Sexually Frustrated Female Cannabis Plants and High-THC Production

Cannabis has been a popular recreational substance for a long time, but the type of weed we consume today has changed dramatically from what our parents and grandparents were smoking decades ago. On average, cannabis available today is about 67% stronger than in the 1970s, and it grows faster and stays smaller in size. Cultivators no longer need 9 full months and space large enough to grow 12-foot-tall plants with buds that only had about 3% THC, if they were lucky. But what factors led to these rapid changes in growth and potency? As it turns out, the secret to getting stronger weed is sexually frustrated female cannabis plants.  

As a dioecious plant, yes, cannabis be either male or female, and yes, it can be sexually frustrated. What you’re smoking on right now are flowers from a female plant; and if your current stash is really dank and covered in sticky THC trichomes, then those buds came from a sexually deprived female.

Cannabis is such a fascinating plant and we continue to learn more about it every day. In addition to learning about the plant itself, we also enjoy exploring the wide array of products available on the market today. If you’re interested in trying fun products, rare cannabinoids, and new strains, make sure to subscribe to The CBD Flowers Weekly Newsletter, your top source for all things cannabis-related. If exotic products is what you want, such as Delta 8, Delta 10 THC, THC-O, & THCV make sure to subscribe below to Delta 8 Weekly, and enjoy from our exclusive deals.


Male vs Female Cannabis Plants

Female cannabis plants produce those large, resin-secreting, psychoactive buds. Females are the industry’s superstar because they’re the ones that produce the most cannabinoids. Anytime you buy weed or look at pictures of marijuana with flowers, you’re looking at female plants.

Male cannabis plants do not grow flowers. Instead, they develop pollen sacs around the nodes and tips of the branches, with which they can pollenate any nearby female plants. When female plants are pollinated, they begin to produce seeds, but since no one wants to smoke low-THC schwag with seeds in it, the males are usually thrown out pretty early.

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On the public side of the cannabis market, females get all the glory. However, when we look more at the botany behind the bud, male plants have some very important functions as well. Like humans, when a female plant is pollinated, half of the genetic makeup of the seeds produced will come from the male plant. Aside from potency and flavor, many other important characteristics can be passed on from male plants including growth rate, bud size and shape, resistance to mold and pests, and general resilience.

The buds we prefer to consume are seedless female plants with good genetics, referred to as “sinsemilla”, which means “without seeds” in Spanish. To ensure that plants will be sinsemilla females, growers can used feminized seeds or grow clones by replanting small clippings from their existing plants.

How To Tell The Difference

At first, you won’t be able to. Once your plants are roughly 4-6 weeks old and entering the flowering stage, you can start looking for “pre-flowers”. Cannabis pre-flowers are comparable to sex organs, and the females’ look quite different from the males’.

To determine their sex, you’ll need to look between the plant’s nodes (where the leaves and branches extend out from the stalk). Males will have pollen sacs to help spread pollen to the female plants, and females develop two bracts and hair-like stigmas to catch the pollen. Click here for a great guide with photos to help you more easily determine sex.

Female Preflowers
Male pollen sacs

Sexually Frustrated Females

Back in the 1970s, cannabis growers made a game-changing cultivation discovery: isolating female plants produced extra potent flowers. When females are pollinated, they halt resin/THC production and begin producing seeds. However, when the sexes are separated, females do not get pollinated and thus, they don’t produce seeds and ramp up the resin production. Sinsemilla weed, on average, has a THC content around 6-10% higher than seeded strains.

Simply put, this cultivation method results in ‘sexually frustrated’ female plants. It’s strange, but it works, and the reason for this is because cannabis is one of the few plant species that elicits a physical response to prolonged virginity. Meaning, the longer she feels ‘sexually deprived’, or the longer pollination is put off, the larger and more resinous her sex organs (flowers) become.

Some growers would go so far as to say their plants are somewhat ‘masochistic’, in addition to being horny. Apparently, when the flowers begin to form, some plants will repeatedly bend their branches to the point of almost breaking, a process that helps facilitate resin production in the buds. As one popular Redditor so eloquently put it, “you’re all high on horny plant vaginas.” It’s strangely accurate.

Cannabis Resin, Pollination, and THC Production

Cannabis resin is a rich brown, sticky, gooey substance found on the flowers and leaves of the plant. It’s similar to tree sap, but the main distinction between the two is that cannabis resin is held together by fatty structures called trichomes. These are the plant’s resin glands that contain THC, CBD, terpenes, flavonoids, and other therapeutic cannabinoids and compounds.

To us, trichomes are an amazing and delicious plant byproduct that offers endless medicinal and recreational benefits; but to the cannabis plant, trichomes are one of its most important defense mechanisms. As cannabis flowers develop, they are vulnerable to so much harmful external stimuli such as pests, infections, herbivores, damaging UV rays, and pollution. In the wild, trichomes offer a certain level of protection from all of these things.

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Additionally, cannabis resin aids in seed production by catching pollen from the male plants. One male plant can produce an estimated 350,000 pollen grains, and cannabis pollen is airborne so a little bit can go a very long way. As a matter of fact, a study published in 2000 found that cannabis pollen made up just under 36% of total airborne pollen counts in Midwest states during harvest months. This is why it’s important to remove the male plants from the grow area as soon as you determine the sex.

The good news is, you don’t have to go through this process every time you want high-THC, seedless flower. Realistically, isolating your female plants would only be necessary if you’re using the male’s genetics to create new strains. To skip the pollination process, a modern grower can either buy already feminized seeds, or use a clone from an existing female plant.

Hermaphroditic Plants

Cannabis is a bit of a rarity because only about 6% of flowering plants are dioecious. However, on rare occasions, hermaphroditic weed plants containing both male and female parts are known to occur. In general, most plants are hermaphroditic, but this is not very common for cannabis. Sometimes, hermaphroditic cannabis plants can self-pollinate, but they usually produce seeds, lower levels of THC, and they can pass on hermaphroditic genes, so they’re not ideal. Also, true hermaphrodites produce sacs that need to rupture.

There are two types of hermaphrodite plants: those that develop both sexual organs (buds and pollen sacs), and those that develop anthers. Anthers are oval-shaped, pollen-producing sacs found at the end of the stamen. Some growers call them “bananas” because of their elongated appearance.

When cannabis plants turn hermaphroditic it’s sometimes referred to as “herming out”. This is usually a result of excessive environmental stress such as damage to the plant’s physical structure, bad weather, disease, and/or nutrient deficiencies. Bad genetics and previous hermaphroditic development can also be a risk factor. Basically, if you notice any pollen sacs or anthers, get that plant away from your females ASAP.

Final Thoughts on Female Cannabis Plants, Sexual Frustration, and THC Production

To reiterate, if you want big, potent buds that are covered in those flavorful, cannabinoid-filled trichomes, the key is sexually frustrated female plants. Cannabis plants basically live to be pollinated and produce more plants, so when pollination doesn’t occur, the female plant begins to overcompensate by creating bigger flowers with thicker resin.

The fact that cannabis plants are dioecious and respond in such complex ways to sexual stimulation (or lack of it), really makes them even more relatable. We are so incredibly connected to the universe around us which makes it that much more important to understand the complexities of other living creatures.

Thank you for stopping by CBD TESTERS, your source for all things cannabis-related. For more articles like this one and exclusive deals on flowers and other products, subscribe to The CBD Flowers Weekly Newsletter.

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High Potency: How THC-O Acetate Is Made

The question of how a cannabinoid is “made” does not come up very often. That’s because it’s usually pretty simple, they are “made” by the cannabis plant. However, there are a few compounds that are byproducts of phytocannabinoids and some other type of chemical catalyst… meaning they aren’t 100% naturally derived. THC-O Acetate falls under this category. So, how exactly is this exciting and very potent cannabinoid created?

The psychedelic THC-O Acetate sure sounds interesting, and goes to show just how many different products can be made from cannabis. Compounds like that one, THCV, Delta-8 THC and Delta 10 are the newer face of the cannabis industry. We support the expansion of cannabis use, and have some really great deals for delta-8 THC and many other compounds. Take a look at our selection, and join the cutting edge of marijuana use.
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What is THC-O?

In short, THC-O is an analog of THC, meaning is has a similar chemical structure but, as is the case in chemistry, minor differences often lead to substantial changes. THC-O is short for THC-O-Acetate, or THC Acetate/ATHC. Most of the time you’ll see it written and referred to as THC-O. It’s important not to confuse ATHC with THCA, the parent molecule of THC which found in raw plants that have not yet been decarboxylated.

In tetrahyrdocannabinolic acid (THCA) the A stands for acid, NOT acetate like with ATHC. THCA can be converted to THC-O, but THCA is a natural phytocannabinoid and THC-O is not. THC-O is a synthetic cannabinoid that can only be produced in a laboratory setting, preferably by an experienced chemist. With the rise of DIY technologies, it can be tempting to try and make THC-O yourself, but the process can be difficult and quite dangerous, so it’s best left to the professionals.  

Because it is an artificially produced cannabinoid, what you see is what you get – meaning all you get is THC-O and none of the beneficial terpenes and flavonoids that are found in natural oils. This is an obvious issue for whole-plant advocates and proponents of the entourage effects, but when it comes to pharmaceutical formulations, isolated cannabinoids are always preferred.

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The purity of these compounds means that 1 milligram of isolate equals measures out to exactly 1 milligram of cannabinoid, whereas 1 milligram of full-spectrum plant extract might have 0.5 milligrams of THC, 0.3 milligrams of CBD, and 0.2 combination of other terpenes and compounds. This makes isolate very easy to use for specific dosing and product production.

According to Serge Chistov, the inventor of Nanobidiol Technology, says his team has found a safe and efficient method to acetylate THC using only approved solvents. Chistov says his team “developed the analytical standard for testing for THC-O, as well as being in the final stages of introducing products to retail outlets.” So, if everything stays on track, we can expect to see THC-O therapeutics relatively soon.

