minor cannabinoids Archives

Got THC In Your Milk? Maybe You Can…

March 18, 2023 Published by SDZ News

The question over how breast milk is affected by drug intake is big these days, what with all the prescription and non-prescription drugs flying around. The same issue technically goes for other animals, including cows; which have the designation of providing us milk. A recent study shows how cows that consume cannabis, have cannabinoids like THC and CBD in their milk. Is this okay for cows? And could this be a new way to use cannabis?

Drugs passing into breast milk

When it comes to human childbearing, there are certain issues that arise in terms of how to protect a fetus from chemicals. There is sometimes bickering over what can cross the amniotic sac and get to the baby. Likewise is the argument that a breastfeeding mom is likely to pass on the chemicals she ingests to her baby byway of breastmilk. As of yet, while mothers are often warned away from drugs like cannabis, evidence of it being damaging when consumed in breast milk is inconclusive at best. But that doesn’t mean other drugs can’t cause harm.

It’s even said that if you’re a woman breastfeeding who wants to do certain drugs, like “amphetamines, ecstasy, cocaine or heroin, you should not breastfeed for 24 hours after use.” And that for things like smoking or drinking, that breast feeding should come first. In fact, if a woman feels her breast milk is unclean, she can ‘pump and dump’, meaning pumping out a round, so that new clean milk is produced.

It’s generally recommended not to drink or take drugs within the first month of breast feeding, and some women maintain this for the entirety of the breast feeding experience. Of course, there are so many prescriptions that we take for so many things, that these days, its sadly hard to imagine that many babies get through without exposure to something.

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The reason this happens is because many compounds can pass through biological membranes, so long as they’re not too big (like insulin). The drugs are transferred from the mother’s plasma to the milk through passive diffusion across the membranes. This transfer is effected by things like protein binding, lipid solubility, and ionization. When the mother’s plasma protein binding is low and with high lipid solubility, this transfer is strongest. The other issue is that milk has greater acidity levels than plasma, which lets drugs with weak bases transfer more easily (think amphetamines and opioids).

This is the issue as seen for human mothers in our society. But it exists in another arena. We’re big drinkers of cow milk (whether it makes sense or not), and the same idea applies. If a cow is fed specific drugs, how likely are they to end up in the cow milk that we then consume? A recent study highlighted the ability for THC and other cannabinoids to be transferred to cow’s milk, when the animals are fed hemp.

The study on THC passing into cow’s milk

In November 2022, this study was published in Nature Food, called Transfer of cannabinoids into the milk of dairy cows fed with industrial hemp could lead to Δ9-THC exposure that exceeds acute reference dose. The idea was to establish if cannabinoids get transferred through animal milk (and in what amounts), when industrial hemp is used in animal feed products. In order to shine some light on the topic, this study was done by feeding cows hemp.

Got Synthetic Milk? Coming Soon To A Store Near You

Researchers “collected and analyzed milk, blood plasma and feces, measured physiological parameters and observed animal behavior.” They also used “a liquid chromatography–tandem mass spectrometry-based analytical technique that ensures differentiation between Δ⁹-THC and Δ⁹-THCA in various matrices,” which “enables quantification of the cannabinoids Δ⁸-tetrahydrocannabinol (Δ⁸-THC), Δ⁹-tetrahydrocannabivarin (Δ⁹-THCV), CBD, cannabinol (CBN), cannabidivarin (CBDV) and the two Δ⁹-THC metabolites 11-hydroxy-Δ⁹-THC (11-OH-THC) and 11-nor-9-carboxy-Δ⁹-THC (THC-COOH).”

The data collected was then used to “develop a predictive toxicokinetic model, which can be used to simulate other exposure scenarios and to assess the transfer of different cannabinoids into cow milk when using industrial hemp as a dietary supplement for dairy cows.”

What did the study find in terms of cow health when ingesting hemp?

Researchers specifically used Holstein Friesian dairy cows, and first partially replaced their corn silage with hemp silage, which came from the whole plant and had a low cannabinoid level. This was the adaptation phase. After this, they were fed hemp silage which came from the cannabis leaves, flowers and seeds, and which contained high levels of cannabinoids. This was the experimental phase.

Cow milk is a product of what cows are fed

This experimental phase was done at two different levels. Group L was fed 0.84 kg a day for the low hemp group; and group H was fed 1.68 kg a day for the high hemp group. After this came a final phase – depuration, in which no hemp was given and the cows cleaned the hemp from their systems.

Results show that when fed up to .92kg/day from the lower cannabinoid hemp option (standard industrial hemp used in adaptation phase), there was no difference in physiological parameters or overall health issues. On the other hand, cows fed the higher cannabinoid hemp did experience effects in both experimental groups. Both feed intake (and therefore) milk production went down greatly after Day 2 with both groups. Results also showed that respiratory rate and heart rate both went down in a matter of hours for both experimental groups. With some animals, they fell enough to be considered bradypnea or bradycardia.

Changes were also seen in the animals’ behavior and physical appearance. They had greater tongue play, yawned and salivated more, had more nasal secretions, experienced reddening and prolapse of the nictitating membrane (third eye lid), and appeared tired. Some animals in the higher consumption group stood abnormally, and for longer periods of time; and walked unsteadily and carefully.

A Complete Look at Cannabis and CBD Use While Pregnant or Breastfeeding

All changes to the cows lasted until about two days after the hemp feeding stopped. The hemp didn’t affect basic milk constituents like fat and lactose, nor did it affect body temperature or body weight. To be clear, these cows were not fed a normal amount of THC, even for their body sizes. They were fed approximately 86X (per their sizes) the minimum amount of THC to cause adverse effects in humans. This makes the health results a bit questionable in term of what should actually be expected. Other studies have not shown negative reactions with standard industrial hemp feed.

Cannabinoid transfer when cows are fed hemp

The cow milk was tested after hemp consumption. During both the adaptation phase and experimental phase, “measurable levels of ∆⁹-THC, ∆⁹-THCA, ∆⁹-THCV, CBD, CBN and CBDV in cow’s milk” were found. On the last day of the cleaning out phase, THC and CBD were still detected in the breast milk. Other cannabinoids were not detected during any of the study. When compared to corresponding blood plasma levels, delta-9 THC was found at concentrations 6-26X higher after the experimental period, whereas it was 3-5X higher for THCV, and 11-32X higher for CBD. This implies the cannabinoids can accumulate in the milk.

Not all cannabinoids seemed to accumulate though. THCA and CBDV didn’t show this, and CBN couldn’t be detected in plasma, so no comparison was made. Though urine was collected, there were some issues that essentially kept it from being evaluated and used in the data; so all information that could have come from that, is missing.

THC is naturally infused into milk when cows eat hemp

Study investigators concluded that “Our study shows that feeding cannabinoid-rich industrial hemp silage made from leaves, flowers and seeds leads to a decrease in feed intake and milk yield in dairy cows.” In terms of cannabinoids passing into milk, they go on to say that “The toxicokinetic modelling has shown that the transfer rates of the examined cannabinoids from feed to milk were less than 1%.” Let’s remember, these cows were fed huge amounts of cannabinoids like THC, so 1% is still a lot under the circumstances.

They go on, “Nevertheless, due to the high feed intake, cow’s milk reached substantial levels of Δ⁹-THC such that the exposure might exceed ARfD in some population groups in our exposure scenario based on the transfer properties presented here.” They also stipulate, “For other cannabinoids, in particular for CBD, which was present in high amounts in industrial hemp (and thus also in cow’s milk after feeding), the data are currently insufficient, thereby preventing an assessment of possible health risks.”

Conclusion

This is an interesting study which backs up what we already kind of knew, that some constituents of the cannabis plant should make it into cow milk when hemp is eaten. One of the issues with the results however, is that the cows were fed such large amounts of THC. When fed the lower THC hemp, there were no issues, indicating the likelier feed option, probably won’t cause a problem.

THCM: And What It Means for Pregnant Women

Regardless, it does go to show that milk can be engineered to have cannabinoids, by changing the diet of the cow. However we should remember that cows are living things, and using them to produce natural THC infused milk, brings up even more ethical issues, than the ones that come with the existence of the industry in general. Perhaps this is a good reminder of the on-the-horizon synthetic milk, which is yet another strange breakthrough in the general milk industry; though also not one without a lot of controversy.

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THCM: And What It Means for Pregnant Women

March 11, 2023 Published by SDZ News

It’s not good to smoke when pregnant, but that’s obvious because it’s not good to smoke in general. Recently pregnant women have been checked for the compound THCM, to see if they’ve smoked weed while pregnant. What are the implications of the test, and does this make sense?

What is THCM?

First it was THC, and that’s all we talked about with weed. Several years ago CBD became a big name what with the 2018 US Farm Bill. In the last few years, its been all about other minor compounds found in the plant, like delta-8 THC, HHC, THCO, and synthetics like delta-10. There are so many letter combinations, its hard to follow, and even now we don’t really know a lot about these compounds. What we do know, is that they either occur in nature, or were made in a lab.

THCM doesn’t fit into either of those categories. Officially called 11-Nor-Delta-9-Tetrahydrocannabinol-9-Carboxylic Acid {Carboxy-THC}, it was discovered in 1997 (or 1977 depending on your source, for which there aren’t many good ones), and has never been isolated from the cannabis plant, so its effects – and most other information – are unknown. It’s not actually found in the plant, but it is used for a specific purpose.

So far, THCM has only been found, not in cannabis, but as a byproduct of cannabis smoke. To be clear, its not a byproduct of using cannabis in general, but a byproduct that comes from lighting the weed on fire and breathing it in. So if you’re tested for it, and you use cannabis edibles, or vapes, a test for THCM won’t turn up anything. The testing for it is highly specific, and only applies to pregnant women right now.

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How is a person tested for cannabis?

A regular weed test is generally done using urine. And the results depend greatly on the amount a person uses. It picks up THC that entered the system in any way (edibles, vaping, smoking, etc…) For an occasional smoker, it might only show up in the urine for a few days, but this varies by person. Things like body fat content, exercise regimen, and diet can play a big role in how long THC stays with us. For a heavy user, it can take as long as 30 days after the final smoke. For moderate smokers, its likely to be in the middle – maybe 10-15 days.

Then there are blood tests for THC, but we don’t hear about them often. They’re used when the circumstance of testing involves some kind of criminal activity. For example, this testing method is employed more and more on roadways, if a state designates a blood THC level for driving. These tests are way more accurate, but can only tell if weed was used within the last two days. So they don’t cover as much time, and are best for circumstances that involve very recent use.

