If You’re a Lazy Stoner, It Might Be Genetic

One of the most common misconceptions about cannabis users is that marijuana makes them lazy, unmotivated, slothful bums that just lay around watching movies, playing video games, and eating a pantry’s worth of snacks on the daily.

While no one can deny that you might get the munchies and want to relax after smoking weed sometimes, the fact of the matter is, these side effects are related to the strain of cannabis you’re using and that plant’s specific genetics. It can’t be blamed on cannabis use as a whole. So, although many people think cannabis users are lazy because of the cannabis, the real reason might be something else entirely. Actual scientific research suggests that the “lazy stoner” stereotype is not only inaccurate, but the complete opposite is true in most cases.  

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The Lazy Stoner Stereotype and Why It’s Nonsense

It still remains unclear where this stereotype originated, or why it continues to have such a stronghold over public perception of cannabis users. What we do know is that the lazy stoner stereotype is overplayed, inaccurate, and downright damaging. Outdated cannabis stigma is one of the primary reasons that people continue to vote against legalization measures.

“If we think about the typical ways you think of cannabis, it’s making you more relaxed and maybe not as motivated to get out of the house, and as an exercise researcher, that’s concerning,” says Angela Bryan, a professor in CU Boulder’s Department of Psychology and Neuroscience. “On the other hand, there’s some really good longitudinal data that shows that long-term cannabis users have lower weight, lower risk of diabetes, better waist-to-hip ratio, and better insulin function. It’s kind of a scientific quandary, so we thought we should do investigations to see whether there really is a problem that might be happening, or if cannabis could even be a benefit to physical activity.”

It’s true that cannabis can help people relax and even sleep better, but according to a study of 2,092 U.S. adults, frequent and light cannabis users generally reported more physical activity than non-users. The results were published last week in the Harm Reduction Journal. When compared to earlier researched conducted at the University of Colorado a couple years prior, the picture is pretty clear: cannabis users are definitely NOT lazy.

In both studies, participants had their physical activity monitored by accelerometers, which are devices used to track the length and intensity of physical activity (not including water sports). This is much more accurate than just relying on respondents to fill out questionnaires, as that method is often subject to self-reporting biases.

Researchers found that overall, occasional cannabis users had activity rates that were similar to non-users, although slightly better. However, “frequent cannabis users engaged in more physical activity than non-current users,” the researchers wrote in their findings. There were a few limitations to account for, like the fact that many cannabis users were starting off with lower body mass indexes than non-users, and respondents who smoked tobacco in addition to cannabis tend to be less physically active. Either way, the lazy stoner as we know it from media portrayals, simply does not exist.

The Lazy Gene

So that brings us to the main point, that cannabis use is unrelated to laziness, and there could be deeper, underlying issues at hand. Regular physical activity is a crucial part of living a healthy lifestyle – this is a hard fact, but the majority of Americans spend their waking hours sitting: be it driving from place to place, sitting in front of the tv or computer, or even sitting outside watching their kids play, fishing, etc. Many of our recreational activities have grown quite sedentary. A lifestyle void of physical activity can lead to a variety of health issues including obesity, cardiovascular disease, and cancer.

While most of us are inclined to see laziness as a character flaw, Frank Booth, a professor in the University of Missouri College of Veterinary Medicine has a different theory. When observing the animal world, we can see that some species are more likely to be physically active while others are known to be “lazy” – like German Shepherds vs American Bulldogs. Focusing on this concept, booth was able to identify a specific gene related to physical inactivity in rats that he believes can also play a roll in human sedentary behavior. He published his results, titled “Overexpression of Protein Kinase Inhibitor Alpha Reverses Rat Low Voluntary Running Behavior”, in the journal Molecular Neurobiology.

“Previous research has shown us that genes play some role in physical inactivity,” said Frank Booth, a professor in the MU College of Veterinary Medicine. “As inactivity leads to chronic disease, we wanted to identify which genes were involved and discovered one in particular, the Protein Kinase Inhibitor Alpha gene, that played a significant role.”

In the 2009 study, Booth took 80 male rats and bred them with 80 female rats. He then placed the rats in voluntary running wheels, similar to those sold in pet stores, and kept track of which rats ran the most and least. Over the next decade, Booth selectively bred the active rats with other active rats, and the lazy rats with other lazy ones, to see if genetics are at play. He found that the “lazy” rats, had significantly less of the Protein Kinase Inhibitor Alpha gene.

