’t have to be boring, and ReCreate is proving itself to be one of the most innovative brands on the market.

Minor (But Mighty) Cannabinoids:

All ReCreate products are formulated with their full-spectrum extract and fast-acting nanotechnology to provide one of the most efficacious products available in the market. Categorizing products by effect rather than strain helps those who are new to cannabis more easily understand how the products work, and which one is best suited to meet their needs. When utilized correctly, THC and CBD can play a big role in any wellness routine. These products are designed to help enhance any aspect of daily life, harmoniously blending your routine with the medicinal benefits of THC, CBD and adaptogenic botanicals.

Now, let’s look a closer look at the effects of these new products, and how each minor cannabinoid works to provide more targeted results. We’ll also touch on each product’s infused functional botanicals which have natural properties, intended to amplify and augment your ReCreate experience. 

  • THCv: This cannabinoid helps cut down on insulin resistance and regulate blood sugar levels making it perfect for those looking for an uplifting boost throughout the day.
  • CBG: Look no further than CBG for an immunity boost and powerful effect. Coined the “Mother of all Cannabinoids,” CBG is the original compound from which other cannabinoids were created. It is currently being evaluated in numerous studies to determine the full extent of its wellness benefits.
  • CBN: This cannabinoid touts powerful anti-inflammatory results, as well as sedative effects. CBN has been shown to help calm the mind and support sleep cycles within the body, making it a great addition in products designed for relaxation and sleep.

THE EFFECTS

BOOST Gummies

  • 1:1 with THCv: These Watermelon Lemonade Gummies are jam-packed with cannabinoids and beneficial botanicals specially formulated to help uplift your spirits. Recommended for those needing an extra lift in no time.
  • Botanical Booster: Yerba Mate. Popular across South America, Yerba Mate is a traditional drink well known for its energy-boosting properties and support in reducing fatigue.

IMMUNITY Tincture

  • 3:1 with CBG: Naturally flavored with mocha, the 3:1 oil Immunity tincture is packed with Echinacea and 30mg of CBG to help support your immune system.
  • Botanical Booster: Echinacea. Also known as coneflower, Echinacea is a flowering plant found in the daisy family. Native to North America, these plants have been widely used to support the immune system.

RELAX Gummies and Tincture

  • 2:1 with CBN: The 2:1 Relax oil tincture and Strawberry Kiwi Gummies are packed with 10MG of CBN and beneficial botanicals specially formulated to help support a sense of calm. Recommended for those searching for sweet, sweet relaxation. Ashwagandha and 10mg of CBN to help support your sense of calm.
  • Botanical Booster: Ashwagandha. This Ayurvedic herb that has been cultivated in India for generations. Classified as an adaptogen, it’s used to help support a sense of calm and manage everyday stresses.

RELIEF Gummies & Tincture

  • 2:1 with CBG. The Relief oil tincture and Tangerine Gummies are formulated to help your body recover from exercise-induced inflammation. Perfect for those who need that extra bit of recovery after an intense workout.
  • Botanical Booster: Cordyceps Mushrooms. Originally used by Tibetans, Cordyceps has powerful compounds that help protect and support joint health and mobility.

SLEEP Gummies & Tincture

  • 1:2 with CBN. Tart Cherry Gummies are jam-packed with cannabinoids and beneficial botanicals specially formulated to help support healthy sleep cycles. These Sleep Gummies are perfect for those who want to fall asleep easily while developing healthy sleep cycles.
  • Botanical Booster: Passionflower. Used across native populations worldwide, Passionflower is known for its calming and soothing effects. Research from the National Institute of Health shows that Passionflower may help adults who suffer from mild sleep irregularities.

MICRODOSE Gummies & Tincture

  • 6:1 with THCv: These Peach Dragonfruit Gummies are specially formulated to help provide daily support for your endocannabinoid system. By combining full-spectrum CBD with low levels of THC, these gummies are designed for microdosing and formulated to release the benefits of the entourage effect. These fast-acting gummies are formulated to help you find your daily balance and feature a variety of vitamins for additional support. Both the gummies and tincture are designed to be easy to microdose and incorporate into your daily wellness practice.
  • Heightened CBD: Increased levels of CBD for a balanced, well-rounded experience
  • Vitamin Blend: ReCreate’s proprietary superfood vitamin blend is made from whole foods like banana, papaya, oranges, and shitake mushrooms, and includes folate for maximum benefits.

Providing specific results that you can count on, there is no guesswork involved when it comes to ReCreate’s products. Reliability is important when it comes to integrating cannabis and wellness, and the brand prides itself on consistent results. By breaking down the focused advantages of individual cannabinoids, ReCreate was able to improve the reliability and effectiveness of their product. Not to mention, every product is non-GMO and ethically sourced.

The Brains Behind the Operation

Founded by the Stanley Brothers in an effort to incorporate cannabis seamlessly into the world of wellness, ReCreate has gained recognition for its innovative botanical blends. By combining the benefits of cannabinoids with adaptogens like Yerba Mate, Ashwagandha, Cordyceps and Passionflower, the brothers were able to create formulas that break free from traditional cannabis expectations.

As the world of cannabis continues to grow and expand, so does the demand for products that go above and beyond. Recognizing that THC and CBD are a powerful tool in treating a plethora of ailments, the Stanley Brothers created the well-known CBD brand, Charlotte’s Web, setting the stage for the brothers’ goals in the healthy and mindful segment of the cannabis industry.

Wellness, Meet Weed

Cannabis as a market has evolved greatly since we first saw California legalize medical marijuana in 1996. Since then, the work to destigmatize cannabis continues, and the plant is much more widely utilized for its recreational and medicinal properties. Historically, integrating marijuana into your daily routine was frowned upon. But the desire for a product that merges the worlds of wellness and cannabis is rapidly growing. By merging two booming industries, ReCreate is helping new and veteran cannabis users find a holistic alternative for enhancing body and mind.

The post New ReCreate Products Highlight Minor Cannabinoids appeared first on Cannabis Now.

THCV From Cannabis Might Be Best Bet For Treating Diabetes

The diabetes issue is one of the many growing health problems in the US, and beyond, spurred on, no doubt, by modern food systems, and generally unhealthy lifestyles. Though taking a medication will never take the place of healthy living behaviors, cannabis compound THCV might be the best bet for treating the symptoms of diabetes.

For those with weight issues, using THCV for help with diabetes symptoms, might be the best bet. Cannabis and Hemp provides tons of useful medical and recreational compounds like THCV, Delta 10, THC-O and Delta-8 THC. This alternate form of THC produces less psychoactive effect, less couch locking, and less anxiety, while providing nearly all the benefits of delta-9. We believe in making sure people get the products they need. Take a look at our selection of Delta-8 THC products, as well as THCV, and many more compounds, to find the right product for you.

