Positive Results From Study on Self-Treating with Psychedelics

The psychedelics market is getting wider, and actually goes way beyond psychedelics, to include many different hallucinogens. As more treatment options come out, so does the question of how effective self-treating with psychedelics is. A recent study sheds light on the benefits of getting high on your own.

Self-treating vs therapy sessions

First and foremost, when getting into self-treating with psychedelics, its good to know what we’re talking about. Psychedelics are a class of drugs under the heading of hallucinogens. And while there are tons of hallucinogens that aren’t directly called ‘hallucinogens’ (like Amanita mushrooms), there are three classes of hallucinogens, which are directly referred to as hallucinogens: psychedelics, dissociative (that’s ketamine), and deliriants (which include Benadryl).

Hallucinogens in general are drugs that cause the user to have a sensory experience that isn’t real, or is altered in how a person perceives it. Many different compounds from different drug classes, are considered hallucinogens, and this means that its not just psychedelics that cause people to hallucinate. In fact, when using the term ‘psychedelics,’ we only refer to LSD, psilocybin, mescaline, and DMT. Even MDMA is technically a psychostimulant, NOT a psychedelic.

If a person wants to use a psychedelic or hallucinogen for treatment, there are two ways to do it. One is with the help of a second person, generally in a therapeutic capacity; and one is by self-treating with the psychedelic, or other hallucinogen. The first includes some kind of setup process, with the help of a facilitator; and one is just about hoping to get a therapeutic response, but on one’s own.

Self-treating with psychedelics outcomes

There is no hard and fast answer to which is better. There does seem to be a massive value in psychedelic-assisted therapy for some, in that the therapist presiding can push a patient to cross limits, which might help with establishing new neural connections. But there are also drawbacks, like being in a less comfortable situation, and often one that feels ‘medical.’ Doing it oneself might be more relaxing, but comes with is own drawback that just because the drug is being used, doesn’t mean that a person’s brain gets pushed across boundaries. Different people require different things.

When done as drug-assisted therapy, its definitely a process. The patient and doctor must get acquainted. The patient must feel comfortable with the doctor, and the doctor must come to understand the ins and outs of what a patient is suffering from. All together this can mean several preliminary sessions, and several integration sessions after, wherein the doctor helps the patient examine and understand their experience.

With self-treating using psychedelics or other hallucinogens, these other steps are not involved, and the person simply takes the drug and has the experience. With no one to help them through, explain anything, or provide feedback. This might be perfectly fine for some, but could be a drawback to the treatment value, for others.

Recent study on self-treating with psychedelics

The first thing to understand about the study, is that the data collected for it, was not designed by the study investigators. They simply used existing data from the Global Drug Survey for 2020, which is available to the public. The investigators therefore had no way to control for anything outside of what was already collected; or to clarify any information, or interact with participants.

The new study is called Investigation of self-treatment with lysergic acid diethylamide and psilocybin mushrooms: Findings from the Global Drug Survey 2020 and was headed up by PhD student Emma Kopra, at King’s College London’s Institute of Psychiatry. She, and the other researchers involved, were most interested in use of LSD and psilocybin for self-treatment of mental health issues.

Of the purpose of the analysis, Kopra explained, “Increasing publicity of psychedelic’s therapeutic potential is attracting growing numbers of people to ‘self-treat’ with these substances independently outside clinical settings. However, there is very little research on the patterns, outcomes, and safety of this type of use.”

Respondents answered questions on self-treating with psychedelics
Respondents answered questions on self-treating with psychedelics

The survey was taken in 2020, and 113,000 people completed it. Though 10,268 reported that they’d used psychedelics of some kind within the past year to treat a mental health issues, only 3,364 were included in the study. All had taken either LSD or psilocybin. Depression and anxiety were the most commonly treated issues, and respondents answered questions relevant to changes they noticed in themselves after their self-treating with the psychedelics in question. This included negative outcomes as well.

The study measured the responses to 17 different criteria for well-being with self-treating, as well as assessing psychiatric symptoms, social-emotional skills, health, and overall behaviors. Items were judged by a 7-point scale that went from -3 – +3; with -3 relating to negative outcomes, and +3 relating to positive outcomes. 0 was the middle point, which represented no change.

In terms of evaluating negative experiences, the respondents also answered a 10-part survey on negative results, if they had them. Only those that gave numerical values relating to a negative experience, answered this part. These questions came with four options: none, mild, moderate, and severe.

Results of study about self-treating with psychedelics

All 17 measures on average showed positive change, across the board. The 17 items: ‘Changes in my understanding of why I feel the way I do,’ ‘Changes in mood or reduced depression,’ ‘Changes in my understanding of my condition or how I relate to it,’ ‘Change in overall symptoms of your psychiatric condition,’ ‘Changes in productivity, motivation or confidence,’ ‘Changes in my tolerance towards others,’ ‘Changes in empathy, sociability and communication skills,’ ‘Changes in ability to control negative thoughts/persistent worryings,’ ‘Changes in self-identity,’ ‘Changes in life priorities,’ ‘Changes in feelings of frustration/anger,’ ‘Changes in energy, alertness and/or focus,’ ‘Changes in anxiety, including social anxiety,’ ‘Changes in my use of alcohol/other drugs,’ ‘Changes in sight, smell or hearing,’ ‘Changes in concentration/memory,’ ‘Changes in sleep.’

Of the respondents, 22.5% did experience a negative outcome. Whether the connection actually exists or not, investigators found links between “High intensity of psychedelic experience, seeking advice before treatment, treating with psilocybin mushrooms and treating post-traumatic stress disorder” as being associated with higher scores and better outcomes. On the other hand, younger participants with high intensity of experience, and self-treatment with LSD, were associated with a greater number of negative outcomes.

Though each individual had their own responses for each of the 17 categories, 94.6% scored a +2 or +3 on at least one item. These respondents also answered questions about duration of effects and onset times. The majority (64.3%) noticed the positive result within 24 hours, about 9.9% took about a week to see the result. 52.7% had positive results that lasted at least four weeks. 17.6% said their positive effects lasted more than six months.

Study investigators were interested in psilocybin mushroom and LSD experiences
Study investigators were interested in psilocybin mushroom and LSD experiences

In terms of negative effects, respondents only had to have one to answer the negative effects questionnaire. The majority who did, reported ‘Mental confusion, memory problems, or racing thoughts’ or ‘Feeling disconnected from the world around you.’ Lesser experienced issues were persistent worrying; unpredictable outcomes or bad interactions with other substances; bad mood or emotional regulation issues; worries about the come down, building tolerance, dependence, or creating addiction; more irrational fears; ongoing issues with perception; negative hallucinations; and bad health results.

The majority reported that the negative outcome happened within 24 hours, while 1/5 claimed it happened as much as a week or more later. The majority of these negative outcomes were gone within seven days. 27%, however, said they lasted for more than a month. 4.2% of respondents who had a negative response, sought emergency care; however, no deaths or long-term issues are associated with the study.

Conclusion

I am always a bit wary of studies like this that don’t seek to create their own test populations. And there are definitely some things to consider; like if the anxious responses were a part of someone’s existing anxiety, or actually related to the drug. Even so, this study does indicate that self-treating with psychedelics has a generally positive outcome for most who do it; and is a plausible answer for some. It does not in any way assume that psychedelic-assisted therapy won’t provide better results, or that psychedelics will help everyone.