THC-O Acetate: More Potent, Psychedelic and Spiritual Than Delta 9 THC

THC-O potency: Delta-9 THC vs THC-O

We already know that THC and THC-O are chemically similar, but that small variation in molecular structure translates to a huge difference in potency. While it may seem like a stretch, this is very common in chemistry – think CO vs CO2, the former being a manmade potentially dangerous substance, and the latter a natural gas required for plant and human life. Another well-known example is H2O vs H2O2, water vs hydrogen peroxide. Small molecular changes can make a world of difference.  

To be specific, THC-O potency is so high, that THC-O is considered to be three to four times stronger than Delta 9 THC. There are times when THC, despite how amazing it is, doesn’t seem powerful enough to accomplish the task at hand, especially when used for pain, digestive disorders, and other chronic health conditions. THC-O is not only much more potent, but our bodies recognize it as a completely different compound. This means THC-O can be used in place of Delta 9 THC if you have built up a tolerance.

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“The prodrug [THC-O] enters the system as a Trojan horse. The body sees the horse, the body tries to destroy the horse, keeping the insides of the horse available for the body to process. This means the THC inside of the prodrug preparation will not be metabolized into 11-hydroxy-THC at the same rate and speed as the native THC molecule. That change in the metabolic perception of the body is what is partially responsible for the effect that most people describe as different,” Chistov explains.

Even recreationally, it has its place in the industry, and honestly, it sounds like a lot of fun. There is a huge market of people searching for cannabis products with more of a kick, which is exactly how concentrates came to be. It’s certainly not for everyone, but for people who like to experiment with pot products and psychedelics (myself included), it sounds like something worth trying at least once.

Those who have had the opportunity to try it claim that THC-O produces a much more spiritual, psychedelic, and introspective high than what they are used to from Delta 8, 9, or 10. Even habitual cannabis users noticed a difference. As a daily user, this alone has me sold, and I know many other people who feel the exact same way (hey subscribers, products will be available in our newsletter very soon!)

How THC-O is Made

Circling back, let’s talk a bit more about the THCA and THC-O connection. I have already covered the difference between the two (acid vs acetate), now it’s time to discuss how THCA can be converted to THC-O. Again, it’s a complex chemical process that should only be attempted by experienced chemists, this is NOT something that can be done safely at home.

In raw cannabis plants, cannabinoids are found in carboxylic acid from. Carboxylic acids are any of class of organic compounds in which a carbon atom is bonded to a hydroxyl group via a single bond, and to an oxygen atom by a double bond. When exposed to heat, the compounds lose their carboxylic acid groups and become the cannabinoids most consumers are familiar with.

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Carboxylic acid and hydroxyl groups are both polar and hydrophilic, meaning small amounts of THCA (or any other cannabinoid acid) are water soluble. Using two chemicals – sulfuric acid and acetic anhydride – the conversion can begin. Summarized, the process goes like this: THCA + heat > D9 + sulfuric acid + acetic anhydride = THC-O Acetate. When THCA is converted to THC-O, the polar C-OH becomes C-O-CH2C=O-CH3. The carboxylic acid group is hydrolyzed by the heating with the sulfuric acid, which then reacts with excess anhydride to produce acetic acid. This acid reacts with regular THC at the hydroxyl group and becomes the potent THC-O-Acetate.

To reiterate, sulfuric acid and acetic anhydride are both very corrosive and hazardous chemicals that should not be in the hands of amateurs and everyday consumers. Attempting this process at home is incredibly risky.

THC-O Acetate Production – Final Thoughts

THC-O is such an interesting compound. Not only is it four times stronger than Delta 9, which as far as we know, is the most potent of THC’s, but it is so pure and had limitless therapeutic potential. You might be eager to try it, but since it’s too risky to make at home, your best bet is to check out some of the existing products the are just hitting the store shelves. For more articles like this one, and for access to exclusive deals on all the newest, rare cannabinoid products, make sure to subscribe to The Delta 8 Weekly Newsletter.

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THC-O Acetate: More Potent, Psychedelic and Spiritual Than Delta 9 THC

THC-O gets very little attention in the cannabis industry and most consumers are probably completely unaware of its existence, but wrongfully so as it is many times more potent than Delta 9 THC and said to produce very uplifting and spiritual experiences. The purity, strength, and consistency of this compound could have several implications for both the medical and recreational markets.

The emergence of THC-O can take the world of cannabis into a whole new direction. However, we know way less about it than we do about delta-8 THC, another newcomer to the cannabis products market. Delta-8 is interesting because it functions much like delta-9 THC, but without producing anxiety and paranoia, or couch locking users. In fact, delta-8 is associated with a more clear-headed high and more energy in general, which makes it preferable for many cannabis users. Are you one of them? Check out our assortment of Delta-8 THC deals and order some today.

What is THC-O?

THC-O is short for THC-O-Acetate, or THC Acetate/ATHC. Most of the time, you’ll see it written as THC-O or ATHC. It’s important not to confuse ATHC with THCA. In tetrahyrdocannabinolic acid, or THCA, the A stands for acid (not acetate like with ATHC). THCA is the parent molecule of THC, found in raw plants that have not yet been decarboxylated.

THC-O is a synthetic cannabinoid that can only be produced in a lab. While it may be tempting to try and make some at home, the process can be volatile and dangerous, so it’s best left to the chemists. In short, THC-O is an analog of THC, meaning is has a similar chemical structure but, as is the case in chemistry, minor differences often lead to substantial changes.

Because it’s an artificially produced cannabinoid, what you see is what you get – meaning all you get is THC-O and none of the beneficial terpenes and flavonoids that are found in natural oils. This is an obvious issue for whole-plant advocates and proponents of the entourage effects, but when it comes to pharmaceutical formulations, isolated cannabinoids are always preferred.

The purity of these compounds means that 1 milligram of isolate equals measures out to exactly 1 milligram of cannabinoid, whereas 1 milligram of full-spectrum plant extract might have 0.5 milligrams of THC, 0.3 milligrams of CBD, and 0.2 combination of other terpenes and compounds. This makes isolate very easy to use for specific dosing and product production.

According to Serge Chistov, the inventor of Nanobidiol Technology, says his team has found a safe and efficient method to acetylate THC using only approved solvents. Chistov says his team “developed the analytical standard for testing for THC-O, as well as being in the final stages of introducing products to retail outlets.” So, if everything stays on track, we can expect to see THC-O therapeutics relatively soon.

The THCA to THC-O Conversion

Back to the THCA vs ATHC/THC-O. We covered the difference between the two (acid vs acetate), now it’s time to discuss how THCA can be converted to THC-O. Again, it’s a complex chemical process that should only be attempted in a professional laboratory setting, this is NOT something that can be done safely at home.

Carboxylic acid and hydroxyl groups are both polar and hydrophilic, meaning small amounts of THCA (or any other cannabinoid acid) are water soluble. Using two chemicals – sulfuric acid and acetic anhydride – begins the conversion process.

When THCA is converted to THC-O- Acetate, the polar C-OH becomes C-O-CH2C=O-CH3. The carboxylic acid group is hydrolyzed (forms water) by the heating with the sulfuric acid, which then reacts with excess anhydride to produce acetic acid. This acid reacts with regular THC at the hydroxyl group and becomes the potent THC-O-Acetate.

THC-O is 300 Percent More Potent Than THC

We already know that THC and THC-O are chemically similar, but that small variation in molecular structure translates to a huge difference in potency. To be specific, THC-O is about 300 percent stronger than regular Delta 9 THC (a 300 percent increase would be 4 the original value). It really makes you appreciate the tremendous impact of these tiny molecules.

There are times when THC, despite how amazing it is, doesn’t seem powerful enough to accomplish the task at hand, especially when used for pain, digestive disorders, and other chronic health conditions. THC-O is not only much more potent, but our bodies recognize it as a completely different compound, so although you may have developed a tolerance to THC, you can still use THC-O and experience the full effects.

“The prodrug [THC-O] enters the system as a Trojan horse. The body sees the horse, the body tries to destroy the horse, keeping the insides of the horse available for the body to process. This means the THC inside of the prodrug preparation will not be metabolized into 11-hydroxy-THC at the same rate and speed as the native THC molecule. That change in the metabolic perception of the body is what is partially responsible for the effect that most people describe as different,” Chistov explains.

Even recreationally, it has its place and definitely sounds like fun. There is a huge market of people searching for more potent cannabis products, which is exactly how concentrates came to be. It might sound intimidating to some, being considerably stronger than D9 THC, but for people who like to experiment with psychedelics (myself included), it sounds like something worth trying at least once.

Those who have had the opportunity to try it have state that it’s a much more spiritual, psychedelic, and introspective high than what they are used to from regular THC. Even regular cannabis users noticed a difference. This alone has me sold, and I know many other people who feel the exact same way (hey subscribers, stay tuned for when products begin to launch).

Final Thoughts

Although THC-O is very tempting and highly beneficial, you’re unlikely very many products containing this compound just yet. Some online retailers are selling THC-O vape carts and similar, but without knowing much about these companies it’s hard to say whether the products are legit or not. When it comes to cannabis, especially newer compounds, it’s best to stick to the most reputable retailers you can find. If you need guidance, you can always check with your local dispensary to see if they have any leads, although it is not guaranteed they will know where to find any.

Regardless, if you can find it, THC-O is a wonderful cannabinoid for both therapeutic and recreational purposes. The acetate version of THC can be helpful when the real compound doesn’t work as expected. And, since every human is at least slightly different biologically, some patients need different products to achieve the desired effect. “Because THC-O-Ac affects the receptors differently, the effect might be beneficial to people who might not receive relief from conventional THC or other formulations,” Chistov says.

As cannabis legalization measures continue to progress throughout the world, more will be available to us in both the recreational and pharmaceutical sectors. Once the research floodgates open up completely, we can look forward to some incredibly pure and potent cannabis products hitting the store shelves. For now, remember to check out or Delta 8 Weekly Newsletter for more articles and exclusive deals on legal psychoactive cannabinoids.

Thank you for stopping by CBDtesters.co, the #1 location for the most relevant cannabis-related news from around the world. Give the site a read-thru every day to stay on top of the ever-changing world of legal marijauna, and sign up to receive our newsletter, so you’re always in the know.

