Illegal Synthetics, Amanita Hemp Cup Products, Cannabis Music Banned – The Cannadelics Sunday Edition

Welcome to our weekly newsletter, The Cannadelics Sunday Edition, emailed to our subscribers every Sunday morning 11am est, with the main items of the week. This week we look into Illegal Synthetics, new Amanita mushroom Hemp Cup products, Cannabis music and media getting banned, Cannabis tourism in Uruguay, Trainspotting, Argentina hemp laws, Amanita beginners guide and types of hangovers and more.

As always, In addition the weekly digest, the newsletter comes with few of our Deal Of The Day offers. As always, the best Cannabis and Psychedelic products are reserved for our readers, so subscribe today or use the sign-in form below:

 Keep yourself updated with the latest Cannabis & Psychedelic stories, such as Illegal Synthetics, Amanita hemp cup products and more: 
Subscribe to our newsletter

The Cannadelics Sunday Edition (2/26/2023) – Illegal Synthetics, Amanita Hemp Cup Products, Cannabis Music Banned and more


Welcome to the Cannadelics Sunday edition, going out every Sunday with the top stories from the cannabis and psychedelics industries. This week we have a mixed bag of stories as well as a few deals from our deal-of-the-day segments.

Thanks for stopping by!


Amanita HHC Gummies

Amanita HHC Gummies

Be a part of history by trying out the latest Cannadelic additions to the 2023 High Times Hemp Cup – the new Amanita HHC gummies and Amanita HHC joints, both featuring psychedelic mushrooms. High Times has never before included these types of products in their hemp cup, making this a groundbreaking event. 

Of particular interest are the more potent offerings, such as the Amanita HHC Amanita gummies and the Amanita D8 joints. The HHC gummies stand out for two reasons: they feature HHC (hexahydrocannabinol), a simplified version of THC, and they’re a rare combination of gummy and chocolate. 

If you’re curious to try them out, CLICK HERE and use the “cannadelics” coupon code to save 20% on your order. 

Click here to buy Amanita HHC gummies

(With Cannadelics coupon code)


This week we have a pretty even mix of both cannabis and psychedelics news. Among this stories, we have one explaining the DEA’s clarification on Illegal Synthetics. We’re also covering a recent ban on cannabis themed music and media in the Dominican Republic, a federal judge’s rule on cannabis and guns in Oklahoma, new Amanita mushroom products in hemp cup and so much more!

Illegal Synthetics:

Illegal Synthetics: DEA Reiterates That Synthetic Cannabinoids Are Illegal

Illegal Synthetics: DEA says synthetic cannabinoids are illegal
Illegal Synthetics: DEA Reiterates That Synthetic Cannabinoids Are Illegal

This debate has been raging on for years- are synthetic “hemp-derived” cannabinoids federally legal or not? Some claim vehemently that they are, while others remain skeptical. However, a recent statement from the FDA offers us some clarity, claiming that synthetic cannabinoids are in fact, illegal, even if they are hemp-derived. 

Continue reading »

Amanita Mushroom Products at 2023 High Times Hemp Cup Kits

Amanita Mushroom Products at 2023 High Times Hemp Cup Kits
Amanita Hemp Cup products
(Screenshot from

The 2023 High Times Hemp Cup is introducing a new product to the competition – Amanita Hemp Cup products that contain muscimol from Amanita muscaria mushrooms, combined with popular cannabinoids. The Amanita Hemp Cup products include gummies and pre-rolled joints containing muscimol combined with HHC, Delta 8 THC, and CBD.

Continue reading »

Special deal on Amanita Muscaria gummies: only $2.4/gummy

Dominican Republic Banned Cannabis Themed Music & Media

Dominican Republic Banned Cannabis Themed Music & Media
Dominican Republic cannabis

While most of the cannabis-related news stories these days show different regions relaxing regulations against the plant, some places, are heading steadfast in the opposite direction. Take the Dominican Republic, for instance. Not only are they not even considering any type of cannabis legislation, they actually took things a step further and banned cannabis themed music and media.

Continue reading »

Uruguay Working Toward Cannabis Tourist Industry to Fight Black Market

Global cannabis tourism
Global cannabis tourism

Although it often flies under the radar in many discussions on the subject, Uruguay is the world’s oldest, legal recreational cannabis market. If we follow what happens there, it can give us a good indication of what may transpire in other legal markets throughout the world. Currently, Uruguay is working on bolstering the cannabis tourism industry in order to thwart the still-thriving black market. 

Continue reading »


Save big on high-THCA flower

THCA Flower Bundle

Introducing an exclusive high-THCA flower bundle – a very limited edition discounted bundle sampler featuring some of the freshest flowers you can buy online . 

This bundle includes 8 eighths of the strains listed below:

  • 3.5g of Afghan THCa Hemp Flower
  • 3.5g of Miracle Alien Cookies THCa Hemp Flower
  • 3.5g of Grand Daddy Purple THCa Hemp Flower
  • 3.5g of Death Star THCa Hemp Flower
  • 3.5g of Hippie Crippler THCa Hemp Flower
  • 3.5g of Gorila Glue Pheno 1 THCa Hemp Flower
  • 3.5g of Green Crack THCa Hemp Flower
  • 3.5g of Blueberry Pheno 1 THCa Hemp Flower

Act fast to get your hands on this exclusive bundle before it’s gone!

Save big on high-THCA flower

Additional Reading:

A few more articles for your reading pleasure, such as the 2023 farm-bill, medical cannabis, salvia, Delta 9 vs Delta 8 etc.

Trainspotting: The Truth about Scotland and Heroin

trainspotting heroin / Illegal Synthetics
Trainspotting: The Truth about Scotland and Heroin

When Trainspotting, written by the Irvin Welsh and directed by the equally wonderful Danny Boyle, was released in 1996, people knew that they had a nuanced and well-thought-out film about heroin addiction on their hands. Trainspotting forced its way into many viewer’s ‘best films of all time’ list and rightfully so. But why did a movie about a group of Scottish friends dealing with drug and life issues become such a cult classic? Perhaps, simply, because told the sad truth about opioid addiction.

Continue reading »

Amanita Muscaria Beginner’s Guide: Everything You Need to Know

Amanita Muscaria Beginner's Guide
Amanita Muscaria Beginner’s Guide

Amanita muscaria, also known as Fly Agaric, is a fascinating old world mushroom that has recently grown in popularity due to the fact that it is very loosely regulated compared to other types of psychedelic mushrooms. If you’re a beginner looking to try Amanita Muscaria, it’s crucial to take the necessary precautions before consuming it, as all good things comes with responsibility and any drug can be problematic when used incorrectly.

Continue reading »

Clearance sale: 50% off THCO carts, disposables, gummies, tinctures and dabs

New Argentina Hemp Law Expected to Widen Domestic and Export Markets

New Argentina hemp law in place, Illegal Synthetics
New Argentina Hemp Law Expected to Widen Domestic and Export Markets

With the help of activist groups like Mama Cultiva, Argentia forced its way into the medical cannabis market. Now, Argentina making even bigger moves by opening the doors for increased hemp production for both domestic and export markets. The announcement for the implementation of the Regulatory Agency for the Hemp and Medical Cannabis Industry (ARICCAME), came out on January 25th, with its first working group to start immediately.

Continue reading »

Why All Types of Alcohol Cause the SAME Hangover?

Alcohol hangover, Illegal Synthetics
Alcohol hangover

Some people swear that certain alcohols produce different types of hangovers, similar to the way the produce different drunk effects. While that may be true for certain people, it’s more of a matter of personal body chemistry rather than the alcohol itself. As a matter of fact, scientific literature indicates that all alcohols actually result in the exact same hangover. 

Continue reading »


Medical Cannabis Card Online

At, you can obtain your medical marijuana card online from a state-certified medical marijuana doctor. Thousands of patients have already received their new MMJ card, renewal, or 12-month prescription – and now it’s your turn! 
Rest assured that you’ll receive the doctor’s certification or they will give you your money back with as it is 100% money-back guarantee

Don’t wait any longer – get started now and experience the convenience of obtaining your medical marijuana card from the comfort of your own home.

Click here to get your Medical Card


Amanita HHC Gummies & Amanita Delta 8 Joints

Amanita Delta 8 Joints
Amanita HHC Gummies & Amanita Delta 8 Joints

Get ready to experience the latest addition to the 2023 High Times Hemp Cup – the Amanita Mushroom products featuring muscimol from Amanita muscaria mushrooms, combined with popular cannabinoids. These products are sure to give you a unique and exciting experience, producing psychoactive effects that will transport you to another world. 
Among the offerings are the Amanita HHC gummies and Amanita D8 joints, both featuring rare and potent combinations. 
posables, dabs, tinctures, and edibles at prices never seen before.