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Muscimol Isolate: A Potent Extract from Amanita Muscaria – Properties, Effects, and Usage

Muscimol Isolate is a highly concentrated form of Muscimol, one of the two active compounds found in Amanita Muscaria mushrooms, alongside Ibotenic acid. These mushrooms, recognizable by their red caps dotted with white speckles, have long fascinated various cultures due to their unique psychoactive properties, which are often associated with spiritual and shamanic experiences.

Since Ibotenic acid can have harsh side effects, but it converts into Muscimol when dried or heated, people who want to experience the benefits of Amanita mushrooms often look for products made from pure Muscimol, rather than Amanita powder (which includes a small amount of Ibotenic Acid, as not all of it has been converted into Muscimol when dried), such as Muscimol gummies, Muscimol tinctures, Muscimol isolates, and so on.

That said, most people who use Amanita products still prefer the more natural forms of this product, which contain both Muscimol and Ibotenic acid (even though some of the acid has converted to Muscimol in the drying process), such as Amanita gummies, Amanita mushroom caps, Amanita tinctures, Amanita powder, Amanita chocolate and so on.

Amanita Tincture: A Potent Elixir for a Mind-Bending Experience

While both options are valid, each person reacts differently to Muscimol and Ibotenic acid. If you choose a blended product, you should always start low and grow slow until you find your sweet spot. This rule applies to all psychoactive compounds, so take it easy and avoid forcing yourself into the ‘rabbit hole.’ There is plenty of room there for everyone, but you should only go there when you are ready.

One last thing before we move on: Unless you are an experienced user and Amanita Tea is what you start your day with, you should avoid using raw mushrooms as they need to be carefully dried or heated to avoid sickness. Again, take it easy, start low, and grow slow. There is a world of wonders waiting for you, if only you approach it with caution.

Muscimol isolate: The main active compound in Amanita Muscaria

Muscimol is the primary psychoactive component in Amanita Muscaria mushrooms, and most people who use these fungi do so to experience this compound. It arises from the decarboxylation of ibotenic acid, another active compound present in these mushrooms. When consumed, muscimol binds to GABA receptors in the brain, leading to a range of effects that may include sedative, hypnotic, depressant, and hallucinogenic states.

Muscimol Isolate
Muscimol Isolate (Image credit: Amanita Mushrooms)

However, it is important to note that the hallucinogenic properties of muscimol differ significantly from those typically associated with psilocybin mushrooms, also known as magic mushrooms.

People often mistakenly confuse the effects of Amanita mushrooms with psilocybin mushrooms and expect them to produce visual hallucinations, which they won’t. Amanita Muscaria mushrooms should not be reffered to as psychedelic mushrtooms (even they might be, when high doses are involved), but more as spiritual mushrooms, as the effects are very different from the ones you expect to feel when taking psilocybin.

However, it is important to note that the hallucinogenic properties of muscimol differ significantly from those typically associated with psilocybin mushrooms, also known as magic mushrooms. People often mistakenly confuse the effects of Amanita mushrooms with psilocybin mushrooms and expect them to produce visual hallucinations, which they won’t. While Amanita Muscaria mushrooms can have somewhat of psychedelic effects at high doses, they are more accurately referred to as spiritual mushrooms due to their dream-like experience and different effects compared to psilocybin. To be more specific, the experiences with Amanita Muscaria mushrooms are not characterized by the same visual hallucinations commonly associated with psilocybin mushrooms, but on other sensations, provoked from the inside.

Try working with the raw material itself: Amanita and Pantherina mushrooms

Muscimol vs. Psilocybin: Key Differences

Muscimol and psilocybin are both psychoactive compounds found in different species of mushrooms. As a result, they act on the brain in distinct ways and produce different effects.

Psilocybin is a compound found in certain types of mushrooms, commonly referred to as “magic mushrooms”. Upon ingestion, psilocybin is converted in the body to psilocin, which acts primarily on the serotonin receptors in the brain. The effects of psilocybin are typically characterized by profound changes in consciousness, perception, and mood, often including visual and auditory hallucinations or distortions.

Muscimol, on the other hand, is the active compound in Amanita mushrooms. It acts on the GABA receptors in the brain, a different class of neurotransmitter receptors than those targeted by psilocybin. This results in a distinct set of effects, which can include sedative, hypnotic, and hallucinogenic states. However, the hallucinogenic effects of muscimol are different from those induced by psilocybin. While psilocybin often produces vivid visual hallucinations and profound shifts in perception, the effects of muscimol are more likely to be described as dream-like or surreal, and do not typically involve the intense visual effects associated with psilocybin​.

In case Magic Mushrooms is what you are looking for…

In terms of safety, both substances carry risks and should only be used under appropriate guidance and in a safe, controlled context. It’s also worth noting that while both compounds are found in mushrooms, the species of mushrooms in which they are found are different, and many species of mushrooms are toxic. Therefore, it is critical to accurately identify any mushroom before it is consumed. When it comes to Amanita mushrooms, proper preparation is important, as we want most if not all of the ibonetic acid to be converted into Muscimol, so they need to be carefully dried and heated (170f / 80c for at least 30 minutes).

Understanding Muscimol Isolate: A Potent Extract

Muscimol Isolate, the highly purified extract of Amanita Muscaria, can be utilized in various product forms, including capsules, gummies, chocolates, powders, tinctures, and more. It is also available in its pure form. Typically, this isolated compound tests at a potency of 65%, meaning it contains 650 mg of muscimol per gram. The significant potency of this extract allow companies to create potent products using the isolate and provides users with enhanced control over dosing.

Dosing and Microdosing with Muscimol

Microdosing typically involves taking the smallest dose necessary to achieve subtle psychoactive effects while still maintaining functional capabilities. In contemporary culture, microdosing often refers to consuming a dose low enough to “feel something” without inducing full psychoactive or psychedelic effects.

Great for microdosing: the new Muscimol gummies

Determining the appropriate muscimol dosage for microdosing is highly individualized and depends on factors such as body composition, metabolism, and tolerance levels. Therefore, it is challenging to provide specific dosage numbers. However, many sources suggest aiming for 0.1-0.2 grams of dry powder for microdosing, while high-potency products may start at 0.5 grams and above. That’s why most products today use the dosage of 350mg/gummy (0.35 gram).

It’s important to note that some sources may suggest higher doses to feel the desired effects, while other advise caution and smaller dosages.

Since the potency of mushrooms can vary, and different batches may contain varying amounts of muscimol, it is advisable to avoid strict reliance on specific dosage ranges. It is recommended to find your own personal dosage levels. Starting with low doses and gradually increasing them is a safer and more mindful approach. This method is also gentler on your mental and physical well-being, especially when experimenting with compounds that are new to you.

Another common way for microdosing is by using capsules

Experienced users often recommend drying several Amanita Muscaria mushrooms and blending the powdered forms together to create an average dosage from the entire batch. If you choose to do this, ensure that you store the mushrooms in a dry environment, preferably in a sealed jar, as they are organic matter.

How Muscimol Isolate is Obtained

To extract and isolate muscimol from Amanita mushrooms, the process could be generally summarized into these steps:

  1. Harvesting: Gather mature Amanita mushrooms.
  2. Drying: Dry the mushrooms to remove water content.
  3. Extraction: Extract muscimol and other compounds from the dry powder.
  4. Filtration: Filter the solution to get rid of the mushroom solids.
  5. Evaporation: Remove unwanted materials, used for the extraction, leaving behind the extracted compounds.
  6. Purification: Purify the extract to isolate muscimol from the other compounds.

This is a simplified explanation and the actual process can be complex.