Resources

Exploring Raw Cannabinoids – What is THCa and What Can it Do For You?
It’s Not Your Parents’ THC – Welcome Cannabidiolic Acid Methyl Ester The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc), the Best Delta 8 THC Deals and the Best Delta-10 THC deals CBG, CBN & CBC: Benefits of the Lesser Known Cannabinoids
Delta 8 / 9 / 10 / 11… How Many THCs Are Out There? Extra Potent 11-hydroxy-THC and the Power of Cannabis Edibles
The Question of Delta-8: Recreational or Medicinal?
Delta 10 THC Disposables
What is Delta 10 THC & Does it gets you high?

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Misconceptions About CBD Explained – For One, It’s Psychoactive!

CBD has been the motor powering the cannabis legalization movement. As the part of the plant deemed ‘non-psychoactive’, CBD has gotten a pass that the rest of the plant has not. And this is great! But it’s also led to some rather intense confusion, and longstanding misconceptions.

Are you a delta-8 user? You know, the alternate form of THC that leaves users energetic and clear-headed, without the anxiety produced by delta-9 THC, the standard THC associated with cannabis? Good choice, if you are. Not only are you experiencing THC in a different way, but you’re at the forefront of cannabis technology. We’re here to make sure you’ve got what you need, with a range of Delta-8 THC deals to keep your shelves stocked.

Why are we talking about CBD?

CBD – cannabidiol – came into the spotlight around 2018, with the advent of the most recent US Farm Bill. The US Farm Bill is a range of legislation that governs the agricultural world, like what can be grown and how, crop insurance for farmers, farmer training, sustainable farming practices, and ways to get healthy food for low-income families. Basically, anything covered under farming and food, is governed by the Farm Bill, which is put out every five years (approximately).

The 2014 Farm Bill legalized ‘non-viable hemp material’ sales in states with participation in the Hemp Pilot Program. The 2018 Us Farm Bill removed hemp from the Controlled Substances list, making the production and sale of products possible on a large scale. Since cannabis is federally illegal, in order to do this, the definition for ‘hemp’ was set at the following, allowing for a break from the rest of the plant and the ability for a different set of regulatory laws:

“…the plant Cannabis Sativa L. and any part of that plant, including the seeds thereof and all derivatives, extracts, cannabinoids, isomers, acids, salts, and salts of isomers, whether growing or not, with a delta-9 tetrahydrocannabinol concentration of not more than 0.3 percent on a dry weight basis.”

CBD oil

Effects of the Farm Bill

This, of course, opened up a huge debate about the legality of compounds like delta-8 THC, which is minutely different from delta-9 THC. Though delta-8’s illegality is based on several factors including the Federal Analogue Act, and the inability to have more than .3% in a finished product (as specified by the Interim Final Rule and Final Rule), the US government did make a quiet move to ban it fully by officially putting the words ‘delta-8 THC’ on the Controlled Substances list (page 17). It was updated to include in ‘other names’ for ‘tetrahydrocannabinols’, “THC, Delta-8 THC, Delta-9 THC, dronabinol and Others”, with the ‘and others’ denoting any other relevant compound with the same chemical formula.

However, though delta 8 THC didn’t make it, it did create itself a little industry. And more importantly than that, CBD became the new darling of the medical world. The basis for this is that CBD is not psychoactive like other components of the plant. Since CBD can be easily sourced from low-THC hemp plants, the compound was able to slip through to legalization, even getting a global legalization by being rescheduled in the Single Convention on Narcotic Drugs treaty in 2020.

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What does ‘psychoactive’ mean, and does it apply to CBD?

According to ScienceDirect, the definition of a psychoactive drug is a “chemical substance that acts primarily upon the central nervous system where it alters brain function, resulting in temporary changes in perception, mood, consciousness and behavior.” The site goes on to make this statement, which is highly important:

“These drugs may be used recreationally to purposefully alter one’s consciousness (such as coffee, alcohol or cannabis), as entheogens for spiritual purposes (such as the mescaline-containing peyote cactus or psilocybin-containing mushrooms), and also as medication (such as the use of narcotics in controlling pain, stimulants to treat narcolepsy and attention disorders, as well as anti-depressants and anti-psychotics for treating neurological and psychiatric illnesses).”

If you’ll notice, this includes some of the main functional medical components of CBD – it controls pain, can treat attention disorders, and is considered for its anti-depressant effects. In fact, I doubt there’s anyone out there who can say they took CBD, and didn’t feel different. That feeling different is a psychoactive effect, and CBD most certainly creates it. CBD is a psychoactive compound, and I say this as a statement, since it meets the medical definition of psychoactive. It just doesn’t cause euphoria.

Where did this ‘non-psychoactive’ idea come from, when it so obviously is by definition? The term ‘psychoactive’ in the context of CBD, seems to have been confused with the idea of being ‘very high’ or intoxicated. My guess, is that to show CBD doesn’t create the same kind of high as other parts of the plant, the term ‘non-psychoactive’ was applied. Does it really not make a person high? I’ve taken it plenty of times, and I’d say the feeling it gives is tantamount to a minor high, and even without that, it certainly changed how I was feeling.

cannabis is psychoactive

Unfortunately, with a massive market out there that depends on marketing strategies to sell products, and tons of writers trying to make a buck, these inconsistencies have been repeated over time until they became a part of standard culture, so much so that they’re not questioned anymore. Until someone like me feels like writing about it.

CBD might be a THC

This to me is the much more interesting misconception about CBD. The term ‘THC’ is often used colloquially to refer specifically to ‘delta-9 THC’, the standard THC associated with cannabis plants. But that’s the equivalent of using slang, it doesn’t modify the actual definition. In fact, the term ‘THC’, simply denotes the term ‘tetrahydrocannabinols’. The term ‘tetrahydrocannabinols’ – which is the term found in the Controlled Substances list as a Schedule I substance, regulated by DEA criminal code 7370 – refers to many different compounds.

The reason for this, is that it denotes a chemical formula. All drugs on the Controlled Substances list, are ultimately attached to their chemical formulas. The chemical formula for tetrahydrocannabinols is this: C21H30O2. If you’re thinking ‘that makes sense, that’s the chemical formula for THC’, you’re correct! That goes for delta-9 THC, delta-8 THC, delta-10 THC, or any other delta THC. This is because they are all isomers of each other, in this case, stereoisomers, that are completely identical except for the placement of a double bond.

An isomer in general, refers to two compounds that have the exact same chemical formula, but differ in structure. There are different kinds of isomers depending on how the structures differ from each other. Delta-8 and delta-9 are double bond stereoisomers because they differ only in the placement of a double bond.

This is where it gets trickier. CBD has the same chemical formula as delta-9 THC. The two compounds are isomers of each other. By definition of having that chemical formula, CBD could be defined as a tetrahydrocannabinol as well. Much like with the term ‘psychoactive’ to denote ‘high’, it seems this may have been made purposefully confusing to users, but not for a bad reason. Let’s be honest, chemistry ain’t easy, and most people aren’t functionally trained to understand it.

Trying to explain to the masses – who are only just becoming okay with cannabis – that the component being pushed for its medical benefits is the same chemical formula as the part of the plant that’s been demonized for decades, would’ve been more difficult.

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The idea that CBD fits under the umbrella term of tetrahydrocannabinols is backed up in the medical-dictionary, where the first definition of ‘tetrahydrocannabinol’ is: “the active principle of cannabis, occurring in two isomeric forms, both considered psychomimetically active.” This implies both delta-9 and CBD, though neither is directly stated.

The second definition is: “A compound, C21H30O2, obtained from cannabis or made synthetically, that is the primary intoxicant in marijuana and hashish.” It could be argued this only relates to delta-9, but as ‘delta-9’ isn’t specifically stated, and the wording is ‘a compound’ with the chemical formula, it doesn’t rule out other compounds then delta-9. The idea that CBD IS psychoactive means it can be called an ‘intoxicant’. Let’s remember that caffeine is considered an intoxicant, and it doesn’t make a person high.

isomers THC and CBD

And a third definition: “Tetrahydrocannabinol – Any of a family of compounds present in Cannabis sativa var indica, the major constituent of which is the Δ1-3,4-trans isomer, 9Δ-THC.” Though this doesn’t rule out that only delta THCs are included, along with the other two definitions, it points to both CBD and delta-9 being included.

When looking at the DEA’s 2003 Clarification of Listing of “Tetrahydrocannabinols” in Schedule I, it actually specifically says this: “Furthermore, the commonly understood meaning of “Tetrahydrocannabinols” includes both natural THC and synthetic THC, since “Tetrahydrocannabinols” is simply a name that refers collectively to a category of chemicals–regardless of whether such chemicals occur in nature or are synthesized in a laboratory.” While this is technically talking about classifying synthetic THCs, it also backs up the idea that the term ‘tetrahydrocannabinols’, refers to a ‘category of chemicals’, NOT specifically delta-9 THC.

Why doesn’t the public know this?

By creating this separation, it allows the public to think of CBD differently. Part of the reason for this separation might have been for defining CBD as ‘non-psychoactive’, without the confusion of its half-brother delta-9 getting in the way. By creating a definition for hemp, CBD was able to legally move away from its delta half-brothers in terms of what it’s regulated by, but this does nothing to change the fact that its chemical definition, seems to be as a tetrahydrocannabinol. When looking back at the Farm Bill and the definition of hemp, you’ll notice it doesn’t use the term ‘THC’, it specifically names ‘delta-9 THC’, since simply saying ‘THC’, could include so many other compounds.

It should be mentioned, just because two compounds share the same chemical formula, it doesn’t mean they ever have to be scheduled the same. Delta-9 THC and CBD have different effects, related to their different configurations, so it does make sense to view them differently. In reference to drug scheduling lists, the DEA makes this statement: “These lists describe the basic or parent chemical and do not necessarily describe the salts, isomers and salts of isomers, esters, ethers and derivatives which may also be classified as controlled substances.” This means that though similar, related substances might be controlled the same way, they don’t have to be.