Buy Amanita HHC gummies & Amanita Delta 8 joints

Keep Yourself Informed

All the latest from Psychedelics and Cannabis - Illegal Synthetics
All the latest from Psychedelics and Cannabis

For all the latest from Psychedelics and Cannabis, follow our Telegram Channel.

 Get our daily updates

News from the Week:

*** Coco Puffs – What’s the Deal with Mixing Cannabis and Cocaine?

*** What’s The Deal with Shoddy Vape Carts Lately?

*** Worse Than Fentanyl? New Opioid Isotonitazene Deepens Opioid Crisis

*** 2023 Farm Bill Under Construction: What to Expect For Hemp

*** Does A Medical Setting Affect Psychedelic Treatment?

*** How Legal Cannabis Affects Pharmaceutical Sales

llegal Synthetics, Amanita Hemp Cup Products, Cannabis Music Banned – Conclusion

We hope you enjoyed this week’s review. We work hard to find and verify the best products, so we may include affiliate links to support the maintenance and development of this site. 

The Cannadelics team 

*** Disclaimer: As the legality of cannabinoids and psychedelics changes between state to state, you should always check with your local authorities first.

The post Illegal Synthetics, Amanita Hemp Cup Products, Cannabis Music Banned – The Cannadelics Sunday Edition appeared first on Cannadelics.

DEA Rules Delta-8 And Delta-9 THCO Are Controlled Substances

The Drug Enforcement Administration (DEA) ruled earlier this week that the cannabinoids delta-8 THCO and delta-9 THCO are controlled substances that are illegal under federal law, even if they’re synthesized from legal hemp. The two cannabinoids, which don’t occur naturally but can be synthesized from hemp, have become popular in some markets across the country, particularly in states that haven’t yet legalized adult-use cannabis. 

The 2018 Farm Bill legalized hemp and products derived from it, leading to a significant increase in the cultivation of the crop as farmers and processors sought to take advantage of consumer interest in CBD. Since then, products made with the novel cannabinoid delta-8 THC, which naturally occurs in cannabis in trace amounts and can be synthesized in large quantities from CBD, have also become popular. Last year a federal court ruled that delta-8 THC is legal when derived from hemp. Products containing the intoxicating cannabinoid have become popular from coast to coast, with availability in specialty shops, convenience stores and gas stations, among other retailers.

In 2022, attorney Rod Kight sent a letter to the DEA inquiring about the legal status of delta-8 THCO and delta-9 THCO, according to a report from Marijuana Moment. After he repeated the request earlier this month, the DEA sent a response letter to Kight on February 13, saying that the two cannabinoids “do not occur naturally in the cannabis plant and can only be obtained synthetically, and therefore do not fall under the definition of hemp.”

In the letter, Terrence L. Boos, the chief of the DEA’s Drug & Chemical Evaluation Section of the Diversion Control Division, wrote that “delta-9-THCO and delta-8-THCO are tetrahydrocannabinols having similar chemical structures and pharmacological activities to those contained in the cannabis plant. Thus, delta-9-THCO and delta-8-THCO meet the definition of “tetrahydrocannabinols,” and they (and products containing delta-9-THCO and delta-8- THCO) are controlled in schedule I” of the federal Controlled Substances Act.

In a blog post about the letter from the DEA, Kight wrote “although I don’t always agree with the DEA’s view on cannabis matters, I agree with this opinion and, frankly, am not surprised. This is what I’ve been saying for a while. I’ve been concerned about the proliferation of THC acetate ester (THCO) for a while. It has always been my view that THCO is a controlled substance under federal law. Although it can be made from cannabinoids from hemp, THCO isn’t naturally expressed by the hemp plant. It’s a laboratory creation that doesn’t occur in nature, at least not from the hemp plant.”

Shawn Hauser, a partner at the cannabis and psychedelics law firm Vicente Sederberg LLP, says that the DEA’s ruling doesn’t impact the regulated cannabis industry because of the plant’s continued illegality under federal law. The determination could, however, lead states to only allow synthetic cannabinoids under cannabis regulatory regimes rather than permitting them under hemp regulations. 

Definition Required Around Term “Synthetic” Cannabinoid

The determination is also significant because while the DEA has been clear in its Interim Final Rule implementing the 2018 Farm Bill that the agency doesn’t consider “synthetic” hemp products to be legal hemp and were therefore federally illegal controlled substances, it didn’t define the term “synthetic” as the term is applied to cannabinoids. Hauser notes that without further clarification or enforcement action, the Interim Final Rule led to confusion among the industry and consumers about the legality of novel cannabinoids that don’t occur naturally in the hemp plant.

“This federal ambiguity and a growing and innovating hemp market resulted in states taking varying approaches as to how they define and regulate ‘synthetic’ cannabinoids, and substantial confusion for industry, consumers and regulators as to the legality and safety of certain products,” Hauser says. “While this provides some long-overdue clarity as to the illegality of certain cannabinoids not naturally occurring in the plant under the Controlled Substances Act, this determination underscores the mess the DEA and FDA have created in failing to appropriately regulate both synthetic and natural cannabinoids to ensure consumer safety.”

Advocates contend that consumer and producer confusion about the legality of novel cannabinoids could be eliminated with the federal legalization of marijuana. Once prohibition is lifted and natural cannabinoids are available to the public, demand for intoxicating novel cannabinoids would likely dry up.

“Whether they’re synthetic or naturally occurring, psychoactive cannabinoids need to be regulated responsibly to protect public health and safety,” Aaron Smith, CEO of the National Cannabis Industry Association (NCIA), said in a statement. “The only way to successfully achieve that end is to finally end national prohibition, enact sensible regulations at the federal level and allow state cannabis laws continue to work across the country.”

The post DEA Rules Delta-8 And Delta-9 THCO Are Controlled Substances appeared first on Cannabis Now.

DEA States that Delta-9-THCO, Delta-8-THCO Are Not Hemp

In an email response sent to Rod Kight of Kight Law Office PC on Feb. 13, the Drug Enforcement Administration (DEA) stated that because delta-9-THCO and delta-8-THCO are synthetic and are not found naturally in cannabis, they do not count as hemp, and are therefore controlled substances.

Kight’s letter was originally sent in August 2022 (and a follow-up email sent last week on Feb. 7) with a request for the status of THC acetate ester (THCO) under the Controlled Substances Act (CSA).

Terrence L. Boos, Chief Drug & Chemical Evaluation Section Diversion Control Division penned the response, and clarified the agency’s stance on delta products. “The only substances of which the Drug Enforcement Administration (DEA) is aware of the THC acetate ester are delta-9-THCO (delta-9-THC acetate ester) and delta-8-THCO (delta-8-THC acetate ester),” Boos said. “The Drug Enforcement Administration (DEA) reviewed the CSA and its implementing regulations with regard to the control status of these substances.”

Boos explained that the CSA classifies “tetrahydrocannabinols,” or THC, as “naturally contained in a plant of the genus Cannabis (cannabis plant), as well as synthetic equivalents of the substances contained in the cannabis plant and/or synthetic substances, derivatives, and their isomers with similar chemical structure and pharmacological activity to those substances contained in the plant.”

Because of this definition, neither delta-9-THCO or delta-8-THCO are considered to be hemp by the DEA. “Delta-9-THCO and delta-8-THCO do not occur naturally in the cannabis plant and can only be obtained synthetically, and therefore do not fall under the definition of hemp,” wrote Boos.

He added that delta-9-THCO and delta-8-THCO have “similar chemical structures and pharmacological activities to those contained in the cannabis plant,” and thus meet the definition of “tetrahydrocannabinols,” which the agency classifies in Schedule I. He also included the molecular structure of delta-9-THCO and delta-8-THCO for reference at the end of the letter.

In a written statement from Michelle Bodian, a partner at Vicente Sederberg, Bodian explained what this news could mean for the industry. “While the latest statement from DEA does not clarify the legal status of all novel hemp derived cannabinoids, it does clarify that DEA believes Delta-9THCO and Delta-8THCO are controlled substances,” said Michelle Bodian, Partner at Vicente Sederberg. “Hopefully, there is Congressional action soon to address the legality of all hemp derived cannabinoids, so the industry is not left with a patchwork of law, regulation, policy and now, letter statements.”

While the government has been silent on a definitive course of action in regard to regulating delta products, state legislators have been left to take action on their own.

Delta-8 products were banned in New York in May 2021. Ohio created new rules to govern delta-8 products in June 2021, including production and sales. A new law introduced in Michigan in July 2021 also created regulations that limited the sale of delta-8 products to only cannabis businesses that were licensed by the Michigan Marijuana Regulatory Agency. Later in November 2021, a Texas judge issued a temporary injunction that removed delta-8 from the state’s list of Schedule I substances.

In May 2022, governmental agencies such as the Food and Drug Administration (FDA) sent out warning letters to businesses selling delta-8 products. “The FDA is very concerned about the growing popularity of delta-8 THC products being sold online and in stores nationwide,” said FDA Principal Deputy Commissioner Janet Woodcock. “These products often include claims that they treat or alleviate the side effects related to a wide variety of diseases or medical disorders, such as cancer, multiple sclerosis, chronic pain, nausea, and anxiety.”

