Isreali Nextage Explores Effective Delivery of Psychedelic Compounds

Israel is one of the leading countries for medical cannabis research and has held this title for decades; since the 1960s to be exact. Now, they’re joining efforts to study the benefits of psychedelics in a clinical setting as well.

Of the main areas of focus is using psychoactive compounds to treat clinical depression and other psychiatric disorders. One Israeli company, Nextage Therapeutics, is looking specifically at utilizing ibogaine, along with their own patent delivery system, to better treat people with these conditions.

When it comes to treating psychological disorders and minimizing the risk of side effects, psychedelics are the way of the future. Check out our newsletter, The Delta 8 Weekly, to learn more about these incredible compounds as well as gain access to exclusive deals on flowers, vapes, edibles, and other products.


What are Psychedelics?

Psychedelic drugs are a subset of hallucinogens. They contain psychoactive compounds that are capable of altering a person’s mood, perception, and cognition; sometimes permanently. The active compounds are usually found in nature, like psilocybin or mescaline, but they can also be manmade, like LSD.

Psychedelics are known for causing ‘trips’, which is what the high is referred to. When a person is tripping, they may have altered perceptions of the world around them. Many people believe this is limited to visual and auditory hallucinations, but it can also include feeling, tasting, and smelling things that are not real, as well as a heightened sense of connection and understanding, and greater feelings of introspection.  

The trips that people most commonly associate with these types of the drugs are the ones in which a state of hallucinogenic delirium is reached, but that is not always the case. Many times, it is more of an experience than a trip, and something can be learned and achieved psychologically with every small dose.

The word itself, ‘psychedelics’, was first used in 1957 to recognize substances that were said to open the mind, however, the more accurate term for them is ‘entheogens’. This term was adopted, not necessarily for the sake of being scientific, but rather to allow the sector to operate without all the stigma attached to psychedelics from smear campaigns and restrictive policies throughout history. The term entheogen comes from Greek where it means ‘building the god within’.

Different psychedelics produce different trips. For example, with DMT you can expect a short high lasting less than 1 hour, whereas LSD, psilocybin, and mescaline trips can last up to ten hours. Some hallucinogens are more potent than others, like mushrooms vs acid. The active compounds are different in each drug so there is a lot of variation to the effects that can be felt.  

Some people experience bad trips in which negative, or even scary, hallucinations are experienced, and/or a rapid heartbeat, sweating, nausea, disorientation, and fatigue occur. There is indication that the majority of these symptoms can be controlled through proper dosing. This is why most modern-day, therapeutic users of psychedelics consume the drugs in micro-doses.

Nextage Pharmaceuticals and MindMend

According to Nextage Founder and CEO Abraham Dreazen, “there has been a shift in the last decade. The US Food and Drug Administration, for example, is starting to see quality of life as a factor in evaluating medicine, opening the door to these drugs.”

Earlier this year, Nextage signed a collaboration agreement with industry trailblazer Mindmend, to use their proprietary new technology known as Brain Targeting Liposome System (BTLS) – a delivery system Dreazen claims will “optimize the delivery of drug products based on noribogaine, and ultimately other ibogaine derivatives.”

Ibogaine is a naturally occurring psychoactive substance found in Apocynaceae plant family in Gabon, a small coastal country in central Africa. Although minimal research exists, a handful of clinical studies found that Ibogaine and its derivatives can be used to combat addiction, and it was looked at particularly for the treatment of opioid addiction, for which the results were promising.

Unfortunately, when used at high doses over a longer period, there are potential side effects. In a recent press release, reps from MindMend explained that, “orally administered ibogaine and noribogaine present unacceptable safety risks due to their torsadogenic effects at high systemic concentrations.”

Simply put, there’s a moderate risk of heart attacks when using noribogaine. However, Dreazen believes that if the drug is administered using certain methods that better permeate the blood-brain barrier, so more of the drug actually reaches the brain rather than going to other parts of the body, including the heart. He described it as “the winning lottery ticket.”

Permeating the Blood-Brain Barrier

When it comes to treating psychological and neurological disorders, or really any other disease or condition affecting the brain, the main challenge is permeating the blood-brain barrier. The purpose of the blood-brain barrier is to protect the brain from foreign substances, and as such, can prevent up to 95% of molecules from reaching the brain.