There are also hair tests, but they’re not very reliable. THC in hair can be detected for months after use, but these tests aren’t terribly specific to use. How many times have you sat in a room filled with weed smoke? You know what else was with you? Your hair. Testing hair doesn’t necessarily mean that a person smoked, it just means they were around smoke. Realistically, you likely won’t ever be given a hair test because of the lack of accuracy.

How Long Does THC Stay in the System?

Why is THCM tested for?

All the above tests are essentially looking for THC, as that’s the psychoactive part of the plant. And while urine tests can usually pick up that a heavy smoker smoked within the past month, and a blood test can tell the same for the past couple days, there is one other way to test for longer periods. Whether it’s actually useful or not is hard to say, but its certainly happening, so I’ll share it with you.

As mentioned, THCM is a byproduct of cannabis smoke. Not of other forms of weed use. It acts as a biomarker, which is “A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.” In this case, it marks whether a person smoked cannabis within the five months before birth.

Yup, it’s used on pregnant ladies to determine if they smoked weed. So let me repeat again, its not whether a person ‘used’ weed in the five months prior to birth, it’s whether a woman ‘smoked’ weed in that time. So, its not testing for weed use technically, its testing only for if a woman smoked it. While it can detect if a fetus was exposed to cannabis smoke in-utero, it doesn’t apply to other forms of weed intake within that same time period; that will only show in urine or blood.

The dangers of smoking while pregnant

We already know smoking is bad. In general, and during a pregnancy. Let’s remember, smoking is the #1 death toll drug; even if its not about a specific compound, but a means of intake. And that’s what it is about. It doesn’t matter if its weed, cigarettes, or some herb given to you by a shaman; if its lit on fire and breathed in, its smoking. And that’s the issue. Tobacco, for example, has plenty of medicinal uses, and its simply the lighting it on fire and breathing it in that’s bad.

As far as what it can do during pregnancy? This isn’t like weed where there are questionable studies making questionable connections. We have years of data on this. Cannabis is not related to the health issues of smoking; so it makes sense to question whether its the cause of issues in-utero, especially when smoking is included. Smoking is not just about cigarettes. (And as a side note, its horrifying I have to keep pointing this out; and that its repeatedly confused in the minds of the public what the actual risks of smoking are, and where they come from.)

Study after study has turned up the results that this review did: Health outcomes of smoking during pregnancy and the postpartum period: an umbrella review. Main results of the 64 studies it analyzed when looking at smoking during pregnancy (SDP) and 46 different health issues?

Bad Study Highlights Misunderstanding About Where Smoking Risks Come From

“The highest increase in risks was found for sudden infant death syndrome, asthma, stillbirth, low birth weight and obesity amongst infants. The impact of SDP was associated with the number of cigarettes consumed. According to the causal link analysis, five mother-related and ten infant-related conditions had a causal link with SDP. In addition, some studies reported protective impacts of SDP on pre-eclampsia, hyperemesis gravidarum and skin defects on infants. The review identified important gaps in the literature regarding the dose-response association, exposure window, postnatal smoking.”

Even this insinuates that how much is smoked and when its smoked is important, and still unaccounted for in much of the research out there. All included studies were done prior to 2017, but I don’t see that as making much difference at this point. What it does show is the continued and measurable aspect of the negative effects of smoking on a fetus.

Dangers of smoking vs vaping while pregnant

So much research comes up on the topic that its hard to deny. Take this paper that was published in The Obstetrician & Gynecologist in 2019 called Smoking in pregnancy: pathophysiology of harm and current evidence for monitoring and cessation. It also reviews tons of literature to come up with many of the same issues. Its first key point is that “Smoking in pregnancy is a risk factor for miscarriage, stillbirth, placental abruption, preterm birth, low birthweight and neonatal morbidity and mortality.”

Having said that, even this study shows gaps in understanding. While it mentions in one place that “The adverse effects of cigarette smoke are primarily driven by carbon monoxide, tar and nicotine,” it goes on to stipulate later that “Electronic cigarettes are more popular among smokers, but evidence of their safety and effectiveness in pregnancy are lacking.” This actually indicates that nicotine isn’t where the risk is. If it were, electronic cigarettes would automatically come up as causing the same damage, and as of yet, they have not. Contradictions like this should always be noticed in a study, as they can be factors of personal bias, or a researcher’s own misunderstanding of the research they review.

Vaping has shown specifically not to cause the same issues like cancer, heart disease, and pulmonary disease in the general population. And definitive links to the same birth issues are not found with vaping, whereas you literally can’t get away from them when looking at smoking studies. Which indicates again, this isn’t about tobacco or nicotine, no matter how many times the line is said. This doesn’t mean that inundating a fetus with nicotine is okay either, but the bigger health implication, is simply in the act of smoking something.

Do THCM tests matter then?

The reality is that the jury is out on why picking up THCM matters. Cannabis itself is not definitively associated with birth issues, so it’s a bit odd. Studies blaring titles like Birth Outcomes of Neonates Exposed to Marijuana in Utero, go on to stipulate “However, at this time, there are no data to differentiate smoking itself (ie, inhalation of marijuana smoke) vs ingestion of the cannabinoids as the main factor associated with an increase in adverse events, to our knowledge.” As in, this whole study was done, without considering how the cannabis was used. And that if it was smoked, these results are more likely related to the actual smoking, than the weed.

At Your Own Risk: Top 5 Death Toll Drugs

In fact, that study is scarily similar to this study which attempted to link using cannabis to a raised rate of heart attack (myocardial infarction). The big, glaring issue? It only looked at people who smoked it; as in, no other cannabis use was a part of the study at all. And at not one point did the investigators speak about the general dangers of smoking. Its an entire study that backs up that smoking can lead to increased risk of heart attack, but not cannabis.

I have yet to see a real connection made anywhere beyond these smear campaign articles (what else can you call that?) The pregnancy study is no different. As the main method of cannabis consumption in the world is still smoking, that study likely acted as a study on the effects of smoking to a fetus in-utero, not on the effects of cannabis use to a fetus in-utero.

Since there isn’t great research on the actual topic of the direct effect of weed compounds on a fetus when the co-morbid factor of smoking is eliminated; there’s no real reason for the test in my mind. Co-morbid means the existence of two different factors. In research this can cause problems because if one specific thing is being studied (cannabis use on a fetus), and a co-morbid factor exits (smoking), if the co-morbid factor isn’t controlled for, the results are useless. With a lack of info on weed effects to babies in-utero, a THCM test has no value beyond the idea of smoking in general.

Conclusion

Truth is, a THCM test like this can cause problems for an expecting mother, which are unnecessary. After all, pregnancy is stressful enough, and as cigarette smoking (the real danger) isn’t illegal while pregnant, there’s no reason to test a woman for this. Especially when it might indicate nothing more than a single joint hit from a months before; and that it hasn’t been ruled out that simply having been in a smokey room, won’t bring on a positive result.

*As a note, I am not encouraging any pregnant woman to use any substance. I am merely questioning the usefulness of this specific test.

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DEA & FDA: The Confusion Over Legal Drugs VS Legal Products

February 27, 2023 Published by SDZ News

This fight is ongoing. Are all cannabinoids that have to do with hemp, legal? Are hemp-derived cannabinoids that are completely or partially synthetic, legal? Are the cannabinoids that show up in nature, but are only used for production as synthetics, legal? And what about the products that are made from these compounds? Are they legal? There’s a mass amount of confusion on this, and on one end, a pretty discreet answer. So here we ago, when it comes to the DEA and FDA, what’s the difference between legal drugs, and legal products?

DEA, FDA, and USDA: what do these government agencies do?

For the most part, we have a generally good idea about this, but just to be clear, let’s quickly go over on a broad scale, the purpose (and power) of these government agencies. We’ll start with the DEA.

According to the agency, “The mission of the Drug Enforcement Administration (DEA) is to enforce the controlled substances laws and regulations of the United States and bring to the criminal and civil justice system of the United States, or any other competent jurisdiction, those organizations and principal members of organizations, involved in the growing, manufacture, or distribution of controlled substances appearing in or destined for illicit traffic in the United States.”

Amanita Mushroom Products at 2023 High Times Hemp Cup Kits

On another hand, according to the FDA, “The Food and Drug Administration is responsible for protecting the public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, and medical devices; and by ensuring the safety of our nation’s food supply, cosmetics, and products that emit radiation.”

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It goes on, “FDA also has responsibility for regulating the manufacturing, marketing, and distribution of tobacco products to protect the public health and to reduce tobacco use by minors.” And, “is responsible for advancing the public health by helping to speed innovations that make medical products more effective, safer, and more affordable and by helping the public get the accurate, science-based information they need to use medical products and foods to maintain and improve their health.”

As the FDA controls the regulation of all tobacco products, as stated, this includes vapes. Vapes are currently regulated under tobacco law, meaning all usage of vapes (e-cigarettes) falls under FDA regulation as electronic nicotine delivery systems (ENDS).

As far as the USDA, “We provide leadership on food, agriculture, natural resources, rural development, nutrition, and related issues based on public policy, the best available science, and effective management. We have a vision to provide economic opportunity through innovation, helping rural America to thrive; to promote agriculture production that better nourishes Americans while also helping feed others throughout the world; and to preserve our Nation’s natural resources through conservation, restored forests, improved watersheds, and healthy private working lands.”

2023 Farm Bill Under Construction: What to Expect For Hemp

These three agencies all play a role with cannabis in some way. The USDA regulates industrial hemp cultivation; the DEA regulates the legality of drug compounds; and the FDA regulates cannabis in products like foods, cosmetics, medicines, and supplements. These designations are important when looking at the controversy over the cannabinoid industry (and the cannabis industry as a whole), and the idea of legal drugs vs legal products.

The part of the USDA

There is a huge argument right now over which cannabis compounds are legal, and which products are legal; and these two questions are fundamentally different, because they’re governed by different agencies. So, to get an idea how it works with cannabis, let’s go over the breakdown between the legality of one vs the other.

To start with, the USDA’s 2018 Farm Bill legalized the cultivation of industrial hemp. And set a definition for ‘hemp’, which is the basis for a huge, and ongoing, argument, over exactly what this refers to; particularly in the case of wholly synthetic, or partially synthetic compounds. The ambiguity is partly related to the US not having a general definition for ‘natural’, meaning, there are no definitions for other thing like ‘naturally-derived’ either. Such a term is often used to greenwash products (make them sound more natural than they are), which has led to multiple lawsuits.