This is shown in this Wikipedia listing of different drugs that fall under the chemical formula of C21H30O2. Some of the entries on this list are actually hormones, which quite obviously would not put them under the title of tetrahydrocannabinols. In this listing, tetrahydrocannabinols are separate from CBDs, which does give more credence to the idea of them being two completely separate groups of cannabinoids.

psychoactive CBD

In the end, it can probably be argued in either direction, as there is plenty to back up CBD as a tetrahydrocannabinol, and as a separate cannabinoid not under that heading. Of course, the medical dictionary definition does state that tetrahydrocannabinols are anything with that chemical formula that come from marijuana or hash (its good to remember here that ‘marijuana’ used to be the only term to denote the plant), and this would imply that even with non-cannabinoid compounds under the same formula that are obviously not THCs, that CBD is.

CBD, and its closely related isomers form their own group of cannabinoids. In today’s world, this category is looked at as being different from tetrahydrocannabinols, however, medical definitions seem to point in a different direction. Much like with ‘psychoactive’ starting to denote the term ‘high’, even though this is not a medical definition, so has ‘tetrahydrocannabinols’ been altered in common slang to denote only delta-9 THC, when in fact, it applies to many other compounds.

Conclusion

The idea that CBD is indeed psychoactive, or technically fits under the umbrella category of tetrahydrocannabinols, doesn’t make a lot of difference for most people, and it shouldn’t. I point this out today as a way of showing how information gets shifted, changed, and then repeated into what seems like truth. However, simply repeating things lots of times doesn’t make it true. CBD is psychoactive, and though it is within its own set of cannabinoids, it still remains the same chemical formula denoted by ‘tetrahydrocannabinols’.

Welcome. You’ve made it to CBDtesters.co, your one-stop-shop for the most up-to-date cannabis-related news from around the world. Join us daily to stay abreast of the quickly changing world of legal cannabis, and sign up for our newsletter, so you always know what’s going on.

Resources

The Question of Delta-8: Recreational or Medicinal?
Cannabis Remains Schedule I After UN Vote
What is Delta 10 THC & does it gets you high?
The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc), the Best Delta 8 THC Deals and the Best Delta-10 THC deals

The US Government Secretly Illegalized Delta-8 THC Colorado Just Banned Delta-8 THC! Who’s Next?
CBD Is Not Dangerous Drug, Says Israel

The LGBTQ Community Fought for Cannabis Reform, Now the Industry is Leaving Them Behind

DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

The post Misconceptions About CBD Explained – For One, It’s Psychoactive! appeared first on CBD Testers.

Before It Even Took Off, Some States Already Want to Ban Delta 10 THC

Whenever a new cannabis trend emerges, we tend to get the same reactions every time: excitement from consumers and industry stakeholders, followed by a wave of legislation trying to regulate or prohibit the new product. Typically, by the time a product gets on the radar of the general public, it’s already on its way to becoming illegal.

Why ban the new Delta 10 THC? It happened with many cannabinoids and products already, most recently, Delta 8 THC. Despite the fact that it falls under a legislative loophole that makes it federally legal, technically; many states have completely outlawed its production and sale. And you might be inclined to assume that it’s only the most restrictive states taking these steps, but then you would be completely wrong. For example, some legal states including Colorado and Arizona don’t allow the possession or distribution of any products containing Delta 8 THC.

But we’re not here to talk about D8, today we’re discussing how this same exact dilemma is unfolding in the small but fast-growing Delta 10 THC market – which states are trying to ban this new cannabinoid?

To learn more about Delta 8 and Delta 10 THC, and for exclusive deals on vapes, gummies, flowers and other products, make sure to subscribe to The Delta 8 Weekly Newsletter


What is Delta 10 THC?

Following in the footsteps of many cannabis trends prior, Delta 10 THC was first noted in California, although in this case, the discovery was purely accidental. It all began when an Adelanto-based company called Fusion Farms bought some outdoor flower to manufacture concentrates. Because of the wildfire-prone climate in California, the biomass they purchased had been sprayed with fire retardant, although Fusion Farms believed the flower they were getting was pure.

Being unaware of the contamination, they continued with the extraction as planned but some unusual crystals began to form after the distillation process. These crystals had a completely different structure than previously observed cannabinoid crystals. After conducting some laboratory tests, it was determined that these crystals were most similar to CBC (cannabichromene), but still not an exact match. For several months, they continued testing this structure against all the known cannabinoids and no match was found.

Eventually, they found out that it was yet another variation of tetrahydrocannabinol, formed because of plant exposure to those fire retardants – dubbed Delta 10 THC. So basically, D10 is an artificial cannabinoid, formed by converting D9 or other cannabinoids using some type of chemical catalyst. In this case, it was fire retardant, but obviously that’s not something people want in their cannabis products, so companies are looking at various – greener – methods of creating Delta 10 THC.

In chemistry, “Delta” refers to the double bond in a compound’s molecular structure. Delta compounds have more electrons and interact with the body in different ways than single bond cannabinoids do. The variation between the Delta THC analogues comes down to where the double bond is located on their chain of carbon atoms. Delta 8 has this bond on the 8th carbon chain, Delta 9 on the 9th chain, and Delta 10 THC has the double bond on the 10th carbon chain. Although it seems miniscule, it makes a substantial difference.

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Is it federally legal?

Although all tetrahydrocannabinols are supposed to be on the FDA’s list of Schedule 1 narcotics, some of them remain permissible on technicalities. In short, if the THC (regardless of which Delta) was extracted from legal hemp, or chemically converted from CBD or another legal cannabinoid, then the THC itself is LEGAL.  

Since everything regarding Delta 10 THC specifically is a bit new, let’s once more take a look at Delta 8 for reference. Last year there was some controversy and confusion about whether Delta 8 would be added to the DEA’s list of controlled substances. Many in the industry believed it would be prohibited under the DEA’s Interim Final Ruling over “synthetically-derived” cannabinoids but, fortunately, this turned out not to be the case.

Although a few changes were made, the final result was this: if the end Delta 8 product is derived from hemp and has less than 0.3% Delta 9 THC, then it’s legal. The DEA does include Delta 8 THC on its list of controlled substances which was just updated in August 2020. But since the 2018 Farm Bill expressly exempts “tetrahydrocannabinols in hemp”, this means that any form of THC derived from hemp that falls within the already established limits will remain legal.

So yes, Delta 10 THC is federally legal… however, states can override federal laws if they choose to. It happens all the time with industries like alcohol, tobacco, and gambling. So, while Delta 10 may be federally legal, some states governments are already taking steps to ban the new THC.

What states are working on bans?

The Alabama Senate Judiciary Committee recently approved a measure that would prohibit Delta 8 THC and Delta 10 THC, along with Delta 9 which is already illegal. The original intent of this bill was to regulate a new synthetic opioid, Tianeptine, by adding it to the state’s controlled substances list. The bill was amended by Republican Senator Arthur Orr who added the sections about THC at the very last minute.

The Alabama Cannabis Industry Association starkly criticized the proposal in a blog post: “It’s premature to outlaw these potentially beneficial treatments for very serious conditions until research has been done. What we do know is that there have been no deaths attributed to delta-8-thc and cannabis is generally safer than even some over-the-counter medications. The Alabama Senate has the opportunity to regulate delta-8-thc and delta-10-thc in The Compassion Act so it is controlled but still accessible to people who will benefit from it in reducing suffering and improve quality of life.”

In North Dakota, not only did the Senate quickly shut down a bill that proposed legalizing cannabis, but a new bill that would outright ban the manufacture, sale and possession of ALL tetrahydrocannabinols (specifically Delta 8, 9, and 10) is quickly gaining traction. The governor has 10 days to sign the bill which would then go into effect immediately. If it passes (and it’s expected to), anyone found buying or selling products containing any type of THC could face criminal charges.

Final thoughts – Delta 10 ban

It’s hard to say what exactly will happen with Delta 10 THC on a national scale. So far, these are the only two states that I’ve heard of that are actively trying to ban Delta 10. It seems like a lot of wasted time and effort, considering anything with Delta 10 THC is difficult to find as it is, and all cannabis products will inevitably become legal in the very near future anyway (or at least we hope).

For now, the best thing you can do is stay up to date on your local news and laws, and make sure to stock up on your favorite products if you start hearing talk of new legislation.

Thank you for stopping by CBD TESTERS, your hub for all things cannabis-related. Don’t forget to subscribe to The Delta 8 Weekly Newsletter for more articles and exclusive deals on flowers and other products!

The post Before It Even Took Off, Some States Already Want to Ban Delta 10 THC appeared first on CBD Testers.

Delta 8 / 9 / 10 / 11… How Many THCs Are Out There?

We all know about delta-9 THC, the main psychoactive cannabinoid of the cannabis plant. Recently, delta-8 THC started making a strong impression as an alternate form of THC, with slightly different benefits. We even know there’s a delta-10 THC. So, how many THCs are there out there, and how are they similar?

Well, it’s finally happening, the new vape ban will stop retailers from being able to send vape products through the mail in the US. Luckily, you can still pick up products in dispensaries, and you can still order until the ban starts. Just a few days left, so check out these great Delta-8 THC deals before we can’t send them out to you anymore!

Delta-9 and delta-8 THC

The first guy to synthesize THC was chemist Roger Adams. He was the first to identify the compound in the 1940’s, although he was not able to isolate it. This was done in 1964 by Raphael Mechoulam and his team, although Adams was the first to isolate CBD. Mechoulam was able to benefit from Israel’s less restrictive cannabis research laws. He and his team wanted to figure out what it was in Indian hash that was making people act so intoxicated.

The answer, he found, was THC, or tetrahydrocannabinol. To be more specific, he isolated the most common form of THC found in cannabis plants, delta-9 THC. Delta-9 THC itself does not actually exist heavily in any cannabis plant, but is instead produced from THCA which decarboxylates (generally through sun exposure or heat) to become delta-9 THC. It was learned in the 1940’s that there were many different forms of THC, although how many THCs can be created, was a mystery (and still is).

In the last year or so, another form of THC has been getting more popular, partially due to the 2018 US Farm Bill which legalized the cultivation of industrial hemp for certain purposes. As a form of THC which does not exist in large enough amounts on its own, delta-8 THC requires being sourced from delta-9 THC. It’s formed through an oxidation process, which results in a compound that has shown in testing to have less psychoactive response, to produce less associated anxiety and panic symptoms, to be effective for use with nausea and vomiting due to illness and treatments, and which, due to the oxidation process, is actually more stable over time than delta-9.