So far, the most common way to work around that is by giving prescribing these drugs at extremely high doses, and that, needless to say, can have numerous unwanted and severe side effects. Using a more effective model, The BTLS platform, licensed from the Technion-Israel Institute of Technology, has been making use of a “liposomal vehicle with a unique targeting complex” that allows for blood-brain barrier permeation at much lower doses of various pharmaceutical agents.

This is a relatively well-known concept, but according to Dreazen, Nextage took it a step further and attached a “small arrow of seven amino acid peptides – essentially a very small protein – which is part of a much larger protein that is native to the brain and has a way of actively transporting the liposomal capsule through the blood-brain barrier. Once the capsule is drawn into the brain with the arrow, it gets lodged there and starts dissolving, facilitating release of the active material – the drug.”

What the Future Holds for Nextage

Nextage has been working in the drug delivery sector for 14 years and their daughter company, IMIO, is focused solely on psychedelics. The company completed most of required preclinical worked needed to determine the potential efficacy and generality of their new patent technology. They have already worked with CBD and THC-based medications and Nextage/IMIO plans to explore the potential of lysergic acid diethylamide (LSD).

Dreazen says LSD “is a really promising drug.” Its challenge is that when taken, people can “trip” for 15 to 17 hours, making it very unfeasible as a chronic treatment. But just like with ibogaine, he believes that if the dose can be reduced and the least amount possible gets into the body as opposed to the brain, “you could potentially get the same therapeutic effect without the longevity of the trip.”

“In the US, the psychedelic movement has exploded in the last 12 months,” Dreazen added. “I think psychedelics in Israel are just emerging, and we are the first public company to really put our teeth into it. Israel has always been in the forefront of research and development and we are committed to spearheading this industry.”

Final Thoughts

As you can see, conversations surrounding the use of psychedelics to treat mental health and neurological disorders is reaching nearly every corner of the globe, and the countries that have been more accepting of cannabis are also spearheading the medical psychedelic revelation. Psychedelics are here to stay, and in the very near future, we can expect to see a lot of these compounds being safely used in clinical and therapeutic settings.

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Celebrities Who Were Helped By Psychedelics

The psychedelics industry has seen massive attention and growth in the past couple years, with more and more of the stigma once attached to them, disappearing into thin air. As it becomes acceptable to speak about their use, celebrities have been more open with their stories, and how they’ve been helped in life by psychedelics.

It’s not that shocking so many celebrities have been helped by psychedelics, the growing body of research is very positive. The same is true for cannabis, which has been expanding out very quickly in the last few years, with tons of people backing it in the media, and with all new products coming out. One interesting addition is delta-8 THC, an alternate THC which doesn’t cause the same anxiety, couch locking, or cloudy head as delta-9. We’ve got a great array of delta-8 THC, delta 10, thco, thcp, thcv & even hhc deals, so check out the selection, and stay on top of what’s new in the world of cannabis.

Celebrities and drug use

First and foremost, there’s nothing actually special about celebrities, at least not as a rule. There are plenty of non-celebrities that can compete with the famous on pretty much any metric. This isn’t meant to undermine the special qualities of those who have made it big, but it is meant as a reminder that celebrities are still human, and representative of the human population. What makes them interesting, however, is how known they are. If I have an interesting experience, there might be a few people that care about it, but the story isn’t going to go far. If the same thing happens to Justin Bieber, or Samuel L. Jackson, or Lebron James, it gets echoed around the world.

Plenty of people in the world have drug problems, but the overdoses and deaths of celebrities make the biggest news. From Kurt Cobain to Heath Ledger to Johnny Depp, we never seem to be able to get enough of celebrities and their problems. In just the last few years, the following celebrities have all made headlines with their drug issues, and all of them ended up dead (whether drug-induced or not): Anthony Bourdain, Tom Petty, Prince, Philip Seymour Hoffman, Amy Winehouse, Mac Miller, and Chester Bennington.