Muscimol Isolate (Image credit: Amanita Mushrooms)

Conclusion

Muscimol isolate offers a unique opportunity to explore the effects of a potent, naturally occurring psychoactive and somewhat psychedelic substance. As the popularity of Amanita mushrooms and muscimol products continues to grow, the demand for muscimol isolate is expected to skyrocket. Consequently, following the success of muscimol gummies and similar products made from isolate, we can anticipate a surge in such products on the market as early as this summer.

Remember, the safety, legality, and efficacy implications of using and producing these products should always be considered. This industry is only beginning, and on our quest to produce the best products, we should always keep the well-being of our clients at the center of our attention.

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Lucy Drops Amanita Mushroom-Based Microdose Line

The ancient use of mushrooms to improve physical and mental well-being is coming back full-swing. On Monday, Lucy Scientific Discovery Inc. unveiled Mindful, a functional Amanita mushroom-based product line that is now available at multiple retailers. 

British Columbia, Canada-based Lucy Scientific Discovery is a psychedelics manufacturing company focused primarily on emerging psychotropics-based medicines, the latest being its new microdose product line. 

Mindful by Lucy is designed to enhance well-being and promote a mindful approach through the power of microdoses. Each capsule is carefully crafted, incorporating quality natural ingredients. Mindful by Lucy comes in jars of 60 capsules containing a microdose of Amanita muscaria-based compounds.

“We are thrilled that Mindful will be available to consumers, and are excited about the revenue potential,” said Chris McElvany, CEO of Lucy Scientific Discovery Inc. “Our goal is to offer Mindful to consumers directly through our platform and a variety of 3rd party platforms and traditional retail channels. Mindful by Lucy is a testament to our dedication to providing exceptional quality and a mindful approach to wellness.”

A recent renewed interest in the potential improvements in cognitive function and memory with the help of mushrooms is sweeping the industry, using them as adaptogens. Dividing up doses into capsules makes it easier to titrate. Mindful by Lucy contains ingredients, some mushroom-based, including the following:

  • Lion’s Mane Mushroom: Ignite cognitive function, memory, and nerve growth factor production.
  • Reishi Mushroom: Adapt to stress and bolster well-being with adaptogenic properties.
  • Cordyceps: Elevate energy levels and amplify physical performance.
  • Bacopa Monnieri: Boost memory and learning with traditional Ayurvedic wisdom.
  • Rhodiola Rosea: Combat stress, fatigue, and sharpen mental performance.
  • Ginkgo Biloba: Enhance memory and focus through optimal brain circulation.

Mindful by Lucy can be purchased on the company’s online store and through Hightimes.com. High Times has an ownership stake in Lucy Scientific Discovery.

Lucy Scientific Discovery and Psychotropic Products

Lucy Scientific Discovery has explored a number of psychotropic substances including controlled substances. How is this possible? The company holds a Controlled Drugs and Substances Dealer’s License granted by Health Canada’s Office of Controlled Substances. Lucy Scientific Discovery and its subsidiary, LSDI Manufacturing Inc., operate under Part J of the Food and Drug Regulations promulgated under the Food and Drugs Act in Canada. This specialized license enables the company to develop, sell, deliver, and manufacture pharmaceutical-grade active pharmaceutical ingredients (APIs) used in controlled substances as well as their raw material precursors. 

The Amanita muscaria mushroom has been used medicinally for hundreds of years, and it is not a controlled substance in the U.S. Proponents of Amanita microdosing believe that it can improve creativity, focus, productivity, anxiety and overall well-being. 

The company is exploring other types of fungi as well, including mind-altering varieties that are commonly known. Work at Lucy is underway to develop psilocybin mushroom-based products which are believed to be invaluable in psychotherapy. Lucy Scientific Discovery announced a partnership with TheraPsil to advance medical psilocybin access and research.

Opportunities to discover these new products are approaching. Lucy Scientific Discovery also announced that it will be a sponsor at the Multidisciplinary Association for Psychedelic Studies (MAPS) Psychedelic Science Conference taking place June 19-25 in Denver, Colorado. 

The conference is expected to attract 10,000 attendees, and will feature five days of panels, workshops, and lectures from leaders in psychedelic research, education, policy, business, culture, and communities. It will also feature athletes such as Aaron Rodgers as well as musicians including Melissa Etheridge.

Lucy is a Nasdaq-listed (LSDI) licensed producer of compounds for medicinal products. Check out Lucy Scientific Discovery’s website to learn more about the company and its products.

The post Lucy Drops Amanita Mushroom-Based Microdose Line appeared first on High Times.

Oregon 1st Magic Mushroom Center Released Expensive Pricing

We’ve been talking about it for a while, and speculating on what to expect. Even as the cannabis industry takes a nose dive due to high regulatory and tax costs, it seems no lesson was learned for the legal psychedelics industry. Something made clear when an Oregon company released information for the first magic mushroom center; which is incredibly expensive.

The first Oregon psilocybin treatment center is expensive

There was a lot of speculation in the last year, and particularly in the last several months; as Oregon slowly unraveled its regulatory plans for its voted-in psychedelics industry. And the reality is now here, that this new magic mushroom industry will be quite expensive for users. Recently, information came out for Eugene Psychedelic Integration Center (EPIC Healing Eugene), the first facility to receive a license to provide services.

And, as stated, it’s not exactly cheap. One session will run a person $2,800 for 2 ½ grams, and for a four-gram sessions? That’ll cost about $3,500. The difference here is 1 ½ grams of mushrooms, which equals an increase of $700. No matter how you look at it, these are not prices everyone can drop for a treatment.

What’s more? Not only is this cost already high, but medical insurance won’t cover it, not at EPIC, and not with most insurers until more inroads are made federally. Which means those who want services must pay this amount without any reimbursement. Overall prices do vary based on the amount of mushrooms used, and the amount of people (group or individual), but regardless, the new magic mushroom industry in Oregon, is expensive.

The expensive cost of mushroom therapy in Oregon

Why is the magic mushroom industry in Oregon so expensive?

These costs, are at least in part because of expensive regulatory measures put on the magic mushroom industry by Oregon regulators. EPIC’s founder Cathy Rosewell Jonas told Williamette Week that she was required to pay $12,000 just to get certified, as well as a $10,000 annual fee, and a $60,000 insurance fee. That means, just to get going, Jonas has to pay out a whopping $82,000 on top of regular costs.

Beyond what she’s paying out to have the business, she also can’t make deductions for income tax for standard things like rent, which other business-owners can. This is because psilocybin is still Schedule I in terms of the federal government, and therefore illegal. In fact, Jonas falls into the same problem area as cannabis companies which operate similarly, with the same federal tax issue. She cannot make standard deductions, which means overpaying in taxes to the federal government. For those paying attention, it means the federal government most certainly collects tax money, while considering the industry illegal.

It does so by way of Section 280E in the country’s tax code. This law is applied to traffickers of Schedule I and II substances, and is meant to ensure such traffickers can’t make standard deductions. Just like with cannabis markets, this is not real trafficking though. The industries are 100% legal within their states, which means this is just another form of bullying by the US government. This, in turn, forces Jonas to set prices at 30% higher to make up for these expenses. In fact, for about every $3,000 charged, about $1,000 must be reserved for the federal government…which is quite a bit considering the entity is not ‘officially’ taxing the market.

Then added on to everything else, is the price of the therapists. A prospective client must first undergo both a screening, and three prep sessions, before the actual treatment. And then that’s followed by integration sessions after. The therapists for these sessions generally charge approximately $150 to $200 an hour, as per Therapsil, which must be factored into the overall cost.

Is this worth it?