“What makes gene therapy difficult is that most chronic diseases are not caused by just one gene,” Booth said. “For example, there are more than 150 gene variations involved in type 2 diabetes. However, this study is paving the way for future research to identify other genes that might be involved in physical inactivity in humans as well.”       

According to government statistical data, diseases associated with physical inactivity account for more than 11% of total health care spending in the United States, a whopping $138 billion. “Physical inactivity contributes to more than 40 chronic diseases,” Booth said. “Rather than focusing on ways to treat chronic diseases after they have already developed, understanding the contributing factors to physical inactivity could help prevent those chronic diseases from occurring in the first place.”

In addition to genetics, many other factors can contribute to feelings of laziness. Prescription medications, poor diet, alcohol, tobacco, and lack of exercise can keep someone in the cycle of inactivity.

… Or Maybe It’s All in Your Head

Often, we confuse the state of feeling lazy, with actually being lazy as if it’s an inherent character trait. Although some may experience genetic issues like I mentioned above, many just get stuck in the psychological cycle of being lazy. If you think about it, even most of people we personally view as lazy in our own lives are able to find tasks and activities that motivate them.

This applies to most people, honestly. The majority of us are very driven in areas that we find easy, stimulating, or worthwhile. Activities that provide instant gratification (like shopping, gaming, messaging with friends, posting on social media, etc.) are much easier to do willingly and without procrastination.

Activities that require serious effort and long-term commitment can be more difficult to see through to the end, because it takes much more time and work to reap the rewards. For someone to put forth the effort to begin a project, they need to value the reward more than their loss of comfort. Unfortunately, many people are reluctant to trust that their efforts will even pay off at all. Simply put, if there’s no guarantee that they’ll succeed, why bother trying at all? People who are already confident and self-aware are more likely to take on challenging endeavors and overcome any existing lazy tendencies, because they trust in their ability to succeed.

Another consideration is that many of humans just lack the foresight to think about the long-term effects of their actions. Like binge drinking all weekend without caring about how tired, hungover, and awful you may feel and look the following day. Remember, just because something feels good in the moment does not necessarily mean it should be pursued, just like some situations that are hard or painful don’t need to be avoided.  

You can think of the brain as a road map, or large web, in which all the possible mental states exist. Happiness, sadness, anxiety, jealousy, and yes, laziness, are all in this web. At multiple times throughout every day, we make decisions that move us in a certain direction, and it can be very easy to get stuck going in the same direction.

For instance, you just experienced a painful breakup and you’re feeling a bit depressed. You’ve been holed up in your home for weeks and some of your close friends call, urging you to spend time with them and get your mind away from things. You can chose to go with them, which could break the cycle of sadness that you’re current trapped in… or you could chose to stay in, and continue wallowing in misery. It might feel awkward, going out for the first time in so long and conversating with people when you’re used to being alone, but it will be rewarding and beneficial for your mental health… whereas the alternative seems easier but keeps you stuck in the same emotional state.

The same thing applies to lazy tendencies. We can make choices that keep us sedentary (scrolling social media, watching tv, etc.), or we can take actions that push us in a different direction (working out for 30 minutes, going for a walk, bike ride, etc.). In many situations, laziness is just a state of mind that we need to actively overcome.

Final Thoughts on the Lazy Stoner

Cannabis does NOT make people lazy… the lazy stoner does NOT exist. It’s a nonsense stereotype that serves no purpose other than to keep cannabis prohibited. Stop thinking of yourself as inherently lazy. True laziness can be caused by any number of factors such as genetics, diet, health conditions, medications, and mental state. Sometimes, these issues can be exacerbated by cannabis (let’s face it, we all know a lazy stoner that seems to live up to every negative stereotype that exists), but that doesn’t mean there is always a correlation.

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Why Cannabis Edibles Don’t Work For Some People

Cannabis edibles are trending big time. Not only do they offer many advantages that smoking simply does not, such as added discretion and no carcinogens, but for most users, they also provide a much more potent and long-lasting high. Unfortunately for some people, edibles just don’t work… at all.