Go back even further and you can include Janis Joplin, Heath Ledger, Kurt Cobain, Jim Morrison, Michael Jackson, Jimi Hendrix, Elvis Presley, Whitney Houston, Brittany Murphy, and River Phoenix just to make a short list. And let’s not forget some of the biggest names in drug headlines that have made it through this far, like Johnny Depp, Charlie Sheen, Drew Barrymore, Lindsay Lohan, Steven Tyler, Demi Lovato, and Robert Downey Jr, just to name a tiny number. Regardless if the story is watching someone fall from grace, or watching them get their problems under control in an act of strength, if it’s happening to someone in the spotlight, we all know about it.

celebrities and drugs

Just like many celebrities have openly spoken about how cannabis has helped them, many celebrities will also openly speak now about how their lives were helped by the use of psychedelics. Here are a few interesting stories.

Celebrities who say they were helped by psychedelics

Mike Tyson

Mike Tyson is an all around interesting character, reigning for years as a heavyweight boxing champion, doing short-lived stints in reality TV, showing up in films, getting his face tattooed, spending some time in jail, and reemerging in the past few years as an entrepreneur in the world of cannabis. First, Tyson opened Tyson’s Ranch in California, meant for the recreational use of cannabis. He even started setting up shop in Antigua, and has tons of expansion plans for both locations, with the vision of creating entire entertainment complexes with hotels, stores, entertainment venues, and more. Tyson promotes the production of high-quality products, and high quality experiences when it comes to cannabis, and has been using his celebrity to help bolster his moves in the cannabis field. Mike Tyson also hosts a popular podcast called ‘Hotboxin’.

But Tyson doesn’t stop with cannabis. He’s also an avid promoter of psychedelics. In fact, Tyson is a great example of celebrities who have been helped by psychedelics. Earlier in 2021 Tyson was interviewed by Reuters Magazine, he not only says psychedelics helped him revive his career, but that they helped save his life as well. In his own words about magic mushrooms:

“To think where I was—almost suicidal—to this now… Isn’t life a trip, man? It’s amazing medicine, and people don’t look at it from that perspective.” He went on to say: “Everyone thought I was crazy, I bit this guy’s ear off…I did all this stuff, and once I got introduced to the shrooms … my whole life changed.”

Megan Fox

Another celebrity who has been open about her psychedelic experience, is Megan Fox. During a trip to Costa Rica with boyfriend Machine Gun Kelly, Fox took part in an ayahuasca ceremony. In these hours long ceremonies, ayahuasca is given to participants in a ritualistic way, and they are guided through their experience. Ayahuasca is the mix of two different plants, Psychotria viridis which contains DMT, and the caapi vine, which produces an MAO inhibitor which activates the DMT orally, and keeps it from breaking down so quickly, enabling a much longer trip experience. Ayahuasca is known for creating intense hallucinogenic experiences that many credit with helping to deal with emotional and mental wounds and issues. This is what she had to say about the experience:

“You have to walk a very far distance to get your water. You can’t shower because they’re in a drought. Nothing glamorous about it. It’s all part of making you vulnerable, so you surrender to the experience…You have to vomit a certain amount before they let you back… It’s such a good bonding experience. That gets you ready to go into the ceremony that night because your vanity’s gone.”

Ayahuasca

While fox had expected a more glamous camping experience (glamping), what she got was a dose of life medicine. If this doesn’t sound like the amazing spiritual awakening most hope for, she went on to say that ayahuasca: “goes straight into your soul, and it takes you to the psychological prison that you hold yourself in.” She said, in the end, ayahuasca “surpasses talk therapy or hypnotherapy.”

Kristen Bell

Yet another example of celebrities who say they were helped by psychedelics, is actress Kristen Bell. Bell has been open about dealing with anxiety and depression in life, and has had issues with treatment resistance, to the point that she decided to give magic mushrooms a shot.

“I really wanted to try some psilocybin and feel what kind of doors open, have a trip that was my own,” she explained on the podcast ‘Hypochondriactor’, hosted by actor Sean Hayes and Dr. Priyanka Wali. In order to make sure she was safe during her experience, she heavily researched psychedelic medicine, and made sure her husband Dax Shepard was there to watch over her.