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Some even say it produces a very clear high, and heightens the senses of users. And since it can be sourced from any delta-9 THC, it can just as easily be sourced from delta-9 coming from industrial hemp, as from high-THC marijuana, creating a legal loophole for production. Even this THC isn’t quite as ‘new’ as current interest would have you believe, though. Delta-8 THC has been known about since it was fully synthesized in 1965 by Raphael Mechoulam.

Mechoulam even published research back in 1995 showing how delta-8 THC eradicated the nausea and vomiting of children receiving cancer treatments. Yet, of course, we didn’t hear much about it. What makes delta-8 THC relevant currently, is that it’s being produced in the very gray area of the 2018 Farm Bill, which has therefore permitted – to a degree – legal sales of THC (or gray-area sales). The two compounds are nearly identical, and have similar properties, it is only the sourcing of delta-8 THC from hemp that creates this legal quandary.

Delta-10

What else have we missed about THC? How many other THCs might exist?We know about delta-9 and delta-8, and that they’ve both been around for awhile. We even recently found out about delta-10 THC. Delta-10 also isn’t new, having been first synthesized back in the 1980’s. In fact, it was discovered accidentally by the contamination of outdoor flowers used to make concentrates, with flame retardant chemicals for dealing with wildfires in California, where the company creating the extracts was located.

The company, Fusion Farms, wasn’t aware that their product had issues and went on with the extraction process, just to find strange crystals forming. It was eventually realized that these strange crystals were another form of THC, this time delta-10. Delta-10 THC is an artificial cannabinoid that was formed when delta-9 THC was converted after being exposed to a catalyst, in this case the flame retardant material, though there could be less toxic catalysts out there.

As far as what delta-10 does, it’s hard to say. It came into existence through an accident, and has not been through even the compulsory scientific research that delta-9 THC and delta-8 THC have. It likely has similar mechanisms of action in the brain, attaching to CB1 and/or CB2 receptors, but nothing specific about the molecule can be said, other than that the double bond (the delta) exists on the 10th carbon atom of the chain, rather than the 9th like delta-9, or the 8th, like delta-8. That is, in fact, what defines a type of THC, where the double carbon atom is located.

Delta-3, delta-4, delta-6, delta-7

Now we know that the THC molecule can exist in different forms, depending on where the carbon double bond is located, which is what brings up the whole question of how many THCs are out there. Could that double bond be located on the 3rd, 4th, or even 7th carbon atom? Seems like it.

Delta-3 THC, delta-4 THC, and delta-7 THC were all identified during the 1940’s when THC was first starting to be synthesized in laboratories by researchers like Adams. These are entirely synthetic, and developed as a way to establish a synthetic form of a plant product (likely to get around patent issues). Though research has been done into these compounds, it has remained limited. It is generally thought that these synthetic isomers are less potent than delta-9 or delta-8 THC, but this may not be true all the time.

The more we go into the question of how many THCs currently exist, or can be created, the more we find that there are quite a few, with plenty we don’t know about yet or haven’t worked with. And some, just like the original finding of THC, that just don’t get the attention they deserve.

Take this, for example, a study from 1980 highlighting how delta-6 THC, and some other cannabis compounds, effect mice brains. The study found that several cannabinoids or isomers are correlated with an up-to-60 minute cataleptic effect in mice. Catalepsy is a disorder in which the body doesn’t respond to external stimuli, with overall muscular rigidity, and an inability to move.

While delta-6 THC didn’t create the highest correlation with cataleptic symptoms, it did show to be one of the most potent cannabinoids in the brain. The study authors concluded that psychoactive features of cannabinoids and their metabolites, are more likely related to structural features than pharmacokinetic ones. This was back in 1980, and yet a look at the medical cannabis landscape of the last few decades shows a massive deficit in follow-up research.

11-hydroxy-THC

We know that THC molecules vary between each other slightly, but what about once THC is metabolized by the body? The reason that THC edibles are so strong is the conversion of THC into 11-hydroxy-THC. When delta-9 THC (C21H30O2) is ingested, it gets processed into 11-hydroxy-THC (C21H30O3) by way of the liver and digestive tract. The difference is explained well by the publication Leafly’s primary researcher, Nick Jikomes:

“The real difference between edibles and smoking or vaping is that with edibles, a much larger fraction of Delta-9-THC makes it to the liver first. There it gets converted to 11-hydroxy-THC.” He continues, “So in other words, if you smoke or vape, the ratio of 11-hydroxy-THC to Delta-9-THC is quite low, and if you take an edible it’s much higher.” This helps explain why edibles can cause very intense highs, and why the high lasts so much longer. 11-hydroxy-THC is not naturally occurring, and requires the body to break down THC to produce it. Perhaps future research will find a way to synthesize it, without consumption.

This isn’t a standard version of THC, but it does go to show the other possibilities out there when asking the question of how many THCs there are.

cannabis medicine - using the many THCs for our own benefit

So, how many THCs are there?

With the ability to synthesize cannabinoids, the ability to create new versions of THC has been available for some time. Research into THC back in the 40’s identified much of this information, but little has been done to effectively use it. By now, years of intense research into THC should have been done, but decades after these forms of THC were found, we’re still asking the question of how many THCs are even out there. The reason things are this way is highly debatable, with some people holding true to beliefs about inherent drug dangers and black markets, a holdover from previous smear campaigns, no doubt.

Others might argue that the pharmaceutical industry couldn’t compete with a plant, and found it easier to suppress information about it, essentially ending research, or bringing it down to a trickle throughout the world, until it could be monetized properly. The latter argument makes way more sense considering the new pharma-cannabis industry, which seems to have no problem with people using the drug and sees no reason for danger, so long as the money goes into pharmaceutical pockets. Of course, that’s just my interpretation.

It could be that hundreds of versions of THC can be created, or maybe there are strictly 15. In a research field so wide open, with so much to investigate, it’s impossible to say just how many THCs exist. It’s not even possible to say if delta-9 is the strongest form, or what other kinds of psychoactive and medical effects could be hidden therein. One of the more interesting things to understand about THC, is just how much more there is to learn about THC.

Conclusion

The same issue that comes up with delta-8 THC is also relevant with other forms of THC that are sourced from delta-9. They can come from high-THC marijuana, or low-THC hemp, which means these compounds are falling into a legal gray area in many places like the US and the UK. They are being ruled illegal by drug scheduling legislation that names THC and all its derivatives as narcotics, but at the same time, they are starting to be sourced from places that are not considered illegal, making it questionable whether products made from them would therefore be legal or not.

Either way, the world of THC is opening up more and more, and proving to be a surprising and interesting place. In the next few years we might even get a better answer to the question of how many THCs are out there in the world.

Welcome to CBDtesters.co, your best location for cannabis-related news from everywhere in the world. Stop by regularly to stay current on the exciting world of legal cannabis, and sign up to our newsletter so you never miss a thing!

How Many THCs – Resources

It’s Not Your Parents’ THC – Welcome Cannabidiolic Acid Methyl Ester
Delta-8 THC Exploits Fantastic Legal Loophole

Why Using THC Is Good for the Eyes
New Vaping Bill: Effective March 2021 No More Mail Order Of CBD & Delta-8 THC Vape Carts
What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8THC)

Delta-8 THC Contaminated Products, or Just Bad Press?
11-hydroxy-THC and the Power of Edibles
The CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers).  Hemp-Derived DELTA 8 THC Products Now Available Online Best Delta-8 THC Vape Bundles – Winter 2021
New Vaping Bill: Effective March 2021 No More Mail Order Of CBD & Delta-8 THC Vape Carts

The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc) and the Best Delta 8 THC Deals. The Bizarre History and Promising Future of Delta 10 THC
What Are Delta-8 THC Moon Rocks And Where To Get Them? INSIGHT: Delta-8 THC Pricing – The Fair Price for Delta 8 Vapes, Tinctures, Gummies and The Many Faces of Tetrahydrocannabinol – Different Types of THC and Their Benefits
Delta-8 THC and the UK: Is It Legal?
Delta 8 Update: Shipping Vape Ban Goes Into Effect Soon. Are You Ready? Delta 8 Flowers – Milder Than Cannabis, But Very Relaxing and Uplifting Now it’s the time to Stock-Up on Delta-8 THC Products

Disclaimer: Hi, I’m a researcher and writer. I’m not a medical professional, I have no formal legal education, and I’ve never been to business school. All information in my articles is sourced from other places which are always mentioned, and all opinions stated are mine, and are made clear to be mine. I am not giving anyone advise of any kind, in any capacity. I am more than happy to discuss topics, but should someone have a further question or concern, they should seek guidance from a professional in the relevant field for more information.

The post Delta 8 / 9 / 10 / 11… How Many THCs Are Out There? appeared first on CBD Testers.

All About Delta 8 THC Distillate

Delta 8 THC is a shelf-stable, mildly psychoactive, minor cannabinoid that has been quickly gaining popularity over the last couple years. Also climbing into the mainstream are products made with cannabis distillates, which allow for incredibly potent products with accurate dosing. When combined – Delta 8 THC Distillate – we have a powerhouse product that’s full of therapeutic benefits and steadily flying off the shelves.

To learn more about Delta 8 THC, and for exclusive deals on flowers and other products, subscribe to the Delta 8 Weekly Newsletter


What is Delta 8 THC?

Before we talk about the medical benefits of this cannabinoid, let’s talk about what exactly Delta 8 THC is, and how it’s different from the more well-known, Delta 9 THC. Delta 8 THC (tetrahydrocannabinol) is a naturally occurring, minor cannabinoid found in the cannabis plant. Although it’s structurally similar to Delta 9 THC, there are some major differences as well.

For example, Delta 9 THC is the cannabis plant’s most abundant psychoactive compound, whereas Delta 8 is only found in trace amounts. As a matter of fact, Delta 8 is not even produced by the enzymes in cannabis, rather, it is created when Delta 9 THC oxidizes and slowly degrades into Delta 8. Further degradation of Delta 9 would create the cannabinoid CBN (cannabinol).  

