How to Invest in Multi-Billion Dollar Medical Psychedelics Industry

As the legal cannabis market booms, another class of drugs on the horizon is getting closer to legalization, with its own impending boom coming. And that means a whole new place for investment. So as MDMA, psilocybin, and DMT work their way through medical trials, here’s how to invest in this new medical psychedelics field.

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What are psychedelics?

Psychedelics are a subset of hallucinogenic drugs, which themselves are a subset of psychoactive drugs. Whether made in a lab like LSD, or found in nature like psilocybin or peyote, psychedelics are known for causing ‘trips’. When a person is tripping, they may have altered perceptions of the world around, experience/feel/taste/see/hear things that are not real (hallucinations), feel a heightened sense of connection to those around them, experience euphoria, feel a sense of spirituality and connectedness with the universe, and a greater sense of self-introspection. A large percentage of psychedelics are serotonergic, meaning they effect serotonin receptors in the brain, though they can do this in different ways.

Some drugs like DMT produce short trips of less than an hour in duration. While other drugs like LSD, psilocybin, and mescaline can cause trips that last for many hours, as many as eight or ten. Sometimes people experience bad trips in which negative, or even scary, hallucinations are experienced, and/or a rapid heartbeat, sweating, nausea, disorientation, and fatigue occur. There is indication that the majority of these symptoms can be controlled through proper dosing. In fact, many therapeutic psychedelic users consume the drugs in micro-doses.

All psychedelics are Schedule I in the Convention on Psychotropic Substances, a drug scheduling treaty which defines the legality of different compounds globally. Starting with the Staggers-Dodd bill in 1968 which illegalized LSD and psilocybin, and finishing with the placement in the Convention, making all such substances illegal to buy, sell, or consume, with no purported medical value.

psychedelics

Psychedelics have been used for thousands of years, all throughout the world, though their uses in medicine in the mid-1900’s, and proposed uses today, are generally different than the shamanistic/ritualistic way they were primarily used in history, although this is not to say that there were not traditions that did use psychedelics therapeutically. Technically, if a shaman is consuming ayahuasca to get rid of demons, I suppose that could be thought of as therapeutic anyway.

Medical psychedelics research

Psychedelics, particularly, LSD, were introduced to modern medicine around the 1950’s after Albert Hoffman synthesized the compound in Switzerland in 1938. Several psychotherapists at the time, like Humphry Osmond and Ronald Sandison caught onto the idea, bringing these treatments to England and America. Hoffman conducted, among other research and therapy, the Saskatchewan trials, and ultimately came up with the idea of ‘psychedelic therapy’ in which a single large dose of LSD was given along with therapy sessions.

‘Psycholytic therapy’ is what Ronald Sandison’s version became known as in the UK, with the difference being that Sandison’s treatment style was to do multiple sessions with smaller amounts of the drug that increased through the process. Both doctors found great success particularly with alcohol addiction. How much success? According to the Saskatchewan trials, as many as 40-45% of drinkers were still not drinking a full year after the therapy session.

Unfortunately, when the drugs were made illegal, all ability to continue such treatments ended, and the ability for research into the field was completely stymied, and did not pick up again until much more recently. However, to give an idea of the massive turnaround that has been going on when it comes to psychedelics, consider that the US’s Food & Drug Administration (FDA), singled out both psylocibin in 2019 and MDMA in 2017 as ‘breakthrough therapies’ for depression and PTSD respectively. Such a designation by the FDA is meant to speed up research and development for products deemed necessary for health.

This indicates a desire by a US government agency to not only test these drugs, but to get them to market. And they’re all schedule I right now. One exception to psychedelics all being schedule I, however, is magic mushrooms. Though its psychoactive components like psilocybin are Schedule I, and therefore illegal, the plants themselves are not outlawed, creating a bit of gray area in terms of mushroom use, cultivation, and production. This gray area could prove useful in the future.

What can be expected?

If you’re wondering why this matters, consider how massive – and growing – the legal cannabis markets are. Well, psychedelics offer many of the same medical benefits, especially psychologically, with possibly added abilities in other departments. And they’ve proven to be very safe. As an industry in which much of it is pharmaceutical to begin with, it’s a safe bet that these drugs are going to pick up quickly. Because the pharma world is sure to take a massive interest, it gives even more reason to invest in medical psychedelics now, before everything explodes.

psychedelic-assisted therapy

So how much is it worth? I’m not the kind of writer who generally likes to get into these numbers. Every publication makes its own predictions, off its own information, and very rarely do these predictions seem to consider world changes. Whatever the size of the CBD industry was originally predicted to grow to a few years ago, that number would be invalid by now because it didn’t account for THC-based medicines growing in popularity, or legal markets, or psychedelics.