Post experience, Bell says she’s in a better place with her anxiety and depression, but that it still comes back in waves. However, concerning these waves, she explains, “But my waves are never suicidal or anything… So I’m very lucky because that does happen to people.”

Bell encourages people to really do the research and understand themselves and their issues, she says, “During your treatment, you’ll learn a lot about what this disease is, and you may or may not decide a medication is right for you… But there’s a lot of different routes to feeling better, I guess is what I’d say, a lot.”

Steve Jobs

Steve Jobs isn’t around today to further confirm his use of psychedelics, but during his life he spoke about them enough. Jobs, who co-founded Apple in 1976, went on to become one of the most important people in computing and technology, creating a massive empire for himself that included being chairman of Pixar, on the board for Disney, and founder, chairman and CEO of NeXT. Jobs died in 2011 of respiratory arrest, due to pancreatic cancer he had been battling since 2011.

LSD

Steve Jobs was known for being a little eccentric, and for trying things not everyone else would. For example, he actually embraced a fruitarian diet on-and-off for many years, which includes eating nothing but fruit, a rather extreme form of veganism. In the 70’s, during his college years, Jobs experimented with LSD. Of these trips, which he said took place between 1972-1974 he later stated:

“Throughout that period of time I used the LSD approximately ten to fifteen times… I would ingest the LSD on a sugar cube or in a hard form of gelatin. I would usually take the LSD when I was by myself. I have no words to explain the effect the LSD had on me, although, I can say it was a positive life changing experience for me and I am glad I went through that experience.” He also said of these experiences,

“Taking LSD was a profound experience, one of the most important things in my life… LSD shows you that there’s another side to the coin, and you can’t remember it when it wears off, but you know it. It reinforced my sense of what was important — creating great things instead of making money, putting things back into the stream of history and of human consciousness as much as I could.”

Conclusion

It might not require celebrities to get behind them, but any measure is no doubt helped along by the public push of those who everyone knows. And this includes psychedelics. If anything, by the time celebrities are willing to start talking about something, it says a lot for how far that topic has come. And celebrities are opening up more and more about their psychedelic use, and how its helped them in life.

With cannabis working its way to complete legalization, the DEA requesting more cannabis and magic mushrooms to be grown, with psilocybin and MDMA earmarked as breakthrough therapies by the FDA, and considering the legalization of esketamine in 2019 for depression, and for suicidal thoughts (updated 2020), the world of medicine is certainly shifting. In fact, in another decade, cannabis will likely be smoked freely, and psychedelics might be the basis of every psychiatric medication.

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DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

The post Celebrities Who Were Helped By Psychedelics appeared first on CBD Testers.

New Psychedelic Anti-Depressant Esketamine: What the Patients Have to Say

Psychedelic-assisted therapy, and the legalization pf psychedelic drugs, is most definitely a thing. We know this, because the psychedelic drug esketamine is already legal for use, with MDMA and psilocybin on the way, and being pushed by the FDA. Is esketamine an effective treatment, here’s what the patients have to say.

Esketamine therapy is a real thing with plenty of patients letting us know what they have to say. If you’re not quite ready for psychedelics, there’s always cannabis, and plenty of different options. Like delta-8 THC, an alternate form of THC which leaves users with more energy, less cloudiness in the head, and no anxiety. There are so many compounds to choose from, that there’s something for everyone. Take a look at our selection of THCV, THC-O, Delta 10 THC and Delta-8 THC deals, and figure out your best option.

What is esketamine?

Before getting into esketamine treatment and what patients say about it, let’s cover what it is. If the name ‘esketamine’ sounds incredibly similar to a popular party drug, that’s because it is. The drug ketamine has been a staple of the party circuit since the 80’s and 90’s, and esketamine is its close cousin. Ketamine was discovered in 1962 by scientists at Parke-Davis. They were in search of a strong anesthetic, and after creating, testing, and ultimately rejecting PCP, and other closely related compounds, ketamine was discovered. It was described as a compound with “cataleptic, analgesic and anesthetic action but without hypnotic properties.”