In the most recent string of delta-related news, Connecticut Attorney General William Tong recently announced that his office was suing five retailers selling cannabis without a license, specifically in relation to delta-8 THC. “Cannabis products in Connecticut cannot be sold by unlicensed retailers and must meet rigorous testing and packaging requirements. Period,” said Tong in a statement. “Any unlicensed Connecticut retailer selling delta-8 THC products that purport to contain high levels of THC is breaking the law and may be subject to both criminal and civil penalties.”

The post DEA States that Delta-9-THCO, Delta-8-THCO Are Not Hemp appeared first on High Times.

Understanding HHC, the Latest Contentious Cannabinoid

The cannabis plant naturally produces more than 100 cannabinoids, and the 2018 Farm Bill legalized all but one of them. The ruling paved the way for the dawn of the CBD age and opened the floodgates to hemp farms from coast to coast. The surge in hemp production subsequently created a surplus amount of CBD, which caused commodity prices to crash, sending extractors and processors scrambling to find alternative opportunities to convert the glut into fresh revenue streams.

A loophole in the bill meant that intoxicating cannabinoids, including delta-8, delta-10 and the hot new kid in town, hexahydrocannabinol (HHC), could be created and sold legally in states where adult-use cannabis remains illegal, as long as they contain less than 0.3% delta-9-THC.

Although a relatively new market offering, HHC was created in the 1940s by Roger Adams. The American chemist added hydrogen to the THC molecule, altering its physical properties. The process, called hydrogenation, changes the molecular weight and increases the stability of delta-9 THC by replacing a double bond with two hydrogen atoms. (Cannabinoid synthesis isn’t the only application of hydrogenation; margarine is made from vegetable oil using a similar process.) This means HHC is a synthetic cannabinoid instead of naturally occurring in the cannabis plant. 

To make sense of HHC is cannabis scientist Dr. Markus Roggen, president and chief scientific officer at Vancouver-based Delic Labs. Dr. Roggen has been on the Cannabis Scientist Power List for three consecutive years and is considered one of the leading organic chemists in cannabinoid and psilocybin research.

Dr. Markus Roggen PHOTO Delic Labs.

Cannabis Now: So, what exactly is HHC?

Dr. Markus Roggen: HHC is the reduced form of THC. THC is a tricyclic molecule with a cyclohexene moiety, meaning it’s a six-membered ring with one double bond. If you reduce that, you get a six-membered ring with no double bond, which is HHC. There are two isomers of HHC because the double bond was next to a methyl group. There are two forms of HHC, and there isn’t any literature discussing which one of those two diastereomers is psychoactive, or if both are and in what ratio they’re formed. 

How is HHC made?

The primary source of HHC is CBD, which we know is in extreme abundance. CBD is a bicyclic structure with the same molecular weight as THC, meaning CBD converts into THC, both delta-8 and delta-9, by adding acid, which turns this bicyclic compound into a tricyclic structure. If you play with the acid or the temperature, you can push the balance between the ratio of delta-8 and delta-9. You now have THC, a tricyclic structure with a double bond. To reduce the structure with palladium catalysis—i.e., a transition metal catalyst—you use hydrogen gas and add two hydrogens across the double bond. Now you have a reduced form, HHC or hexahydrocannabinol—which has six hydrons—THC, tetrahydrocannabinol, has four hydrogens.

What do you see as potential issues to watch out for with HHC?

My main problem is that it’s a synthetic cannabinoid—a new molecule, a new drug—not from the cannabis plant. These new “drugs” are similar to the synthetic cannabinoid scene that started with JWH-018, or “Spice,” i.e., compounds developed in academic laboratories to research the endocannabinoid system. And because these synthetic cannabinoids aren’t structurally related to THC, they don’t come up on a drug test. And as we know, synthetic cannabinoids such as Spice have killed people

Humans have used THC and CBD for thousands of years, so we can say that cannabis is considered safe. HHC, on the other hand, was first identified and produced in the 1940s and wasn’t commercially available until last year. So how should anyone know? Some “researchers” making these compounds have no skill in making clean products; they’re just throwing acid on a cannabinoid to try and get people high. 

Companies are making synthetically produced compounds while saying everything is natural and, therefore, everything is great. That’s blindsiding customers. It’s not fair to say, “this product is natural; it can’t be bad because humans have been using it for thousands of years,” and then slip in an intoxicating drug you just made in your basement. I think that’s a bad idea and it’s very dangerous for the cannabis industry that has built itself on “we’re healing people” and “we’re all natural” mantras to then say, “let’s see what my chemistry starter kit can produce.” We don’t even know if the primary product is safe.

The structural formula of HHC.

I’ve found HHC molecules when testing CBN products. To make CBN, hydrogens need to be removed with either iodine, bubbling oxygen or a metal catalyst. When creating a CBN with metal catalysis, you often get small quantities of HHC as a byproduct. The producer of the CBN products in question saw an unknown spot on their analytics. They sent the product to our lab because we have high-precision instruments only universities have. We isolated this unknown spot and did a full workup of the structure—it turned out to be HHC. 

HHC is known, but the pictures, that is, the mass and NMR spectra of the molecule, aren’t publicly available, meaning people aren’t able to visually identify it. I presented this work at the American Chemistry Society [2022] spring meeting and showed the spectra we produced. Our analytics are available on our website for people to identify HHC in their samples.

What are your thoughts on synthesized cannabinoids?

I’m an organic chemist; I have faith in the pharma industry. If pharma wants to make a synthetic analog of a cannabinoid, go ahead. They know how to make them, clean them up and bring a single drug to the market with all the quality controls and oversights needed. There’s a pharmaceutical aspect to cannabinoids, as we see with GW Pharma; Dronabinol is synthetic THC. But GW was founded in the 1990s, so they’ve had a long time to get this right.

How can consumers and businesses educate themselves?

I wrote an opinion piece for MJBiz Daily as a lead into the recent MJ Biz conference titled, “Using science to create a winning marijuana industry.” One point is you shouldn’t ask yourself if you can, but if you should. My example is that companies make products they can make instead of products that the customer wants. 

And one example was the whole CBD situation of synthetic cannabinoids. CBD commodity prices are so low that companies are asking, “What else can we make money with,” instead of asking, “What does the customer need and how do we make those products.” The customer apparently wants to be intoxicated, but are delta-8 and HHC the right path to go down? 

Closing comments?

Suppose you have markets where you can buy delta-9 THC legally, such as Canada, Colorado and California. In that case, products such as HHC and delta-8 don’t have a need—or much of a market. HHC and delta-8 products are for the customer’s needs and the regulatory situation. So, then we ask ourselves, is the problem the customer’s intoxication wants, or the legal slalom that has to be done?

The post Understanding HHC, the Latest Contentious Cannabinoid appeared first on Cannabis Now.

The Interesting Lack of Info on How Synthetic Cannabinoids Are Made

We hear warnings all the time for these compounds, usually labeled ‘K2’ or ‘spice’, and how dangerous they are; despite a lack of actual deaths directly related to them. But the most interesting part of these warnings, is that they come with no information. If you want to know how synthetic cannabinoids are made, where, or by who, it’s as if the information doesn’t exist, even with our wide-ranging internet. What does this all mean?

To stay current on everything important happening in the industry, as well as gain access to deals on cannabis flowers, vapes, edibles, and much more (various cannabinoids to choose from), make sure to subscribe to The Cannadelics Weekly Newsletter. Enjoy responsibly!

What are synthetic cannabinoids?

These days there are three types. Two get a bad rap, despite not being that bad, and one gets pushed directly at consumers. A real cannabinoid is something like THC, CBD, or CBN which is naturally made by the cannabis plant, and can be extracted in its natural form, without any change to the compound.

A synthetic cannabinoid is a cannabinoid that is made using processing techniques that either change the original molecule, or create a molecule by using component parts, and synthesizing them together with synthetic processes. Therefore, a synthetic cannabinoid is either a direct replica of a real cannabinoid, just made synthetically (like delta-8 THC), or it’s a compound that doesn’t exist in nature, and is simply closely-related to the natural cannabinoids – like delta-10 THC. Synthetic or not, some synthetic compounds mirror compounds found in nature, while some don’t exist in nature at all.

One of the big debates in this industry, is whether these compounds fit under the definition of hemp, a definition that doesn’t allow for synthetic processing of compounds. There are also issues of too-high THC amounts in preparations, as well as additive chemicals. The latter issue has shown to be the actual problem in cannabinoid-related deaths. Something even stated by a recent UK report, though this was about vapes specifically, not synthetic cannabis. As the two fear campaigns for vapes and synthetic cannabinoids are similar, its still interesting to note.