When it comes to the chemical difference between Delta 8 and Delta 9, it all comes down to one molecule. In chemistry, “Delta” refers to the double bond in a compound’s molecular structure. Delta compounds have more electrons and will interact with the body in a different way than single bond cannabinoids. The difference between the Delta THC analogues comes down to where the double bond is located on their chain of carbon atoms. Delta 9 has this bond on the 9th carbon chain, and Delta 8 THC has the double bond on the 8th carbon chain. It seems like a small difference, but it can be significant.

Similar to its more dominant counterpart, Delta 8 THC is a partial agonist for both the CB1 and CB2 receptors, although it seems to have a stronger affinity for CB1. This means there are effects to be felt in numerous different parts of the body, despite having weaker psychotropic potency. The National Center for Biological Information (NCBI) describes delta-8 THC as follows: “An analogue of tetrahydrocannabinol (THC) with antiemetic, anxiolytic, appetite-stimulating, analgesic, and neuroprotective properties.”

What Medical Conditions Could Be Treated With Delta 8 THC

  • Insomnia

Inadequate sleep can have a profound impact on one’s health. In the short-term, it can affect mood and judgement, the ability to learn and retain information, and it can increase the possibility of an immediate accident or injury. Over a longer period of time, lack of sleep can lead to diabetes, obesity, cardiovascular disease, and even early death.

Extensive research tells us that activation of the CB1 receptor leads to better, longer, and more restful sleep, and keeping in mind that Delta 8 THC directly stimulates the CB1 receptor, one can easily come to the conclusion that Delta 8 is good for sleep. REM sleep is an important part of our circadian cycles because it stimulates parts of the brain that are essential for learning new things and forming memories.

Anecdotal evidence leads to the same conclusion with many users claiming that Delta 8 THC helps them fall asleep more easily and stay asleep longer. They also report feeling more refreshed and well-rested when waking up.

It’s believed that Delta 8 THC’s analgesic and anti-inflammatory properties play a major role in its ability to function as a sleep aid. There is a strong connection between pain and sleep. Obviously, someone who is experiencing a lot of pain will have trouble getting comfortable and thus, have difficulty falling asleep. But the relationship goes even deeper – as lack of sleep increases the perception of pain. Breaking the pain/lack of sleep cycle is incredibly difficult, and having a good night’s sleep with both REM and deep sleep stages is key to making improvements.  

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  • Cancer

While I’m not saying that smoking some delta 8 flowers or popping a few gummies will cure cancer, studies have proven that pharmaceutical products with highly concentrated doses of certain cannabinoids will do the trick.

This was first observed in 1974, in none other than Israel, where a study meant to focus on the immune system inadvertently found that Delta 8 THC alone significantly slowed tumor growth in mice. When combined with CBN (cannabinol), tumors actually began to shrink in as little as 3 weeks.

“Mice treated for 20 consecutive days with delta8-THC and CBN had reduced primary tumor size. CBD showed no inhibitory effect on tumor growth at 14, 21, or 28 days. Delta9-THC, delta8-THC, and CBN increased the mean survival time.” Antineoplastic activity of cannabinoids – PubMed (nih.gov)

Another study in 1995 on children with leukemia, showed a high rate of efficacy for treating the cancer, while also controlling side effects like nausea and vomiting caused by more conventional forms of treatment. The study was conducted at Shaare Zedek Hospital, Bikur Holim Hospital and the Hebrew University located in Jerusalem. The creators of the study, led by Raphael Mechulam, noted that “at the same this research was occurring, there had been 480 successful treatments of cancer with delta-8 THC.”

  • Anxiety

If you’re prone to anxiety, the mild and uplifting high you get from Delta 8 THC might be just what you need. Delta 8 THC offers all the medicinal effects of THC, and even some minor psychoactive effects, without the paranoia that often comes with Delta 9. The carefree high that comes with weed is often dampened by the anxious, nervous high some people experience.

Studies show that the endocannabinoid system, mainly the CB1 receptor, is centrally involved in regulating anxiety and depression. When the CB1 receptor is blocked, increased anxiety often occurs. Many people successfully utilize CBD (cannabidiol) to relieve their anxiety, but for many others it’s just not strong enough.

According to the National Cancer Institute, “this phytocannabinoid displays anxiolytic (anti-anxiety) qualities similar to delta-9 THC.” There is little in the way clinical research investing delta-8 THC’s potential to reduce anxiety, however, anecdotal evidence suggests that delta 8 products provide a nice, calm, focused, and stress-free high.

What is Delta 8 THC Distillate?

The scientific definition of distillation is that it is the act of purifying a substance usually through a collection of heating and cooling methods. The end result of a distillation process is known as a distillate.

Delta 8 THC distillate is a highly concentrated extract derived from hemp and cannabis plants, although the latter is not very common. Delta 8 THC distillate typically has upwards of D8 and it’s considered one of the purest and cleanest extracts available on the market.

Distillate retains a minimal amount of other compounds like plant waxes, vitamins, antioxidants, terpenes, and some minor cannabinoids. Whether it contains trace or illegal levels of Delta 9 THC depends on whether it was extracted from cannabis or hemp, although most of the time, hemp is preferred. This makes it great for anyone who needs accurate dosing but also needs the medicinal benefits the come from the entourage effect.

Another reason to choose distillates is that, because of their purity, patients often don’t need as much product to feel the effects. This can be economically advantageous for anyone who needs to use CBG daily but has been roadblocked by the fluctuating but generally high costs of purchasing these products.

How Distillation Works

Delta 8 distillation is a complex refinement procedure that separates the cannabinoid from raw plant material. The process is broken down into a few different steps.

  • Initial Extraction: The first step in the process of creating CBG distillate is to extract the cannabidiol from the hemp plant matter. There are a few different ways to do this including CO2 supercritical extraction, solvent extraction, or the rinsing and sifting method (physical) method.
  • Winterization – This step removes the unwanted impurities that are inadvertently extracted from the hemp plants during step one. During winterization, the extracted solution is placed into an extremely cold (winterized) environment for 24 to 48 hours. At this point, any impurities congeal and separate from the rest of the solution. The impurities are thrown out and the remaining product is filtered.
  • Decarboxylation – Before being exposed to heat or oxygen, cannabinoids exist in an acidic state (CBDA, THCA, etc.). To convert the plant cannabinoids into their active state, the extracted solution is heated thoroughly.
  • Distillation – The final process of distillation, the solution is vaporized and collected in a distillation cooling system. Each compound in the plant can be separated because of the variations in volatility, or boiling point, so the result is a relatively clean product.

The final product is a golden, thick solid product with a consistency that’s similar to honey.

Cannabinoid Distillate: The Future of Medical Cannabis

Distillation allows users to decide how much they want an oil to stray from the original plant extract. So, if you’re making edibles for example, you would want an oil with little to no flavor, so that your edible tastes like food and not cannabis. If you’re creating a vape oil that is supposed to mimic the smell and taste of cannabis, you can reintroduce some of the terpenes that have been removed using a method known as mass spectrometry. Basically, products using distillate are highly customizable.

Not only that, but in the case of medicinal products, reliable, consistent results are extremely important. “If you’re a doctor recommending a treatment, you’re not inclined to suggest something that has a lot of non-medicinal dissolved plant matter in it,” says Summit Research founder Elliot Kremmerman. “Medications have proven, tested chemical profiles, and distillation is letting us create them for cannabis products.”

He continued: “The purity, potency, and long shelf life of distilled cannabis oils mean they have some of the best margins to be found on the modern cannabis marketplace. In the coming years, there are a lot of consumers who aren’t going to be looking for the best flower, but for the best profile that you can put together mathematically.”

Final Thoughts

There are many more medical ailments that Delta 8 THC can be used for, and distillate can allow manufacturers to make products with very high and accurate doses of any cannabinoid that can be chemically extracted from the plant. If you want to learn more about Delta 8, make sure to subscribe to the Delta 8 Weekly Newsletter where you will find more interesting articles and exclusive deals on flowers and other products.

Resources

THC Isolate Explained – Everything You Need To Know
Newest Cannabinoid Powerhouse – CBC – What Can It Do for You?
It’s Not Your Parents’ THC – Welcome Cannabidiolic Acid Methyl Ester
Delta-8 THC Exploits Fantastic Legal Loophole
Everything You Need To Know About CBG Isolate
A Complete Guide To CBN Isolate (Cannabinol)
Everything You Need To Know About CBD Distillate
Get EU GMP-Certified Cannabinoid Isolates and Distillates
Your Complete Guide to EU GMP-Certified CBD Isolate and Distillate (European Market)
Get EU GMP Extracts: CBD Isolate, CBD Distillate and CBG Isolate

CBG Distillate Explained: What It Is, What It’s For, and How It’s Made
New Vaping Bill: Effective March 2021 No More Mail Order Of CBD & Delta-8 THC Vape Carts
Extra Potent 11-hydroxy-THC and the Power of Cannabis Edibles
What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8THC)
Delta-8 THC Contaminated Products, or Just Bad Press?
The CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers).  Hemp-Derived DELTA 8 THC Products Now Available Online Best Delta-8 THC Vape Bundles – Winter 2021
The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc) and the Best Delta 8 THC Deals. The Bizarre History and Promising Future of Delta 10 THC

What Are Delta-8 THC Moon Rocks And Where To Get Them? INSIGHT: Delta-8 THC Pricing – The Fair Price for Delta 8 Vapes, Tinctures, Gummies
The Many Faces of Tetrahydrocannabinol – Different Types of THC and Their Benefits
Best Hemp Flower Deals, Coupons and Discounts
Delta-8 THC and the UK: Is It Legal?
Delta 8 Update: Shipping Vape Ban Goes Into Effect Soon. Are You Ready? 
Delta 8 Flowers – Milder Than Cannabis, But Very Relaxing and Uplifting 
Now it’s the time to Stock-Up on Delta-8 THC Products

The post All About Delta 8 THC Distillate appeared first on CBD Testers.