Natural and naturally-derived

There is more specific regulation on this front in terms of food, however, with organic laws setting particular standards. And with organizations like the ISO (International Organization for Standardization) which set standards for cosmetics and food. Apart from offering the hemp definition that causes so many problems (on one front), the USDA is less involved in the rest of the argument.

Legal cannabis drugs vs legal cannabis products, which is DEA and which is FDA?

USDA aside, the DEA regulates drugs on behalf of the Department of Justice. It holds drug scheduling lists that determine the legality and uses of a drug on a federal level. Schedule I is for 100% illegal drugs with no accepted medical use, a high risk of danger, and a high risk of addiction. These drugs are illegal for any resident to possess, use, cultivate, sell, transport, traffic, or do anything else with. Cannabis is one of these drugs. However, recently, plants with no more than .3% THC were legalized by the most recent farm bill, for industrial use; by moving regulation for cultivation and production (only) to the USDA.

When we want to know if a drug is legal in general, we look to the DEA. And that’s why the agency has fielded inquires, like from the Alabama Board of Pharmacy about delta-8, and more recently, by attorney Rod Kight in terms of two synthetic cannabinoids: Delta-9-THCO and delta-8-THCO. In both cases, it stipulated they’re illegal. These questions are about overall legality, like, can I have it at all as a legal compound, or will simply having it be a federal offense. But that’s where DEA control ends.

DEA Confirms That Synthetic Delta-8 THC is ILLEGAL, But…

The problem with the current debate, is that its essentially over products, rather than standard legality. Whether the DEA says the compounds are legal or not, has 100% no bearing on whether they’re legal to use in products. And that’s because the FDA (NOT the DEA) overseas all uses of cannabis in anything related to medical, supplements, cosmetics, smoking, and food products.

This means anything dealing with cannabis in vapes, is illegal. As is every other kind of cannabis product: oils and tinctures (both supplements, or food), creams, patches, and makeup (cosmetics, or medicine), pills, and treatments of any kind (medicine or supplements). They’re all uniformly illegal; because the FDA never made them legal.

What does the FDA permit? “With the exception of Epidiolex, Marinol, and Syndros, no product containing cannabis or cannabis-derived compounds (either plant-based or synthetic) has been approved as safe and effective for use in any patient population, whether pediatric or adult.”

FDA allows legal cannabis pharmaceutical products

If it needs to be stated more clearly, this ends the question of whether any cannabis product is legal on a federal level. And the answer is no. Once again, this is unrelated to whether the DEA classifies something as illegal or not. In fact, it should be remembered that the DEA has cannabis in Schedule I, yet the FDA approved Epidiolex, Marinol, and Syndros. Which means an illegal drug can still be used in legal products, should the FDA pass them. And a legal drug, is still illegal in products, if the FDA doesn’t make an allowance.

Why do people try to use DEA answers to promote product legality?

Hard for me to say, but I have my theories. One of them is simply confusion. I fully admit I, myself, was quite entangled in the ‘synthetic or not’ aspect of the argument for a long time. And that still matters in terms of legal drugs, but it doesn’t affect legal products. At least not in current circumstances. When an industry has regulation through different government bodies for the same topic, it can get confusing. And for many, it might seem like the DEA holds the answers to issues of product legality.

The other possibility is more a manipulation issue. The ideas generally focused on when speaking of the debate on hemp-derived cannabinoids, are whether they cross the .3% THC level at any point in processing, and whether they’re synthetic to some degree and what that means. That’s because these things can be argued. What is less arguable, is that the agency that allows legal products, never changed its stance. If industry promoters and vendors had the public focus on this, their products would be seen as illegal with no recourse. If response letters from the FDA were published, there wouldn’t be a question.

Artificial High – The History of Cannabis Synthetics

This is similar to how I believe the government uses methods of subterfuge to keep American attention off certain topics. Whether the cannabinoid industry is dirty or not, it simply doesn’t come with any real death toll that can be attributed to anything but additives. As in, not any of the cannabinoids, synthetic or not, have caused an issue to any real degree. On the other hand, while the government talks of them like they’re a massive threat to humanity, it continues to push opioids through regulation, as they now kill close to 100 thousand people a year.

Same concept. By focusing on the DEA, and whether a drug is legal overall, takes attention away from the fact that the FDA regulates products, and the DEA has nothing to do with this. The cannabinoid products industry isn’t going to focus on the legal aspect that renders it completely illegal. It’s going to focus on the debatable part, and sell it products based on the argument therein.

Final thoughts

I really don’t care if the products market continues. I mean, it’s a bit gross, with trademark violations, fake labs, mislabeled products, and no way to know what’s added in. But legal markets tend to have these issues too. And realistically, they ain’t killing anyone. My argument is simply about understanding the legal landscape, and not falling victim to subterfuge marketing moves when it comes to this understanding. But am I parading around for the end of cannabinoids? No. And realistically, illegal or not, there seem to be few, if any, repercussions involved; likely because the US can’t fight another losing drug war.

Issues with mislabeled cannabis products

I’d sure love if everyone had access to the real plant (which seems to lower use of synthetics anyway), but I also know people like to get high and will try what’s available. And if its not going to cause damage, or at least, not in remotely the same ballpark as other drugs like medically approved opioids and benzodiazepines, and illegal ones like meth; it kind of seems like the FDA should suck it up, and allow it to happen. Although, in the world of reality, the market continues regardless.

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Amanita HHC Gummies: Amanita Muscaria Chocolate with HHC

February 27, 2023 Published by SDZ News

The High Times Hemp Cup is an annual competition where hemp cultivators, processors, and brands around the country submit their products for a chance to win the title of the best hemp-derived product. The judge kits are distributed across the country for consumers to test and judge each product inside of their kit. This year, the competition has become more interesting as new psychedelic product has made its debut in the competition, the Amanita HHC Gummies, the Amanita Delta 8 Joint and the Amanita CBD Joint, all from Amanita Muscaria mushroom, a legal trending psychedelic product, sold online.

Click HERE to see the new additions to 2023 High Times Hemp Cup competition:
Amanita HHC Gummies & Amanita Delta 8 Joints

Introducing Amanita HHC Gummies & Amanita Delta 8 Joint

The new Amanita HHC Gummies are lab-tested 25mg HHC gummies dipped in Amanita Muscaria mushroom chocolate. The Amanita CBD mushroom joint is made from amanita infused organic indoor hemp flower, and the Amanita Delta 8 THC mushroom caviar joint contains Amanita + Delta 8 infused hemp flower blend with Muscaria powder coating on the outside, with a total of 500mg.

Al three products are produced by PsiloMart which becomes the first legal magic mushroom company to submit entries for the 2023 High Times Hemp Cup. The company believes that there is an entourage effect between cannabis and mushrooms that needs to be explored, which led them to create a new “Amanita +” line of Muscimol mushroom products blended with hemp-derived cannabinoids. Since the Hemp Cup is the “People’s Choice” edition, we need to wait and see what will be the score given to these products. However, the inclusion of these Amanita Muscaria products in the High Times Hemp Cup competition is a testament to the high demand expected for blended cannabis and psychedelic products.

The new Amanita mushroom products

The new Amanita Hemp Cup products include Amanita HHC gummies, Amanita Delta 8 THC joint, and Amanita CBD joints. These products are also available for purchase directly from the supplier, with the option to use the “Cannadelics” coupon code to save an additional 20%.

Amanita HHC Gummies

One of the Amanita + products submitted to the 2023 High Times Hemp Cup is the Amanita + HHC Magic Mushroom Gummies. These lab-tested gummies contain 25 mg of HHC, a simplified version of THC, and are dipped in Amanita Muscaria mushroom chocolate. The combination of HHC and muscimol from Amanita Muscaria mushrooms creates a unique experience for users.

Amanita HHC Gummies

Amanita HHC Gummies

If you’re curious to try the new Amanita HHC gummies, CLICK HERE and use the “cannadelics” coupon code to save 20% on your order.

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Amanita CBD Joint and Amanita Delta 8 Joints

Another two product submitted to Hemp Cup are the Amanita CBD joints and the Amanita Delta 8 joints. The Amanita + CBD Mushroom Joints, include Amanita Pantherina powder blended with organic indoor hemp flower for a total of 250 mg. The Amanita Delta 8 joint features a blend of Amanita + Delta 8-infused hemp flower with muscaria powder coating on the outside for a total of 500 mg. This product is the more potent one, as it includes both Delta 8 THC and Amanita Muscaria extract, both psychoactive.

Amanita Delta 8 THC Joints

If you’re curious to try the new Amanita Delta 8 joints, CLICK HERE and use the “cannadelics” coupon code to save 20% on your order.

Buy Amanita Delta 8 THC Joints

(With Cannadelics coupon code)

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More on Amanita HHC gummies

Amanita HHC gummies are a new addition to the line of muscimol-infused products, which combines the psychoactive effects of Amanita muscaria mushrooms with lab-tested hemp-derived cannabinoids.

Each gummy contains 25mg of HHC (hexahydrocannabinol), a simplified version of THC, that is dipped in Amanita muscaria mushroom chocolate. This is an interesting blend, as it allows you to experience cannabis and mushrooms at the same time.

Amanita HHC gummies offer a fun yet relaxing experience, somewhat dissociative in nature, with a warm and tingly feeling body high, and a bit of auditory enhancement. As it contains Amanita extract, you can also expect to get some kind of psychedelic experiences, memory flashbacks and changes in the way you experience the world arround you, so use it with caution.

To get your hands on these Amanita HHC gummies, click here and use the “cannadelics” coupon code at checkout for a 20% discount.

Click HERE to see the new additions to 2023 High Times Hemp Cup competition:
Amanita HHC Gummies & Amanita Delta 8 Joints

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About Amanita Muscaria

Amanita muscaria, a legal magic mushroom, also known as Fly Agaric, or simply, Amanita mushroom, is a member of the family of fungi, of the genus Amanita. Although it can be found all over the world today, Amanitas are native to the temperate and boreal regions of the Northern Hemisphere, which includes Europe, North America, and Siberia – where they can be found growing under various types of deciduous and conifer trees, such as birch and pine.