We can see from the costs that EPIC must pay, that there are some steep regulatory and tax amounts tied to running a magic mushroom service center, and the result is that this first center in Oregon, is rather expensive for consumers. Should we expect people to pay this bill? And is it even worth it?

The Psychedelics Spotlight article that relayed the information, makes the point that regular treatment for depression can also be expensive. It speaks of medication costs, for both brand name and generic as costing approximately $62.50 (generic) up to $700 (brand name) monthly. But realistically, these are generally covered by insurance, so the patient will likely only pay a copay, or have the option of a less expensive medication.

Why is magic mushroom treatment so expensive in Oregon?
Why is magic mushroom treatment so expensive in Oregon?

In terms of the cost of actual therapy sessions, its true that this isn’t cheap either when adding up for a year, but this is also often covered. All these costs against one session, (or a few sessions), of mushroom treatment, are still likely way less. And payed in small increments around the year, not all at once. However, having said that, the problem with these other therapeutic avenues, is that if they had actually worked, the person in question probably wouldn’t be seeking out mushroom therapy.

A person paying standard therapy costs (or who has them covered), and who then resorts to mushroom therapy, is essentially saying that all those costs added up to nothing. In this way, mushrooms therapy is the more cost-effective option for actual results – assuming it works.

But there’s something to remember here. It’s not like a person needs to go to an office-like place to get high on something they can get high on at home, and for way less money. No matter how you excuse the costs, or try to compare them, the same thing is coming up here, which comes up in both the weed and ketamine industries; that high prices are driving the industry down. One session at EPIC is between $2,800 and $3,500 for 2.5-4 grams.

But an eighth on the street (3.5 grams) averages at about $30-40. Which would you rather pay? Which would most people rather pay? What can most people pay? Regardless of trying to compare a mushroom treatment to yearly costs of antidepressants and therapy, the reality is that the same thing that would cost thousands in a strange setting, can be under $100 in a comfortable one, of a person’s choosing.

This is seen with weed and ketamine too

The weirdest thing about this happening, is that it shows an almost brazen inability to learn from experience from a government perspective, even as a comparable situation of pricing plays out in front of us all. Sure, it looked for a moment like the weed industry was going to take off to unimaginable levels, but the unimaginable levels, in the end, turned out to be unimaginably low.

There was a good trajectory early on, but then things like overproduction happened, and the black market caught on to all the cool new things like vapes and gummies; offering more extensive and powerful products than what legal operators can. And the extreme taxes and regulatory costs sunk tons of businesses, with more on the way. All this led to the real reality now, that people aren’t going to pay inflated costs, for something they can get cheaper…or even grow on their own.

Overpriced cannabis market having major issues
Overpriced cannabis market having major issues

California made a big deal of finally changing its tax structure, when the market started really tanking out last year. So what did the state do? It did nix a cultivation tax, but did nothing to get rid of the 15% excise tax. That means, on top of any other taxes, like sales tax, cannabis is automatically going to be about 15% higher when coming from a legal location. The changes have done almost nothing to help the state’s industry, which posted losses for the first time in 2022. The state’s next move now? To root out corruption, rather than simply stop unnecessary taxes (much relating to sin taxes).

The ketamine market is experiencing a similar issue. Let’s remember, ketamine gets about the same result as magic mushrooms; it’s a comparable treatment. Unlike magic mushrooms, the industry operates in a gray market. The drug can be prescribed and used legally for pain and emotional issues throughout the US, as off-label uses; but the industry doesn’t get the heavy excise taxes of ‘legal’ industries like weed and mushrooms. As a Schedule III substance, its also not beholden to Section 280E restrictions on deductions.

Even so, the idea of greed is heavy, and what could have been a cheaply-priced industry, instead charges several hundred for a single treatment, and often groups them together in packages that cost thousands. This is still (sometimes) less than mushroom therapy, but its high enough that this industry is having grave issues with sustainability, due to the high costs. And in this case, without the same overhead factors (though it does have to bow to other medical regulation). This should have been a lesson for the magic mushroom industry.

The ketamine reality is that according to the site drugs.com, you can get 200ml for $167.80, and this is 10mg per ml. Most people require about .1-.5mg/kg for a treatment, so if a person weighs 160 lbs, that converts to about 72.5kg. If the person requires on the higher end, it would mean something like 36.25mg, roughly 3.5 ml. Which means that 200ml is good for many, many treatments (like more than 50). And that means the costs in a clinic, are laughable at best.

Conclusion

What should we realistically expect from magic mushroom industries like the new expensive one starting up in Oregon? If it’s anything like its predecessors cannabis and ketamine, probably not what industry officials are hoping for. In fact, it’ll probably just empower the black market. And whereas with weed, maybe some excuses could be made; this time around, the lack of ability for this to work, is squarely on regulators for not learning from the past.

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Cordyceps Gummies: Your Daily Dose of Vitality

Cordyceps gummies are a vibrant and palatable way to harness the remarkable vitality of Cordyceps mushrooms. Hailing from the world of functional mushrooms, these edibles present an array of potential health advantages, such as boosted energy, enhanced athletic performance, adaptability to stress, and improved metabolic function. Let’s plunge into the exciting realm of Cordyceps mushrooms and discover how incorporating them into your everyday regimen can boost your overall vitality.

Currently, as part of our Deal Of The Day, we offer a 20% discount on premium Cordyceps mushroom edibles when using the Cannadelics coupon code. Don’t miss this chance to fill your pantry with the 500mg water-soluble MUSC Cordyceps gummies.

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Cordyceps Gummies: Unleashing the Power of Functional Mushrooms

Unveiling the Benefits

Cordyceps mushrooms have been hailed in traditional Tibetan and Chinese medicine for their remarkable health benefits. By integrating Cordyceps into your wellness regimen with these edibles, you can tap into these potential advantages:

  1. Energy and Stamina: Cordyceps are believed to have adaptogenic properties that may help bolster energy levels and endurance. Regular consumption may offer a sustained energy boost throughout the day, without the unwanted crash of caffeine.
  2. Adaptability to Occasional Stress: The adaptogenic properties of Cordyceps might help the body cope with stress more effectively. This can promote a greater sense of calm and well-being.
  3. Athletic Performance: Many athletes turn to Cordyceps for their reported ability to enhance physical performance and recovery. They may help increase oxygen utilization and aerobic capacity, which can support athletic performance.
  4. Metabolic Function: Cordyceps may support a healthy metabolism, potentially aiding in energy production and overall health.

Cordyceps Gummies – Dosage and Timing

To experience the maximum benefits of Cordyceps, it is recommended to take one gummy daily. As with the Reishi gummies, it is best to consume them on an empty stomach to optimize absorption. This could mean taking them an hour before eating, or two hours after. Consistency is key, so incorporating them into your routine could help you reap the long-term benefits of these yellow mushrooms.

Buy 500mg water-soluble MUSC™ Cordyceps gummies
Cordyceps Mushroom Gummies

Choosing the Best Cordyceps Gummies

When selecting Cordyceps edibles, consider the following factors to ensure you’re getting a high-quality product:

  1. Quality Ingredients: Look for edibles made from pure and potent Cordyceps mushroom extract, free from artificial additives and fillers.
  2. Transparency and Third-Party Testing: Choose brands that prioritize transparency and conduct third-party testing to validate the purity, potency, and safety of their products.
  3. Dosage and Concentration: Opt for edibles with appropriate dosage levels that align with your health goals. Consider the concentration of Cordyceps extract per gummy to ensure optimal effectiveness.
Have you tried the new Muscimol Gummies?