NEW: Delta 8 + THCV Vape Cartridges

Introducing The New Delta 8 + THCV Vape Cartridges

What is diabetes?

Diabetes, technically called diabetes mellitus, is an entire grouping of metabolic disorders that relate to elevated blood sugar levels over time, and a lack of insulin. Diabetes is the root of many other health issues, and when left untreated, can lead to blindness, kidney failure, heart attacks, stroke, the need to amputate body parts, and even death. Here are the different kinds of diabetes, though all types deal with the inability to produce enough insulin, or the body not responding properly to the insulin produced.

  • Type I – Often known as ‘juvenile diabetes’, this type of diabetes is a result of an autoimmune response which causes the death of beta cells in the pancreas. Beta cells are responsible for synthesizing and secreting insulin, which means in these cases, the pancreas does not produce enough insulin, and those with this disorder require insulin from outside in order to survive. Why the autoimmune response happens that causes the loss of beta cells, is unknown. This type of diabetes is often referred to as ‘insulin-dependent diabetes mellitus’.
  • Type II – Often called ‘adult-onset diabetes’, this disorder has to do with insulin resistance, in which case cells don’t respond to the insulin around them appropriately. Progression of type II diabetes can lead to a lack of insulin overall. This type of diabetes is generally caused by being overweight or not getting enough exercise (or a combination of the two.) Since it doesn’t relate to an actual inability of the body to produce insulin, its called ‘non insulin-dependent diabetes mellitus’.
blood sugar levels
  • Gestational diabetes – This third type of diabetes is specific to pregnant women. It occurs in women who have no previous issues with diabetes, but whose pregnancies cause high blood sugar levels to develop. This condition is temporary due to the pregnancy, and the symptoms go away upon the pregnancy ending.
  • Prediabetes – This isn’t a specific type of diabetes, but relates to having high blood sugar levels, that simply aren’t high enough to consider type II diabetes. It can be expected that the majority of people who get this diagnosis, will end up with type II diabetes if they do not change their lifestyle.

A couple things to know: when talking about ‘blood sugar levels’, we’re talking about the glucose level in the blood. And when referring to insulin, we’re talking about the hormone produced by the body in the pancreas that’s responsible for getting the glucose from the bloodstream to the cells of the body. Since this deals with sugars, it means those with diabetes must be careful what they eat in terms of simple and complex sugars. Simple sugars/carbohydrates are what is found in fruits, vegetables, and dairy products. Complex sugars/carbohydrates, are what is found in bread, pastries, and anything else considered a carbohydrate.

What is THCV?

At this point, whether a person agrees or not, it should be well understood that the cannabis plant is being looked to as a remedy for a number of different health concerns, with varying amounts of research, historical evidence, and anecdotal data to back up claims. But this doesn’t mean every part of the plant is good for everything, and sometimes it takes researching different compounds within a plant to establish which parts can be beneficial, and for what.

As it turns out, one of the newer cannabinoids to make headlines recently, and enter into the unregulated cannabis market of America, is THCV. So, what is this compound? THCV stands for tetrahydrocannabivarin, and it’s a homologue of delta-9 THC. This means it differs from delta-9 in terms of a repeating unit, but is otherwise the same. In this case it has to do with propyl side chains. Delta-9 has three carbon atom side chain, whereas THCV has a five carbon atom chain. This difference in the number of carbon atoms in the chain, makes for two compounds which a body responds to differently. THCV is a CB1 antagonist, and a CB2 partial agonist. This means, it disrupts – or interferes with – actions at the CB1 receptors, and binds to CB2 receptors where it can activate it, but not fully. In contrast, delta-9 is a CB1 agonist.

THCV does not start as THCA – like delta-9, but rather has a precursor of CBGVA (cannabigerovarin acid). This then breaks down to THCVA (tetrahydrocannabivarin carboxylic acid), which is then decarboxylated to form THCV.

Cannabis & THCV for diabetes

There are a couple things about THCV that make it a possible answer for the growing diabetes problem. The first thing about THCV is that it can effect appetite. Most of us are aware of the phenomenon of ‘munchies’ whereby you smoke a little pot and then get insanely hungry, sometimes to ridiculous and inhuman levels. This effect can often cause people to overeat, because the delta-9 THC is acting as an agonist at the CB1 receptor.

Conversely, THCV is an antagonist at the CB1 receptor, and has shown to reduce hunger, thereby reducing food intake (or the desire for food intake). While it hasn’t undergone testing in humans, it has shown hypophagia effects in mice, meaning it can suppress appetite and food intake. This was true in mice that had, and had not, eaten. It was found in this study: Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice, that food suppression continued for 6-8 hours after administration, with the same results for four days straight.

NEW: Delta 8 + THCV Carts

Delta 8 + THCV Sour Tangie - Sativa
Delta 8 + THCV Sour Tangie – Sativa

No rebound effect was noticed, meaning the animals went back to their regular feeding routine by the next day. It was found however, that when a THCV-rich extract was used (as opposed to pure THCV), the hunger and food intake suppression didn’t happen, which the scientists expect might have been because of residual amounts of delta-9, which impacted the THCV’s ability to work.

THCV has shown yet another useful property for dealing with diabetes, particularly as it relates to obesity. THCV seems to have properties that can help with the glucose intolerance often experienced by obese people. Once again done with mouse models, this study: The cannabinoid Δ9-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity highlights how THCV can affect insulin resistance.

THCV

The study authors didn’t actually see a significant affect on food intake or weight reduction, but they did see THCV reduce glucose intolerance, depending on the dose given. It reduced the glucose intolerance in genetically obese mice, and improved glucose tolerance with increased insulin sensitivity in dietary-induced obese mice. THCV was also seen to restore insulin signaling in hepatocytes (liver cells) and myotubes (muscle fibers). What this means is, regardless of whether the mice were fat by nature, or by nurture, the THCV improved glucose tolerance, and insulin signaling, and in the case of being fat by nurture, also increased sensitivity to the insulin that was present.

These studies were done in mice, and more will have to be done with humans to verify this is true for humans as well. The preliminary understanding as per the mice studies, is that THCV – at the right doses – can affect appetite and food intake, as well as glucose intolerance and insulin sensitivity and signaling. Considering how much of America, and how much of the world, is growing horizontally, the ability of THCV to provide help for diabetes, might make it one of the best, and most useful, benefits of cannabis.

Save bid on THCV Vape Cartridges

THCV Vape Cartridges
THCV Vape Cartridge 6-pack

Why do we care if THCV is good for treating diabetes?

To give an idea of why this condition deserves some extra attention, according to the World Health Organization:

  • The number of worldwide diabetes cases rose from 108 million in 1980 to 422 million in 2014. Considering that obesity levels have increased threefold since 1975 on a global level, with a staggering 42.4% of the US population weighing in at obese levels in 2017-2018, the expected number of diabetes cases will only rise from here.
  • There was a 5% increase in premature death rates between 2000-2016 due to diabetes.
  • In 2019 alone, there were approximately 1.5 million deaths directly related to diabetes.
  • In 2012 alone, 2.2 million deaths were attributable to high blood sugar levels.