The active ingredients in Fly Agarics are muscimol and ibotenic acid. Muscimol works by activating the major inhibitory neurotransmitter system, gamma amino butyric acid (GABA). As an inhibitory system, muscimol suppresses the activity of certain neurons in the brain, which is how the psychoactive effects are produced.

The ibotenic acid, which is responsible for the sickness and “toxicity” commonly reported from these mushrooms, converts to muscimol during decarboxylation (through the application of heat). If Amanita products are prepared correctly, then at least 70 percent (preferably more) of the ibotenic acid will become muscimol.

Amanita Muscaria Beginner’s Guide: Everything You Need to Know

About the High Times Hemp Cup

The High Times Hemp Cup is a nationwide competition for the best hemp-derived products. Hemp cultivators, processors, and brands submit their products into the competition, which are then packaged by High Times into assorted Judge Kits. These judge’s kits are then distributed across the country for consumers to test and judge each product inside of their kit.

The judge’s kits are available for purchase online, and judges will have until April 2nd to explore their kits and test out the various different products received. They will fill out questionnaires and submit their responses, which will be tallied up in time for the cup that takes place on April 16th.

Amanita HHC products and Amanita Delta 8 Joints at 2023 High Times Hemp Cup Kits — Amanita Mushroom Products at 2023 High Times Hemp Cup Kits
Screenshot from hthempcup

Amanita HHC gummies and Amanita Delta 8 joints – Final Thoughts

The inclusion of Amanita Muscaria products in the High Times Hemp Cup showcases the growing demand for these unique products. The combination of muscimol from Amanita Muscaria mushrooms with popular cannabinoids like HHC, Delta 8 THC, and CBD creates a new and exciting experience for users. This is a major change as never before psychedelic products were included in this competition and we look forward to see the results of the High Times Hemp Cup. Remember, these products can also be bought directly from the supplier, with the option to use the “Cannadelics” coupon code to save an additional 20%.

What do you think? Will Cannabis + Amanita products prove to be an important part of our psychedelic routine? Share your thoughts below.

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So what are you waiting for? Click the links above and enter the code “Cannadelics” to save 20% on your order. And be sure to subscribe to our newsletter for access to awesome deals on cannabis and psychedelic products. Get high responsibly and enjoy the Amanita HHC Gummies today!

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The post Amanita HHC Gummies: Amanita Muscaria Chocolate with HHC appeared first on Cannadelics.

DEA Reiterates That Synthetic Cannabinoids Are Illegal

February 23, 2023 Published by SDZ News

It’s been an ongoing battle for a couple years now, with one side (the industry) claiming synthetic (hemp-derived) cannabinoids are legal, and the other (the government) saying they are not. Now, we have a little more clarity on the legal front, which backs up what is consistently said. The DEA recently made a statement that synthetic cannabinoids are illegal, even if hemp-derived.

What are synthetic cannabinoids?

Synthetic cannabinoids can be looked at two ways, and its up for debate how illegal they are. One is that they’re compounds that never existed in nature, and were just made in a lab. When we think of the word ‘synthetic’, that’s the general thought. But there’s another way to see synthetics. If the parts to build something are extracted from a plant, but then go through some sort of synthetic processing, or are put together with other parts that are synthetic; can the product be considered natural? Unfortunately, the US rarely regulates the term.

Truth is, there isn’t a ‘standard’ definition for ‘synthetic cannabinoid.’ Nor, for ‘natural’. Does it mean the whole thing is synthetic? Does it mean part of it is synthetic? Does it mean that at some stage synthetic processing is used? I don’t know because no one does. Far as I can tell, if comparing it to where we do have regulation, like ‘organic‘ regulation, or ISO regulation (International Organization for Standardization), for food or cosmetics, once something unnatural is involved (or involved past a point), it changes the definition.

Right now, the best I can say is that a synthetic cannabinoid relates to any cannabinoid with some amount of synthetic parts or processing, regardless of whether its capable of showing up in nature on its own; but I’m not the authority. Sure, something like delta-8 is naturally-occurring, but not in high enough amounts to extract for product production. It therefore requires synthetic processing for pretty much anything sold. Does it matter if it shows up in nature if we’re using a synthetic version?

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When it comes to the cannabinoid industry, this becomes problematic due to the definition of hemp; a definition that seems to stipulate any product must come from the plant directly, to be legal. As only ‘hemp’ by definition was legalized, anything that doesn’t fit into the definition, is not considered ‘hemp’, which implies illegality. What about products for cosmetics, food, medication, or treatment of any kind? FDA maintains control, so trying to sort out a hemp definition, or a synthetics definition, doesn’t even matter.

Recent DEA announcement

The back and forth is a little silly, although, to be fair, none of these compounds seem to pose much threat (the government is cool with opioids, remember). Their main ruling-out is more likely a desire to cut into a black market that the government doesn’t profit from, than the oft-touted government line that they’re dangerous (I mean, lowering guidelines for prescribing opioid medications? Come on…)

Are these synthetic cannabinoids a problem? It’s a dirty market sure, but as very few health issues seem to relate to compounds, and instead have to do with things like additives (which can be regulated out to produce cleaner products), the government line about danger is a bit misplaced. Perhaps just a move of subterfuge to get eyes away from the government’s own complicity in the opioid issue, which its involved in by continuing to allow them through regulation. But this article isn’t about whether we agree, its about the fact the government did make clear its position, even if we don’t agree.

Naturally-Derived vs Synthetically-Derived: What’s The Difference?

Recently the government made an action to back up what it already said time and time again. On February 13^th of this year, as reported by Marijuana Moment, the DEA zeroed in specifically on delta-8 THC-O and delta-9 THC-O, along with other synthetic cannabinoids, reminding that they’re illegal. The DEA says both these compound fail to meet the definition of hemp, and are therefore Schedule I controlled substances.

The DEA didn’t make a formal announcement. It did what it, and other government agencies, have done a couple times before; and simply replied to a person/organization that asked a question. In all cases, the answer was then posted as if to say the government organization had made a formal announcement, which it did not. In this case, the person asking the question was attorney Rod Kight, who wrote to the DEA last year about delta-8 THC-O and delta-9 THC-O legality, with a recent follow-up in 2023.

The DEA finally answered via letter by Chief of DEA Drug & Chemical Evaluation Section, Terrence L. Boos, on February 13^th. It stated “Delta-9-THCO and delta-8-THCO are tetrahydrocannabinols having similar chemical structures and pharmacological activities to those contained in the cannabis plant.” And that they “do not occur naturally in the cannabis plant and can only be obtained synthetically, and therefore do not fall under the definition of hemp.”

Extracts made into synthetic cannabinoids, are illegal

Following this, on his blog post, Kight stated: “Although I do not always agree with the DEA’s view on cannabis matters, I agree with this opinion and, frankly, am not surprised. This is what I have been saying for a while.” He continued, “I have been concerned about the proliferation of THC acetate ester (THCO) for a while. It has always been my view that THCO is a controlled substance under federal law. Although it can be made from cannabinoids from hemp, THCO is not naturally expressed by the hemp plant. It is a laboratory creation that does not occur in nature, at least not from the hemp plant.”

Did anything new happen? Nope. Did the DEA make a formal announcement? Nope. Did it say anything it hasn’t said before? Nope. While the DEA itself is pretty bad at responding to many things related to drugs, even to the point of getting sued (lets remember it took Kight a year to get a response), it does seem that sometimes the issue is not liking the answer, more than not getting one.

When else did a government response make headlines as an announcement?

Twice in 2021, for two different reasons. One was about the legal nature of synthetic delta-8 THC (which is pretty much any delta-8 used in products), and CBD, which is often assumed to have a greater level of legality than it actually does.

DEA Confirms That Synthetic Delta-8 THC is ILLEGAL, But…

In terms of delta-8 THC, in September, 2021, the Alabama Board of Pharmacy via Donna C. Yeatman, R.Ph., the executive secretary, requested an answer from the DEA about the legality of delta-8, since there was so much contention on the subject in the media. The DEA didn’t say anything new, just repeated what it has before. It relayed once again that any synthetic does not fit under the definition of hemp.

Yeatman’s original letter was dated August 19^th, 2021, and the response was dated September 15^th, 2021. The response brought Yeatman through a logical process, starting with “D8-THC is a tetrahydrocannabinol substance contained in the plant Cannabis sativa L. and also can be produced synthetically from non-cannabis materials.” Then after explaining THCs, and their place in Schedule I, it continued, “Thus, D8-THC synthetically produced from non-cannabis materials is controlled under the CSA as a “tetrahydrocannabinol.””

Realistically, if delta-8 could be appropriately sourced to not require synthetic processing, then it would fit the farm bill definition of hemp. But we know delta-8 only exists in minuscule amounts, and requires the kind of processing for product production, that takes it away from this definition. This doesn’t mean that it’s not ‘hemp-derived’, but that term doesn’t rule out synthetics at all. Of course, should the government ever want to clearly define what constitutes ‘synthetic’ when it comes to cannabinoids, we could have fewer of these arguments.

'Hemp-derived' implies synthetic cannabinoids — ‘Hemp-derived’ implies synthetic cannabinoids

Another government response statement about CBD

The second example of a letter response from a government agency detailing an already stated policy, had to do with CBD and how it can be used. It happened in regards to Steve Brown, of the Minnesota Cannabis Association board, and a conversation about tinctures and processing facilities that happened in a meeting. Said Brown, “They stated later in the meeting that tinctures are illegal… Then this morning I received information from the Minnesota Board of Pharmacy, sent by a colleague.”

What did it say? It contained a responses by the US’s Department of Agriculture via a representative, saying “The problem here is some of the products you’re mentioning here, Steven, would not be legal food by our definition… The reason for that is all these other cannabinoid products are governed by the Board of Pharmacy.”

Why does this matter? Because a ‘medicine’ (anything to treat something, including supplements), a food product, and a cosmetic, all must get approval by the FDA. It gets worse in terms of ‘supplements.’ Once an FDA approved medication is there, any active ingredient used, is barred from advertisement as a nutritional supplement. Meaning since the FDA-approved a CBD medication, Epidiolex, its not legal to sell CBD for any kind of supplemental, or medical use. As in, its not legally cleared to be used for internal products, or to treat anything, or for cosmetics products, or for food products.