Cannabinoids can be natural or synthetic

The 3 kinds of synthetic cannabinoids we deal with

What are the three types we deal with today? Technically they could all be lumped together, but essentially they make up three different industries. The first has to do with what’s referred to as the cannabinoid market. The biggest products in this market are delta-8 THC and HHC. Though the compounds are sold under the term ‘hemp-derived’, meaning they came from the hemp plant, this doesn’t mean they’re not synthetic.

As only CBD exists in high enough quantities for direct extraction from hemp (in amounts usable for product manufacturing), these compounds are not directly extracted, but made through processing from CBD. Or through some other process not made clear. Whether they are technically legal or not, they are openly sold all throughout the US in stores. How many direct deaths have they caused? None.

The second type is considered downright illegal cannabinoids, and they’re the main reference point when bringing up ‘synthetic cannabis’. These compounds are nicknamed ‘spice’ and ‘K2’, and the reality is that we don’t know much about them. It’s often said that the main chemical constituent is a compound called cannabicyclohexanol (aka (C8)-CP 47,497), or rather, a derivative of it called CP 47,497. The interesting thing about this compound, is that its related to HHC, which was actually discovered by the US government in an attempt to make a watered down version of THC.

We are constantly warned about these drugs. Sometimes we’re told they’re super strong and can therefore cause a bad reaction, sometimes we’re told they’re poisonous. But, are they? Usually, synthetic weed comes as broken up foliage with something sprayed on it. I, myself, once got very sick from fake weed, a story detailed here. But the reaction was so isolated (smoked it a million times, this happened only once), that blaming it on the compound that got me high, is silly. However, if I had died, it would’ve been blamed on the synthetic THC, no doubt.

Thing is, when a drug is sprayed on random foliage, the foliage could have anything on it from rat poison to insecticide; and breathing in chemicals of this nature, can be deadly. It seems no one died directly from the synthetic cannabinoids, but rather from other additives or chemicals used to make the product. The synthetic cannabinoids are directly related to THC, and as of yet, none of the researched cannabinoids – synthetic or not – have ever been associated with causing such problems. They might not have been taken up by the government, but the research around them never showed a deathly issue.

The last type of synthetic cannabinoid? The one sold directly to us. That involves approved pharmaceutical medications like dronabinol and nabilone. Yup, we’re told to fear cannabis synthetics, right alongside being told that if we buy them from a pharmaceutical company, somehow the danger disappears.  Pharmaceutical companies are not in the business of providing non-synthetic medications by default, because they can’t.

Synthetic cannabinoids
Synthetic cannabinoids

Their legal inability to patent a plant dictates that they must create synthetics if they want to use similar compounds. So automatically, these companies are making the same things as the cannabinoid market sells, yet we’re told its totally cool.

These, of course, aren’t any more or less dangerous than any of the other cannabinoid compounds, whether synthetic or not. But they do create a logical discrepancy. It’s not advertised to us that these medications are synthetics, but they are. Just as much as the compounds we’re constantly warned away from. Which means the government, even without legalizing cannabis for medical use, allows the sale of synthetic cannabinoid medicines, while telling the public that synthetic cannabinoids are dangerous.

Okay, so how are synthetic cannabinoids like K2 and spice made?

And this is where it really gets interesting. I want everyone reading this to open an internet browser page, and type in any of the following terms: “how is K2 made”, “how is spice cannabinoid made”, or “K2 recipe”. Seriously, go for it. You’ll find what I did. Tons of fear articles, tons of explanations of how its sprayed on foliage, and tons of stories of injury, sometimes without explaining the idea of additives and other chemicals involved, yet never explaining how exactly the cannabinoids caused the death either.

What you fundamentally won’t find, is how these synthetic cannabinoids are made, where they’re made, or by who. A search of Tic Tok videos turned up some videos of wetting paper in chemicals, which still doesn’t help us at all. And this paper by EMCDDA, which gives about the most detail possible in terms of the compounds, still falls short of explaining how they’re actually made, only giving a few thoughts on it. However, what it does do, is say nothing bad about these compounds, likening them for the most part, to THC. It doesn’t even have a section on danger.

If you’re thinking that this information is never provided for illicit drug markets, you’re wrong. Go back to the browser page. Now search these terms: “meth recipe”, “crack recipe”, and “fentanyl recipe”. You’re going to find plenty of information, even if you specifically don’t have the skills to make them. Sure, it can involve high level chemistry, but the point, is that the information is there. You can also find plenty of information about where these drugs are illegally made, and by who. So easy, that I was able to give a little overview here, in an article about making delta-8 THC, because even that has instructions online.

We have the internet, guys. Even if no step-by-step process is given for making fentanyl, you can gather so much information, that this can be gleaned by those who understand the science. The information is there. And meth? Meth actually kills about 19,447 people a year according to 2020 data.

How meth is made
How meth is made

And yet finding instructions for it…super easy. When it comes to how to make synthetic cannabinoids, where this is done, and with what methods, it’s like all of a sudden, an internet blackout. So we’re told of this danger repeatedly, yet given no backup information for what the stuff really is. To the point that it must be questioned if any of the information we’re given, is correct.

Maybe it’s made by the government and put out on the street. Maybe its fully known that approved or not, there’s no danger. Maybe it’s just used as a fear campaign to drive people toward pharmaceutical options which we’re told are safer, even though they’re essentially the same thing. Let’s not forget how many FDA approved medications consistently must be recalled due to safety issues. And this after passing safety trials, which doesn’t say much for our drug approval process, or the safety of what’s on the market.

If not one death has come directly from these compounds, and just from additives, or other chemicals involved, then any of these removed FDA medications, are way worse than spice or K2 could ever be. Its way easier to scare someone off something, if you control all the information about it. With not one word online about how the stuff is made, the only thing we have, are government fear campaigns telling us of addictions, poisonings, and lack of medical benefit.


How are synthetic cannabinoids made? Well, unlike drugs like meth and crack, the internet doesn’t have a recipe. Or information about who is making it. Or where. It’s kind of like there’s a story out that’s being pushed on us, but all real information is withheld.

I want to take a minute to say that I don’t love this industry. I doubt there’s a problem with any synthetic cannabinoid thus far. But I do understand the detriments of added chemicals, and for this reason, this industry can be dangerous. How dangerous? People have certainly died. However, on its very worst day, it’s not even in the same danger ballpark, realm, or universe, as opioids, meth, benzodiazepines, or cocaine. Two of these are highly prescribed, one is still legal medically, and one is completely illegal, but anyone can find instructions to make it. Just something to keep in mind.

Also, I’ve repeated over and over that no deaths have come directly from a cannabinoid compound, whether natural or synthetic. This is based on no articles being able to specify that the cannabinoid compound was responsible, with the majority actually mentioning the other chemicals involved that did the poisoning. This is highlighted by the CDC itself, which has a page on lung injury from vapes, where it admits that its an additive issue, and literally can’t say that injury came from either tobacco or cannabis directly.

Welcome to the site!! Thanks for dropping by; an independent news source bringing you the best in cannabis and psychedelics coverage. Join us whenever possible to keep updated on all happenings, and sign up for the Cannadelics Weekly Newsletter, so you always know what’s going on.

The post The Interesting Lack of Info on How Synthetic Cannabinoids Are Made appeared first on Cannadelics.

The Danger of Synthetic Cannabis

On the potentially lethal subject of synthetic weed, the news, since legalization, is better, but still not great.

Though not wholly harmless, cannabis itself hasn’t killed anyone through overdose or misadventure. But cannabis prohibition absolutely has a body count. Between 2016 and 2019, at least 61 Americans died after exposure to synthetic cannabinoids, according to recent research conducted by scientists at Washington State University and published in the journal Clinical Toxicology.

Many more have become violently ill or wracked with disturbing mental or psychological trauma after using synthetic cannabis, with more than 64 percent of 7,600 documented exposures over that time frame requiring medical attention, the study found. (These figures don’t capture the full scope of the problem; synthetic cannabinoids are difficult to detect and use is often only detected after the user is in the hospital or the morgue.)

A broad term used generally to describe a range of potent chemicals, intended to mimic natural plant-based cannabinoids and to bind to many of the same receptors—but in some cases, up to 100 times more powerful; the difference in impact comparable “to the difference between a hose hooked up to a fire hydrant versus a faucet with a slow drip,” in the words of Dr. Patricia Frye, a Maryland-based physician and cannabis expert. “Synthetic cannabis” is banned under federal and most state law. (Plant-derived cannabis products created via chemical synthesis, including Delta-8 THC and Delta-10 THC, aren’t in this product category.)

Though not a priority for law enforcement, who still arrested hundreds of thousands of Americans for marijuana possession in 2020, synthetic cannabis is notorious stuff. Most often appearing in large cities, fake weed was the ultimate culprit behind a so-called “zombie outbreak” in 2016 in New York City, after several dozen people exhibited the same troubling dis-associative symptoms after smoking a particularly nasty “incense” product called “AK-47” Karat Gold.