Potential Synergistic Effects

Cordyceps gummies can also be combined with other supplements or wellness practices to enhance their effects. For example, pairing Cordyceps with practices like meditation, regular exercise, or a balanced diet can create a synergistic effect, amplifying the overall health benefits and promoting holistic well-being.

Cordyceps Gummies – Flavors and Varieties

Cordyceps gummies are often available in a variety of flavors, allowing you to choose the one that suits your taste preferences. Whether you prefer fruity flavors or enjoy the earthy taste of the mushroom itself, there is a flavor option that will make your wellness journey a delight.

Cordyceps Mushrooms
“Pairing Cordyceps with practices like meditation, regular exercise, or a balanced diet can create a synergistic effect, amplifying the overall health benefits and promoting holistic well-being”

Quality Assurance and Safety

When it comes to choosing Cordyceps edibles, quality assurance is paramount. Look for brands that prioritize transparency, source their ingredients responsibly, and adhere to strict manufacturing standards. Third-party testing for purity, potency, and safety adds an extra layer of assurance, ensuring that you are getting a high-quality product that aligns with your health goals.

Synergistic Effects with Other Functional Mushrooms

While Cordyceps mushrooms offer an array of health benefits on their own, they can also be combined with other functional mushrooms to create a synergistic effect. Combining Cordyceps with other mushrooms like Lion’s Mane or Reishi can provide a broader spectrum of health benefits, as each mushroom offers its unique set of properties. This combination can amplify the overall wellness support and contribute to a more holistic approach to health.

Try Reishi Gummies for a day of relaxation and a night of peaceful rest

Product Review: Trusted Mushrooms Cordyceps Mushroom Gummies:

Product: Cordyceps Mushroom Gummies (10 Gummies/5000mg)

Brand: Trusted Mushrooms

Price: $39.99

Price with 20% discount (using the Cannadelics coupon code): $31.99

Overview: Trusted Mushrooms Cordyceps Mushroom Gummies are carefully crafted to deliver the potent benefits of these mushrooms in a convenient and delicious form. Each bottle contains 10 gummies, providing a total of 5000mg of Cordyceps mushroom extract. Each gummy contains 500mg of Cordyceps mushroom water-soluble MUSC extract, making it easy to incorporate the recommended dosage into your daily routine.

Additional Ingredients: 25mg GINKO BILOBA, 25mg GINSENG, and 10mg L-ARGININE. Ginko Biloba and Ginseng are known for their energizing properties, while L-Arginine is a beneficial amino acid that contributes to muscle synthesis and overall vitality.

Deal of the Day and Coupon

Don’t miss out on the Deal of the Day, featuring exclusive discounts on premium legal cannabis, psychedelics, and mushrooms. Take advantage of this opportunity to stock up on your favorite products and enjoy additional savings. To sweeten the deal, use the coupon code “Cannadelics” at checkout to unlock a special 20% discount on your purchase. Enhance your well-being with high-quality Cordyceps gummies while saving money.

Buy 500mg water-soluble MUSC™ Cordyceps gummies
Cordyceps Mushroom Gummies

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Cordyceps Gummies – Conclusion

With more than 1,500 years of use in Chinese medicine, these edibles offer a delicious and convenient way to experience the numerous health benefits of Cordyceps mushrooms. Their potential to boost energy, increase stamina, enhance athletic performance, and support metabolic function make them a valuable addition to your wellness routine. Take advantage of the Deal of the Day with the coupon code “Cannadelics” for an exclusive 20% discount.

Cordyceps Gummies – Takeaway Points

  • These edibles offer a convenient and enjoyable way to experience the multitude of health benefits associated with Cordyceps mushrooms.
  • Dosage recommendations suggest taking one gummy daily on an empty stomach for optimal absorption.
  • Consider factors such as quality ingredients, transparency, third-party testing, and dosage concentration when choosing Cordyceps edibles.
  • Cordyceps can be combined with other wellness practices or supplements for potential synergistic effects.
  • Cordyceps mushrooms could possibly add to our general wellness with potential immune-modulating, antioxidant, and anti-inflammatory suggested properties.
Growing Cordy ceps Mushrooms
“These mushrooms present an array of potential health advantages, such as boosted energy, enhanced athletic performance, adaptability to stress, and improved metabolic function.”

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The post Cordyceps Gummies: Your Daily Dose of Vitality appeared first on Cannadelics.

Reishi Gummies: Unlocking the Power of Functional Mushrooms

Reishi gummies are a delicious and convenient way to unlock the transformative power of Reishi mushrooms. Derived from the renowned Reishi mushroom, these edibles offer a range of Potential health benefits, including improved sleep, reduced stress, enhanced immunity, and increased cognitive function. Let’s delve into the remarkable benefits of Reishi mushrooms and explore how incorporating them into your daily routine can elevate your overall well-being.

Currently, as part of our Deal Of The Day, we offer a 20% discount on premium Reishi mushroom edibles when using the Cannadelics coupon code. Take advantage of this offer and stock up on the 500mg water-soluble MUSC Reishi gummies.

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Reishi Mushroom Gummies

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The Power of Reishi Gummies

Unveiling the Benefits

Reishi mushrooms (Lingzhi mushrooms), also known as the “Mushroom of Immortality,” have been cherished for centuries in traditional Chinese medicine for their suggested health benefits. By incorporating Reishi into your wellness regimen, you can tap into these potential advantages:

  1. Improved Sleep: Reishi mushrooms are generally believed to have calming effects, promoting deep and restful sleep. By incorporating them into your nightly routine, you might enjoy improved sleep quality and wake up feeling refreshed and rejuvenated.
  2. Reduced Stress: The suggested adaptogenic properties of Reishi mushrooms might help the body cope with stress more effectively. Regular consumption of Reishi may assist in managing stress levels, promoting a greater sense of calm and well-being.
  3. Enhanced Immunity: Reishi mushrooms are sometimes accepted to have immune-boosting capabilities. The bioactive compounds found in Reishi might sometimes support and strengthen your immune system, helping to ward off illnesses and infections.
  4. Increased Energy: Reishi may possess adaptogenic properties that might help improve energy levels and combat fatigue. By using Reishi, you may experience sustained energy throughout the day.
  5. Cognitive Enhancement: Reishi mushrooms are sometimes believed to have neuroprotective effects that support cognitive function. Regular consumption of Reishi may enhance memory, focus, and overall cognitive performance.

Dosage and Timing

To experience the maximum benefits of Reishi, it is recommended to take one gummy daily. It is best to consume them on an empty stomach to optimize absorption, so do it an hour before eating, or two hours after. Consistency is key, so incorporate them into your routine to reap the long-term benefits of Reishi mushrooms.

Reishi Mushroom Gummies

Choosing the Best Reishi Gummies

When selecting Reishi gummies, consider the following factors to ensure you’re getting a high-quality product:

  1. Quality Ingredients: Look for gummies made from pure and potent Reishi mushroom extract, free from artificial additives and fillers.
  2. Transparency and Third-Party Testing: Choose brands that prioritize transparency and conduct third-party testing to validate the purity, potency, and safety of their products.
  3. Dosage and Concentration: Opt for Reishi gummies with appropriate dosage levels that align with your health goals. Consider the concentration of Reishi extract per gummy to ensure optimal effectiveness.
Have you tried the new Muscimol Gummies?

Potential Synergistic Effects

Reishi gummies can also be combined with other supplements or wellness practices to enhance their effects. For example, pairing Reishi gummies with practices like meditation, yoga, or a balanced diet can create a synergistic effect, amplifying the overall health benefits and promoting holistic well-being.