When looking just at the US, according to diabetes.org:

  • As of 2018 numbers, about 10.5% of the US population has diabetes, which equals about 34.2 million people. Of these cases, only 1.6 million relate to type I diabetes, and the rest denote cases that exist purely because of bad health issues.
  • Only about 26.8 million of the previous number have been diagnosed. The rest are undiagnosed cases.
  • There are approximately 1.5 million new diagnosed cases per year.
  • As of 2015, 88 million people in America have prediabetes.
  • In 2017, diabetes was the 7th leading cause of death in the US, accounting for 83,564 deaths where diabetes was named as an underlying factor on the death certificate, and a total of 270,702 death certificates that year which mentioned diabetes as a cause of death.
  • The previous bullet point only relates to reported diabetic deaths, whereas studies have found that as many as 60% of diabetic deaths may never be attributed properly to the disease, making it highly underreported.
  • The total cost of dealing with diagnosed diabetes is approximately $327 billion per year, based on numbers from 2017.

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Conclusion

That the world is getting fatter at break neck speeds is something we all kind of know. It’s everywhere around us. In the extra-large size clothing, in the horribly unhealthy food (and increasingly large portions of it), in the lack of exercise and sedentary lifestyles, and in the expanding waistlines that just seem to expand out further.

Technically, we don’t need a cannabis compound, we need to eat better and exercise more. But people don’t always have the time or education be as healthy as they should, and for this reason, having something that can aid those having issues, becomes more crucial. In a better world, we’d make sure people were actually taking care of themselves appropriately. In this one, we’re lucky to have cannabis compounds like THCV, which offer help for those suffering from ailments like diabetes.

Welcome to CBDtesters.co, your best online location for the most relevant and interesting cannabis-related news from around the globe. Give us a read-thru every day to stay on top of the ever-changing universe of legal cannabis, and sign up to get our newsletter, so you always know what’s going on.

THC-O Disposables
THC-O Disposables

DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

The post THCV From Cannabis Might Be Best Bet For Treating Diabetes appeared first on CBD Testers.

Introducing The New Delta 8 + THCV Vape Cartridges

Have you tried the new THCV vape cartridges? THCV (tetrahydrocannabivarin) the new cannabinoid everyone is talking about, but what exactly is it good for, why the new blend of Delta 8 THC with THCV works so well together and what are the best THCV vape cartridges?

Before looking at the best Delta 8 + THCV vape cartridges, we would like to remind you that the most attractive Delta 8 THC deals are reserved for the subscribes of the Delta 8 Weekly Newsletter. Subscribe below to be included:

What is THCV good for and why should it be used together with Delta 8 THC?

While Delta 8 THC might give you a great body-buzz and relaxation, THCV might provide mental clarity, productivity and focus. Using them together might create a super sativa effect – mind & body relief.

People who uses THCV sometimes claim that it helps them for improving mood and focus to the mind. In addition, THCV is known by the fact that people are using it to balance their appetite, so if you are getting the munchies after using cannabis, adding THCV to the formula might do the trick for you…

Possible health benefits

While more research is needed, people who have been using THCV (with or without other cannabinoids) already report that it has been helping them with their symptoms.

Unlike regular THC, that increases appetite THCV might be an appetite suppressant and hence, may assist in maintaining your weight. While it is not a miracle diet pill, it will probably won’t produce the same reaction cannabis does and won’t make you run to the refrigerator.

In addition, there is a potential in researching if THCV may help with treating diabetes, by regulation blood sugar levels and reducing insulin resistance (see research). Another potential health benefit could be using THCV to reduce panic attacks, and more research is needed here as-well. Some people are interested to learn if THCV can assist treating the symptoms of Alzheimer’s and finaly, more research is needed to find out if THCV may stimulates bone growth. 

Please be advised that the statements above are not based on research, haven’t been approved by the FDA and shouldn’t be taked as medical advise.

Best THCV Vape Cartridges

We would like to thank the Delta 8 Weekly Newsletter, in preparing this list. SUBSCRIBE today and learn first about new Delta 8 deals, coupons and discount.

BEST CHOICE:

THCV + Delta 8 Vape Cartridges – BUNDLE

THCV + Delta 8 Vape Cartridges – BUNDLE

If you are looking for the perfect blend, try the new THCV + Delta 8 + CBD vape cartridges, currently on sale.

While Delta 8 THC gives a great body-buzz and relaxation, THCV is made to help give mental clarity, productivity and focus. Similar to a “super sativa“. In addition, THCV might be also responsible in balancing your appetite (so if you are get the munchies after using cannabis, THCV might be the one for you…)

Each cart use 20% THCV, 30% Delta 8 THC, 45% CBD/CBN/CBC, and 5% Terpenes.

Current deal: save big on the 6-pack bundle with our Delta25 discount code. The bundle includes 2 of each of the following flavors: Purple Haze (for energy, mood, and creativity), Sour Tangie (for happiness) & Candyland (for feeling social and uplift).

TIP: Choose the 6-pack bundle and don’t forget to use Delta25 coupon code for an additional 25% discount (only valid for the bundles).

Click HERE to get THCV + Delta 8 vape cartridges

(With ‘Delta25’ coupon code)

Purple Haze THCV + Delta 8 THC Vape Cartridge

Loooking for energy, mood, and creativity? Try the Purple Haze THCV + Delta 8 vape cartridge. This Sativa cart, cuurently on sale as part of the 6-pack bundle, is perfect for focusing on tasks, while giving a smooth flavor and a peaceful feeling.

TIP: Choose the 6-pack bundle and don’t forget to use Delta25 coupon code for an additional 25% discount (only valid for the bundles).

Click HERE to get THCV + Delta 8 vape cartridges

(With ‘Delta25’ coupon code)

Candy Land THCV + Delta 8 THC Vape Cartridge

Candy Land THCV + Delta 8 THC Vape Cartridge
Candyland THCV + Delta 8 THC Vape Cartridge

Want to feel social and uplift? Try the Candyland THCV + Delta 8 vape cartridge. This Sativa cart, cuurently on sale as part of the 6-pack bundle, is perfect for social gatherings or creative pastimes, while giving a great slightly sweet flavor and an enjoyable feeling.

TIP: Choose the 6-pack bundle and don’t forget to use Delta25 coupon code for an additional 25% discount (only valid for the bundles).