This can leave a consumer with many questions. Are the edibles bad or is there anther reason why they’re ineffective? Can someone be immune to cannabis edibles? Surprisingly, yes, this is possible; and it relates to the complex way in which our bodies absorb and metabolize cannabinoids.

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The difference between edibles and other consumption methods

Let’s start with the basics… why do cannabis edibles affect our bodies so differently than smoking or vaping? Just like anything else that goes through our digestive systems, cannabis edibles need to metabolize before the effects can be felt. It’s not an instant sensation like the aforementioned alternatives would be and it can take anywhere from 30 minutes to 2 hours to kick in, but the effects last much longer.

Food and supplements need to be processed by the liver, meaning more of the cannabinoid will be filtered out of your system because of the slower absorption time. There are also some individual factors that impact the onset and intensity of the effects, such as the specific cannabinoid consumed or a person’s metabolism.

Take THC for example; whether you’re consuming Delta 8 or Delta 9, the body processes all tetrahydrocannabinols the same, by converting them to a metabolite known as 11-hydroxy-THC. This process is known as first-pass metabolism. According to neuroscientist and medical cannabis adviser, Dr. Adie Rae, “The liver is responsible for this transformation, and specifically, the drug-metabolizing enzyme known as cytochrome P2C9 or CYP2C9. Even when you smoke, your liver still sees some delta-9 and turns it into 11-hydroxy-THC, but you get way more 11-OH when you eat cannabis.”  

When it comes to other cannabinoids, they also produced metabolites as well. Most abundant are hydroxylated 7-COOH metabolites, which are derivatives of CBD/cannabidiol. Like THC, CBD has first-pass effects in the liver. However, our bodies absorb these metabolites differently, and unlike THC, a large portion of CBD is excreted unchanged in the feces. So in other words, when you consumes a CBD edible, a significant portion of the active cannabinoid is going straight to your bowels, waiting to be wasted.  

You will still feel the effects of CBD even orally, but it will take a while longer and won’t be anywhere near as noticeable as the effects from a THC edibles, psychotropic activity notwithstanding. However, the effects you do feel will last much longer than if you had inhaled the CBD, and that rings true with any orally administered cannabinoid.

There are numerous benefits to choosing edibles over smokeables. First and foremost is the impact on your health. When you smoke – anything, cannabis included – you’re exposing your body to carcinogens and other harmful chemicals. Another reason people might choose edibles is because of the long-lasting effects. If you’re using cannabis to manage a chronic condition like ongoing pain, anxiety, etc., it makes more sense to eat an edible a few times a day as opposed to finding somewhere that you can smoke or vape every hour or two. They’re also more discreet, making them easier to travel with and use on the go or in the workplace.

Are some people immune to cannabis edibles?

Technically, yes. Because edibles can be so discreet, potent, and beneficial, many people find themselves seriously disappointment when they take some and realize they don’t work for them. Obviously there is no exact number on this, but even in my personal life I’ve met quite a few people who say they don’t feel anything when they use edibles, myself included.

Ok, to be fair, I wouldn’t say I don’t feel anything… but I definitely don’t experience any type of psychoactive effects. When I use edibles, I feel really tired and nothing more. Estimates indicate that anywhere from 10-15% of cannabis user do NOT experience the desired effects from cannabis edibles, and we can thank our intricate and complicated digestive systems for that.

Research shows that the effectiveness of cannabinoids administered orally can vary based on numerous different factors. Generally speaking, when people are unable to process cannabis edibles it can be narrowed down to one of two complications: digestion/absorption issues or metabolic issues.

Digestive issues

Sometimes, using cannabis for Gastrointestinal disorders can be a bit of a catch 22. On one hand, cannabis can be extremely helpful for someone suffering from these conditions; on the other hand, GI issues can often have a negative impact on how the body digests and absorbs cannabinoids. If a person is unable to absorb fats and nutrients, it’s highly likely that they will not be able to absorb cannabinoids either.

Disorders that can affect how your body absorbs and digests cannabis include: Fat malabsorption syndrome, Irritable bowel disease, Irritable bowel syndrome, gallbladder removal surgery, Lipase deficiency, Pancreatic issues, Issues with bile production, Cystic fibrosis, Chronic diarrhea, or history of other GI surgery.