Extra Potent 11-hydroxy-THC and the Power of Cannabis Edibles

Lately we’ve been seeing quite a few new cannabinoids popping up, especially new forms of THC. Most are naturally occurring in cannabis, but some, like 11-hydroxy-THC, aren’t found in the plant at all. Let’s take a closer look at this ultra-potent psychoactive compound and what it has to do with the human digestive system.

To learn more about THC, and for deals on flowers and other products, subscribe to the Delta 8 Weekly Newsletter


What is 11-hydroxy-THC?

11-hydroxy-THC, sometimes written 11-OH-THC, is one of our naturally occurring endocannabinoids; meaning it’s made in the body. After delta-8 or delta-9 THC has been swallowed, the body breaks it down and metabolizes it via the liver. 11-hydroxy-THC is a metabolize of the other tetrahydrocannabinols and is regarded as being much more potent than its precursors. This is why delta-8 THC edibles are just as potent as delta-9 edibles, but the same can’t be said for flowers or vape products.

According to neuroscientist and medical cannabis adviser, Dr. Adie Rae, “The liver is responsible for this transformation, and specifically, the drug-metabolizing enzyme known as cytochrome P2C9 or CYP2C9. Even when you smoke, your liver still sees some delta-9 and turns it into 11-hydroxy-THC, but you get way more 11-OH when you eat cannabis.”  

A phenomenon known as “first pass metabolism” is the reason why 11-hyrdoxy-THC has such powerful effects on the brain. Oral administration leads to much more potent and long-lasting effects, compared to inhalation. So if you’ve been wondering why edibles get you beyond baked, this why.

As with other cannabinoids, 11-hydroxy-THC binds to the CB1 receptor; but in this case, it mimics all the known effects of delta-9 THC, but tenfold. The peak concentration of 11-OH-THC is about 1.5 hours after consumption. Effects can last anywhere from one hour to six (and some have reported more) depending on the dose and individual’s tolerance level.

The research on 11-hydroxy-THC

Although limited, the research we do have indicates that 11-hydroxy-THC is considerably stronger than delta-9 THC, the compound in cannabis known for inducing a high. One study in particular published in the Journal of Clinical Investigation found that 11-OH-THC is “much more potent at producing a subjective high and racing heart than delta-9.” This was observed in both animal studies and human surveys, which placed hydroxy-11-THC somewhere between 1.5 and 7 times more potent than delta-9 THC.

Dr. Rae claims the reason for this much higher potency “is partially attributable to the metabolite’s higher binding affinity for the CB1 receptor which physically binds more tightly to the receptor than delta-9. Basically, the better it binds, the better it activates the receptor.”

Back in the 1970s is when this cannabinoid was initially noted, in radiolabled THC was utilized in labs to allow researchers to better study these compounds. Radiolabled THC (which yes, is radioactive) behaves just like regular THC but it allows scientists to see where all the metabolites go once it’s broken down within the body. This is how 11-hydroxy-THC was discovered.

At the time, very little 11-OH-THC was available, for obvious reasons, so for a very long time only small animal studies could be conducted. Once they had the ability create this compound on a larger scale, in a lab, seminal studies were launched to characterize the effects of 11-OH-THC in humans. 

Numerous studies of delta 11 taken intravenously showed it was not only more potent, but onset of effects was much quicker than other forms of THC also administered the same way.  

Smoking vs eating cannabis

If you’re anything like me and many other cannabis users I’ve spoken to, edibles hit different than smoking. Even though it takes a while to feel anything, once they kick in, I’m laid out on the couch almost every time. I feel more stoned, I’m laughing at everything, and eventually, I get super tired. This seems to be commonplace when it comes to edibles; but why exactly do they differ so much from smoking, from a scientific standpoint?

It comes down to two factors: the drug-metabolizing enzymes in your GI tract, and blood flow to the liver. When you first eat a cannabis edible, various enzymes in the GI tract begin digesting the food. From that point, blood flow from the GI tract goes through the liver where all these enzymes are metabolized, then the blood continues to general circulation. When the metabolites are formed, that’s when you get the effects of 11-hydroxy-THC.

However, when you smoke cannabis, THC is absorbed through the lungs and distributed directly into the bloodstream. The active compounds make their way to the brain where they interact with the CB receptors that are part of the endocannabinoid system. In this scenario, you are feeling the effects of the phytocannabinoids (plant-cannabinoids) themselves, rather than the compound formed during metabolism.

How to avoid consuming too much 11-hydroxy-THC

When it comes to edibles, it’s easy to go overboard. Because it takes so much longer to notice the effects, a lot of people end up eating more than they should, thinking that the edibles aren’t working, then get surprised when all that THC finally kicks in. According to statistical surveys, the overwhelming majority of ER visits associated with cannabis are because of edibles, and this explains why.

Whether you make them yourself or buy them at the dispensary, if you want to avoid having any of these issues yourself, remember the adjunct “less is more”. That’s very true when it comes to cannabis edibles, especially if you’re a novice user.

It’s also important to remember that not everyone feels edibles the same way. Some people are more sensitive to 11-hydroxy-THC than others. Those people will feel edibles in a much more powerful way than people whose bodies are more resistant to the compound.

“Because 11-hydroxy-THC is made by the liver, and we all have different liver enzymes and genetic mutations in those enzymes, cannabis edibles can affect people very differently. There is a huge range in how individuals metabolize delta-9 into 11-hydroxy-THC, with age, sex, historical cannabis use, concurrent medications, and other factors contributing to variability,” Dr. Rae concluded.

Resources

It’s Not Your Parents’ THC – Welcome Cannabidiolic Acid Methyl Ester
Delta-8 THC Exploits Fantastic Legal Loophole

Why Using THC Is Good for the Eyes
New Vaping Bill: Effective March 2021 No More Mail Order Of CBD & Delta-8 THC Vape Carts
What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8THC)

Delta-8 THC Contaminated Products, or Just Bad Press?
The CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers).  Hemp-Derived DELTA 8 THC Products Now Available Online Best Delta-8 THC Vape Bundles – Winter 2021
New Vaping Bill: Effective March 2021 No More Mail Order Of CBD & Delta-8 THC Vape Carts

The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc) and the Best Delta 8 THC DealsThe Bizarre History and Promising Future of Delta 10 THC
What Are Delta-8 THC Moon Rocks And Where To Get Them? INSIGHT: Delta-8 THC Pricing – The Fair Price for Delta 8 Vapes, Tinctures, Gummies and The Many Faces of Tetrahydrocannabinol – Different Types of THC and Their Benefits
Delta-8 THC and the UK: Is It Legal?
Delta 8 Update: Shipping Vape Ban Goes Into Effect Soon. Are You Ready? Delta 8 Flowers – Milder Than Cannabis, But Very Relaxing and Uplifting Now it’s the time to Stock-Up on Delta-8 THC Products

The post Extra Potent 11-hydroxy-THC and the Power of Cannabis Edibles appeared first on CBD Testers.

The Many Faces of Tetrahydrocannabinol – Different Types of THC and Their Benefits

Although we started off our journey at CBD Testers with a strong emphasis on minor cannabinoids, lately, we’ve been taking a closer look at the most abundant one – THC – and all of its many applications and benefits. Another interesting, and sometimes confusing, point about this compound is how many variations of it exist.

Most people know that THC (tetrahydrocannabinol) is the dominant compound found in marijuana, and also the one that holds the plant’s psychoactive properties. It’s the most popular cannabis compound, for obvious reasons, and it also has numerous medical benefits that we as a society are only beginning to fully understand.

There are 4 major types of THC that are naturally occurring in the plant: THCA, THCV, Delta 8 THC and Delta 9 THC. There is also another type that was very recently discovered – Delta 10 THC – although this one was accidentally manmade, it still has some interesting properties that are worth covering. All of these different types of tetrahydrocannabinol are chemically unique with different medical benefits.

To learn more about cannabis, and for exclusive deals on Delta-8 THC and other products, subscribe to the Delta 8 Weekly Newsletter


THCA – Tetrahydrocannabinolic Acid

For the sake of simplicity, we’ll start at the very beginning by looking at THC in its most natural form: THCA. In short, THCA is the type of THC found in raw cannabis plant. So when you walk into a dispensary and start looking at different bud samples and see how much THC is in each one, what you’re actually looking at is the levels of THCA. Once heat is applied, THCA loses its carboxyl acid group (in a process known as decarboxylation) and becomes THC.

THCA is found virtually everywhere in the plant, including the stems, leaves, and flowers. On its own, it has no psychoactive properties. The mind-altering effects come into play after decarboxylation, as THCA is just a precursor to all the other tetrahydrocannabinols.

THCA is believed to have an assortment of therapeutic uses and is commonly used as a nutritional supplement and dietary enhancement. These benefits can be utilized via eating, blending, or juicing the raw cannabis plant matter along with other superfoods, like berries, kale, and avocados.

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THCV – Tetrahydrocannabivarin

THCV is basically a cousin of THC and another byproduct of the THCA breakdown process. Up for debate is whether THCV actually gets you high like THC does. Most of the available research indicates that, in low doses, THCV is non-psychoactive, but in high doses, it activates the CB1 receptor and induces a high. THCV also has a much higher boiling point than THC (428°F vs 314°F), so if you choose to vape THCV flowers or other products you will need to crank that temperature up to really experience any of the effects.

As far as benefits go, one of the main points of interest regarding THCV is the fact that it suppresses the appetite, rather than engage it like THC does. It’s frequently advertised as a “diet weed” because, as the promotional material states: you can get stoned and lose weight at the same time. Some research say that, if weight loss is the goal, a strain with a fairly even ratio of THCV and CBD will do the trick. Of course, results may vary on that.

Additional studies found that THCV has the ability to regulate blood sugar levals and reduce insulin resistance, making a promising herbal supplement for patients with diabetes. It has also been shown to contain antioxidant and neuroprotective properties. Strains high in THCV include Pineapple Purps, Ace of Spades, Doug’s Varin, Durban Poison, Power Plant, Willie Nelson, Jack the Ripper, and other African Sativa strains.