Click HERE to get THCV + Delta 8 vape cartridges

(With ‘Delta25’ coupon code)

Sour Tangie THCV + Delta 8 THC Vape Cartridge

Sour Tangie THC-V + Delta 8 THC Vape Cartridge
Sour Tangie THCV + Delta 8 THC Vape Cartridge

Searching for happiness? Try the Sour Tangie THCV + Delta 8 vape cartridge. This Sativa cart, cuurently on sale as part of the 6-pack bundle, is perfect for getting a mood boost during the day, while giving a fantastic fruit flavor and a happy feeling.

TIP: Choose the 6-pack bundle and don’t forget to use Delta25 coupon code for an additional 25% discount (only valid for the bundles).

Click HERE to get THCV + Delta 8 vape cartridges

(With ‘Delta25’ coupon code)

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Affiliate disclaimer: We work hard to find and verify the best products, so we may include affiliate links to support the maintenance and development of this site.

The post Introducing The New Delta 8 + THCV Vape Cartridges appeared first on CBD Testers.

Best Hybrid Delta 8 THC Products – With Delta 10, THCV, CBD, CBN, or CBC

In the last few months it has been Delta 8 everywhere. From Delta 8 vape cartridges, to gummies, to tinctures, to moon-rocks and even Delta 8 hash, this new cannabinoid has become the hottest trend of 2021. Now, just in time for the summer, we are looking into the next big thing: Hybrid Delta 8 THC Products.

Hybrid Delta 8 THC products are formulas that are based on a blend of Delta 8 THC with other cannabinoids, usually, Delta 10 THC, CBN, CBD, THCV or CBC. These special formulas have been gaining popularity lately, as people find them to be very effective in reducing their suffering. Whether it is stress, sleep, anxiety or pain, the common problems people use cannabinoids to treat their symptoms, the new hybrid Delta 8 products, offer us new remedy for our suffering.

To help you find the best hybrid Delta 8 THC products we have created a short-list of products that you should try first. Some of of the products below are sold in bundles, perfect for stocking-uo opportunities as the price is very attractive that way.

We would like to thank the Delta 8 Weekly Newsletter, in preparing this list. SUBSCRIBE today and learn first about new Delta 8 deals, coupons and discount.


Best Hybrid Delta 8 THC Products – Summer 2021

#1 Delta 8 + Delta 10 Hybrid Products

Delta 10 THC is The latest cannabinoid to enter the market. While it is still too-early to say if it will become as popular as Delta 8, we can already see that Delta 8 + Delta 10 THC hybrid products are becoming a best-seller.

With ratio of 2:1 (60% Delta 8, 30% Delta 10 THC and 10% terpenes), these new hybrids allow you to experience the unique benefits of the new THC’s.

Choose between Delta 10 vape cartridges, Delta 10 tinctures and Delta 10 disposables.

Want to learn more about Delta 10 THC? Don’t forget to visit the Best Delta 10 THC Deals.

BEST CHOICE:

VIBIN’ Delta-10 THC Tincture

Because you deserve a long-lasting euphoria…

NEW: Delta-10 THC Tincture
NEW: Delta-10 THC Tincture

Want to try something new? The Delta 10 VIBIN’ Tincture is everything you ever hoped for and even more!

With 300mg Delta 10 and 700mg Delta 8 in every bottle, this best-selling product will let you experience the unique benefits of Delta 10 THC, softly blended with Delta 8, which we all know to love. If you are looking for a ‘mental euphoria‘ and wish to feel ‘happy and motivated‘ this product might be the one for you!

Size: 30ml

Strength: 1000mg/Bottle: 700mg of Delta 8 THC + 300mg Delta 10 THC

Terpenes Used: Sour diesel, Blueberry OG

Current deal: Get it for as-low-as $25/bottle, when buying the 3-pack bundle and using the Delta25 coupon for an additional 25% discount.

Click HERE to buy Delta-10 THC Tinctures

(With DELTA25 coupon code)

Want to sell hybrid Delta 8 THC products in your shop?
Click HERE to register a wholesale account

The ‘Euphoria Collection‘ Delta 10 Vape Cartridges

Experience the new high of Delta 10 THC!

The 'Euphoria Collection' Delta 10 Vape Cartridges
The ‘Euphoria Collection‘ Delta 10 Vape Cartridges

Have you ever tried Delta 10 THC vape cartridges?

Experience the benefits coming from the blend of 70% Delta 8, 20% Delta 10, and 10% cannabis terpenes. Thanks to the perfect blend of Delta 8 and Delta 10, these next generation vape carts are proven to take you to a new high

Save big on the ‘Euphoria Collection‘ Delta 10 THC vape cartridges. Use coupon code Delta25 for the additional 25% discount and get a 6 pack or 12 pack bundle for a great price. 

INSTRUCTIONS: Choose between: 6-pack and 12-pack bundle and don’t forget to use Delta25 coupon code.

Click HERE to get the ‘Euphoria Collection‘ Delta 10 Vape Cartridges

(With ‘Delta25’ coupon code)

Want to sell hybrid Delta 8 THC products in your shop?
Click HERE to register a wholesale account


Delta 10 THC Disposable Vapes – Premium Bundle

Lightweight, Compact & Easy-to-use

Delta 10 Disposable Vape Bundle
Delta 10 Disposable Vape Bundle

Need a winning product? Take Delta 10 THC on-the-go with these lightweight, compact & easy-to-use disposables, currently on sale! With the prefect blend of Delta 8, Delta 10 THC & terpenes, the new ‘Euphoria Collection‘ disposables offer us an unforgettable vaping experience.

Each bundle includes the following carts: Blue Candy Kush (Indica), Ekto Kooler (Sativa) and Wedding Cake (Hybrid).

TIP: Choose the 6-pack and get an additional 25% discount using the Delta25 coupon code. That’s only $22.5/cart, the lowest price anywhere for Delta-10 Disposables!

Click HERE to get the Delta 10 disposables

(With ‘Delta25’ coupon code)

Want to sell hybrid Delta 8 THC products in your shop?
Click HERE to register a wholesale account


Delta 8 & Delta 10 Hybrid Moon Rocks

Delta 8 & Delta 10 Hybrid Moon Rocks
Delta 8 & Delta 10 Hybrid Moon Rocks

If you are looking for the next-level experience, we have just found the right product for you!

Imaging a high-quality Delta 8 moon-rock, the one that makes you smile for hours. Now, add to it Delta 10 THC, find a good spot, and take the rest of the day off…

If you are looking for the next-level experience, we have just found the right product for you!

Click HERE to get the Delta 8 + Delta 10 Moon Rocks


Want to sell hybrid Delta 8 THC products in your shop?
Click HERE to register a wholesale account


Delta 8 + Delta 10 THC Hash

Hybrid Durban Poison Delta 10 & Delta 8 Hash
Hybrid Durban Poison Delta 10 & Delta 8 Hash

Some people just love hash, their pipe, or both, and for a very good reason…

The new Hybrid Durban Poison Delta 10 & Delta 8 Hash, is both high on CBD, Delta 10 THC, Delta 8 and CBN. In-fact, it is infused with the same potent D10 distillate used for the Moon-Rocks (above). The result is no-less than amazing and if you ever wanted to try Delta 8 or Delta 10 THC hash, now it’s your chance to do so!