It became known as a dissociative anesthetic, because of how it seemed to disconnect parts of the brain. This was subsequently described as “electrophysiological and functional dissociation between thalamocortical and limbic systems.” Since that time, ketamine has been used as an anesthetic in both animals and humans, as well as being used as a recreational party drug. Essentially it doe three things, provides pain relief, anesthetic affect, and sedation. The chemical formula for ketamine is C13H16ClNO.

Of course, we’re not talking about ketamine, we’re talking about esketamine. Esketamine hasn’t been around as long, making its first appearances in Germany in 1997 as an anesthetic. While it was being used as an anesthetic, it was noticed that the compound had very fast-acting antidepressant effects, and began being investigated for this purpose. In 2017 the drug finished trials in the US for treatment-resistant depression, and in 2018, Johnson & Johnson filed an application with the FDA for a new medication – Spravato. It was approved on March 5th, 2019.

It was technically approved in conjunction with standard antidepressants for the treatment of depression in adults. In 2020, this was updated to include prescription for suicidal thoughts on account of how fast-acting it works. It is already being prescribed for use in psychedelic-assisted therapy.

Esketamine

Esketamine therapy, what the patients say

Pharmaceutical companies put out all kinds of medications, and they promote them all like they’ll save your life, even when going through litigation because of lies. Though psychedelics do seem to have good efficacy for helping people, this does not mean that any psychedelic medication will be okay. So, it suffices to say that hearing directly about esketamine from patients, and what they have to say, is the best thing for understanding the current situation. In the first few years of something being out, it can be hard to find the stories. These are the stories around right now.

One test subject, Amelia D., started receiving esketamine in 2017 at the Rochester Center for Behavioral Medicine. As she explains, she began taking anti-depressants shortly after she finished college, and had been given a range of diagnoses ranging from dysthymia to ADHD to anxiety to major depressive disorder. She explained how after the intake for the study, she was required to take the drug twice a week for at least a month, each time under supervision in the doctor’s office.

She explained how those taking part were not allowed to drive for 24 hours following administration. She says it started with four hours of supervision, but was brought down to between one and two hours over time. This makes sense for shorter acting drugs like ketamine.

By the time a Time article was written about her in 2019, she was going every two weeks for treatment, in which she was administered three nasal doses at five minute intervals, and then watched for an hour or two. She also stated fears of not being able to continue the medication when the trials were over due to insurance not covering it, and not being able to find a therapist. Though she had plenty good to say about the treatment, she highlighted the fact that she had gone from being unemployed for quite some time, to holding a job steadily, and being generally okay. She said she always knows when she’s ready for another dose.

It doesn’t seem like this particular trial included the therapy aspect of it, and was likely more to establish effects of the drug. She did not mention negative side effects, and spoke generally of an improvement in her life.

Esketamine, what more patients have to say

patients say

Esketamine therapy has begun to find its way into the mainstream, and has been spoken about openly by American comedian Theo Von. Von, known for his stand up and podcast work, among other projects, runs a podcast called This Past Weekend with Theo Von. In Episode 341, called Ketamine Therapy, Von talks about his own experiences with depression and ketamine therapy, as well as interviews with founder and medical director of the Chattanooga Ketamine Center, Dr. Jason Pooler.

Von talks about the hallucinations he had while taking esketamine (it is often called ketamine by users, but the drug they are prescribed is esketamine). Theo’s father died when he was young, and through the ketamine therapy, he was able to deal with the subconscious pain of not having his father, and he said that using esketamine allowed him to complete the grieving process.

Yet another public personality, albeit on a smaller scale, is podcaster Ariel Kashanchi who runs the show Mad Genius. In her June 16th episode ‘Ketamine Touchup’, she goes into specifics about getting ketamine therapy. She starts by talking about her 7th infusion. She did six consecutively, followed by the 7th touch-up. She explains how touch-ups can be done per person needs, and that for her it’s every eight weeks or so.

However, before this, she had an April 8th, segment called Ketamine, TMS & My New Brain in which she describes more about the actual process. At the time of the recording she was one week into her esketamine and TMS (Transcranial magnetic stimulation) therapies, having had two ketamine sessions at that time. She talks about her longstanding issues with depression, PTSD and childhood trauma. She said more than once in the episode that she feels like a different person since treatment began.