If you caught on, it means it doesn’t matter whether the DEA says its illegal or not. Not when it comes to any consumer products in the categories above. Since all that is regulated by the FDA, whether delta-9-THCO, delta-8-THCO, CBD, or any other synthetic cannabinoids are illegal in general, has no bearing on whether they’re legal in products. Which makes any product containing cannabis compounds, automatically illegal, whether synthetic or not. This is actually a statement I can make, because the FDA never regulated a consumer product for these uses with any cannabis compound; aside from pharmaceutical medications.

Minnesota States the Obvious: CBD Was Never Legal

In all of these cases, the government agency didn’t make a statement to the press, but had the answer to their question promoted as an answer to the general question people fight over. And in all cases, all that was done, was to point out already existing information to the entities who were confused. Perhaps it would be better if the public understood the difference between general legality (DEA) and product legality (FDA) when it comes to cannabis.

Conclusion

This isn’t actually news, but it is interesting to see the confusion that continues on the topic. We might not agree with the DEA, USDA, or FDA on these matters, but there are answers already for much of it. Are synthetic cannabinoids illegal? Maybe. Probably. But while that answer is murkier due to missing and finite definitions, whether the products that involve these compounds are technically legal or not, is less debatable. Even if we don’t agree.

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Delta-8 THC vs Delta-9 THC: What Are the Key Differences?

February 17, 2023 Published by SDZ News

Cannabis has been a popular substance for centuries, mainly for its psychoactive effects, but also for its medical benefits. Two of today’s most popular psychoactive cannabinoids found in cannabis are Delta-8 THC and Delta-9 THC. While they may sound similar, they have distinct differences in their chemical structure, psychoactive effects, medical benefits, and legality. Delta-8 THC vs Delta-9 THC: what are the main differences between the two?

Delta-8 THC vs Delta-9 THC:

I. Introduction

In recent years the popularity of both Cannabis and hemp have been growing steadily. Both plants contain a range of compounds known as cannabinoids, which have various effects on the body, both medical and recreational.

Two of the most well-known cannabinoids found in hemp and cannabis are Delta-8 THC and Delta-9 THC. While Delta-8 THC is a minor cannabinoid that is found in small amounts, Delta-9 THC, on the other hand, is the primary psychoactive compound in cannabis. Both Delta-8 THC and Delta-9 THC have distinct differences in their chemical structure, psychoactive effects, medical benefits and legality, which we will explore in this article.

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II. What is Delta-8 THC?

Delta-8 THC is a minor cannabinoid that occurs naturally both in hemp and in cannabis plants. However, it is a rare cannabinoid that could be found only in small amounts, usually less than 1% of the total cannabinoid content. Delta-8 THC is created when Delta-9 THC oxidizes, and it is also produced through a process called isomerization, which converts CBD into Delta-8 THC. As it is a rare cannabinoid, most of the Delta 8 we are using today, is hemp-derived, which really means, it was converted from CBD and remain legal, as a result of the farm bill loophole.

Delta-8 THC is known for its ability to induce a milder psychoactive effect than Delta-9 THC. It is believed to be less potent than Delta-9 THC and can provide a more relaxed, calm experience. It is also known for its potential medical benefits, including pain relief, reduced anxiety, and increased appetite.

III. What is Delta-9 THC?

Delta-9 THC is the primary psychoactive compound in cannabis, but also found in smaller numbers in hemp. It is responsible for the desirable euphoric “high” usually associated with using cannabis. As Delta-9 THC is naturally produced by the cannabis plant most of Delta 9 products found in the market today are not using synthetic cannabinoids. However, recently we have seen many Delta 9 products that are hemp-derived, which means that the have started their journey as CBD and converted into THC.

Delta 9 THC becomes psychoactive through a process called decarboxylation, which occurs when the cannabis is heated, such as when it is smoked or vaporized. This is another nice loophole, that allows THCA products to be legally sold, as they only converted to Delta 9 THC when heated. However, as you need to heat it inorder to use it, these legal safe products, are as potent as regular THC is…

Delta-9 THC is known for its potent psychoactive effects, which can include altered perception, increased heart rate, and impaired coordination. It is also associated with a range of potential medical benefits, including pain relief, reduced nausea, and increased appetite.

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IV. Delta-8 THC vs Delta-9 THC

Delta-8 THC and Delta-9 THC are two similar cannabinoids with some key differences in their chemical structure, psychoactive effects, legality, and medical benefits. However, when it comes to products, you can easily find both Delta 9 and Delta 8 coming in a variety of products, such as vapes, gummies, tinctures, edibles, disposables, carts, dabs, flower, capsules, etc.

Chemical structure

The main difference between Delta-8 THC and Delta-9 THC is in their chemical structure. Delta-8 THC has a double bond on the 8th carbon atom, while Delta-9 THC has a double bond on the 9th carbon atom. While it sounds like a small variation, as we can see below, this difference in the placement of the double bond results in some notable differences in their effects on the body.

Psychoactive effects

It is safe to claim that in most cases and for most people Delta-8 THC is less psychoactive than Delta-9 THC, meaning that it has a milder and more relaxing effect on the body. Delta-8 THC is often described as providing a more clear-headed and focused high, with less anxiety and paranoia than Delta-9 THC. Some users have also reported feeling more energetic and creative after using Delta-8 THC. However, as the variety of products in the market is evolving, it is now very common to find blended products, featuting many cannabinoids, which makes it harder to back-up such claims.

On the other hand, Delta-9 THC is more potent and can induce a more intense high, sometimes causing anxiety, paranoia, and even in very rare cases, hallucinations in some users. Delta-9 THC can also cause physical effects such as dry mouth, red eyes, increased heart rate, and impaired coordination. For all trhat matters, when people discuss ‘Cannabis’ or ‘THC’ they usually refer to Delta-9 THC.

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Legality

The legality of Delta-8 THC and Delta-9 THC is a complex and constantly evolving issue. As a result of the 2018 farm bill, Delta-8 THC is legal at the federal level, but some states have banned it, while others have not yet made a decision. In contrast, Delta-9 THC remains illegal under federal law, but has been legalized for medical or recreational use in some states. All that said, a new Farm Bill loophole allows hemp-derived Delta-9 THC to be sold ‘legally’…

As a result, in the US, the legality of Delta-8 THC and Delta-9 THC is largely determined by the source of the compounds and not by its psychoactive abilities. This might be change soom, in 2023 Farm Bill, coming sometime this year.

As we have seen, Delta-8 THC can be derived from hemp or cannabis, while Delta-9 THC is mainly found in cannabis, but also can derived from hemp. Under the 2018 Farm Bill, hemp and hemp-derived products were legalized at the federal level, as long as they contain less than 0.3% Delta-9 THC by dry weight. This includes Delta-8 THC, which can be extracted from hemp. This opening has allowed a whole new market of hemp-derived Delta-9 THC which legality is constantly under quiestioning. However, this market is booming now so anyone can get any products they want, as long as it is coming from hemp…

This means that Delta-8 THC, and in some cases, Delta-9 THC products that are derived from hemp and meet the requirements of the 2018 Farm Bill are legal at the federal level. However, some states have tried to ban it on a state level, while others have not yet made a decision on its legality. It is important to note that until 2023 Farm Bill will address these matters, the legality of THC at the state level can vary widely, and consumers should always check their state’s laws before purchasing or using Delta-8 THC or Delta-9 THC products.

Delta-8 THC vs Delta-9 THC – Legality

Ignoring the Delta 9 loophole, Delta-9 THC remains illegal under federal law, although several states have legalized it for medical or recreational use. However, it is still illegal to possess, sell or use Delta-9 THC products at the federal level, regardless of whether they are used for medical or recreational purposes. As discussed earlier, this is only true unless it is hemp-derived, or unless the new farm bill will decide to make some clear order here.

It is important to note that the legality of Delta-8 THC and Delta-9 THC is a complex issue, and it is important for consumers to do their own research and understand the laws in their state before purchasing or using these products. Good luck with that…

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Medical benefits

Like Delta-9 THC, Delta-8 THC has shown potential in the treatment of various medical conditions. Some studies have suggested that Delta-8 THC may have antiemetic, analgesic, and anxiolytic effects, making it a potential treatment for nausea, pain, and anxiety. Additionally, Delta-8 THC has been found to stimulate appetite and can be used to combat the loss of appetite and weight loss associated with some medical conditions.

As the medical benfits of using cannabis is a huge field of study, we will devote a seperate article to it. However, when all debates are gone one thing remains true, which is the question is it good for you or not… My personal opinion is that if Delta-9 THC or Delta-8 THC have clear medical benefits (or even medicinal benefits) for you, this should be your decision whether or not to use it. However, under current regulations, nost people in the world are still denied this right and this is sad, especially when everyone see the huge medical benefits this plant is bringing us. Just be responsible when using it and act with caution.

As we can see in the article below, even Israel, the homeland of medical cannabis program, is now trying to restrict the access of medical cannabis to new patients.

Updates to Israel’s Medical Cannabis Program: Reduced THC Levels for New Patients

Updates to Israel’s Medical Cannabis Program: Reduced THC Levels for New Patients

V. Delta-8 THC vs Delta-9 THC: Which is Right for You?

For the best deals on Delta-8 THC, De;ta-9 THC, HHC and even on legal psychedelics, check our Deal of the day section, with new exciting opportunities on legal psychedelics and premium cannabis products.

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After comparing and contrasting Delta-8 THC and Delta-9 THC, you may be wondering which one is right for you. The answer depends on your individual needs and preferences.

If you are looking for a milder psychoactive effect and don’t want to experience the anxiety or paranoia associated with high doses of Delta-9 THC, products with low to medium levels Delta-8 THC may be a better option. Delta-8 THC has been reported to have a more relaxing and calming effect than Delta-9 THC, while still providing the euphoria and pain relief associated with cannabis use. It also has less of a “couch-lock” effect, meaning that it is less likely to make you feel lethargic or sedated.

On the other hand, if you are looking for a stronger psychoactive effect, or if you have a high tolerance to cannabis and want a more potent product, Delta-9 THC may be a better choice. Delta-9 THC is more widely available and has been studied more extensively than Delta-8 THC, which means that there is more information available about its effects and potential benefits.

It’s worth noting that the assumptions above are not written in stone and that today’s products are usually high-potency blends, so either you try for yourself to find what is right for you, or you look into the labels and start following how each compound and terpenes is affecting you. If you plan to use it for medical and not for recreational, it might be a smart move to consult a medical proffessional, as this is your health after all.