Click HERE to get Delta 8 + Delta 10 THC Hash


Want to sell hybrid Delta 8 THC products in your shop?
Click HERE to register a wholesale account



#2: Delta 8 + CBN Hybrid Products

Having sleep problems? You might want to try the new Delta 8 + CBN products.

As stress, anxiety and hyper-alertness disrupt our natural sleep-wake patterns, new cannabinoid-based formulas are offering us a very promising solution. While we still don’t know for sure, looks like CBN (cannabinol) might have unique benefits when treating sleep problems. Blend it with Delta 8, and you will go to sleep with a big smile on your face. Happy and relaxed…

Want to play it safe? Try mixing Delta 8, CBD and CBN. A match made in heaven…

Delta 8, CBD & CBN Tincture

D8+CBD+CBN 1500/100/500 Tincture
Delta 8, CBD & CBN Tincture

If you are looking for a powerful relaxation formula, we have found the best one for you! With three powerful cannabinoids in one convenient bottle, the new Delta 8, CBD & CBN 1500/100/500 tincture, is your best choice!

Each bottle cotains 1500mg of Delta 8 THC, 1000mg CBD and 500mg CBN for maximum effectiveness. Looking for a stronger product, look for the 2500/1000/750 or the mighty 5000/1500/1000 DB/CBD/CBN tinctures.

Choose between: CalmEnergyMintNaturalRecoveryRest flavors.

TIP: Use cbdflowers coupon code for an additional 20% discount.

Click HERE for the Delta 8, CBD & CBN tincture

(With cbdflowers coupon code)

Want to sell hybrid Delta 8 THC products in your shop?
Click HERE to register a wholesale account


Comfortably Numb: D8 + CBN Tincture

Beside having a great name, Comfortably Numb by 3Chi is one of the best Delta 8 tinctures available for you today.

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Choose 1200mg for the best results.

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#3: Delta 8 + THCV Hybrid Products

The new cannabinoid everyone is talking about is THCV, but what exactly is it good for?

While more research is needed, we already can identify a few potential medical benefits using THCV (the statements below are NOT based on research and shouldn’t be taked as medical advise!):

Unlike regulr THC, THCV might be an appetite suppressant and may assist in reaching your weight loss goals. this is probably the most important thing we can say about THCV today.
In addition, THCV may help with treating diabetes, by regulation blood sugar levels and reducing insulin resistance (see research), THCV may reduce panic attacks, THCV may even help with Alzheimer’s and finaly, THCV may stimulates bone growth. 

BEST CHOICE:

THCV + Delta 8 Vape Cartridges – BUNDLE

THCV + Delta 8 Vape Cartridges – BUNDLE

If you are looking for the perfect blend, try the new THCV + Delta 8 + CBD vape cartridges, currently on sale.

While Delta 8 THC gives a great body-buzz and relaxation, THCV is made to help give mental clarity, productivity and focus. Similar to a “super sativa“. Relief made for both your body and mind. 

Each cart use 20% THCV, 30% Delta 8 THC, 45% CBD/CBN/CBC, and 5% Terpenes.

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#4: Delta 8 + CBC Hybrid Products

Although much of the global discourse regarding cannabis is focused on THC and CBD, cannabichromene (CBC) is next in line as the third most prominent compound in the plant, and of equal importance therapeutically. 

While more resrearch is needed, initial findings suggest the CBC (like CBD and THC) might assist in suppressing tumor growth. CBC also showed some very promissing anti-depressant activity and were said to have the a significant mood-elevating properties. Lastly CBC may produce an antinociceptive response that helped control pain, minimize digestive issues, and offered neuroprotective qualities.

Limitless Delta 8 CBC Vape Cartridge

The most incredible entourage effect you can imagine!

Limitless Delta 8 CBC Vape Cartridge
Limitless Delta 8 CBC Vape Cartridge

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Limitless Delta 8 CBC Tincture

Providing you all the relief you need

Limitless Delta 8 CBC Tincture
Limitless Delta 8 CBC Tincture

With 1200mg of Delta 8 THC and 500mg CBD, the Limitless Delta 8 CBC Tincture gives you the most incredible entourage effect providing all the relief you need. Choose it if you want a very potent product that will make your life more enjoyable.

Effects: Incredible relief: uplifting yet relaxing, euphoric, clear headed, focus & lucid thinking.

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The post Best Hybrid Delta 8 THC Products – With Delta 10, THCV, CBD, CBN, or CBC appeared first on CBD Testers.

Minor cannabinoids: What are they and why are they trending?

Minor cannabinoids have been getting a lot of attention lately, and for good reason. What exactly are minor cannabinoids and why have they been trending? What are minor cannabinoids? When it comes to cannabis, THC and CBD often take the spotlight. But they’re just two of at least 110 different cannabinoids found in the cannabis […]

The post Minor cannabinoids: What are they and why are they trending? appeared first on Latest Cannabis News Today – Headlines, Videos & Stocks.

Decarboxylation: How Cannabis Becomes Psychoactive

Decarboxylation, which is an essential action in enjoying cannabis flowers and edibles, is a process in which carbon dioxide (CO2) leaves a stable molecule and floats off as a gas. Atoms in a molecule can be thought of like billiard balls, with each one having a size, weight, and exact position. As these atoms float away, the substance left behind will become lighter, like a dry towel being lighter than that same towel soaking wet. The idea is that as the CO2 leaves, the weight left behind is reduced.

Decarboxylation typically occurs by heating, but can also be caused by exposure to certain frequencies of light, and certain substances like molecular oxygen in the air.

If the weight of the molecule before and after its decarboxylation is known, then a percent of mass lost in decarboxylation can be calculated. If the CO2 contributes 10 percent of the weight of a molecule, than 90 percent of the mass remains after decarboxylation. This would mean that continuously heating 100 grams of this substance would eventually yield 90 grams of the decarboxylated substance, as the remaining 10 grams represent the weight of CO2 which gassed off.

How Does Decarboxylation Affect Cannabinoids?

Decarboxylation of cannabinoids and cannabis products is very crucial to understanding the power of cannabis as medicine. The cannabis plant only has the ability to produce cannabinoid acids, like THCA, and THC is only created by decarboxylation outside the plant. This decarboxylation is usually done by fire when smoking, or by baking in edibles. Most cannabinoids lose approximately 87.7 percent of their mass upon decarboxylation. This means that if you had 100 grams of crystalline isolate of a cannabinoid acid, such as THCA, after decarboxylation you would have 87.7 grams left of THC.