Additionally, several medications are known to affect digestion and absorption as well. Just think about how many medicines you’ve come across in life that list “gas, bloating, constipation, diarrhea, nausea, etc.,” as possible side effects. This applies to both pharmaceuticals and over-the-counter medications.

Metabolic issues 

Another possible scenario is that metabolic issues are hindering your body’s ability to process cannabinoids. When using edibles, the cannabinoids are metabolized in the liver before being dispersed into your bloodstream. To be fully processed, the cannabinoids must pass through the incredibly complex CYP450 metabolic pathway, in which metabolic enzymes are produced to help our bodies further utilize certain compounds.

If a person’s body produces too little or too many CYP enzymes, they won’t be able to properly metabolize cannabis products. Some will metabolize them too quickly or too slowly so they won’t be able to properly take effect, others won’t metabolize them at all.

There are many conditions that can affect metabolic enzyme production. According to research from Prof of Pot, one of the reasons could be genetic. “There is a very strong genetic component that influences cannabis metabolism. These genetic components are the reason each individual responds to cannabis so differently. Some people are considered rapid cannabis metabolizers, while others are ultra-slow metabolizers. How your body processes cannabis could be genetic.”

Other elements that could work against your metabolism include age, muscle mass, diet and medications, age, hormone function and production, level of physical activity, and environmental factors such as temperature.

Could it be something else?

The good news is, aside from the above health conditions, there are some simple issues that could be preventing you from experiencing cannabis edibles to their fullest. One of the most obvious being that the dosage is too low, in which case, just find products with a higher concentration of cannabinoids and if that’s not possible, simply eat a few extra.

Assuming you’ve already taken that into account, then you can consider another common issue – maybe you’re using the wrong type of edible. All edibles are made with different strains, meaning they have a different blend of terpenes, minor cannabinoids and other compounds. If you’ve been trying mostly the same types of products to no avail, it might be time to start looking at some different brands and really learning more about the specific ingredients in each edible you’re trying.

And finally, another common issue I hear about is people trying to take edibles on an empty stomach. This is something I typically run into with recreational users rather than medical ones. It’s a commonly held belief that if you’re drinking to get drunk, the quickest way to achieve that is by drinking on an empty stomach, and many people apply the same principal to cannabis.

However, when it comes to edibles, it doesn’t work quite the same way. Yes, the cannabinoids will be processed faster if you take your edible on an empty stomach, but that’s not necessarily a good thing. Again, with cannabis edibles, absorption time and metabolism are everything. If your body metabolizes cannabinoids too quickly, you won’t get the desired effects. Try eating a nice meal, drink some water, and think of the edibles as an ultra-relaxing dessert.

Final thoughts

For some people, edibles simply don’t work no matter what they do. Just like certain types of conventional medications don’t work for everyone – for example, I don’t do well with antibiotics – cannabis edibles don’t work for everyone either. Some patients claim to benefit from dietary supplements (Lipase specifically), or by making sure to accompany their edibles with an additional fat.

If nothing helps, you might want to try a sublingual tincture, nasal spray, or vaping. You could also try speaking to your local dispensary workers or even check out a cannabis helpline to see what options might be more suitable for you.

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How to Test Delta-10 Products to Ensure They Are Real

What to do when a substance is unregulated, but flying off the shelves anyway? The best answer is to make sure there’s some method to test it, to confirm that it is what it’s supposed to be. This is the case for newer forms of THC currently hitting the market. Now, a laboratory has put forth a way to test the authenticity of both delta-8 and delta-10 products, to ensure they are real.

With new ways to test delta-8 and delta-10 products, getting quality vapes and oils is getting much easier. Both of these new THC versions provide slightly different benefits from delta-9, and can be beneficial for people experiencing too much delta-9-related anxiety. We’ve got great delta-8 THC deals for you to check out what it’s like to use an alternate form of THC.

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What are delta-8 and delta-10 THCs?

Delta-8 THC – Delta-8 THC is a naturally occurring derivative of delta-9 THC, the most commonly understood cannabinoid of the cannabis plant. Delta-8 is produced through oxidation when delta-9 THC comes into contact with oxygen, causing small amounts of it to lose electrons, which converts it into delta-8 THC. The only structural difference between the two, is the placement of a double carbon bond. For delta-8, it sits on the 8th atom in the chain, and for delta-9, on the 9th. The chemical structure for both is: C21H30O2.