Whatever you do start low and grow slow, be responsible and use it with caution. Also. last but not least, have fun, as it is cannabis after all…

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VI. Everything might change with the 2023 Farm Bill

The 2023 Farm Bill is currently being constructed, and it is expected to bring changes to the legal status of hemp. A farm bill is an omnibus law that addresses a wide range of agricultural and food programs, and it is renewed every five years. The 2018 Farm Bill legalized industrial hemp, and the Domestic Hemp Production Program established hemp as an agricultural crop that can be eligible for USDA farm programs if it complies with USDA regulations. However, the 2018 bill did not legalize CBD for internal and medical uses, or synthetics like THC-O, which no longer fit the legal definition of hemp.

The industry has taken advantage of this confusion and created other products, such as delta-8 THC, HHC, and hemp-derived Delta-9 THC. As the new farm bill is constructed, it is expected that new policies will be put in place to clarify the legal status of hemp, including CBD and other cannabinoids, and to address any other issues created by the 2018 Farm Bill.

Delta-8 THC vs Delta-9 THC - Farm Bill — Delta-8 THC vs Delta-9 THC – Farm Bill

Once we will see what is the new legality of hemp-derived psychoactive products, we will see what products are going to be legally available in 2024.

VII. Hemp vs Cannabis

As we have seen, the legality of these psychoactive products is mostly determined by the source of the compounds and not by its psychoactive abilities. As both products can be made from either cannabis or hemp, it might help to stop and see the key differences between the two.

Hemp and cannabis are two varieties of the Cannabis plant, but they differ in their chemical composition, physical characteristics, and uses. The main differences between hemp and cannabis are:

Chemical Composition: Hemp and cannabis contain different levels of the cannabinoids THC (tetrahydrocannabinol) and CBD (cannabidiol), which are the two main active compounds found in the Cannabis plant. Hemp contains very low levels of THC, which farmers are trying to be less than 0.3%, while cannabis can contain much higher levels of THC, up to 30% or more. CBD levels can also differ between the two plants.
Physical Characteristics: Hemp and cannabis also have different physical characteristics. Hemp plants are tall, narrow, and have fewer branches, while cannabis plants are shorter and bushier with more branches and leaves. Hemp also has thinner leaves and can grow in a wider range of climates than cannabis.
Uses: Hemp and cannabis have different uses. Hemp was always grown for industrial purposes such as making paper, textiles, and building materials, as well as for its seeds, which are used in food and beauty products. Hemp is an amazing plant with many potential uses, such as Hemp plastic for example, with over 50,000 when last counted. CBD can also be extracted from hemp and used for medicinal purposes. Cannabis, on the other hand, is primarily grown for its psychoactive effects and is used for recreational and medicinal purposes.

In summary, the main differences between hemp and cannabis are their chemical composition, physical characteristics, and uses. Hemp contains very low levels of THC and is often grown for industrial purposes, while cannabis contains higher levels of THC and is used for its psychoactive effects.

Hemp-Derived THC Products vs Marijuana-Derived THC Products

VIII. Conclusion

In conclusion, Delta-8 THC and Delta-9 THC are two different cannabinoids with distinct chemical structures, uses, medical benefts and psychoactive effects. While Delta-8 THC is a newer and less studied compound, it has been usually reported to have a milder psychoactive effect than Delta-9 THC and may be a good option for those who are looking for a more relaxing and less potent cannabis experience. Delta-9 THC, on the other hand, is the more widely known and widely used compound, and has been studied more extensively for its potential medical benefits.

It’s important to note that both Delta-8 THC and Delta-9 THC can have side effects, and their use should be approached with caution. As with any cannabis product, it’s important to ‘start low and grow slow’ to find the right level of effect. That way you wll also avoid from wating medicine… It’s also important to purchase products from reputable sources and to ensure that they have been third-party tested for purity and potency.

Ultimately, the choice between Delta-8 THC and Delta-9 THC depends on your individual needs and preferences. By understanding the differences between these two compounds, you can make an informed decision and choose the product that is right for you.

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IX. Keep Yourself Informed

The world on Cannabis and Psychedelics is constantly changing. To make some order in this caos, we have created a special newsletter: The Cannadelics Sunday Edition, sent directly to your inbox every Sunday at 11am EST.

Join the Cannadelics Sunday Edition and stay up-to-date on the latest news and developments in the cannabis and psychedelics industries. Our weekly newsletter offers a hand-picked selection of industry news and research, along with exclusive insights into innovative products.

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The post Delta-8 THC vs Delta-9 THC: What Are the Key Differences? appeared first on Cannadelics.

2023 Farm Bill Under Construction: What to Expect For Hemp

February 16, 2023 Published by SDZ News

It’s that time again. The time for the federal government to put together another farm bill. The last one sure shook things up with its legalization of industrial hemp and derived products. But it also created many messes. Now with the new 2023 farm bill under construction, the big question is how it will affect the hemp industry.

What’s a farm bill?

What’s a farm bill? According to Congressional Research Services, it’s an “omnibus, multiyear law that governs an array of agricultural and food programs. It provides an opportunity for policymakers to comprehensively and periodically address agricultural and food issues.” It continues, “In addition to developing and enacting farm legislation, Congress is involved in overseeing its implementation. The farm bill typically is renewed about every five years.” As of yet, there have been 18 farm bills since they came into action in the 1930’s.

An omnibus bill is a bill that deals with an array of topics within one piece of legislation. Though it includes many varying and unrelated measures, the whole document gets passed by a single vote. These bills are often used to pass unpopular, and often completely unrelated, legislation that gets crammed in for whatever reason. A multiyear law implies that it sets policy for multiple years, and is only updated in that same time span. In this case, a new one comes about every five years.

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In earlier years, the farm bill was more about supporting commodity programs related to specific crops like “corn, soybeans, wheat, cotton, rice, peanuts, dairy, and sugar.” Things expanded out in 1973 when a nutritional element was included, followed by other elements like horticulture and bio-energy, research, and rural development. Now it encompasses even more.

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Some programs created by farm bills have no expiration date, and have permanent authority. This includes things like crop insurance. Such programs don’t need to be re-authorized per bill, like other programs, including the nutrition assistance program, and the farm commodity support program. Bills in need of re-authorization have a specific end date and expire.

The 2018 farm bill legalized industrial hemp

The last, and currently standing farm bill, is the 2018 farm bill – or The Agriculture Improvement Act of 2018, and it went into effect in December of that year. It expires this year.

Both the 2014 and 2018 farm bills deal with a certain amount of hemp legalization. In 2014, a hemp pilot program was established for research purposes, and ‘hemp’ was re-defined and separated from ‘marijuana’ with the following definition:

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“The plant Cannabis sativa L. and any part of that plant, including the seeds thereof and all derivatives, extracts, cannabinoids, isomers, acids, salts, and salts of isomers, whether growing or not, with a delta-9 tetrahydrocannabinol concentration of not more than 0.3 percent on a dry weight basis.”

In 2018, hemp was legalized for industrial purposes. The bill established the Domestic Hemp Production Program which amended the 1946 Agricultural Marketing Act. With the legalization of plants under the above definition, “This established hemp as an agricultural crop eligible for U.S. Department of Agriculture (USDA) farm programs, if it is grown under license and complies with USDA regulations.”

The legalization of industrial hemp means that hemp can be grown and used for industrial purposes. However, industrial purposes don’t include anything medical, or for any use as a treatment, or for ingestion. While regulation of industrial hemp went to the USDA, all other hemp uses remain under FDA regulation. At one point this was further established by Minnesota as per a Department of Agriculture response to a query by a member of the Minnesota Cannabis Association board in regard to CBD tinctures.

CBD not legal for internal use under 2018 farm bill

The mess created by the 2018 farm bill

The 2018 farm bill never legalized CBD for the internal and medical uses its so often sold for today. Nor did it legalize synthetics like delta-10; as synthetics no longer fit under the definition of a plant, which is integral to the legal definition of hemp. It also didn’t allow for the rest of the cannabinoid market that popped up. But there seems to be mass confusion over why, despite the basic logic of what does and doesn’t fit a definition.

From delta-8 THC to HHC to THCO, producers have taken the confusion of the legalization, and run with it. One of the big misconceptions for the public, is that lesser occurring cannabinoids like delta-8 can’t be extracted directly from the cannabis plant in high enough amounts for product production. Not enough of it exists, plain and simple. As such, for product manufacturing, synthetic processing must be used, which takes these compounds out of the legal definition. If the compounds are extracted naturally, then they fit under ‘hemp’, but none outside of THC and CBD exist in large enough amounts.

What the industry relies on, is the federal government not doing much about it. Going after weed products is getting more unpopular, and it’s a costly process to root out such a massive industry. In light of recent pardons, and its own promise to re-regulate the plant, its not likely the US government will attempt this. Though Shopify dropped clients selling these products (likely at the behest of the US government), stopping sales has proven difficult. In fact, it seems more and more that the best way to get rid of the cannabinoids market, is to offer the real product.

Naturally-Derived vs Synthetically-Derived: What’s The Difference?

Is the cannabinoid market really that bad though? As the only reported problems are associated with additives, no its not technically a big problem for the health and well-being of the population. Sure, its shady, complete with bogus lab testing; but when you consider the number of overdose deaths that come from legal and government-regulated drugs like opioids, and the overall deaths when including smoking and alcohol, its hard to find a reason to have an issue with the cannabinoids market.

Perhaps the worst we’ve seen, is that it breaks trademark law, which is unfair to established brands; and dangerous in terms of putting cannabis products in packaging recognized by children as a specifically known candy. And sure, without regulation we don’t know how clean the products are. But the lack of a direct death toll from cannabinoids in general, makes the industry much more innocuous than the government lets on.

The inconsistency of feelings toward the cannabinoid industry has led multiple states to enact their own legislation, either regulating the compounds or banning them. And the entirety of the industry, including CBD, is now a big topic going into the 2023 farm bill.

How will new farm bill affect cannabinoids like delta-8

What should we expect from 2023 farm bill for hemp and cannabinoids?

Like any bill, the farm bill takes some time to put together. It incorporates a wide range of subjects under the general heading of agriculture (along with whatever else gets shoved in), and requires months of writing, and arguing, and getting mad at one another, as bills tend to do. The 2023 farm bill is likely to include several provisions that relate to hemp and cannabinoids.

For one thing, the current dividing line between hemp and marijuana, is .3% THC. The 2023 farm bill may increase the allowable THC amount to 1%.