This is important for people decarboxylating their cannabinoids themselves, such as producers of cannabis-infused edible products and hash oil producer that wish to sell decarboxylated oil. This is also important for advertisers of raw cannabis products such as cured cannabis flower, who must either report the value of the cannabinoid acid directly observed by the testing lab, use the theoretical conversion, or display both.

This labeling issue with raw flower is not as easy as it seems at first glance. Let’s consider a typical example of THC-dominant cannabis. The lab will test the flower and find 26 percent THCA and 3 percent THC. This is because some of the cannabinoid acids produced by the plant are decarboxylated by air and sun before harvesting and curing. The smaller the amount of THC observed directly by the lab typically indicates that the cultivator has submitted fresh cannabis that has been protected from light and exposure. A very high THC content indicates that the cannabis flower is not as fresh and been more exposed.

Now the dispensary has to either advertise two numbers, 26 percent and 3 percent, or advertise one theoretically calculated number, 25.8 percent, or both. Both allow the patient to access the greatest amount of information and be the best informed, while also reducing liability on the cannabis business involved in label making.

Tetrahydrocannabinol (THC) is a well-known cannabinoid for being the primary intoxicant and euphoriant of cannabis. THC is also one of the most practical and safe treatments for neuropathic, chronic, and other types of pain. THC is effective in addressing both the immunological and symptom component of multiple sclerosis (MS).

Despite the fact that THCA is not an intoxicant, it is a powerful medicine. THCA is one of the strongest anti-inflammatory agents in cannabis. Smokers receive very little to none of this cannabinoid, due to its decomposition in the smoking process. THCA is an anti-inflammatory agent, and according to one study, a more powerful neuroprotective agent than THC. THCA is a powerful COX-1 and COX-2 antagonist, similar to aspirin and ibuprofen, but with far less toxicity to the liver.

The effects of THCA and THC reflect the diversity of action on the human body a cannabinoid and its precursor acid can have. The other cannabinoids, CBD, CBG, CBC, and THCV all have acid forms which have distinct effects on human health.

Cannabidiol (CBD) has been shown to be an effective medicine for people suffering from anxiety. What CBD has also been shown to be effective at fighting is breast cancer cells. Many of these studies find that CBD promotes apoptosis, or cell suicide, in breast cancer cells while leaving the healthy cells unaffected.

Cannabidiolic acid (CBDA) is CBD’s acid precursor from raw cannabis flower. CBDA has also been shown to fight human breast cancer, but in a different way. Whereas CBD causes apoptosis in breast cancer cells, CBDA has been shown to slow or stop metastasis of breast cancer cells by arresting their motility, or ability to move throughout the body. This evidence would indicate that a breast cancer patient may want to talk to their doctor about dual CBD/CBDA therapy, taking both decarboxylated CBD and raw CBDA together.

Cannabigerol (CBG) has been shown to have some potent anti-inflammatory properties that are particularly applicable in inflammatory bowel disease (IBS). Additionally, CBG has been shown to have some properties not known among many other cannabinoids, such as an ability to interact with human adrenal receptors and serotonin receptors. Currently, more studies need to be done on cannabigerolic acid (CBGA) in isolation from CBG to get an understanding what, if any, difference there are between the cannabinoid and its precursor acid on human health.

It is important to note that the mass loss is not a conversion rate. Mass loss assumes that all of a substance will decarboxylate and calculates how the mass will change. An accurate answer must account for how much of the cannabinoid will decarboxylate. Studies indicate that 30-70 percent of cannabinoids undergo decarboxylation under standard smoking conditions. This is why our calculations are only a theoretical maximum, and are not a result with the same standing as those directly observed in the plant. This is also why it can be very important to label your theoretical calculations as such, and provide all original values provided by lab results, as a means of reducing liability upon your business.

TELL US, have you ever heard of decarboxylation?

The post Decarboxylation: How Cannabis Becomes Psychoactive appeared first on Cannabis Now.

Customize Your Cannabinoids – Now You Can Mix’ N’ Match

Most of what’s gone on in the field of medicinal cannabis has been related to simply isolating and/or replicating a specific cannabinoid to get its benefits. In today’s world of cannabis medicine, the new thing is for a customer to order a premium blend of their favorite compounds, because today, you can actually customize your cannabinoids.

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Isolating cannabinoids

There’s plenty in the worlds of medicinal cannabis and recreational marijuana that have nothing to do with isolating anything. If a person wants to smoke hemp flowers, or buy a few grams of high-THC weed, they’re getting the whole plant, no isolation needed. However, the fields of medical and recreational cannabis have been more and more reliant on the idea of isolated cannabinoids. CBD is the most popular right now, with CBD oil and vape cartridges flying off store shelves all over the world.

Much like with other forms of pharmaceutical medicine, where we often pop a pill without really thinking what that circular, chalky, perfectly-shaped tablet contains, where it came from, and how it got to be in the form we take it in, we don’t often question how our CBD oil came to be.

Cannabinoids don’t start out as cannabinoids, but rather as acids that must be heated – or decarboxylated – in order to form into the cannabinoids we are familiar with like THC, CBD, and even the rarer CGBV, and THCV. Solvents are then used to separate certain parts. These can include, ethanol, hydrocarbon (butane, propane…), chloroform, light petroleum, and CO2 – which doesn’t leave a residue.

personalized cannabis medications

After extraction with one of these solvents, the solution is filtered at least a couple times, generally through something like charcoal. Then it should be made more concentrated, down to about half the volume, using a 2% aqueous sodium sulfate solution. When the solvent is stripped out, and the solution is concentrated, its left as a crude oil. At this point it can even be purified further with redistillation or column chromatography.

After extraction, the oil is put in alcohol, mixed, cooled (to remove unwanted terpenes, chlorophyll and flavonoids), and then heated to burn away the alcohol. Something called short path distillation is used to isolate different compounds using their individual boiling points. A pure powder of a specific cannabinoid is left at the end which can then be used in different ways for different kinds of products. It might not be important to know all the steps of isolating a cannabinoid, but understanding it as a process is important, because this process takes time and money.