Why would anyone use such dangerous and toxic stuff? And how can policymakers discourage such self-harm and solve what researchers described to Cannabis Now as a “serious health threat”?

The obvious answer will not shock you.

Nobody Really Likes Synthetic Weed, But…

Initially created in labs to understand how cannabinoid receptors work, synthetic cannabis was never intended for use in humans. And perhaps owing to the nasty side effects, synthetic cannabis use isn’t widespread.

Natural cannabis is far more popular. Even the estimated 0.2 to 0.4 percent of the population who do admit to using synthetic weed say they’d prefer natural cannabis.

However, there’s some societal “encouragement” for synthetic cannabis use: synthetic weed prohibition turns out to be difficult to enforce. Synthetic cannabis doesn’t contain THC. Users won’t show THC metabolites on a urine screening, and so drug tests can’t detect synthetic cannabis, the study noted. Thus, anyone in a position to want a buzz and avoid punishment for weed, including US service members, may decide that fake cannabis is worth the risk.

Users profiled in another recent study, from researchers based in Spain, confirm this ready common-sense explanation: Because drug tests don’t search for synthetic cannabinoids, meaning people worried about losing employment, housing, or other opportunities for a positive drug test are willing to risk serious consequences to achieve something like a weed-like buzz.

In other words, drug laws encourage drug users to risk great bodily and mental harm they wouldn’t otherwise risk. They say so themselves.

Synthetic cannabinoids “exist as a by-product of prohibition,” said Dr. Ethan Russo, a physician, neurologist and prominent researcher and author.

“Following the law of unintended consequences, the continued pervasiveness of urine drug screening for employment has stimulated the popular appeal of synthetic cannabinoids, which are not detectable on routine laboratory tests,” Russo told Cannabis Now. “The result is considerable attendant morbidity and mortality.”

In some places, this situation is getting worse. According to the researchers’ findings, published in the journal Frontiers in Psychiatry, “synthetic cannabinoids are increasingly gaining popularity and replacing traditional cannabis.”

However, that’s not the case in the US, where a simple and popular policy intervention leads to a decline in synthetic cannabinoid exposure (and related deaths and hospitalizations) of more than 37%. Only 5.5% of the synthetic cannabinoid poisonings tracked in the study occurred in states with legalization laws.

This magic public-health solution is allowing people to use cannabis safely and legally.

With Synthetic Cannabis, Legalization Saves Lives

As the Washington state researchers noted, synthetic cannabinoid exposures declined in the US starting in 2016—the same year that four states (California, Maine, Massachusetts and Nevada) legalized adult-use cannabis for adults 18 and over.

Of the exposures that were recorded, most–-56%–-occurred in states “with restrictive cannabis policies at the time of the exposure,” the researchers wrote. When a state passed a law with a more “permissive cannabis policy,” synthetic cannabinoid exposures reduced by 37%, they added.

This amounted to an “association” between “liberal policies (legalization) for natural cannabis and declines in reported synthetic cannabinoid poisonings,” they concluded. “This finding suggests a potential effect of policy change on substance use behaviors that may have long-term public health implications.”

Tracy Klein, the lead researcher and a professor in Washington State University’s College of Nursing, didn’t respond to a request for comment. But other experts, including Frye and Russo and Peter Grinspoon, a Boston-based physician and lecturer at Harvard Medical School, accepted the findings as a strong endorsement for cannabis legalization as a public-health intervention.

Synthetic cannabis harms people, but people don’t want to use it when natural cannabis is available. When natural cannabis is available, people don’t use it. Legalization saves lives. Could there be a simpler proposition?

“The rules of society have created this problem,” Russo said, “one that should no longer exist once a legal and regulated market for cannabis is established.”

“Legalizing cannabis, in the adult-use market, would certainly eliminate the need for experimenting with these potentially deadly chemicals,” Frye said.

The post The Danger of Synthetic Cannabis appeared first on Cannabis Now.

South Dakota Officially Regulates Delta-8, HHC, and THC-O-A

The whole cannabinoid issue has gotten more intense now that Shopify has banned anything that violates the law, likely at the behest of the US government. But in some places, it’s understood that regulating might be a better option than making these compounds illegal. Case in point: South Dakota through a new bill, now officially regulates cannabinoids delta-8, HHC, and THC-O-A.

South Dakota just passed a bill that regulates delta-8 and other cannabinoids by age. How the state will account for other issues of additives and processing has not been stated. We are an independent publication covering everything important in the cannabis field, and you can keep current by subscribing to the THC Weekly Newsletter. This will give you access to premiere deals on products like vapes, edibles, and other paraphernalia, as well as offers on your favorite cannabinoid products like HHC-O, Delta 8Delta 9 THCDelta-10 THCTHCOTHCVTHCP HHC, which are in our “Best-of” lists. Remember… *If you do not prefer to use cannabinoid products, we don’t advise that you do. There are plenty of products in the world of cannabis, and each person should only use what they are comfortable with.

What’s the deal with the cannabinoid market?

The cannabinoid market is an entire market that functions federally illegally at the moment, but under some marketing-pushed misconception that the products are legal. And to be fair, they’re not illegal based on their own dangerous capabilities, since none of the cannabinoids themselves have shown danger. They’re illegal simply because the government hasn’t legalized them, and because of this, a strange black market has opened, which, without regulation, has becomes a rather dirty market.

The cannabinoid market is rather new, coming into being as a side-effect of the 2018 US Farm Bill, which specifically legalized the cultivation and production of industrial hemp, and associated products. In order to do this, and separate said hemp from the rest of the world of marijuana, a new definition was instituted for hemp, which came with two main stipulations, though one is not as clearly outright stated.

The first is that all hemp plants, and associated hemp products, must not surpass .3% THC. And the second is that the only thing legalized, are products directly made from the hemp plant, since nothing synthetically-derived fits the definition of hemp. This was backed up by the DEA in regards to a question asked about synthetic delta-8 THC. In its answer, the DEA referenced the definition of hemp, with that definition being:

“The plant Cannabis sativa L. and any part of that plant, including the seeds thereof and all derivatives, extracts, cannabinoids, isomers, acids, salts, and salts of isomers, whether growing or not, with a delta-9 tetrahydrocannabinol [(D9-THC)] concentration of not more than 0.3 percent on a dry weight basis.”

Where do synthetics come in?

At no point does it say that synthetically-derived compounds are okay, and at no point does it say that a product can include hemp-derived compounds, but not be made completely from them. Thus, anything synthetically-derived, also doesn’t fit the definition, and remains under Schedule I. Why? Because synthetics of any Schedule I substance – or its analogues – (including THC), are also Schedule I, and therefore illegal, according to the Federal Analogue Act.

Why is all this talk of synthetics important? Because the cannabinoids sold are always synthetically made, even if its stated that they’re ‘hemp-derived’. This doesn’t mean that compounds like delta-8 and HHC aren’t naturally occurring, however, they occur in such small amounts, that rather than extract them directly from hemp, they are synthetically-derived from compounds like CBD. CBD and THC are currently the only two cannabinoids that exist in large enough quantities to directly use from extraction.

When it comes to compounds like delta-10 and THC-O-A, the ‘hemp-derived’ part is even more ambiguous, as these compounds are only synthetically made, and not found in nature at all. I should be clear here, ‘hemp-derived’ is being sold as a term that means ‘directly from hemp’, as this makes products fit under the definition of hemp. But what it actually means is ‘indirectly from hemp’, or ‘hemp parts used with synthetic processing’, and this no longer fits the definition.

South Dakota officially regulates delta-8 and other cannabinoids

There are two things to consider here. First, these cannabinoids have already created a widespread market. And though it’s a fringe market, it’s still there, online, as well as in brick and mortar stores. I say ‘stores’ and not ‘dispensaries’ because without regulation, these products are sold in tons of places outside dispensaries. The second thing to consider is that the cannabinoids themselves are fine, but the lack of regulation allows for seedy business techniques, dirty and mislabeled products, fake third party testing, and for chemical additives to be used that could be dangerous.

Which makes regulating the market, a much better idea than trying to backhandedly stop it through forcing sales platforms to stop selling products. This is what just happened with Shopify. Different states are making their own regulations for cannabis in general due to changing laws, and this new cannabinoid market is now factoring into new legislation.

delta-8 THC

In early 2022, The South Dakota House of Representatives initiated HB 1292 which is a bill that regulates cannabinoids delta-8 THC, HHC, and THC-O-A. The bill specifically seeks to set an age limit for sale and purchase of these cannabinoids, restricting anyone below the age of 21 from partaking. The bill doesn’t include anything else besides this idea of regulating their sale by age.