Imagine how much psychedelics could eat away at cannabis revenue. And not only that, any predictions of the future market size for psychedelics would have to take into account the still expanding cannabis markets (with more countries constantly legalizing in some form or another), and the question mark of what currently unforeseen factors could upend the trend a few years down the line. So, I’m not concerned with too many predictor numbers, but here’s just one, in order to get an idea what we’re dealing with.

PRNewswire, citing an analysis by Data Bridge Market Research, explained the forecast for 2020-2027, in which the field is expected to grow to $6.8 billion by 2027. It was worth just over $2 billion in 2019.

Best ways to invest in growing medical psychedelics field

Now that a certain barrier seems to be broken, more companies are conducting clinical trials, getting patents, and starting to get clearances for products. In fact, if you thought the psychedelics market was off limits, you’d be very much mistaken. Not only is this a growing market with a lot of possibility, but companies are already staking their claim, leaving room for you to start investing. So, if you like the idea of getting in on something before it explodes, consider investigating the following companies, and invest in the medical psychedelics field.

Much like with cannabis, Canada is quickly establishing itself as a leader in medical psychedelics, with the top companies coming out of this country. In the first half of 2020, $150 million USD was raised by six different companies: Mind Medicine, COMPASS Pathways, Field Trip Psychedelics, ATAI Life Sciences, Orthogonol Thinker, and Numinous Wellness. Mindmed and Numinous are already publicly listed companies. This is an early stage entry for investors. In fact, to give an idea of how seriously Canada is taking this, the first exchange traded fund – The Horizons Psychedelic Stock Index ETF, made its debut in January. ETF’s are like regular asset exchanges, except that they include a mix of stocks, commodities, and bonds. This exchange is solely for psychedelics.

The CEO of the fund, Steve Hawkins, said that while larger pharmaceutical companies have been admitted to the fund, the idea is to keep it mainly for smaller psychedelics companies. Companies can be added to the fund if they can tick the following boxes: be a part of a regular US or Canada-based stock exchange, be a biotechnology company focusing on medical psychedelic research, be a producer and/or supplier of psychedelic medicines, and be a company that works within the general supply chain for psychedelic medications.

medical psychedelics

Biggest names so far

When it comes to emerging fields and investing, the majority of people will never get there preemptively, and will instead act by reaction. For anyone who wants to get in on it before the top blows off, the following companies currently provide the best prospect for future growth, expansion, approval, and ability for revenue. These names should be noted, they will likely be bringing you the first approved medical psychedelic products, and for anyone looking to invest in this rapidly growing field of medical psychedelics, they stand out as the best options so far.

Mind Medicine is one of the furthest along when it comes to getting a product out there. It’s a pharmaceutical company that specifically works to develop psychedelic medications. The company is currently in the middle of six different trials on drugs like MDMA, LSD and DMT. In January of 2021, MindMed announced the first ever clinical trials to involve a combination of MDMA and LSD, with company president Dr. Miri Halperin Wernli stating:

“I believe that when LSD and MDMA are taken together they have exceptional potential to open a window into our mind which will awaken it to new levels of awareness by changing the fluidity of the ‌state‌ ‌of‌ ‌consciousness, amplifying‌ ‌changed‌ ‌perceptions,‌ ‌intensifying ‌emotions‌, ‌and‌ stimulating ‌novel‌ ‌thoughts. It is like a gateway to a multidimensional universe.”

When it comes to MDMA trials, MAPS – Multidisciplinary Association for Psychedelic Studies,  is also making its way to approval. MAPS entered phase III of its trials into MDMA for PTSD, and aligned this phase with the FDA according to a Special Protocol Assessment made directly with the FDA. This means that so long as the trials show clinically significant results, the study will already check all FDA regulatory boxes, and make it that much easier for approval.

However, a psychedelic drug has technically already been approved by the FDA. In March of 2019, Johnson & Johnson’s Spravato got approval. The spray treatment is considered for those who have not received a benefit from at least two separate anti-depressants. Spravato is a drug that’s a chemical cousin of the drug ketamine, which is classified as a dissociative drug, but also as a psychedelic. The medication is meant for severe depression.