Rare cannabinoids

We’re all familiar with THC at this point, as it is the most prevalent cannabinoid of the cannabis plant (for high-THC marijuana). Most of us now know a good bit about CBD too, which also can be found in plentiful amounts, particularly in low-THC hemp.  We also know there are more than 100 cannabinoids in the cannabis plant, even if some of them appear in only trace amounts. The ability to isolate some of these rarer cannabinoids through the process above, gives users that much more choice in terms of products, and the ability to now formulate different mixtures of cannabinoids. Some rarer cannabinoids, and cannabinoid acids, that are now becoming more popular due to the ability to isolate them, are the following:

  • CBG – Cannabigerol – Comes from acidic precursor CBGA and makes up less than 1% of a cannabis plant.
  • CBN – Cannabinol – A phytocannabinoid with THC as a precursor.
  • CBC – Cannabichromene – The second most prevalent cannabinoid in cannabis.
  • CBCA – Cannabichromenic Acid – The acidic precursor to CBC.
  • CBGA – Cannabigerolic Acid – The precursor acid that transforms into acids THCA, CBDA, and CBCA, which in turn produce other cannabinoids.
  • CGBV – cannabigerivarin – A cannabinoid acid with CBG as a precursor.
  • CBNA – Cannabinolic acid – The parent compound that transforms to CBN through decarboxylation.
  • CBCV – Cannabichromevarin – Closely related to CBC, with the difference of a propyl chain.
  • CBDV – Cannabidivarin – Closely related to CBD, and mainly found in cannabis indica landrace strains, generally from Asia and Africa.
  • THCV – Tetrahydrocannabivarin – Similar to THC, and does produce a psychoactive effect.
  • CBDA – Cannabidiolic acid – The precursor to CBD that exists in acid form.
  • THCA – Tetrahydrocannabinolic acid. The precursor to THC that exists in acid form.

And many more, most of which have gotten so little attention as of yet, that there isn’t much written about them, or studies yet performed on them. Whereas major cannabinoids like THC and CBD can take up about 2-20% of a plant’s biomass, these lesser cannabinoids generally make up less than 1%.

medicinal cannabis

One of the interesting things about cannabinoids, though, is that they each have their own medicinal profile, as they are all unique compounds unto themselves. Sometimes you might want something pure, like CBD oil. Maybe other times you want the whole plant, and the synergistic effect of all parts working together. And on other occasions, you might want to mix and match the different parts and pieces available, to customize your cannabinoids to create medicines very specific to your particular wants and needs.

Mix n match

This new industry of customizing cannabinoids is only just beginning, but it does seem to be taking off. The companies that offer this service are offering a way to create custom medicines, while also introducing customers to lesser known cannabinoids, and cannabinoid acids. The idea of personalized medication is conceptually new to Western medicine. While different people are given different medications to take, in different quantities, pharmaceutical medications are not formulated with a specific person in mind, or tweaked to meet that specific person’s needs. Natural medicine traditions are much more likely to create specialized medication for patients, and this new movement towards the ability to customize your cannabinoids is a mirror of this concept. Instead of the standard ‘trial and error’ in standard medicine, where a person might be cycled through tons of different medications to find something that works specifically with their genetics, the idea is now to tweak the meds to meet the person’s needs.

Companies getting in on it

Global Cannabinoids is a Las Vegas based CBD oil company that now offers something else. CBD oil, and other private label products, that can be customized by the buyer to have an exact profile of cannabinoids – rare and not rare – to meet their needs. This is twofold in that it exposes people to more rare options than the standard CBD, while also giving a level of personalization.

Global Cannabinoids is already one of the biggest white label and private label suppliers of CBD, as well as a leading ingredient supplier for brands that use hemp-derived cannabinoids for their product lines. The company is one of the biggest suppliers for wholesale and bulk cannabinoids, even rarer ones. Customers can purchase CBN, CBC, CBG, and CBDV in the ratios of their choosing. Obviously, there are plenty more rare cannabinoids, as mentioned above, but this opens the door, and gets the ball rolling for using rare cannabinoids at all.

Another company moving in the same direction, is Socati, a company based out of Houston, Texas with a Montana-based facility for manufacturing cannabinoid ingredients, that is known for producing USDA certified organic hemp products. Now, they’re opening up their offering a bit more, just like Global Cannabinoids. Socati recently launched a line of private label products offering the ability to customize your cannabinoids. Custom ratios of CBD, CBG, CBN, and other rare cannabinoids can be made per personal desire in the following products: gummies, tinctures, crystalized flavor powder, pressed tablets, softgels, and capsules.

medicinal cannabis

Precision Plant Molecules is another company now offering a tailored cannabinoid experience. The company is a specialty cannabinoid-based ingredient supplier. It extracts and processes hemp to create distillates, oils, concentrates, extracts, and isolates. While there isn’t much press about the company’s ability to customize your cannabinoid experience, it is explained on their website. PPM uses several minor cannabinoids along with CBD, like: CBN, CBC, CBG, CBT, CBDV, THCV, CBGA, CBDA, and others. According to its website: “Fully customizable ratios of cannabinoids afford more effective health and wellness products. Enriching to achieve a specified ratio of cannabinoids smooths the variability in even Mother Nature’s most stable chemovars.” I expect we’ll be hearing more about this company in the news soon.

The same can be said for Trait, which also hasn’t quite made big news, but which now with Trait Tailored, is also offering customized cannabinoid combinations. According to its website, “Trait Tailored’sTM patent pending technology enables growers to perfectly customize the cannabinoid profiles of their hemp or cannabis strains with ground-breaking precision.” It goes on to say, “With TailoredTM, growers are able to produce strains with greater volumes of CBD, CBG, CBC and other less common cannabinoids to make more refined and desirable products for consumers.”

Conclusion

Customizable medicine is certainly a new thing for most people. As the field of medicinal cannabis grows bigger and bigger, more options are being made available that were never a part of standard Western medicine before. Now, instead of cycling through tons of meds to find the one that works, you can customize your cannabinoids to create the perfect combination for all your health needs.

Thank you for stopping by CBDtesters.co, your hub for all cannabis-related news. Stop by regularly to stay up-to-date, and sign up to our newsletter so you’re always in the loop.

Resources

What are THCV Flowers, and How Are They Different from What You’ve Been Smoking? (Why THCV flowers are unique)
Everything You Need To Know About CBD Isolate (a deep look into hemp extracts)

German Cannabis Flower Market is Ready to Explode
Delta-8 THC Contaminated Products, or Just Bad Press?

Everything You Need To Know About CBG Isolate
Newest Cannabinoid Powerhouse – CBC – What Can It Do for You?
What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8THC)

Cannabis Cosmetics: What’s Allowed, What’s Not, and Where to Find Them (What is the latest regulations in Europe and which products are allowed)
CBG Study Shows Antimicrobial Properties of Cannabis
The CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers)
The Medical Cannabis Weekly newsletter (International medical cannabis business report)
The Legal Landscape Of CBD Hemp Flower In Europe

The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc)Regulators Go After Smokable Hemp Flower – What Does The Future Hold?
Investing in Delta 8 THC Flowers – Is It The Right Move For Your Business? (All you need to know about the latest hot trend: Delta-8 THC)

The post Customize Your Cannabinoids – Now You Can Mix’ N’ Match appeared first on CBD Testers.

Everything You Need to Know About the Science Behind Cannabinoids

The cannabis plant produces literally hundreds of specialized molecules — cannabinoids, terpenes and flavonoids — that have been shown to deliver medicinal efficacy, lifestyle enhancement and even performance enhancement to human beings. For those afflicted with disease, medical cannabis has been found to offer a wide range of health benefits, from killing cancerous tumors to alleviating the pain of arthritis to reducing the number of seizures experienced by epileptic children.