The two compounds are very similar, producing many of the same medical effects, however, they have some stark differences as well. Delta-8 THC produces less psychoactive effect, so users don’t experience as intense of a high. It also causes less anxiety and paranoia in users, making it the optimal answer for cannabis aficionados who experience a lot of anxiety with delta-9. Delta-8 is also associated with a more clear-headed and energetic high, something that makes it better for physical activities, even athletics.

Delta-8 THC is not newly discovered, but has been known about since around the time delta-9 was found. It was partially synthesized by Roger Adams in 1941, with total synthesis established by Raphael Mechoulam in 1965, along with delta-9 THC which was isolated first in 1964. It was even the subject of medical testing, particularly by Mechoulam, who established delta-8 THC as a treatment for the nausea and vomiting associated with cancer treatments in kids, actually showing an elimination of vomiting in the children. As we know already though, the world was slow to catch on.

Delta-8 made a resurgence recently with the application of the 2018 US Farm Bill which opened the door for industrial hemp cultivation, and production of hemp-based products. As a naturally occurring derivative of THC that can come from hemp, but one that requires human processing in order to create large enough amounts for use, delta-8 THC might fit into a legal loophole – but not for sure. This has not been specified further to give clarity to the situation by either the DEA’s Interim Final Rule, or the more recent USDA Final Rule. Until the definition of ‘synthetic’ is updated to identify if human processing fits the definition, delta-8 will likely remain legally ambiguous.

Delta-10 THC Delta-10 THC, though nearly identical in structure to both delta-8 and delta-9 THCs, is a little different. The first difference should be obvious. The double carbon bond sits on the 10th atom in the chain. However, more importantly, it cannot be created on its own in nature. It is a 100% synthetic compound that requires human help for chemical processing, which puts it in a different category than its previously mentioned counterparts. We’ll get to why this matters in a second, but for now, let’s take a quick look at the strange story that brought us delta-10 products.

Delta-10 THC was brought to scientific attention later than delta-8 and delta-9, and happened as part of an accident at the company Fusion Farms, in California, in the year 1980. California is the location for raging forest fires, and flame retardant chemicals are used frequently to limit, or stave off, the damage of these fires. Fusion Farms was in the business of creating cannabis oil extracts at the time, and didn’t realize that their outdoor flowers were being contaminated by these (toxic) chemicals.

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No one thought it would be an issue at the time, and the company personnel continued producing the oil, just to find strange crystals that had never been seen before, forming. Upon further and more intricate inspection, it was found that these crystals were actually a different form of THC, this time, the never-before-seen delta-10, with the double helix on the 10th atom. So, unlike it’s THC brothers already mentioned, delta-10 can only be synthesized by way of a chemical catalyst, in this case, flame retardant chemicals. Other, safer catalysts, have been used since that time.

Unlike delta-8 and delta-9 which are naturally occurring, and therefore capable of falling under the definition of hemp, delta-10 does not. As such, it remains regulated under DEA criminal code 7370 which lists anything not under the definition of hemp, to be a controlled substance. This goes for all synthetic THC compounds. Whereas the Farm Bill allows hemp derivatives with up to .3% THC, it does not cover synthetics at all, and this means that regardless of the THC quantity in the product, or where the product is sourced from, it’s still illegal.

In that way, delta-10 does not fit into a legal loophole, and remains a schedule I controlled substance for now. Of course, lots of cannabis products fit under this definition federally, but with the growing number of locations in the US and worldwide that have approved legal medical or recreational cannabis programs, the use of delta-10 is perfectly fine in many places. Plus, with such constant changes, and an inability to catch up legislatively, it’s quite possible that being federally illegal won’t stop the growing delta-10 market at all.

How to test delta-8 and delta-10 products

It should be clear from everything just written, that these two compounds are highly unregulated, with confusion about the legal loophole of one, and even more confusion online about the illegality of the other. With no government standard for the production of these products, or standards for final products, users are at the mercy of sellers and their claims, which can often be a dicey prospect.