Flavors and Varieties

Reishi gummies are available in a variety of flavors, allowing you to choose the one that suits your taste preferences. Whether you prefer fruity flavors like strawberry, raspberry, or blueberry, or enjoy the earthy taste of the mushroom itself, there is a flavor option that will make your wellness journey a delight.

Reishi Mushrooms
“Reishi mushrooms possess immune-modulating, antioxidant, and anti-inflammatory effects”

Synergistic Effects with Other Functional Mushrooms

While Reishi mushrooms offer an array of health benefits on their own, they can also be combined with other functional mushrooms to create a synergistic effect. Combining Reishi gummies with other mushrooms like Lion’s Mane or Cordyceps can provide a broader spectrum of health benefits, as each mushroom offers its unique set of properties. This combination can amplify the overall wellness support and contribute to a more holistic approach to health.

Quality Assurance and Safety

When it comes to choosing Reishi edibles, quality assurance is paramount. Look for brands that prioritize transparency, source their ingredients responsibly, and adhere to strict manufacturing standards. Third-party testing for purity, potency, and safety adds an extra layer of assurance, ensuring that you are getting a high-quality product that aligns with your health goals.

“enhance your cognitive abilities, boost your energy levels, and improve your overall well-being”

Product Review: Trusted Mushrooms Reishi Mushroom Gummies:

Product: Reishi Mushroom Gummies (10 Gummies/5000mg)

Brand: Trusted Mushrooms

Price: $39.99

Price with 20% discount (using the Cannadelics coupon code): $31.9

Overview: Trusted Mushrooms Reishi Mushroom Gummies are carefully crafted to deliver the potent benefits of these mushrooms in a convenient and delicious form. Each bottle contains 10 gummies, providing a total of 5000mg of Reishi mushroom extract. Each gummy contains 500mg of Reishi mushroom water-soluble MUSC extract, making it easy to incorporate the recommended dosage into your daily routine.

Additional Ingredients: 25mg Kava and 10mg 5-HTP. Kava is known for its calming properties, promoting relaxation and stress relief. 5-HTP is a precursor to serotonin, supporting a positive mood and overall well-being.

Deal of the Day and Coupon

Don’t miss out on the Deal of the Day, featuring exclusive discounts on premium legal cannabis, psychedelics and mushrooms.. Take advantage of this opportunity to stock up on your favorite products and enjoy additional savings. To sweeten the deal, use the coupon code “Cannadelics” at checkout to unlock a special 20% discount on your purchase. Enhance your well-being with high-quality Reishi gummies while saving money.

Buy 500mg water-soluble MUSC™ Reishi gummies
Reishi Mushroom Gummies

Buy 500mg water-soluble MUSC Reishi gummies

(With Cannadelics coupon code)


Reishi Gummies – Conclusion

Reishi gummies offer a delicious and convenient way to experience the numerous health benefits of Reishi mushrooms. Their potential to improve sleep, reduce stress, boost immunity, and support cognitive function makes them a valuable addition to your wellness routine. Take advantage of the Deal of the Day with the coupon code “Cannadelics” for an exclusive 20% discount.

Reishi Gummies – Takeaway Points

  • These edibles offer a convenient and enjoyable way to experience the multitude of health benefits associated with Reishi mushrooms.
  • Dosage recommendations suggest taking one gummy daily on an empty stomach for optimal absorption.
  • Consider factors such as quality ingredients, transparency, third-party testing, and dosage concentration when choosing Reishi edibles.
  • Reishi can be combined with other wellness practices or supplements for potential synergistic effects.
  • Reishi mushrooms could possibly add to our general wellness with potential immune-modulating, antioxidant, and anti-inflammatory suggested properties.
Scientific research supports the immune-modulating, antioxidant, and anti-inflammatory properties of Reishi mushrooms

Buy 500mg water-soluble MUSC Reishi gummies

(With Cannadelics coupon code)


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The post Reishi Gummies: Unlocking the Power of Functional Mushrooms appeared first on Cannadelics.

Muscimol Gummies: A New Way to Microdose Amanita Muscaria

The world of psychedelic science is constantly evolving, offering new avenues to explore the potential of natural substances. Among the latest developments are the practices of microdosing Amanita mushrooms and the introduction of Muscimol gummies, which provide a convenient way to engage in microdosing. These innovative gummies have captured the interest of individuals seeking to experience the distinctive benefits of Amanita Muscaria mushrooms. If you’re interested to learn how to microdose Amanita Muscaria, or want to try the new Muscimol gummies, read on to satisfy your curiosity.

Microdosing, the practice of consuming small, sub-perceptual amounts of psychedelic substances, has surged in popularity over the past decade. It has proven to be rewarding for individuals in stressful jobs as well as those seeking spiritual growth and overall well-being. By offering benefits without disrupting the daily routine, microdosing has grown in popularity. The concept revolves around taking a minuscule dose, significantly smaller than a typical recreational dose, with the intention of enhancing cognition, creativity, and emotional well-being, all while avoiding the overwhelming effects associated with a full psychedelic trip.

While substances such as LSD and psilocybin (found in “magic mushrooms”) have traditionally been the primary focus of microdosing, there is a growing interest in Amanita muscaria mushrooms due to their spiritual and historical significance. Now, with the availability of Muscimol gummies, you have the opportunity to explore microdosing Amanita muscaria for yourself!

Take advantage of our exclusive ‘Deal of the Day‘ and get 10 gummies with 2.5 mg of Muscimol each, for only $8 using the cannadelics coupon code. Stock up on these comfortable and convenient products today!

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Microdose Amanita Mushrooms: The Game-changing Role of Muscimol Gummies

Muscimol, Ibotenic Acid and Amanita Mushroom

Amanita muscaria, commonly known as the fly agaric, is a mushroom native to many areas in the Northern Hemisphere. It is recognizable by its distinctive bright red cap with white spots. Unlike psilocybin mushrooms, which is a controlled substance, Amanita muscaria contains ibotenic acid and muscimol, which are legal psychoactive compounds.

Muscimol is the primary psychoactive compound found in Amanita muscaria mushrooms. It is responsible for the unique effects experienced when consuming these mushrooms. As a GABA receptor agonist, muscimol interacts with the brain’s neurotransmitters, leading to potential relaxation, calming effects, and altered states of consciousness. However, it’s important to note that the effects of psychoactive compounds can vary among individuals.

Muscimol, the primary psychoactive compound in Amanita Muscaria mushrooms. Used for the creation of Muscimol gummies.
Muscimol, the primary psychoactive compound in Amanita Muscaria mushrooms

Ibotenic acid is a powerful neurotoxin that can cause a range of effects, from mild agitation to seizures or even death in high doses. However, when dried or heated, ibotenic acid is converted into muscimol, and that’s why the process of preparing Amanita edibles usually involves drying, heating and only then consuming.

Microdose Amanita Muscaria

While the Amanita muscaria does not contain psilocybin, the compound typically associated with the benefits of microdosing, it contain muscimol which makes it very attractive. It’s important to note that there is far less research on microdosing Amanita muscaria when compared to psilocybin or LSD. However, as this product have been used for hundreds of years, and perhaps even more, it is safe to believe that microdose Amanita Muscaria will soon become a common practice, among the followers of the many ways for self-discovery and enlightment.

Potential Benefits & Risks

While research is only in its early stages, historical usages and anecdotal reports from individuals who have tried to microdose Amanita muscaria often mention improved mood, increased energy, and heightened creative thinking. Some users have reported a reduction in their symptoms of depression and anxiety, while others have noticed improved focus and cognitive function.