There are tons of companies popping up. Apart from the companies already listed, prospective investors should check out Champignon Brands, Hollister Biosciences, Better Plant Sciences, Captiva Verde Land, Core One Labs, Cybin, Empower Clinics, Ehave, Jazz pharmaceuticals and EGF Theramed Health. All of these companies are associated in some way or other with the production of psychedelic medications. And while I have yet to see it mentioned in an article, it seems to me that what might upend everything I just said, is the ability to cultivate magic mushrooms.

LSD

Something to consider

Much like cannabis, mushrooms come with the ability for easy self-cultivation, as well as large scale cultivation. People who invest in today’s cannabis cultivation already know the value of having growing fields. Imagine the same thing, but with mushrooms. I personally believe that the biggest way in the future to invest in medical psychedelics, will be through the growing of mushrooms.

As stated, this is my opinion, and has not been discussed much as far as I can tell. This is not shocking though, and really doesn’t mean much, as this topic is also an undesirable one for any biotech or pharmaceutical company that – much like with cannabis – would much prefer you know nothing about how to do this on your own. And much like cannabis, it’s easy enough to learn how for anyone who needs some help getting started. Plus, since cultivation and sale of the mushrooms themselves is actually legal in many places, it’s way more legal to grow a field of mushrooms in much of the world, than to grow a field of cannabis.

How to invest in Medical Psychedelics – Conclusion

That the medical psychedelics field is coming is not as much up for debate as many would believe. It might be growing in the shadow of the cannabis market, and being kept quiet until the ability for large scale monetization is possible, but it’s coming, and it will be big. For those who want to invest in the growing medical psychedelics field, getting in now is probably the best idea, and with all the new companies popping up every day, it’s sure to become a heated race very soon.

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References

Why the Vape Ban Is Happening, and How It Will Impact Delta-8 THC
Florida Bill Aims to Legalize Medical Magic Mushrooms

DIY: How to Make Delta-8 THC at Home
Here is everything wrong with Biden’s “forced rehab” plan for drug reform
What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8THC)

Can LSD Treat Your Mental Illness?
Welcome to the World’s 1st DMT Trials into Depression
The CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers). Delta 8 / 9 / 10 / 11… How Many THCs Are Out There?
The New Rise of Medical Psychedelics

The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc) and the Best Delta 8 THC Deals. How To Choose Delta-8 THC Flowers?
Ayahuasca In the Fight Against Drug Addiction The Many Faces of Tetrahydrocannabinol – Different Types of THC and Their Benefits Psychedelic-Assisted Therapy, and How It Works
Desert Tripping – A Closer Look at Peyote: Spiritual, Medicinal, & Controversial Nature’s Magic – The Health Benefits of Psilocybin Mushrooms

Disclaimer: Hi, I’m a researcher and writer. I’m not a medical professional, I have no formal legal education, and I’ve never been to business school. All information in my articles is sourced from other places, which are always referenced, and all opinions stated are mine, and are made clear to be mine. I am not giving anyone advise of any kind, in any capacity. I am more than happy to discuss topics, but should someone have a further question or concern, they should seek guidance from a professional in the relevant field for more information.

Yup, there’s a vape ban in the USA, but that doesn’t mean we can’t get you any delta-8 THC products at all. Delta-8 THC is the less psychoactive THC compound that produces less anxiety and panic for users. Check out the great delta-8 THC deals we’ve got, and start experiencing delta-8 in a whole new way.

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Welcome to the World’s 1st DMT Trials into Depression

As research into medical psychedelics heats up, more drugs have been brought into the spotlight for medical testing. The FDA is pushing for research and products with MDMA and psilocybin in the US, and over in England, the world’s 1st DMT trials into depression have begun.

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What is DMT?

DMT – N,N-Dimethyltryptamine, is a hallucinogenic compound that can be found in nature in many plants like Psychotria viridis and Banisteriopsis caapi. It is processed into a white powder that can be vaporized or smoked, brewed into a drink like ayahuasca, snorted like cocaine, or even injected. It has been used as a medicine, and in spiritual applications, for thousands of years. DMT trips can be as short as 30-45 minutes, or as long as 4-6 hours when taken as ayahuasca.

Evidence of DMT use has been found going back at least 1,000 years in the Sora River valley in southwestern Bolivia with the finding of a pouch which contained both DMT and harmine. Together they imply the use of ayahuasca (a psychedelic tea made from the combination of Psychotria viridis – which produces DMT, and Banisteriopsis caapi vine – which produces MAO inhibitors which keep the DMT from breaking down, allowing for the longer trip time.)