In fact, without regulation, when dealing with extracts of these kinds, it’s hard for the buyer to know they’re getting the right product at all. Think about how easy it is to buy a vape cartridge without really knowing what’s inside? Sales industries – especially unregulated ones – are not generally known for their complete upstandingness, often passing off fake or low-quality products since, in the most essential way of putting it, no one is legally watching.

And this is where ACS Laboratory comes in. In an effort to institute some sort of testing ability to confirm that these substances are really these substances, ACS created the Potency 12 test to identify delta-8 and delta-10 products. ACS is a DEA-licensed, 3rd party, independent testing facility that provides analysis for products in the cannabis industry.

With the invention of Potency 12, ACS now provides an answer above general industry standards, which haven’t caught up to these new products yet. The Potency 12 test “specifically targets and separates Delta-8, Delta-9, and Delta-10 THC”, according to ACS Laboratory’s principal scientist, Aixia Sun, who also serves as a certified lab director for cannabis. She went on to say, “Many labs cannot test Delta-10 without a DEA license and often misidentify lesser-known analytes as Delta-9 in the process.”

In answer to the question of what creates this difficulty in testing, Sun continued, “The problem is Delta-9 and Delta-8 THC are positional isomers, making it difficult for laboratories to separate the two during testing. Two Delta-10 THC stereoisomers are also challenges because they are so elusive that laboratories often misidentify them for CBC or CBL using the industry-standard methodology.”

ACS isn’t just looking for ways to identify these compounds, it also looks to ensure certain levels of safety. One of the things it continues to do, is develop new and improved safety tests to make sure extracts don’t contain residual solvents in them. The Potency 12 test is actually an offshoot of the standard Potency 11 test, which is already capable of quantifying the total of 12 different cannabinoids: Delta-8, Delta-9, Delta-10, THCA, THCV, CBDA, CBD, CBDV, CBGA, CBG, CBN, and CBC, in products.

delta-10 THC

According to ACS Laboratory president and founder, Roger Brown: “As the hemp industry evolves, laboratories must continuously re-evaluate methods to ensure they are producing valid results… Laboratories who fail to rise to the occasion will ultimately put their clients at risk.”

Conclusion

When it comes to new products in an unregulated market, it can really be a free-for-all, with anyone capable of putting out a halfway decent product (or half-way decent looking product), edging in, with little regard as to what they’re passing off to customers.

This makes it great to have some way to test delta-8 and delta-10 products to separate good from bad (or better from worse). ACS Laboratory and the Potency 12 test inject a little more clarity as to the quality of products on the market, how many fakes are flying around, and where to find the best products. It’s nice to know that if you’re being sold a delta-8 or delta-10 THC product, that its authenticity can now be verified.

Hi there, and welcome to CBDtesters.co, your best location for all cannabis-related news globally. Join us regularly to stay on top of the quickly changing world of cannabis, and sign up for our newsletter so you always know what’s going on.

Resources

All About Delta 8 THC Distillate
The Many Faces of Tetrahydrocannabinol – Different Types of THC and Their Benefits

Why Using THC Is Good for the Eyes
DIY: How to Make Delta-8 THC at Home New Vaping Bill: Effective April 26th Extra Potent 11-hydroxy-THC and the Power of Cannabis Edibles
What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8THC)

What Are Delta-8 THC Moon Rocks And Where To Get Them?
The CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers). The Legality of Delta-10 THC – Where It Stands
What Medical Conditions Could Benefit Most from Delta 8 THC?

The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc) and the Best Delta 8 THC Deals. The Marijuana Conspiracy and the Strangest Experiment in Modern History
Delta-8 THC and Athletics – Why the Two Go Together Delta 8 / 9 / 10 / 11… How Many THCs Are Out There? The Bizarre History and Promising Future of Delta 10 THC
Delta-8 THC Exploits Fantastic Legal Loophole Precise Cures – How Nanotechnology Enhances Cannabis Products
Delta-8 THC Delivery Methods: Best Way to Get It in You

delta-8 and delta-10 products

DisclaimerHi, I’m a researcher and writer. I’m not a medical professional, I have no formal legal education, and I’ve never been to business school. All information in my articles is sourced from other places which are always mentioned, and all opinions stated are mine, and are made clear to be mine. I am not giving anyone advise of any kind, in any capacity. I am more than happy to discuss topics, but should someone have a further question or concern, they should seek guidance from a professional in the relevant field for more information.