Amamita Muscaria and Amanita Pantherina mushrooms

Due to the sedative effects of muscimol, some users find Amanita muscaria helpful in managing insomnia or other sleep disorders. The muscimol may also interact with GABA receptors in the brain, which can lead to feelings of relaxation and calmness.

The consumption of Amanita muscaria is not without risks. The mushroom’s psychoactive compounds, particularly ibotenic acid, can cause adverse effects ranging from mild symptoms like nausea, dizziness, and incoordination, to more severe ones such as hallucinations, agitation, and seizures. However, it’s worth noting that when ibotenic acid is dried or heated, it converts into Muscimol, which is considered to have milder effects on the body.

Moreover, as with any product we use, whether it’s sugar, tobacco, coffee, smartphones, TV, or drugs, there is a potential risk of developing tolerance or dependency when its use is abused. It is important to approach the consumption of any substance with moderation and mindfulness.

Learn how easy it is to properly prepare Amanita Muscaria

Preparation and Consumption Methods

As we have discussed, proper preparation of Amanita muscaria is crucial due to the presence of ibotenic acid. The mushrooms should be dried, heated, or both to safely convert ibotenic acid into muscimol. Traditionally, the mushrooms are dried in the sun or over a fire, but nowadays, you can also use methods like drying in an oven at a minimal temperature with an open door or placing them near a heat source. However, it is important to avoid excessive heat, as even when making tea, the water should not exceed 170 degrees Fahrenheit (77 degrees Celsius). Once dried, the mushrooms can be consumed as they are, brewed into a tea, or used to prepare a tincture.

Microdosing typically entails ingesting a minute quantity of the mushroom, commonly in the form of a powdered substance enclosed in capsules. As is the case with any consumption, it is vital to commence with a low dose to gauge individual tolerance, gradually augmenting it if needed. Following the fundamental principle of ‘Start Low and Grow Slow‘ is advised for all substances, including when you microdose with Muscimol gummies.

Make your life easier with dry Amanita Muscaria powder

Exploring Amanita Products

As interest in Amanita muscaria grows, so too does the range of products available. Here’s a brief overview of some of the most common Amanita products:

  • Amanita Mushroom Caps: Dried mushroom caps are one of the most traditional forms of Amanita muscaria available. They can be consumed as is or used to make tea.
  • Amanita Powder: This product offers a finely ground version of the mushroom, which can be encapsulated for easy consumption or added to food and drink.
  • Amanita Tincture: A tincture is a liquid extract of the mushroom, often made with alcohol. Tinctures can be a convenient way to consume Amanita muscaria, as they can be easily measured and administered.
  • High-Potency Amanita Gummies: Usually with 500mg per gummy or more. Use it if yu are looking for a strong product and already have some experience with Muscimol.
  • Amanita Chocolate: An edible made from mixing Amanita extract with Chocolate, blending the flavors of cocoa with the potential benefits of Amanita muscaria.
  • Muscimol Isolate: This is a purified form of the muscimol. It provides a way to consume the active compound without the other components of the mushroom, or serve as the raw material for many products.

Each product provides a unique way to engage with Amanita muscaria, and the best choice depends on individual preferences and needs.

Have you tried the new legal psychedelic tinctures?

Deal of the Day: Muscimol Gummies

To those interested in exploring the potential benefits of muscimol in a very convenient format, we’re offering a special discount on the new Muscimol Gummies. Each gummy contains 2.5 mg of muscimol, carefully extracted from Amanita muscaria. Using our Deal of the Day, you can get a 20% discount and get a pack of 10 gummies for just $8 by using the Cannadelics coupon code. You can use this coupon as many times as needed and stock-up on this great edible.

This is a great opportunity for both newcomers and regular customers to save on this popular product.

TIP: Use the Cannadelics coupon code for an additional 20% discount.

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Keep Yourself Informed

Microdose Amanita muscaria is an emerging practice that has been adopted by some within the psychedelic community. With anecdotal reports suggesting a range of potential benefits, from improved mood and cognition to better sleep, the new Muscimol gummies makes microdosing easier than ever.

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Psilocybin Research Approved in Arizona Appropriations Act Budget

Arizona senators voted to approve a general appropriations act 2023-2024 on May 10. Within the appropriations bill is a multitude of funding proposals from the governor’s office, which includes everything from Alzheimer’s disease research ($4.1 million), a newborn screening program ($12 million), and the Arizona nurse education investment pilot program ($15 million), but it also includes $5 million earmarked for psilocybin research.

A health care bill, SB-1726/HB-2816, recently receive a hearing on May 10 as well, which shows what that $5 million in research would go toward “research grants for whole mushroom psilocybin phase one, phase two and 41 phase three clinical trials that are capable of being approved by the 42 United States food and drug administration…” The bill cites a number of medical conditions, including PTSD, symptoms of long COVID-19, depression, anxiety disorders, and nine more.

If passed it would instruct the Department of Health Services to open up applications for research, which would be awarded no later than February 1 of each year. The department would be limited to spending a maximum of 2% of the money for psilocybin grant research each fiscal year.

Research subjects would specifically include “veterans, first responders, frontline health care workers … and persons from underserved communities.”

Protections are also included for both the grant receiver as well as any employees working on a study, stating that they “may not be charged with or prosecuted for possession … of psilocybin when the person is working on the clinical trial.”

A psilocybin research advisory council would be tasked to manage the program to provide “recommendations to the governor, the speaker of the House of Representatives, the president of the Senate and the department on psychedelic-assisted therapy based on current federal and state research policy.” It would be made up of multiple key individuals, including a member who holds a federal license to study psychedelics and is a licensed physician, a military veteran, an Arizona law enforcement officer, and a professor or researcher who specializes in psychedelic studies.

On February 13, legislators unanimously passed a different psilocybin research bill in the House Military Affairs & Public Safety Committee, which would have given $30 million in grants to psilocybin researchers. “Today HB 2486 (clinical research; psilocybin; grants; appropriation) passed MAPS Committee by a unanimous vote of 15-0! Thank you to brave bipartisan lawmakers sponsoring this bill to study veterans & first responders! @KevinPayne4AZ @TJShopeforAZ @JenLongdon @TraversforAZ,” said Dr. Sue Sisley, who is well known for her research work on cannabis and psychedelics. HB-2486 has not received any further discussion as of this writing.

While cannabis studies continue to grow, the number of psilocybin research efforts have been growing. In February, city officials in Ferndale, Michigan voted to decriminalize mushrooms as well as other psychedelic substances such as DMT and ayahuasca, and Utah officials introduced a psilocybin bill. In March, Nevada lawmakers introduced a psilocybin and MDMA research bill, and the Missouri House of Representatives approved a psilocybin research bill.

On May 10, Washington State Gov. Jay Inslee signed a bill that creates a psilocybin therapy pilot program, although he did so with a partial veto for specific sections. On that same day, the Connecticut House of Representatives approved a psilocybin decriminalization bill. 

Oregon is farthest ahead in terms of progress. Earlier this month, Oregon awarded its first license for a psilocybin service center, following the finalization of rules back in January. “This is such a historic moment as psilocybin services will soon become available in Oregon, and we appreciate the strong commitment to client safety and access as service center doors prepare to open,” said Oregon Psilocybin Services Section Manager Angie Albee.

The post Psilocybin Research Approved in Arizona Appropriations Act Budget appeared first on High Times.

Ohio State University Gets DEA License To Grow Psilocybin

The U.S. Drug Enforcement Administration has issued a license to Ohio State University that allows researchers to cultivate psilocybin mushrooms for use in scientific studies. The license, which was awarded to Ohio State and partner Inner State Inc., a mental health and wellness research and development company, is the first license issued by the DEA for the cultivation of whole psilocybin mushrooms for research.