The bill, brought forth by republican representative Rep. Taylor Rehfeldt, first sought only to regulate delta-8, but was then expanded to include HHC and THC-O-A as well. An earlier bill in the session merely sought to outlaw these substances, but Rehfeldt introduced 1292 as an effort to responsibly regulate the substances instead.

Will it pass?

It did! After passing both the South Dakota House and Senate, the bill was signed into law by Gov. Kristi Noem on March 10th. Does this make all delta-8, HHC, and THC-O-A products legal to adults 21 and above? It’s hard to say, especially considering that the biggest issue in the field, is the question of regulating the actual products to make sure they are what they’re supposed to be, and to fit into laws regarding synthetics.

Bill author Rehfeldt admits that there’s more to be done in terms of regulating the industry. In regards to chemical additives, and to deal with these possible dangers, she states: “it will be important to address those issues with all stakeholders including public health, the hemp/marijuana industry, and the business community.” She stipulates that simply starting the process by setting an age limit, is a decent beginning measure.

Currently, the bill is very brief, only accounting for the age a person must be in order to buy these products. There is absolutely nothing in the bill that further regulates these products, or what’s in them. This promotes a lot of new questions. Like, are these compounds regulated the same way as regular cannabis? And, are synthetic versions allowed? And, if so, are there specific processing techniques that must be used? Without anything else said, it means South Dakota is literally promoting the dirty tactics of the cannabinoid industry, and offering no safety to consumers.

Into the future

I have yet to see anything further stated about how South Dakota plans to deal with this issue, though I do expect some sort of follow up. What’s weird about the whole thing, is why such a parse bill would be introduced, and then passed so easily. Perhaps this could be due to two different factors.

South Dakota regulates delta-8

First off, South Dakota legalized cannabis in 2020 via a ballot measure (54%), which should have included the state among 19 legalized states. In fact, South Dakota pulled double duty at the November 3rd elections, legalizing both medical and recreational cannabis with Measure 26, and Amendment A, respectively. In what I can only call a horribly corrupt tactic, South Dakota’s governor Kristi Noem conspired with local law enforcement to bring a case forward to invalidate Amendment A. They did this on the grounds that South Dakota only supports single ballot measures. The Supreme Court of the state backed Noem, and the legalization was taken away. Perhaps one reason for the new bill, is that blow-back from the removed legalization has inspired Noem to be a little looser if she wants to keep her seat.

The second thing to consider, is that these cannabinoids are based on hemp, even if they use synthetic processing techniques for the final product. This means the hemp industry wants the products to be legally available, because it spurs on the hemp industry. It has been reported that South Dakota wants to double its hemp-growing acreage, as well as to start fiber and seed processing within state. This is impressive considering South Dakota only legalized hemp production in 2020.

According to the USDA National Hemp Report for 2021, a total of 54,200 acres  of hemp were planted in the US, but only 33,500 acres were harvested. This is split into four categories: floral hemp (16,000 acres), fiber hemp (12,700 acres), grain hemp (8,255 acres), and seed hemp (3,515 acres). Hemp grown under protection is technically another category as well (358 acres). South Dakota came in 8th place with 1,850 acres planted, but had the highest harvest rate of any state with 1,700 of those acres harvested.

Of those 1,700 acres harvested, over 1,500 were dual purpose plants that can be used for both grain and fiber, which are harvested separately. South Dakota Industrial Hemp Association executive director Katie Sieverding used the report to ascertain that the value of South Dakota’s crop was $1,789,000 for grain hemp and $480,000 for fiber hemp in 2021.

When it comes to regulation, all hemp is regulated the same. And this is probably because, while there is differentiation in how the seeds are planted, and the processing methods after, all forms can produce CBD, except for seeds. So it’s quite possible that this new and growing hemp industry, also played a major role in South Dakota and its recent bill that regulates delta-8 and the cannabinoid market. A market which relies heavily on CBD, and therefore, hemp.


South Dakota is definitely promoting its newly won hemp industry, and the state is probably a little angry from having its voted-in recreational cannabis legalization taken away. How much these issues factor into South Dakota passing a law which regulates cannabinoids like delta-8, is hard to say. But the one thing for sure is, South Dakota certainly opened that door, and we can only speculate as to next moves.

Welcome everyone! You’ve arrived at, the penultimate web spot for the best and most comprehensive independent coverage of cannabis and psychedelics news. Give the site a read-thru frequently to stay on top of the exciting universe of cannabis and psychedelics, and sign up for The THC Weekly Newsletter, to keep up on all the industry talking points.

Disclaimer: Hi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advice, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

The post South Dakota Officially Regulates Delta-8, HHC, and THC-O-A appeared first on CBD Testers.

Where Cannabis Synthetic Spice Came From and Is It Related To HHC?

Cannabis synthetic ‘Spice’ has been the center of controversy for many years, with government lines saying its highly dangerous, but its massive ubiquitous nature (and the lack of any real issues), saying otherwise. Where did this synthetic compound come from? And how is it related to cannabis synthetic HHC?

Cannabis synthetic compounds like HHC and Spice are available for those who want to try them, but users should beware of where they get their products from. On the other hand, plenty of companies are selling more above board products like delta-8 THC, which is a naturally occurring alternative to delta-9, which creates less psychoactive effect, and produces less anxiety, making it preferable for many people. Make sure to subscribe to The Delta 8 Weekly Newsletter for exclusive deals on Delta 8Delta 10THCV, and THCO, and to find out which THC is best for you.

What is HHC?

The reason I’m starting with the cannabis synthetic HHC, is because it happens to be the newest cannabis compound to make it to the public. In the last couple years, tons of cannabis compounds have made an appearance on the pubic stage, to varying levels of interest. For the most part, many of these compounds are found to be interesting, but haven’t done much to drive sales extensively. Some of this is probably because of shaky legal ground, and some of it is probably because the compounds themselves appear in small amounts only, and often require synthetization techniques that go far beyond basic extractions.

There are different kinds of compounds that have come to the public’s attention of late. Other delta-THCs like delta-8 and delta-10. Other cannabinoids like CBL, CBC, and CBN. And a range of synthetics like THC-O-Acetate, and now HHC. What is this last one? Well, it’s actual name is a long one: 9-Nor-9β-hydroxyhexahydrocannabinol. Quite a mouthful, huh? And it’s a synthetic cannabinoid derivative, which came from when THC was being studied early on, and modifications were made to its structure. The goal had been to find the simplest compounds that could still bind to receptors and produce a response. HHC is therefore a more simplified version of delta-9, and closely related to it.

HHC compounds have been studied a little, but not a huge amount is known about them. Interested parties can check out studies like this one to gain a little more info, but for the most part, very little exists in the medical world to speak of. This has not stopped the compound from being sold, although whether this is a good idea or not, is certainly debatable.

What is HHC and is it safe to use?

What is Spice?

Spice’ is a term to designate a synthetic cannabinoid, not unlike any other synthetic cannabinoid that we speak about on this site. Synthetics bind to the same receptors, creating essentially, the same response in users, which is often why a user won’t know if they’re using a natural compound, or a synthetic. Honestly, I’ve smoked plenty of black market vapes which I know were some kind of synthetic, and I found very little difference.

Since the majority of synthetics were designed off of delta-9, they act as agonists at receptor sites, meaning they promote a response. Sometimes, the synthetics have even stronger binding abilities than their naturally occurring counterparts. There isn’t just one kind of synthetic. In fact, there are several classes of synthetic cannabinoids that are given names based on structural attributes, though in the past they were named in different ways, often by the place where they were found.

If you’ll notice, none of this is specific to the term ‘Spice’, as ‘Spice’ is simply a name used to denote ‘synthetic cannabinoids’. Just like it’s other well-known name, K2. These are simply street names, and do not denote a specific synthetic necessarily.

What’s the connection between cannabis synthetic HHC and Spice?

So how is the synthetic cannabis compound HHC related to synthetic cannabinoids considered Spice? Good question. HHC was studied a bit when it was first found, and even went through animal testing which showed it to be a safe compound. However, it never caught on, and it never developed into any kind of pharmaceutical product. That might have been the end of the story, except that about 25 years after HHC was being studied, a derivative of it was found out on the street as the main ingredient in synthetic cannabis being sold.

This derivative, considered obscure at the time (though not so much now), is called cannabicyclohexanol, or (C8)-CP 47,497. Where did it come from, though? Was it made for the street specifically in some basement lab? Not at all. This compound was made by the pharmaceutical company Pfizer in 1979. In 2009, a German report came out saying that it had found an analog to CP 47,497, and that it was being used in an incense product called ‘Spice’.

Obviously, Pfizer never did anything with this compound, which isn’t terribly weird considering how many compounds were created and studied, just to be tossed aside, much like HHC. And much like synthetic HHC, it made a name for itself not by being used by the company that found it, but as a street drug. HHC was not found to be dangerous in testing, so the idea it wasn’t used for safety issues, doesn’t seem to be the case. And considering how widespread Spice is, and how few problems there are related to it, it also would appear to be generally safe, although the government has certainly put a lot of effort into having you think otherwise, probably because its a synthetic not being profited from by big pharma.

synthetic HHC

Are synthetics dangerous?