The current farm bill actually only deals with cultivation. As during product production, the THC can go above the boundary line, its thought that a provision might be included to allow higher THC amounts in what are called “work-in-progress” products, or products in the interim-processing phase when THC amounts might cross the line temporarily.

The 2023 farm bill may also erase the need for DEA lab testing; a provision instituted for the asinine sounding reason that if THC goes over .3%, then it becomes illegal to have…apparently even for a testing facility (you do the math on that one). Obviously it makes more sense to use other testing facilities to promote testing availability.

It also might take off the ban on obtaining a hemp license that those with drug convictions are subject to.

And last but not least, it may seek to officially close the loophole – perceived or real – that drives the confusion (and industry) of hemp-derived cannabinoid products.

What Does Federal Appeals Court Ruling Mean for Delta-8 THC?

In 2022, a federal appeals court (The Ninth Circuit panel in San Francisco) made a ruling on trademark infringement specifically, saying one company accusing another of selling counterfeit versions, was correct in its accusation. The product in question was a delta-8 THC vape cart. As you can’t trademark an illegal product, this ruling worked to legitimize the delta-8 industry; but never commented on basic product legality requirements, or issues of synthetics.

Different congressional bills have been introduced to close these gaps with specifics, but none passed yet. Its thought that there are a couple which have a chance of being included in the upcoming farm bill. HR 841 and S. 1698, the “Hemp and Hemp-Derived CBD Consumer Protection and Market Stabilization Act of 2021” and “Hemp Access and Consumer Safety Act”, respectively, deal with the allowance of CBD and other cannabinoids in dietary supplements and food.

Other laws to come up, and which could be at least partially included, include H.R. 6134 which seeks to establish safety standards and labeling requirements for cannabinoid products; and H.R. 6645 which seeks to attack the issue of synthetics by officially excluding synthetic derivatives.

2023 farm bill and synthetic cannabinoids

Conclusion

The 2018 farm bill created a lot of confusion around hemp and cannabinoids. Now we’ll have to wait and see what the 2023 farm bill does to clean up the mess. Or if it ignores it entirely.

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Deal Of The Day: 25% Off The Knockout Blend Gummies

January 30, 2023 Published by SDZ News

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What are the Knockout Blend Gummies and what makes it so special?

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As always, the best deals on high-potecy gummies, as well as other products featuring THC-P, THC-H and HHC-P are reserved for the subscribers of the Cannadelics Newsletter.
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Learn more about the Knockout Blend Gummies

What are high-potency gummies

High-potency gummies are edibles that contain a high dose of THC (Delta-9 THC or similar cannabinoids, such as THC-P, THC-H, HHC-P etc.). Hige-potency gummies are available in various shapes, flavors, and potencies, and are designed for recreational use, but some also find them effective for therapeutic use.

High-potency gummies made of Delta-9 THC usually contains 50 to 100 mg of THC in each, compared to the regular ones, with only 10 to 25 milligrams in each. Howeber, when you replace Delta-9 THC with THC-P or HHC-P the numbers are disfferent, as these strong cannabinoids could create in some people a much stronger effect.

What other high-potency edibles are there

High-potency edibles are any food or drink products that contain high levels of THC, or any alt-product that acts like Delta-9 THC, such as THCP, HHC-P, etc..

Here are some examples of other high-potency edibles: Brownies and baked goods,chocolates, gummies and candies, beverages, tinctures, capsules, softgels and concentrates.

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What other cannabis-based gummies are there?

There are many different types of cannabis-based gummies, beyong thos who contain THC or alt-THC. Some examples may include: CBD gummies, CBN gummies, THC/CBD combination gummies, Terpene-infused gummies, Multi-cannabinoid gummies: and more.

How to store the high-potency knockout blend gummies

Storing high-potency THC gummies, like the Knockout Blend gummies, is important to maintain their potency, flavor, and shelf life. Here are a few tips:

To keep the gummies fresh, keep them in an airtight container.
Protect them from high temperatures and humidity by storring them in a cool and dry place.
Avoid direct sunlight.
Always keep high-potency gummies out of reach of children and pets.
As an option, try storing them in the refrigerator (but be sure to keep them in an airtight container).

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How long do high-potency gummies take to kick in? What is the duration of the effects?

The onset and duration of effects from high-potency gummies can vary depending on several factors, including potency, dose, individual’s tolerance, personal spped of metabolism, and other factors.

All that said, usually it takes 30 minutes to 2 hours for edibles to take effect. Sometimes, the onset time can be faster when the gummies are consumed on an empty stomach. The effects of gummies and other edibles can last for 4 to 8 hours, but this can also vary.

As edibles takes a longer time to kick in, than smokables, It’s important to start with a low dose and to wait for the effects to take hold before consuming more. It’s a common thing among unexperience cannabis users to take a too-high dosage of edibles, in the first hour, as they are not aware that edibles needs their own time to take effect. As overconsumption of THC can lead to unpleasant side effects, you might want to take your time with edibles.

It’s also important to know that the effects from edibles might be stronger than from what you feel after smoking, so afain, take your time and enjoy the ride.

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What are the possible effects of using high-potency gummies

High-potency edibles like Knockout Blend gummies can have both therapeutic benefits, recreational and psychoactive effects, including: Relief of pain, anxiety, and depression, improved sleep, increased focus and creativity, euphoria and relaxation.

But, when consuming a too-high dosage (start low and grow slow!) you might also experience some unwanted side-effects, such as: anxiety, paranoia, and short-term memory impairment. Therefor, it’s important to consume high-potency gummies with caution. As always, it’s important to consult with a healthcare professional before using any new substance, including high-potency THC gummies.

Like with any substance, high-potency THC gummies like can carry some short-term effects, such as: overconsumption, drug interactions and cognitive and motor impairment.

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In conclusion, the high-potency Knockout Blend gummies offers a great choice for all cannabis lovers. Made from a perfect mix of three strong cannabinoids: THC-P, HHC-P, and THC-H, Knockout Blend offers a long-lasting and effective way of consuming cannabis.

With the current ‘Deal of the day’, you can get the Knockout Blend gummies with a 25% discount using the Delta25 coupon code and even save more by buying the 3-pack bundle. Subscribe to our newsletter to stay informed about the latest in cannabis and psychedelics and take advantage of all the exclusive offers and deals we have in store for our subscribers.

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About BinoidCBD

BinoidCBD, founded by health-conscious individuals, aims to promote CBD wellness by offering top-notch products that are both pleasurable and beneficial, without sacrificing quality and ingredient standards.

In their store, you can find products infused with various cannabinoids, including Delta-9 THC, Delta-8, Delta-10, Delta-11, THC-P, THC-O, THC-H, THC-B, HHC, HHC-P, THCV, and others. Popular offerings include vape carts, disposable vape pens, gummies, tinctures, diamonds, and flower products.

And with the Delta25 coupon code, you can save 25% on both individual products and bundles, making it a fantastic opportunity for anyone looking to purchase high-potency products.

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Deal Of The Day: 30% Off High-Potency Gummies

January 18, 2023 Published by SDZ News

If you want to try a real high-potency product, you would love our Deal Of The Day: 30% Off High-Potency Gummies, made from an effective blend of strog cannabinoids.

With 175mg in each of these tasty high-potency gummies and 20 gummies per jar (that’s 3500mg total!), you don’t need to take much in-order to feel the effects. Evolving from the previous popular 2000mg lights out collection, Delta Extrax made an extra effort to come with even better flavors, such as Blackberry Acai, Wedding Cake, Mango Coconut, Sour Peach, Root Beer and Kiwi Watermelon.

Each one of these high-potency gummies was created by an effective blend of 87.5mg Delta-8 THC, 70mg Delta-10 THC, 5mg THC-JD, 5mg Delta-9 THC, 5mg THC-H and 2.5mg THC-P. Looking on all these strong ingredients, melded together for an effective outcome, no suprise the lights out collection has become a top-selling line.

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Learn more about High-Potency Gummies and Edibles

What are high-potency gummies?

High-potency gummies (in most cases THC gummies, as this term usually refer to cannabis products) are candies with high levels of THC. Such gummies are often used for recreational purpose, but also for medical and medicinal. Using them properly can produce desirable effects such as euphoria, relaxation, focus, mental alertness, increased appetite and other feelings, usually associated with being ‘High’.

As High-potency gummies have high level of THC, they can be more potent than ‘regular’ cannabis products, with average levels of THC, so consume them in a responsible way, to avoide having negative effects if consumed in excessive amounts.

While you can find THC gummies with anywhere between 5mg and above, high-potency gummies usually have up to 100mg THC (Delta-9 THC) in each. Any products with more than 100mg Delta-9 THC is considered to be very high-potency and should only be taken by experienced users.

Examples of other high-potency edibles

Other examples of high-potency edibles may include any product that is eaten, such as: Cannabis-infused brownies or cookies, Cannabis-infused chocolate bars, Cannabis-infused tinctures or oils, Cannabis-infused butter or oil, Cannabis-infused honey, etc.

It is rare to find edible with over 100mg Delta-9 THC in each and as discussed before, unless you are an experienced user, you should always ‘Start low and grow slow’ to find your own perfect spot.

Risks of using high-potency gummies

The use of high-potency gummies may lead to a number of risks associated with it. Rare as they are, you need to be aware of the risk and consume THC in a responsible way.

Some of the potential risks include: Overdose (which can lead to unwanted symptoms such as anxiety, paranoia, panic attacks, and in very rare cases, even worse), Dependence (which can make it harder for you to stop taking THC), Impaired judgement (which can lead to accidents or injuries, especially when driving or operating heavy machinery) and Interaction with other substances.

Best practices when using high-potency gummies

When using high-potency gummies, it’s important to follow a few simple guidelines:

Start low and grow slow: Unless you have prior experience with the product, start with a relatively small amount and wait for a while before consuming more. It is especially important when using edibles, as they need much more time to take-effect.

Be aware of the legality: Be aware of the laws and regulations regarding these specific products in the area you are currently medicating. While using hemp-derived THC products are usually safe in the US, you should use common-sense and avoid medicating near kids, in schools, etc. Generally speaking it is also unwise to solisitate solicitate to other people… Try not to it.

Don’t mix high-potency gummies with other products or even worse, with other psychoactive substances. No really, don’t! Mixing any drug with another might end bad to you. High-potency products are strong enough, trust them.

Keep out of reach of children and pets. No furthere explanation is needed here, just don’t fo it. Ever.