Delta 8 THC

In chemistry, “delta” refers to the double bond on a molecule’s carbon chain. In the case of THC, we have a few different variations. With delta 8 THC, the double bond is on the 8th carbon chain, whereas with the more common Delta 9 THC, the double bond is on the 9th chain. In cannabis plants, delta 8 is only present in trace amounts. As delta 9 THC ages and oxidizes, it converts to delta 8. As a result of this conversion process, Delta 8 THC remains stable when exposed to air, meaning it could have more potential medical applications than delta 9, although Delta 8 is less potent.

The high you get from Delta 8 THC can vary based on tolerance, personal body chemistry, or strength and type of the product used. For example, if you smoke Delta 8 flowers, the high will be different than delta 9 flowers, but if you eat edibles, all of them will have a similar effect in the body. Typically, a Delta 8 THC high is said to be clear-headed, energetic, and uplifted than D9.

Because of the milder head high, Delta 8 THC is great for helping people deal with anxiety, depression, post traumatic stress disorder, and other mental health disorders. And while studies remain limited on this particular cannabinoid, it has been determined to have a few health benefits of its own such has neuroprotective, antioxidant, and analgesic properties. To learn more about Delta 8 THC and try out some products (with exclusive discounts for our subscribers) makes sure to sign up for the Delta 8 Weekly Newsletter.

Delta 9 THC

When people think of “THC”, Delta 9 is what they’re thinking of. Delta 9 THC is the main psychoactive compound in the cannabis plant, minus a few CBD-dominant strains. For decades, THC has been a controversial and illegal compound because lawmakers were to heavily focused on its psychoactive properties while completely ignoring all of its many possible uses in the health and wellness sector.

One of the most common, non-recreational uses for THC is to manage pain. Whether that pain stems from inflammation, headaches, injury, chemotherapy, menstrual cramps, injury, or neuropathic pain – cannabis seems to equipped offer relief in every scenario. Anecdotal evidence, as well as some studies that have recently emerged, will tell you that THC is actually one of the best remedies on earth for treating digestive issues such as nausea and wasting syndrome.

Another important use for THC is brain cell regeneration… which is particularly interesting since one of the main points on keeping cannabis illegal is how bad it is for the brain, but that is actually not always the case. This is especially true for elderly patients who use THC products. Studies show that it helps with more than just brain function and improving memory, but THC actually helps change the structure of the brain cells to who traits of cognitive youth.

Other therapeutic uses for THC include: sleep aid, antioxidant, antimicrobial, epilepsy relief, glaucoma, and muscle relaxer.

Delta 10 THC

Unlike the other THCs on this list, Delta 10 is not a naturally occurring plant compound, although it does start off that way. This molecular sibling does have many commonalities with Delta 9 and Delta 8 tetrahydrocannabinols, but there are some key differences as well.

As with many of the nation’s cannabis trends, Delta 10 THC started in California too. However, this time, it was purely accidental. An Adelanto-based company, Fusion Farms, bought some outdoor flower to manufacture concentrates. As many already know, California is subject to very large, nearly annual wildfires; and unbeknownst to Fusion Farms, the biomass they purchased was contaminated with fire retardant. Since they were unaware of the contamination, they continued with the extraction as planned but after the distillation process, unusual crystals began to form.

These crystals had a completely different structure than previously observed cannabinoid crystals. After conducting some laboratory tests, it was determined that these crystals were most similar to CBC (cannabichromene), but still not an exact match. They continued testing this structure against all the known cannabinoids and no match was found. This went on for several months.

Final Thoughts

With all the different articles we have on THC, it seemed logical to combine them all in one place to make things easier for our readers. Tetrahydrocannabinol is such a fascinating compound and it’s incredibly important for people to realize that it’s much more than just a recreational substance. It’s a complex cannabinoid with a long list of possible medical uses, from mental health benefits to pain relief to treatment of neurological disorders, there’s very that all the different types of THC can’t do.

Thank you for stopping by CBD TESTERS, your hub for all things cannabis related. Make sure to subscribe to the CBD Flowers Weekly Newsletter for more information about cannabis and exclusive deals on flowers and other products.

The post The Many Faces of Tetrahydrocannabinol – Different Types of THC and Their Benefits appeared first on CBD Testers.

What Medical Conditions Could Benefit Most from Delta 8 THC?

Delta 8 THC is one of the most popular products in the recreational cannabis market today. It’s a legal alternative to THC that offers users a mild but fun and uplifting high. But did you know that Delta 8 also has numerous medical benefits, many of which have been studied and proven through scientific research?

To learn more about Delta 8 THC from a medical and recreational standpoint, and for exclusive deals on Delta-8 THC vapes, gummies, flowers and other products, subscribe to the Delta 8 Weekly Newsletter


What is Delta 8 THC?

Before we talk about the medical benefits of this cannabinoid, let’s talk about what exactly Delta 8 THC is, and how it’s different from the more well-known, Delta 9 THC. Delta 8 THC (tetrahydrocannabinol) is a naturally occurring, minor cannabinoid found in the cannabis plant. Although it’s structurally similar to Delta 9 THC, there are some major differences as well.

For example, Delta 9 THC is the cannabis plant’s most abundant psychoactive compound, whereas Delta 8 is only found in trace amounts. As a matter of fact, Delta 8 is not even produced by the enzymes in cannabis, rather, it is created when Delta 9 THC oxidizes and slowly degrades into Delta 8. Further degradation of Delta 9 would create the cannabinoid CBN (cannabinol).  

When it comes to the chemical difference between Delta 8 and Delta 9, it all comes down to one molecule. In chemistry, “Delta” refers to the double bond in a compound’s molecular structure. Delta compounds have more electrons and will interact with the body in a different way than single bond cannabinoids. The difference between the Delta THC analogues comes down to where the double bond is located on their chain of carbon atoms. Delta 9 has this bond on the 9th carbon chain, and Delta 8 THC has the double bond on the 8th carbon chain. It seems like a small difference, but it can be significant.

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Similar to its more dominant counterpart, Delta 8 THC is a partial agonist for both the CB1 and CB2 receptors, although it seems to have a stronger affinity for CB1. This means there are effects to be felt in numerous different parts of the body, despite having weaker psychotropic potency. The National Center for Biological Information (NCBI) describes delta-8 THC as follows: “An analogue of tetrahydrocannabinol (THC) with antiemetic, anxiolytic, appetite-stimulating, analgesic, and neuroprotective properties.”

What Medical Conditions Could Be Treated With Delta 8 THC

Insomnia

Inadequate sleep can have a profound impact on one’s health. In the short-term, it can affect mood and judgement, the ability to learn and retain information, and it can increase the possibility of an immediate accident or injury. Over a longer period of time, lack of sleep can lead to diabetes, obesity, cardiovascular disease, and even early death.

Extensive research tells us that activation of the CB1 receptor leads to better, longer, and more restful sleep, and keeping in mind that Delta 8 THC directly stimulates the CB1 receptor, one can easily come to the conclusion that Delta 8 is good for sleep. REM sleep is an important part of our circadian cycles because it stimulates parts of the brain that are essential for learning new things and forming memories.

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Anecdotal evidence leads to the same conclusion with many users claiming that Delta 8 THC helps them fall asleep more easily and stay asleep longer. They also report feeling more refreshed and well-rested when waking up.

It’s believed that Delta 8 THC’s analgesic and anti-inflammatory properties play a major role in its ability to function as a sleep aid. There is a strong connection between pain and sleep. Obviously, someone who is experiencing a lot of pain will have trouble getting comfortable and thus, have difficulty falling asleep. But the relationship goes even deeper – as lack of sleep increases the perception of pain. Breaking the pain/lack of sleep cycle is incredibly difficult, and having a good night’s sleep with both REM and deep sleep stages is key to making improvements.  

Cancer

While I’m not saying that smoking some delta 8 flowers or popping a few gummies will cure cancer, studies have proven that pharmaceutical products with highly concentrated doses of certain cannabinoids will do the trick.

This was first observed in 1974, in none other than Israel, where a study meant to focus on the immune system inadvertently found that Delta 8 THC alone significantly slowed tumor growth in mice. When combined with CBN (cannabinol), tumors actually began to shrink in as little as 3 weeks.

“Mice treated for 20 consecutive days with delta8-THC and CBN had reduced primary tumor size. CBD showed no inhibitory effect on tumor growth at 14, 21, or 28 days. Delta9-THC, delta8-THC, and CBN increased the mean survival time.” Antineoplastic activity of cannabinoids – PubMed (nih.gov)

Another study in 1995 on children with leukemia, showed a high rate of efficacy for treating the cancer, while also controlling side effects like nausea and vomiting caused by more conventional forms of treatment. The study was conducted at Shaare Zedek Hospital, Bikur Holim Hospital and the Hebrew University located in Jerusalem. The creators of the study, led by Raphael Mechulam, noted that “at the same this research was occurring, there had been 480 successful treatments of cancer with delta-8 THC.”

Anxiety

If you’re prone to anxiety, the mild and uplifting high you get from Delta 8 THC might be just what you need. Delta 8 THC offers all the medicinal effects of THC, and even some minor psychoactive effects, without the paranoia that often comes with Delta 9. The carefree high that comes with weed is often dampened by the anxious, nervous high some people experience.

Studies show that the endocannabinoid system, mainly the CB1 receptor, is centrally involved in regulating anxiety and depression. When the CB1 receptor is blocked, increased anxiety often occurs. Many people successfully utilize CBD (cannabidiol) to relieve their anxiety, but for many others it’s just not strong enough.

According to the National Cancer Institute, “this phytocannabinoid displays anxiolytic (anti-anxiety) qualities similar to delta-9 THC.” There is little in the way clinical research investing delta-8 THC’s potential to reduce anxiety, however, anecdotal evidence suggests that delta 8 products provide a nice, calm, focused, and stress-free high.

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Final thoughts

There are many more medical ailments that Delta 8 THC can be used for, but these are some of the more studied and most frequently cited uses for this cannabinoid. If you want to learn more about Delta 8, make sure to subscribe to the Delta 8 Weekly Newsletter where you will find more interesting articles and exclusive deals on flowers and other products.

The post What Medical Conditions Could Benefit Most from Delta 8 THC? appeared first on CBD Testers.