“This license is a major milestone not only for Inner State and Ohio State, but for the entire field of psychedelic research,” Inner State CEO Ashley Walsh said on Wednesday in a statement quoted by the Columbus Dispatch.

Multiple studies have shown that psilocybin, the primary psychoactive compound in magic mushrooms, may have extraordinary potential as a treatment for several serious mental health conditions. But studies of psilocybin normally use forms of the drug that have been synthesized in a laboratory. The new license issued by the DEA allows Ohio State and Inner State to grow whole psilocybin mushrooms to produce the compound naturally. Under the terms of the license, all cultivation of psilocybin mushrooms will take place in a federally registered facility in accordance with strict DEA regulations.

“By combining cutting-edge techniques in genomics and metabolomics, we have the opportunity to obtain a high-resolution picture of the chemical diversity of mushrooms that have remained difficult to study for several decades,” said Ohio State researchers Dr. Jason Slot and Dr. Kou-San Ju.

Researchers believe that using whole mushrooms in mental health studies could give participants the advantage of other compounds besides psilocybin, potentially offering additional therapeutic benefits. Walsh said that it is possible that psilocybin mushrooms “have multi-dimensional healing properties” that could more effectively improve the quality of life for people with severe mental illness.

Continuing research into psychedelics including psilocybin, MDMA and ketamine has shown that the drugs have potential therapeutic benefits, particularly for serious mental health conditions such as depression, addiction and anxiety. A study published in the peer-reviewed journal JAMA Psychiatry in 2020 found that psilocybin-assisted psychotherapy was an effective and quick-acting treatment for a group of 24 participants with major depressive disorder. Separate research published in 2016 determined that psilocybin treatment produced substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer.

In 2017, the U.S. Food and Drug Administration designated MDMA as a breakthrough therapy for PTSD, a move that streamlined clinical trials to test the effectiveness of the drug. The following year, the FDA granted the same status to psilocybin as a breakthrough therapy for treatment-resistant depression.

Alan Davis serves as the director of the Center for Psychedelic Drug Research and Education in the College of Social Work at Ohio State University, which he launched last year with the assistance of a private donation of $1.5 million. The center has developed a 25-hour continuing education program and an undergraduate minor in psychedelic studies. In January, the center launched its first clinical trial to explore the use of psilocybin as a treatment for military veterans diagnosed with PTSD.

“Currently, there have been clinical trials completed for people with addiction, depression, PTSD, obsessive-compulsive disorder, social anxiety [and] end-of-life distress in patients who are terminally ill,” Davis told Columbus Monthly earlier this year. “All of those studies so far have shown really promising effects.”

The ongoing research suggests that treatment with psychedelics such as psilocybin, when combined with psychotherapy, can “reduce and, for some, ameliorate, the mental health problems that they are dealing with,” Davis said. “With some studies, they’ve seen that those positive effects can last six to 12 months.”

Other universities are also studying the therapeutic value of psilocybin and other psychedelics, but Davis says Ohio State is the first to create such a center in a social work setting. He added that educating professionals with social work degrees is essential because they are the biggest part of the workforce dealing directly with patients in a clinical setting.

“Usually, the only message that’s been out there is, ‘drugs are bad, drugs are dangerous, don’t do drugs,’” Davis said. “This is meant to provide that foundational knowledge for people so that they can understand all the interdisciplinary work that’s been done about psychedelics.” 

Slot believes that we can learn a lot from mushrooms, noting that government prohibition has hindered study and set back researchers decades during an era of significant advancement in the biological sciences, especially genetics. He hopes that recent efforts to destigmatize psychedelics are successful so that the research can continue to advance.

“I don’t think psychedelics are going away. They get at the nature of consciousness, of the relationship between the mind and the body,” said Slot. “These are questions fundamental to our nature.”

The post Ohio State University Gets DEA License To Grow Psilocybin appeared first on High Times.

Riverside County Law Enforcement Seizes $1 Million in Illegal Cannabis, Mushroom Products

According to a press release from the Riverside County Sheriff’s Department, the raid occurred on May 4 around 5:30pm. The Jurupa Valley Sheriff’s Station Special Enforcement Team (SET) responded to a disturbance at the 1700 block of Production Circle, located within a business area that is home to other businesses off of Rubidoux Boulevard.

Multiple people attempted to flee the scene, but the sheriff’s department reports that many were detained. “Jurupa Valley SET deputies located evidence of an illegal/unlicensed marijuana dispensary and secured the location. Jurupa Valley SET deputies obtained a search warrant for the property and requested assistance from the Riverside Sheriff’s Marijuana Enforcement Team (MET),” the department stated.

On site, officers found a variety of illegal cannabis products. “During the service of the search warrant, deputies located approximately 115 pounds of processed marijuana, 10 pounds of psilocybin mushrooms, 100 pounds of marijuana concentrate, 2,400 marijuana vapes, and 1,200 edible marijuana items. The estimated value of the seized items was determined to be over $1,000,000,” the department reported.

As of May 9, the investigation is still ongoing and no further information has been shared at this time.

Last summer, the California Department of Cannabis Control (DCC) announced that between 2021-2022, law enforcement had seized more than $1 billion worth of illegal cannabis products. “This important milestone was reached through close collaboration with local, state, and federal partners and furthers California’s efforts to go after activities that harm communities and the environment, including water theft, threats of violence, elder abuse, and human trafficking to name a few,” the DCC stated. “These operations and the products they produce threaten consumer safety and the vitality of legal and compliant licensees.”

More recently in March, the DCC released its enforcement statistics for 2021 and 2022. During that time frame, search warrants increased from 62 in 2021 to 155 in 2022, with over 41,726 pounds of illegal product seized in 2021 and 144,254 pounds in 2022. 

Bill Jones, the DCC’s Chief in the Law Enforcement Division, explained the importance of continuing to target illegal operations. “Through each enforcement action our teams gain a better understanding of how these criminal operations work which helps us better focus our resources and amplify our results to protect the health and safety of all Californians,” said Jones. “I would like to thank the dedicated group of officers in our department who work closely with our law enforcement partners to make these operations successful. Together, we are cracking down on the illicit cannabis market and ensuring California maintains a well-regulated and legal marketplace that benefits Californians.” 

Additionally, the DCC reported that it destroyed 19,221 illegal cannabis plants in 2021, and 264,196 plants in 2022—a 1,274% increase.

The city of Riverside is one of many that are still working on establishing a regulatory framework in their respective areas. According to The Press Enterprise, the Riverside City Council recently approved an ordinance on Feb. 28 that would allow up to 14 cannabis retail permits. On March 1, a city press release shared statements from a few key individuals.

According to Councilmember Ronaldo Fierro, it’s high time Riverside kept up with the times. “Today’s long overdue decision to overturn the ban on cannabis retail was the result of a multi-year effort that included intensive community and stakeholder input,” said Fierro. “This is the first step in a pragmatic and sensible policy process that is centered around providing benefit and opportunity for all Riverside residents.”

Riverside Mayor Pro Tem Clarissa Cervantes also released a statement about cannabis finally moving forward in Riverside. “With a little over 18 months until the November 2024 ballot, we have the time we need to create a program that is socially equitable and ensures voters are informed about what the tax measure will do,” Cervantes said. “Riverside voters approved this measure years ago, and the Council voted to move forward with creating a pathway for safe access, and quality workforce opportunities.”

City staff will continue to develop a process for permit review and implementation, and plan to propose their plan to the Riverside City Council sometime this summer.

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