Like many psychedelic drugs, DMT acts on serotonin receptors, particularly the 5-ht2a receptor. It acts as a non-selective agonist at most/all receptors. Serotonin is a hormone that’s known for mood stabilization, happiness, well-being, anxiety levels, and feelings of depression. It also plays a big role in communication within the nervous system, and to help regulate basic functions like eating, digestion and sleeping. Too little serotonin has been associated with depressive disorders, and too much is often associated with excessive activity in nerve cells.

DMT trials depression

There is growing evidence that the human body can actually produce DMT itself by way of the pineal gland in the brain. There has even been research into whether DMT is released right before death in order to quell the anxiety of dying. Most testing into this has been done on animals thus far. Recent research has shed light into the similarities between near-death experiences and DMT use.

DMT was first synthesized by Richard Manske, a Canadian chemist, in 1931. It was not actually located in plants until 1946 when Oswaldo Gonçalves de Lima, a microbiologist, was able to find the compound in nature. The hallucinogenic aspect wasn’t discovered until 1956 when Hungarian chemist and psychiatrist Stephen Szara self-administered DMT he had extracted from the plant Mimosa hostilis.

What are psychedelics in general?

Psychedelics are psychoactive substances with a powerful ability to alter perception, mood, and cognitive processes. Psychedelics are a subset of hallucinogens, and can cause a person to perceptually experience things that are not actually happening – aka a hallucination. Psychedelics are also known for promoting self-introspection, feelings of connection between people, mystical experiences, relaxation, feelings of overall well-being, and euphoria.

They are also associated with negative side effects like bad trips which can cause negative hallucinations and feelings of anxiety and fear. Bad trips, and other negative effects like sweating, vomiting, chills, numbness, and dizziness, can often be entirely avoided with correct dosing. Psychedelics can be made in laboratories, like LSD, or found in nature like DMT and psilocybin. They are not associated with causing major injury or death.

Currently, plenty of research is going on into psychedelic drugs, though research was stymied for years due to psychedelics being made globally illegal with placement in Schedule I of the Convention on Psychotropic Substances 1971. This treaty defines drug legalities worldwide. The scheduling implies the drugs in this category are uniformly dangerous, with no medical value, and the grouping includes DMT and other psychedelics. Even so, plenty of research is going on right now into LSD, MDMA, psilocybin (magic mushrooms), ayahuasca and more.

Psychedelic-assisted therapy

When it comes to psychedelics for therapy, there isn’t a model that I’ve seen where a subject is simply given a dose of a drug and told to have a good time. In the past, and in more recent testing, psychedelics have been/are used as part of psychedelic-assisted therapy. The basic model involves three phases: preparation, psychedelic experience, and integration. Research from the 1950’s-1970’s involves two ways of doing the second phase.

major depression

One method was developed by Humphry Osmond, a Canadian psychiatrist, who used one large dose with a therapeutic session, which was termed ‘psychedelic therapy’. Conversely, UK psychiatrist Ronald Sandison used smaller doses that gradually got bigger, over several sessions, which became called ‘psycholytic therapy’. Here is an overview of the three basic stages, regardless of which methodology is used in terms of number of sessions and amount of drug per session:

Preparation phase– In this first stage, the doctor and patient get to know each other, which is important because the relationship between the doctor and patient can affect the psychedelic session. This phase generally involves talk therapy sessions where the patient’s issues can be identified and flushed out, and the patient can be prepared for the following phase. Preparation can involve behavioral directives for the experience, like explaining to the patient they should open a door if one appears in his/her experience, or to go up to a scary creature to ask questions rather than run away, as a way to encourage a patient to deal with difficult situations instead of avoiding them.

Psychedelic phase – In this phase, the patient is given a psychedelic, and then experiences their trip while their doctor gives them general guidance, with little or no analysis at this time. The session can last as long as 8+ hours as it must last as long as the drug. It’s usually carried out in a space that looks and feels comfortable to the patient. In testing, the space is usually set up to look like a living room. These sessions have two doctors present, likely for safety reasons as the patient is being put in an altered state of mind. This phase varies greatly depending on the methods used by the particular doctor. But at all times during this phase, the patient is attended to by their doctor.

Integration phase – This phase occurs soon after the psychedelic phase and can be done in one or multiple sessions, much like the other phases. The doctor facilitates this session, and helps the patient make sense of their experience. To process what happened during the session, to gain some kind of positive value from it, and to integrate an understanding between the psychedelic experience and their issues in reality.