Of these molecules, cannabinoids are the most cited and understood. The most infamous cannabinoid is tetrahydrocannabinol (THC), the molecule responsible for most of the psychoactive (psychotropic) and euphoric effects of cannabis, but that also has been found to successfully treat serious conditions, such as PTSD and cancer. Another notable cannabinoid is cannabidiol (CBD), a mostly non-psychoactive chemical that has been found to provide a wide range of medicinal benefits, including reductions in pain, anxiety and depression.

Endocannabinoids vs. Phytocannabinoids

First discovered in 1964 by Israeli researcher Raphael Mechoulam, phytocannabinoids from the cannabis plant interact with the human body by mimicking the molecular characteristics of chemicals produced internally. Called endocannabinoids, these internally manufactured molecules include anandamide and 2-AG.

Anandamide has been dubbed the “bliss molecule” because of its ability to decrease depression in humans. It plays a central role in the regulation and modulation of critical bodily functions such as mood, appetite, sleep, immune system efficiency and one’s ability to deal with stress and anxiety.

Synthetic Cannabinoids

Synthetic cannabinoids emerged in the 1970s and are created in a laboratory. An example of it would be dronabinol (Δ9-THC synthetic), which is the active compound of Marinol, a medicine that comes in capsules and has been consumed in the US since 1985 to prevent nausea, vomiting, loss of appetite and loss of weight.

The Endocannabinoid System

All mammals, not merely humans, have evolved with a network of specialized cellular receptors throughout their bodies that are designed to bind with cannabinoids — both endocannabinoids such as anandamide and phytocannabinoids from cannabis — that is called the endocannabinoid system (ECS).

The fact that the ECS is present in all mammals is why companies and product lines dedicated to the health and wellness of household pets are beginning to emerge in legal cannabis markets. Dogs and cats suffering conditions such as arthritis, digestive issues, anxiety and pain can gain significant benefit from the cannabinoids in cannabis and hemp.

Anandamide production has been found to increase and temporarily spike in those who engage in endurance exercise on a regular basis. However, it metabolizes quickly, exhibiting a relatively short duration of effect. Anandamide hints at the chemical underpinnings of the significant health benefits of frequent and intense exercise—and the fact that the mere consumption of cannabinoids is not enough to establish and sustain optimal health of the ECS (a condition called homeostasis that means “balance”).

Both internally produced endocannabinoids and plant-based phytocannabinoids interface with the ECS via specialized cellular receptors that were discovered in the 1990s and called CB1 and CB2. CB1 receptors are found mostly in the brain and central nervous system, whereas CB2 receptors are located primarily in the organs and tissues of the immune system—including the thymus, skin, bone marrow, lymph nodes, spleen, bowel and the mucous membranes of the bladder, genitals, nose and throat.

Major Cannabinoids + Acidic Precursors

More than 113 cannabinoids have been isolated and identified within the cannabis plant — which is, technically, also a vegetable. Beyond the two major cannabis-derived molecules, THC and CBD, are a plethora of healthful cannabinoids that deliver a slew of desirable and beneficial efficacies for lifestyle consumers and patients alike. Among these are cannabichromene (CBC), cannabigerol (CBG), cannabinol (CBN) and tetrahydrocannabivarin (THCV).

Additional healthful cannabinoids include tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA). These chemicals represent a class of cannabinoids dubbed acidic precursors. Think of acidic precursors as the larval caterpillar stage of what becomes the butterflies of THC and CBD.

While they provide significant benefits in terms of health and wellness, the exact effects of these molecules differ from their non-acidic versions. For example, while strains of cannabis that are potent in THC can exact a significant toll in terms of psychoactivity and euphoria, THCA delivers no such psychotropic effect. THCA does, however, offer anti-inflammatory and neuroprotective effects, making it helpful for conditions as wide-ranging as Alzheimer’s disease, arthritis, cancer, Crohn’s disease, fibromyalgia, multiple sclerosis and Parkinson’s.

Understanding Decarboxylation

The process by which the transmogrification from the chemical state of acidic precursor (THCA) to its child molecule (THC) occurs is significant (and can be accurately controlled by anyone). A process called decarboxylation, this conversion involves the application of heat (via flame, as in combustion, or from a hot surface or airstream, as in vaporization) to catalyze a chemical reaction in which the THCA molecule drops a carbon and two oxygen atoms (called a carboxyl ring, or COOH) to become THC — and gain its euphoric effects based on its newfound binding affinity with the CB1 receptors of the ECS.

Technically, maximum decarboxylation for a sample of cannabis flowers occurs most effectively when exposed to 220 degrees F (104 degrees C) for a period of 30 to 45 minutes. Decarboxylation is easy and convenient because it can be accomplished using a standard consumer oven.

Thus, one who eats the raw flowers of cannabis will gain significant medicinal benefits, but no euphoria. The simple application of a flame or hot air, however, leads to the nearly instantaneous transformation of these molecules into their chemical cousins, delivering beneficial — but sometimes very different — effects.

The Research

2017 research study entitled “Medicinal Cannabis: History, Pharmacology and Implications for the Acute Care Setting” that was published in the journal Pharmacy & Therapeutics found the cannabinoids of cannabis, such as THC and CBD, to be effective in the treatment of a wide range of diseases and conditions.

The study’s researchers stated, the “Beneficial cannabinoids exist, as evidenced by single-entity agents derived from cannabis containing the compounds THC and CBD.” The study concluded that “cannabis is relatively safe; therapy is self-titratable by the patient; and…therapy is relatively inexpensive compared with pharmaceutical agents.”

CBC is a powerful cannabinoid first isolated in 1964 by Israeli researcher Raphael Mechoulam. It is considered one of the “big six” cannabinoids that, according to Steep Hill Labs in Berkeley, California, is ten times more effective than CBD in treating anxiety and stress.

In a 2011 study conducted by cannabis research pioneer Ethan Russo entitled “Taming THC: Potential Cannabis Synergy and Phytocannabinoid-terpenoid Entourage Effects” and published in the British Journal of Pharmacology, Russo found that a CBC-extract displayed “pronounced antidepressant effect,” meaning it may be helpful for humans suffering from anxiety and depression.

Additional evidence of the medical benefits of cannabinoids derived from cannabis — this time for an ocular disease — was revealed in a 2008 study entitled “Possibilities of Applying Cannabinoids in the Treatment of Glaucoma” that was published in the journal Klinika Oczna. The study concluded that cannabinoids like CBG are “able to decrease intraocular pressure. These compounds are characterized by neuroprotection and vasodilatation properties that additionally substantiate their therapeutic utility in conservative treatment of glaucoma.”

Originally published on cannabisaficionado.com.

The post Everything You Need to Know About the Science Behind Cannabinoids appeared first on Cannabis Now.