She explains that in her case its administered via IV. She talks about being in a comfortable setting, with a comfortable chair and blankets, eye mask, and noise canceling headphones. She talks about being hooked to the IV for about 40 minutes, with a doctor checking on her every so often (not the standard format for psychedelic-assisted therapy). She was told she had to have an intention the fist time she went in, and hers was to feel valuable and lovable. She said the experience felt a bit like virtual reality…but her overall sentiment was that prior to this she didn’t think she’d ever feel okay, and now she does. She also – like Von, spoke about hallucinations of dead loved ones, and how it created a positive situation to experience them like that.

What is psychedelic-assisted therapy?

When we talk about the new rise in medical psychedelics, it’s not about a doctor blindly giving out a prescription for a drug and saying ‘go take a trip’. In fact, quite the opposite. Perhaps in the future this will be less restrictive, but for now, the only legalization for psychedelics is for medical use, and this goes for Oregon, the first state to legalize for use in this way (although that state, and others like Denver do have decriminalization policies for drugs like psilocybin from magic mushrooms).

magic mushrooms

If you’ll notice, esketamine only has an approval at the moment for use in conjunction with other antidepressants. I don’t expect this will last forever, but this is the first one to get a legalization like this, so it’s not shocking that there are several caveats attached that don’t make a lot of sense. If this stuff works better than standard antidepressants, which actually come with a lot of warnings, why not just use it? In the future, this stipulation will probably be cleared, but for now, that’s the way it’s been legalized.

So, if standard treatments are not working, the doctor can prescribe esketamine to be taken under the supervision of the doctor. There are a few different steps in the process of psychedelic-assisted therapy, and it goes something like this, though the process could certainly be tweaked as the industry progresses. This model may also be more relevant for psychedelic trips on drugs like ayahuasca, LSD, or psilocybin, which create much longer experiences.

  • Preparation – These are initial sessions in which the psychiatrist gets to know the patient, and the issues the patient has. In this phase it’s important to build repour between the two in order to facilitate a meaningful psychedelic session. In this phase, the doctor provides instructions for the psychedelic phase, that include things like not running away from something scary, but approaching it and asking a question instead, or opening a door if one is there. These instructions are meant to help the patient face their issues when they encounter them in the next phase.
  • Psychedelic session – This phase is done in a comfortable setting, which is important, because the setting can affect the patient’s mindset. Two doctors are generally present, likely as safety since the patient is being put in an altered state. The drug is given to the patient, and the doctor guides them through the experience, but does not perform any analysis at this time.
  • Integration – This phase takes place soon after the psychedelic phase, and is meant to help the patient make sense of their experience. This is where the doctor can help the patient analyze their experience to gain meaning out of it.

To be clear, it does not sound like the esketamine therapy model matches this one exactly, but that could be on account of it being very short acting.

Into the future

mdma

Esketamine might be the only legalized psychedelic at the moment, but that should change soon. In 2017 the FDA granted a ‘breakthrough drug’ designation for MDMA for the treatment of PTSD, and in 2019, the FDA granted not one, but two ‘breakthrough drug’ designations for psilocybin from magic mushrooms, also for the treatment of severe depression.

These designations are granted when a drug company finds in testing that a new compound might work better than existing alternatives, and is meant to quicken research and production to get products to market. In this way, the FDA is outwardly pushing for the approvals of these two psychedelic compounds.

To give an idea of how much the FDA seems to want this to happen… the organization running the MDMA studies, MAPS (Multidisciplinary Association for Psychedelic Studies), actually planned its third MDMA trials in conjunction with the FDA to ensure that the results would fall in line with existing regulation. I’m not sure there’s a better indication of what’s to come, than an actual government agency helping to design drug trials. With all this going on, it becomes that much more important to get first hand descriptions of esketamine from patients, who are right now the only people who can say anything about it.

Conclusion

Psychedelic-assisted therapy is a real thing, and esketamine in the first drug to get approval. In understanding how esketamine works, it helps to hear what patients themselves have to say. It should never be assumed that every medication will be an answer for everyone, but the information trickling in shows esketamine to be a very promising drug.

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DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

The post New Psychedelic Anti-Depressant Esketamine: What the Patients Have to Say appeared first on CBD Testers.