Store high-potency gummies properly: Keep them carefully secured in an airtight container and in a cool, dry place. As before, try to move it as far as possible from the reach of children and if possible, use child-safe mechanism to avoide unwanted small hands reaching these gummies.

Consume responsibly. These are high-potency products, so act accordingly.

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THC Edibles 101: Everything You Need to Know

Each method of consumption has its own benefits, processes and effects. The way in which THC is consumed can affect the way it feels. We’re going to take a look at the traits of edibles, how they’re made, how they work and our top 5 products of 2022. Let’s do this.

THC Edibles 101: Everything You Need to Know

Everything You Need to Know About Cannabis Gummies

Currently, cannabis gummies are trending big time. Not only do they offer many advantages that smoking simply does not, such as added discretion and no carcinogens, but for most users, they also provide a much more potent and long-lasting high.

Everything You Need to Know About Cannabis Gummies

What Makes the Best CBD Gummies?

When searching for the best cannabis gummy, you’ll want to look at ingredients, dosing, and where they source their CBD from. CBD is now legal in most of the world and, with this, transparency should come. We’re going to take you through all of the important information surrounding CBD and, of course, our top CBD gummy products. Let’s go.

What Makes the Best CBD Gummies?

Learn more about edibles

Best Deals On Amanita Muscaria Mushrooms – A New Magic Mushroom

Just in time for 2023, the list of legal psychedelic products is extending with the introduction of Amanita Muscaria mushrooms, the first ever legal magic mushroom to become widely available to us all. Currently, in you live in the US (unless you live in Louisiana…) you can get this product shipped to you by regular mail. The same applies to most of the world, as this magic mushroom never found its way to the ist of controlled products, so it is legal to buy, sell and use!

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How To Make Your Own Weed Gummies

Are you interested in learning how to make your own weed gummies? This can be done with standard cannabis oil or tinctures, with CBD, delta-9 THC, THC-H, THC-P, or even delta-8 THC. Here are some basic instructions for how to make high-potency gummies all by yourself.

How To Make Your Own Weed Gummies

Shrooming the Modern Way, With Psilocybin Edibles

Over the last few years what was once a niche and relatively underground product has been taking the recreational drug world by storm. Psilocybin edibles… Learn more about how to make and use these attractive high-potency gummies.

Shrooming the Modern Way, With Psilocybin Edibles

Learn more about cannabinoids

Learn more about Delta 9 THC, Delta 8, Delta 10, HHC, THC, THC Edibles and Psilocybin Mushrooms.

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The post Deal Of The Day: 30% Off High-Potency Gummies appeared first on Cannadelics.

Counting Sheep: Cannabis Improves Insomnia in Recent Study

January 5, 2023 Published by SDZ News

When looking at the population at large, certain specific issues shine through as growing problems that affect a large percentage of people. Like stress, diabetes, and insomnia. A new study now adds to the growing body of information on sleep disorders, and indicates that cannabis improves insomnia in a large number of sufferers.

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The insomnia problem

We’ve all got our issue in life, some of us more than one. For some its an inability to keep off that belly fat, for others it might be that bad back that never seems to get better. And still others aren’t capable of having just one drink without becoming the ultimate party animal every time. There are plenty of problems to have in life, and for some of us, it’s not a during-the-day issue, but a through-the-night issue.

According to the Sleep Doctor, approximately 70 million people have some sort of sleep disorder. Insomnia is just one of these issues, but the main one, with 30% of adults experiencing this problem at any given time. About 2/3 of the population total have the issue in their lives. It’s one of the most common medical issues that drives people to seek medical help.

What exactly does ‘sleep disorder’ indicate? “Sleep disorders are conditions that disrupt healthy sleep and also cause daytime symptoms. Sleep disorders can affect when you are able to fall asleep, how much sleep you get, and the quality of your sleep.”

Insomnia

In terms of how these disorders are classified, “The most widely used system for classifying sleep disorders is produced by the American Academy for Sleep Medicine (AASM). The third edition of the International Classification of Sleep Disorders (ICSD-3) describes 60 sleep disorders, divided into seven categories. These main categories include:

Insomnia
Sleep-related breathing disorders
Circadian rhythm sleep-wake disorders
Central disorders of hypersomnolence
Parasomnias
Sleep-related movement disorders
Other sleep disorders”

So, this insomnia, what does it mean? “Insomnia occurs when people who have plenty of opportunities for rest find themselves unable to fall asleep, waking during the night, or waking up earlier than they’d like. Insomnia may be diagnosed as short-term or chronic.”

Ask A Doctor – Types And Causes Of Insomnia

And how are those two differentiated? Short term indicates “fleeting symptoms of sleeplessness that last for less than three months. Often related to stress, short-term insomnia can sometimes develop into a chronic condition”. While chronic indicates “When the symptoms of insomnia are more persistent — happening at least three days a week for three months or more — a doctor may diagnose chronic insomnia.”

If you’re wondering what other sleep disorders exist, the list includes breathing issues, like sleep apnea; circadian rhythm sleep-wake disorders, like irregular sleep-wake rhythm disorder; central disorders of hypersomnolence, like narcolepsy; parasomnias, like sleep terrors; and sleep-related movement disorders, like restless legs syndrome. All other issues fit under ‘other sleep disorders’.

Recent study shows cannabis improves insomnia

Cannabis is under investigation for tons of things at this point, and sleep disorders are just one subject of interest. By now, there is already plenty of evidence of cannabis as a tool to aid in healthier sleep. But it always is good to have more reports confirming something, than less. So a recent study which shows that cannabis improves insomnia symptoms in a large percentage of participants, is just more ammunition in the fight for legalization.

The study, entitled Medicinal cannabis improves sleep in adults with insomnia: a randomised double-blind placebo-controlled crossover study, “aimed to assess the tolerability and effectiveness of the Entoura-10:15 medicinal cannabis oil on sleep in adults with insomnia.” The study was a six week trial, which was a randomised, crossover, double-blind, placebo-controlled investigation, with a total of 29 participants. This is a generally small number.

Participants received either a placebo or cannabis oil called Entoura-10:15, which is comprised of 10 mg/ml delta-9 THC and 15 mg/ml CBD. The amount was titrated over a two-week period from 0.2–1.5 ml/day. After that came a washout week, and then crossover (a term that indicates everyone is in an experimental group at some point). Participants kept daily diaries to keep track of tolerability. Investigators measured effectiveness in three ways: 1) Measuring saliva midnight melatonin levels; 2) Validated questionnaires, like the Insomnia Severity Index; and 3) Fitbit activity tracker on the wrist.

Results indicated that Entoura-10:15 was well tolerated overall. In terms of how effective, 60% of the study participants didn’t qualify any longer as insomniacs after a two-week period. This was seen through improvement in nighttime melatonin levels by 30% (the placebo group experienced a 20% decline).

CBN Yourself to Sleep Tonight with These Products

Results also showed improvement in time asleep and quality of sleep. In the experimental group, light sleep went up by 21 minutes per night in comparison to the placebo group. And the quality of sleep in the experimental group improved by 80%, which led to higher levels of daily functionality. Overall, study investigators concluded that “Our trial suggests Entoura 10:15 medicinal cannabis oil to be effective in improving sleep in adults with insomnia within a 2-week intervention period.”

The role of CBN

The cannabis oil used in the previous study was formulated of THC and CBD. So, all effects are related to these compounds specifically. However, there are other aspects of the cannabis plant that are looked into for their sleep-improving benefits. One such compound of interest is the cannabinoid CBN. This cannabinoid actually has the designation of being the first cannabinoid isolated from the cannabis plant, and it was thought for quite some time, that it was the psychoactive constituent.

CBN (cannabinol) is not a delta THC, as in, it doesn’t share the same chemical formula as delta-9, delta-8, or delta-10. Instead, its chemical formula is C₂₁H₂₆O_2,and it doesn’t share this formula with any other compounds. However, much like the THCs, CBN does activate CB receptors in the brain. CBN comes with the positive of not being mentioned in the Single Convention on Narcotic Drugs or the Convention on Psychotropic Substances, which means there is no global mandate to regulate the compound.

This doesn’t make it legal necessarily in any given location, either. For example, in the US, as an analogue of THC, CBN activities can be prosecuted under the Federal Analogue Act. Like the rest of the cannabis plant, years of prohibition slowed study on this compound, and even what I’m mentioning next, still lacks the kind of repeated testing that can really draw effective conclusions. Some studies that show positive benefits, do so in conjunction with THC use, making it hard to know which compound is exerting the beneficial effect, or if the combination is required.

Back in 1975 (yup, that long ago), these two studies were done: Effects of delta9-tetrahydrocannabinol and cannabinol in man, and Pharmacologic interaction between cannabinol and delta9-tetrahydrocannabinol. Both studies turned up the possible results that CBN acts a bit like delta-9, and that in conjunction, it might cause more extreme effects. They were not concerned specifically with sleep though, or done on CBN alone.

More research is now trickling in. Like this study, Use of a water-soluble form of cannabinol for the treatment of sleeplessness, led by Dr. Robert Kaufmann who is the Director of Research for Shaman Botanicals, LLC. The study allowed participants to access the product on their own, and choose their own dosage.

DIY: How to Make Your Own CBN

The study “surveyed individuals with sleeplessness who were taking a water-soluble product of cannabinol (CBN) treated using nano technology, which has recently become available.” It came to the conclusion that “This nano treated CBN product rapidly induced sleep initially and after awakening, increasing the time and quality of sleep in most individuals suffering from sleeplessness.” This was based on the results of 60 respondents who completed surveys.

Another study by the company Zelira Therapeutics used the drug ZTL-101, which is a combination of THC, CBN, and CBD in the ratio of 20:2:1. There were 23 participants, and researchers determined that “Two weeks of nightly sublingual administration of a cannabinoid extract (ZTL-101) is well tolerated and improves insomnia symptoms and sleep quality in individuals with chronic insomnia symptoms.” This is a study by a company into their own product, however, and should be taken with a grain of salt. This second one also uses a combination only, and does not speak to the individual benefits of CBN.

Conclusion

Whether looking at it from the perspective of THC and CBD, or other cannabinoids like CBN, recent research has done much to elucidate how cannabis improves insomnia in many people. Does this mean everyone will benefit? No, of course not. And it doesn’t mean that smoking the plant has the same benefits as specialized medications either. But what this research shows, is that cannabis can serve many purposes, and helping people count sheep, seems to be one.

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