This is an interesting question, and requires a bit of critical thinking and general logic. Now if you ask the US government, it’ll tell you ‘yes’. Of course, the US government also likes to say that there’s an ‘epidemic’ of vape deaths, which actually only equals 68 confirmed deaths over nearly 20 years of time – which is laughable compared to the 480,000 that die a year from smoking cigarettes. If anything, their attempt to demonize vaping really only highlights what a safe alternative it is. In fact, the best the government has actually been able to do, is point the finger at vitamin-e-acetate and/or other additives, which don’t have anything directly to do with the cannabis plant.

Dealing with synthetics is similar. While the US government – and other governments around the world that bow to big pharma – like to go on about how dangerous ‘Spice’ and ‘K2’ are, and how synthetics are bad, it has no problem allowing synthetics that pharmaceutical companies profit off of. Perhaps the reason the Spice synthetic is so badly demonized, is nothing more than saltiness on the part of a pharmaceutical company that lost out on the profits.

There have been stories about people getting sick from synthetics like Spice. In 2016, about 70 people in Connecticut ‘overdosed’ on synthetic cannabinoids. Only, it had nothing to do with the synthetic cannabinoids, but, rather, the fact that the synthetic marijuana was laced with what they thought was fentanyl. Kind of a big difference. In the same year, about 300 people in the Washington DC area had a similar result. And this too was due to contaminated products. Now the thing about synthetics of this nature, is that they aren’t themselves plant material, but generally a liquid solution that can be sprayed on plant material to create a marijuana-like substance.

When I lived in Tel Aviv about 10-11 years ago, a synthetic dubbed ‘Mr. Niceguy’ became very popular. If it was really that dangerous, there would be an entire dead city, as we were all smoking it, partly because at the time, regular cannabis was hard to find. On the other hand, I myself had a very negative experience with another brand that came out a bit later, and which stopped me from using these products again. Basically, I got very sick from smoking it.

It could have been a pesticide, or fentanyl, or who knows what. Whatever gave me that reaction, was certainly not related to cannabis, either synthetic or regular. And that seems to be the case with most/all of the injuries mentioned, meaning just like with vapes, the danger issue has nothing to do with the cannabis plant, or the synthetics made from it. It also makes it highly unethical, and misleading, that the government publicizes big statements about the dangers of such compounds, when the danger has nothing to do with the plant. In fact, I have yet to see a complaint or death count associated with the actual plant, or the synthetics made directly from it.

More stories

In another story also from 2016, many people in New York had to be hospitalized after smoking a synthetic called AMB-FUBINACA, which was also made by Pfizer in 2009. It was somehow decided that this was because the synthetic had caused it to happen, since a metabolite was found in all the people hospitalized. And while it almost sounds like it could mean that this really was caused by a dangerous synthetic, it also happens to be that this particular synthetic, was the one most found in drug seizures in 2017, and part of 2018, indicating extremely wide use, and pointing to the idea that the New York issue was likely not about the synthetic cannabinoids, but something added in, like in the other cases. Otherwise, the New York story would have been an everywhere story, and it wasn’t.

smoking synthetics

In 2017-2018 there were also about 60 deaths in New Zealand, but once again, this wasn’t an ongoing issue, but something isolated in a specific time period, indicating once again that the issue related to specific batches, and not the synthetics. The same synthetics are still out there, so without added issues, it clears the synthetics of being the cause of the problem.

Does this mean a synthetic can’t be dangerous? Some might be, but it doesn’t look like that’s what has caused any issues thus far. If so, the problem would be more continuous, and not in isolated incidents in isolated locations. When someone cuts a batch of heroin with fentanyl and people die, it doesn’t mean all heroin will do that (although its also really not a good idea to do heroin). But what it does mean, is that that particular batch will cause problems to whoever uses it. This is the same concept. And much like in tainted heroin cases, the problem shows up in an isolated place, and then isn’t an issue anymore.

For me, the bigger concerns are making synthetics of compounds that don’t actually exist in nature, because then it becomes hard to know how it will behave in nature. And the idea that harsh chemicals could be used in the production of these compounds for which there is no regulation.


To me, one of the more interesting aspects of Spice, and cannabis synthetic HHC, is that they were created by pharmaceutical companies which chose not to use them, just to have them swiped out from under, to be sold illegally with no gain to the companies. I like to think of that as poetic justice for a pharmaceutical company. And in a sort-of coming full circle way, not only is Spice being sold out there, but so is its predecessor HHC.

Hi and welcome! You made it to, your #1 spot for the most relevant and interesting cannabis-related news from around the world. Read through the site every day to stay abreast of the constantly-changing world of legal cannabis, and sign up for our newsletter, so you never miss a story.

Best THC-O Deals, Coupons & Discounts

DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

The post Where Cannabis Synthetic Spice Came From and Is It Related To HHC? appeared first on CBD Testers.

What Is HHC (Hexahydrocannabinol) and Is It Safe To Use?

The race is on to discover and develop new, more potent cannabinoids. It seems like everywhere you look there are novel compounds, different types of THC, or various cannabis synthetics hitting center stage. For the most part, these compounds have been met with initial interest that eventually wavers, so longevity in these markets is questionable. The latest on the market is hexahydrocannabinol, or HHC,

Cannabis is the name and products are our game. If there are new products on the market, we always strive to be among the first to try them and write about them, so our readers can have a clear idea of what they’re getting into before making a purchase. Now that HHC is finally available, make sure to subscribe to The Delta 8 Weekly Newsletter for exclusive deals on Delta 8, Delta 10, THCV, and THCO, and to learn more about the industry.

What is HHC?

Honestly, the available information on HHC, scientifically known as 9-Nor-9β-hydroxyhexahydrocannabinol, is extremely limited and somewhat contradicting. Let’s start with whether it’s natural or synthetic: well, it can be both. There is a biologically active naturally occuring (−)-hexahydrocannabinol, as well as its synthetic enantiomer (+)-hexahydrocannabinol – the latter being what you’ll find in consumer products since natural HHC is only present in very trace amounts.

As the name suggests (Hexahydrocannabinol vs Tetrahydrocannabinol), HHC has many similarities to THC. It’s basically a simplified version of Delta 9 THC. Both HHC and THC have very similar molecular structures and comparable effects. It was discovered during research in the 1960s and 70s in which the goal was to find the most basic cannabinoid-like substances that could still bind to CB receptors.

HHC Vape Cartridges Sunset Sherbert
HHC Vape Cartridges Sunset Sherbert
(From the Delta 8 Weekly newsletter)

Very limited studies indicate that HHC has a decent safety profile in animal models and that it could have some medical potential, but we’ll get more into that a bit later. However, claims made by retailers regarding its legality and where it comes from are misleading at best.

What the Retailers Say

Let me start by saying that not many retailers are selling HHC yet. As a matter of fact, I’ve been able to find only three so far. All three of them have almost the exact same description on their sites for HHC, claiming that it is a naturally derived compound (found in cannabis pollen), extracted from hemp and federally legal.

I personally could not find anything to support the claim that HHC is found in cannabis pollen, or where exactly in the plant it’s found in highest concentrations. Also, what you’re getting in an HHC vape cart is a synthetic, as it would take way too much plant matter to extract a noticeable amount of this cannabinoid.

And because it’s synthetic, it’s also likely not legal. Because a version of the compound is naturally derived, that could fall under the industrial hemp legal loophole. The unnatural enantiomer of HHC is illegal because it is created using a chemical catalyst.

It’s important to remember that retailers might not always have all the information about rare and specialty cannabinoids. Their goal is to sell, so naturally, they will try to paint their new products in the most favorable light. This why you have to do your own research before trying new things, just because a statement is posted on a retailers website does not necessarily mean it’s true.

Best THC-O Carts: Top THC-O Vape Cartridges of 2021

Cancer Research

As far as HHC research goes, it’s nearly non-existent. However, both natural and synthetic cannabinoids have been found to suppress tumor growth in numerous different animal studies. One study in particular examined the angiogenic effects of several hexahydrocannabinol analogs to see how they can be used in cancer therapies.

As per the study: “Two analogs LYR-7 [(9S)-3,6,6,9-tetramethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-1-ol] and LYR-8 [(1-((9S)-1-hydroxy-6,6,9-trimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-2-yl)ethanone)] were selected based on their anti-angiogenic activity and lack of binding affinity for cannabinoid receptors. Both LYR-7 and LYR-8 inhibited VEGF-induced proliferation, migration, and capillary-like tube formation of HUVECs in a concentration-dependent manner.”