World’s 1st DMT trials for depression

Most of the studies in the 1900’s revolved around testing LSD for use with alcohol addiction. In today’s world, there is growing interest in several compounds. The new trend can be seen clearly in the US (FDA) Food & Drug Administration’s push to get some of these compounds tested and brought to market. In 2017, the FDA designated MDMA as a ‘breakthrough therapy’ for PTSD, and in 2019 it made the same designation for psilocybin from magic mushrooms for major depression.

According to the FDA, the ‘breakthrough therapy’ designation is meant “to expedite the development and review of drugs for serious or life-threatening conditions…” So it suffices to say, that legal or not, there is a growing pressure even within the US government to get these drugs to market.

DMT and ayahuasca

It’s therefore not shocking that the 1st DMT trials into depression recently started. It was announced in December 2020 that the (MHRA) UK Medicines and Healthcare products Regulatory Agency approved the use of DMT in the first ever clinical trial of the compound, specifically for the treatment of depression. The trials are being done as a collaboration between Small Pharma and Imperial College London. In this first trial, considered a phase I/IIa trial, the drug is being given to a small number of healthy individuals to establish safety and efficacy. A second trial is expected, in which patients will be given DMT in trials as a part of psychedelic-assisted therapy for depression.

The explanation for the first trials, according to Small Pharma’s chief scientific and medical officer Carol Routledge, is that “Taking the drug before therapy is akin to shaking up a snow globe and letting the flakes settle.” She says, “The psychedelic drug breaks up all of the ruminative thought processes in your brain – it literally undoes what has been done by either the stress you’ve been through or the depressive thoughts you have – and hugely increases the making of new connections.” She goes on to say:

“Then the [psychotherapy] session afterwards is the letting-things-settle piece of things – it helps you to make sense of those thoughts and puts you back on the right track. We think this could be a treatment for a number of depressive disorders besides major depression, including PTSD, treatment-resistant depression, obsessive-compulsive disorder, and possibly some types of substance abuse.”

Unlike an LSD, psilocybin, or even ayahuasca trip (in which DMT is mixed with another compound to make it last longer), all of which can last many hours, DMT trips are significantly shorter, usually over within a couple hours max. This might prove preferable to the aforementioned drugs which require significantly more time for therapeutic sessions. These DMT trials into depression can help establish if DMT is suitable for treatment, and if the shorter time period really is beneficial.

Conclusion

While everyone focuses on every minute detail of the fight for cannabis legalization, most people are ignoring the rise in medical psychedelic research and use. Maybe because the topic just hasn’t been promoted enough, which is possibly because there isn’t yet a product to make money off of. But there will be soon, and then, what I’m writing about now, will be front page news in every publication. For now, though it’s still a minor story to the average person, it’s a major one in the medical/pharmaceutical world, with these 1st DMT trials into depression signaling even further expansion of an industry ready to blow off the roof.

Hello! Welcome to CBDtesters.co, your #1 location for the best cannabis-related news from everywhere in the world. Check us out frequently to keep up on the ever-changing world of legal cannabis, and sign up to our newsletter so you’re always in the loop!

Resources

Psychedelic-Assisted Therapy, and How It Works
South Africa Introduces Some of the Most Lax Laws on Cannabis Yet

The New Rise of Medical Psychedelics
Next Stop for Cannabis Industry Investors: Malawi
What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8THC)

Opening Your Third Eye – How Cannabis Affects the Pineal Gland
Ayahuasca In the Fight Against Drug Addiction
The CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers).  MDMA – The New Way to Treat PTSD Desert Tripping – A Closer Look at Peyote: Spiritual, Medicinal, & Controversial
The Medical Cannabis Weekly newsletter (International medical cannabis business report)
Florida Bill Aims to Legalize Medical Magic Mushrooms
The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc) and the Best Delta 8 THC Deals. Best Delta-8 THC Vape Bundles – Winter 2021 Can LSD Treat Your Mental Illness?
Plant Power: Everyday Plants That Activate the Endocannabinoid System Sinaloa Cartel Might Run Mexico’s New Cannabis Industry Merry Cannabis! Christmas and Marijuana
Denver Residents Vote to Decriminalize “Magic Mushrooms”
Africa’s Green Rush and the Mad Dash to Update Cannabis Regulation Nature’s Magic – The Health Benefits of Psilocybin Mushrooms Cannabis Election Results – What Just Became Legal in the United States

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