HHC Vape Cartridges lucid blue
HHC Vape Cartridges lucid blue
(From the Delta 8 Weekly newsletter)

“The inhibitory effect of the compounds on cell proliferation was more selective in endothelial cells than in breast cancer cells (MCF-7 and tamoxifen-resistant MCF-7). We also noted effective inhibition of VEGF-induced new blood vessel formation by the compounds in the in vivo chick chorioallantoic membrane (CAM) assay. Furthermore, both LYR analogs potently inhibited VEGF production and NF-κB transcriptional activity in cancer cells.”

“Additionally, LYR-7 or LYR-8 strongly inhibited breast cancer cell-induced angiogenesis and tumor growth. Together, these results suggest that novel synthetic hexahydrocannabinol analogs, LYR-7 and LYR-8, inhibit tumor growth by targeting VEGF-mediated angiogenesis signaling in endothelial cells and suppressing VEGF production and cancer cell growth.”

Simply put, these compounds block the growth of the blood vessels that feed tumors, rather than blocking growth of the tumor itself. So, it basically works as an angiogenesis inhibitor that starves any tumors.

Final Thoughts – HHC

Again, since research on HHC is so limited on this cannabinoid, there really is very little for me to share with you all. However, since it is being sold online already, you will have to do your due diligence and make sure that the product you’re getting is safe and the company you’re buying it from is legit. Other than that, we will continue to make updates to this article as more information on hexahydrocannabinol becomes available, so check back periodically for more.

Thank you stopping by CBD TESTERS, your hub for all things cannabis-related. Remember to subscribe to The Medical Cannabis Weekly Newsletter for more articles like this one, and check out The CBD Flowers Weekly for exclusive deals on flowers and other cannabinoids.

Affiliate disclaimer: We work hard to find and verify the best products, so we may include affiliate links to support the maintenance and development of this site.

The post What Is HHC (Hexahydrocannabinol) and Is It Safe To Use? appeared first on CBD Testers.

High Potency: How THC-O Acetate Is Made

The question of how a cannabinoid is “made” does not come up very often. That’s because it’s usually pretty simple, they are “made” by the cannabis plant. However, there are a few compounds that are byproducts of phytocannabinoids and some other type of chemical catalyst… meaning they aren’t 100% naturally derived. THC-O Acetate falls under this category. So, how exactly is this exciting and very potent cannabinoid created?

The psychedelic THC-O Acetate sure sounds interesting, and goes to show just how many different products can be made from cannabis. Compounds like that one, THCV, Delta-8 THC and Delta 10 are the newer face of the cannabis industry. We support the expansion of cannabis use, and have some really great deals for delta-8 THC and many other compounds. Take a look at our selection, and join the cutting edge of marijuana use.
To get our latest deals on THC-O vape carts, and to learn more about THC-O potency subscribe to the Delta 8 Weekly newsletter, below:

What is THC-O?

In short, THC-O is an analog of THC, meaning is has a similar chemical structure but, as is the case in chemistry, minor differences often lead to substantial changes. THC-O is short for THC-O-Acetate, or THC Acetate/ATHC. Most of the time you’ll see it written and referred to as THC-O. It’s important not to confuse ATHC with THCA, the parent molecule of THC which found in raw plants that have not yet been decarboxylated.

In tetrahyrdocannabinolic acid (THCA) the A stands for acid, NOT acetate like with ATHC. THCA can be converted to THC-O, but THCA is a natural phytocannabinoid and THC-O is not. THC-O is a synthetic cannabinoid that can only be produced in a laboratory setting, preferably by an experienced chemist. With the rise of DIY technologies, it can be tempting to try and make THC-O yourself, but the process can be difficult and quite dangerous, so it’s best left to the professionals.  

Because it is an artificially produced cannabinoid, what you see is what you get – meaning all you get is THC-O and none of the beneficial terpenes and flavonoids that are found in natural oils. This is an obvious issue for whole-plant advocates and proponents of the entourage effects, but when it comes to pharmaceutical formulations, isolated cannabinoids are always preferred.

Best THC-O Carts: Top THC-O Vape Cartridges of 2021

The purity of these compounds means that 1 milligram of isolate equals measures out to exactly 1 milligram of cannabinoid, whereas 1 milligram of full-spectrum plant extract might have 0.5 milligrams of THC, 0.3 milligrams of CBD, and 0.2 combination of other terpenes and compounds. This makes isolate very easy to use for specific dosing and product production.

According to Serge Chistov, the inventor of Nanobidiol Technology, says his team has found a safe and efficient method to acetylate THC using only approved solvents. Chistov says his team “developed the analytical standard for testing for THC-O, as well as being in the final stages of introducing products to retail outlets.” So, if everything stays on track, we can expect to see THC-O therapeutics relatively soon.

THC-O Acetate: More Potent, Psychedelic and Spiritual Than Delta 9 THC

THC-O potency: Delta-9 THC vs THC-O

We already know that THC and THC-O are chemically similar, but that small variation in molecular structure translates to a huge difference in potency. While it may seem like a stretch, this is very common in chemistry – think CO vs CO2, the former being a manmade potentially dangerous substance, and the latter a natural gas required for plant and human life. Another well-known example is H2O vs H2O2, water vs hydrogen peroxide. Small molecular changes can make a world of difference.  

To be specific, THC-O potency is so high, that THC-O is considered to be three to four times stronger than Delta 9 THC. There are times when THC, despite how amazing it is, doesn’t seem powerful enough to accomplish the task at hand, especially when used for pain, digestive disorders, and other chronic health conditions. THC-O is not only much more potent, but our bodies recognize it as a completely different compound. This means THC-O can be used in place of Delta 9 THC if you have built up a tolerance.

Best THC-O Carts: Top THC-O Vape Cartridges of 2021:

THC-O Vape Cartridge Maui Wowie
THC-O Vape Cartridge Maui Wowie

“The prodrug [THC-O] enters the system as a Trojan horse. The body sees the horse, the body tries to destroy the horse, keeping the insides of the horse available for the body to process. This means the THC inside of the prodrug preparation will not be metabolized into 11-hydroxy-THC at the same rate and speed as the native THC molecule. That change in the metabolic perception of the body is what is partially responsible for the effect that most people describe as different,” Chistov explains.

Even recreationally, it has its place in the industry, and honestly, it sounds like a lot of fun. There is a huge market of people searching for cannabis products with more of a kick, which is exactly how concentrates came to be. It’s certainly not for everyone, but for people who like to experiment with pot products and psychedelics (myself included), it sounds like something worth trying at least once.

Those who have had the opportunity to try it claim that THC-O produces a much more spiritual, psychedelic, and introspective high than what they are used to from Delta 8, 9, or 10. Even habitual cannabis users noticed a difference. As a daily user, this alone has me sold, and I know many other people who feel the exact same way (hey subscribers, products will be available in our newsletter very soon!)

How THC-O is Made

Circling back, let’s talk a bit more about the THCA and THC-O connection. I have already covered the difference between the two (acid vs acetate), now it’s time to discuss how THCA can be converted to THC-O. Again, it’s a complex chemical process that should only be attempted by experienced chemists, this is NOT something that can be done safely at home.

In raw cannabis plants, cannabinoids are found in carboxylic acid from. Carboxylic acids are any of class of organic compounds in which a carbon atom is bonded to a hydroxyl group via a single bond, and to an oxygen atom by a double bond. When exposed to heat, the compounds lose their carboxylic acid groups and become the cannabinoids most consumers are familiar with.

Best THC-O Products
(Summer 2021 Edition)

New: THC-O Products
New: THC-O Products

Carboxylic acid and hydroxyl groups are both polar and hydrophilic, meaning small amounts of THCA (or any other cannabinoid acid) are water soluble. Using two chemicals – sulfuric acid and acetic anhydride – the conversion can begin. Summarized, the process goes like this: THCA + heat > D9 + sulfuric acid + acetic anhydride = THC-O Acetate. When THCA is converted to THC-O, the polar C-OH becomes C-O-CH2C=O-CH3. The carboxylic acid group is hydrolyzed by the heating with the sulfuric acid, which then reacts with excess anhydride to produce acetic acid. This acid reacts with regular THC at the hydroxyl group and becomes the potent THC-O-Acetate.

To reiterate, sulfuric acid and acetic anhydride are both very corrosive and hazardous chemicals that should not be in the hands of amateurs and everyday consumers. Attempting this process at home is incredibly risky.

THC-O Acetate Production – Final Thoughts

THC-O is such an interesting compound. Not only is it four times stronger than Delta 9, which as far as we know, is the most potent of THC’s, but it is so pure and had limitless therapeutic potential. You might be eager to try it, but since it’s too risky to make at home, your best bet is to check out some of the existing products the are just hitting the store shelves. For more articles like this one, and for access to exclusive deals on all the newest, rare cannabinoid products, make sure to subscribe to The Delta 8 Weekly Newsletter.

Want hemp flowers? Look at the best smokable hemp flowers

The post High Potency: How THC-O Acetate Is Made appeared first on CBD Testers.