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Edibles and children: Poison center calls rise

If a 3-year-old finds a cookie on the table, chances are they are going to eat it.

Even if it is made with marijuana or THC, CBD, or other components of cannabis.

As more states have legalized the use of marijuana and an ever-widening range of derivative products, it’s not surprising that more children are being exposed — including by eating marijuana edibles. A research brief published in the journal Pediatrics found that between 2017 and 2019, there were 4,172 calls to regional poison control centers about exposures to cannabis in babies and children through age 9. About half of the calls were related to edibles.

The frequency of these calls, and the percentage related to edibles, went up over the two-year period. Not surprisingly, the exposures were about twice as common in states where marijuana use is legal as in those where it is not.

More calls about edibles involving younger children

The most common age group involved was 3- to 5-year-olds, which makes sense: this is the age where they are old enough for parents to take their eyes off them for a minute or two, but not old enough to understand why they shouldn’t eat that brownie, gummy bear, or piece of chocolate.

Thankfully, the effects of these exposures were mostly minor — but in 15% they were moderate, and in 1.4% they were severe. In rare cases, significant ingestion can lead to trouble breathing or even coma. That’s the problem with edibles: it’s hard to know how much cannabis is in each one, it’s easy to ingest a lot, and the effects can last a long time.

It’s important to remember, too, that this was just a study of calls to poison centers. It’s impossible to know how many exposures there have been that were never reported — including how many went completely unnoticed by parents or caregivers.

Safety first: Children and cannabis

Clearly, there will need to be some regulation around labeling and child-safe packaging. But as an immediate step, parents and others shouldn’t buy marijuana edibles that might appeal to children (just like it’s best not to buy detergent pods that look like candy). If you do buy marijuana edibles that a child might want to eat, they need to be stored securely, out of reach, always.

When parents bring their children to visit friends, it may be a good idea to add marijuana edibles to the list of safety issues to ask about. Think of something along the lines of, “Hey, our daughter is still little and curious, so we like to ask about things like matches, guns, medications, marijuana edibles, or other things that might be dangerous for her if she gets into them. Is there anything that might be in her reach?”

It might be a bit awkward, but if you make it quick and routine, you can decrease the awkwardness. And ultimately, it’s worth a bit of awkwardness to keep your child safe.

Follow me on Twitter @drClaire

The post Edibles and children: Poison center calls rise appeared first on Harvard Health Blog.

The Marijuana Conspiracy and the Strangest Experiment in Modern History

What do you get when you combine the progressive atmosphere of the 1970s, clashing cultural views and restrictions imposed on women, and an extensive and very secretive government study on cannabis with results that mysteriously vanished? You get one hell of a marijuana conspiracy, that’s what.

Who doesn’t love a good conspiracy theory right? I mean, the entire history of marijuana in the western world is shrouded in conspiracy. A healing plant, one that can possibly heal cancer, with no real side effects… and it’s banned for decades all to fulfil the agendas of some greedy politicians and business owners. Nothing really screams machination louder than that.

Even in stoner legends we hear the tales of “secret government facilities” running experiments on unsuspecting potheads. You know, the stories of your old college roommate’s second cousin who participated in the one, he was locked in a room decked out with psychedelic décor while nerdy scientists watched him smoke unbelievably dank government super-weed. He went home stoned, thousands of dollars richer, and with a seriously interesting story to tell during the next smoke sesh.

On the surface, the real-life version of these government funded cannabis studies weren’t much different. Participants were housed in a research facility that was arranged to feel somewhat leisurely, and they got paid good money to smoke extremely potent government pot. But what exactly was going on behind the scenes? Surely they weren’t just lounging around, watching movies, eating snacks, and smoking good weed for months on end? What was the objective here? What was the Canadian government trying to accomplish and learn with these studies? To this day, the answers to these and many other questions remain uncertain.

As study participant Sharon Purdy mentions, “It was such an upside-down set of circumstances. Here you were under the best medical supervision available with the best pot available, kind of, doing something illegal legally.”

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About the Movie

The movie, titled The Marijuana Conspiracy – set to debut for streaming on 4/20, tells the story of this dubious study from the perspective of the women involved in it. The idea for the film came from none other than a study participant herself, Doreen Brown. Many years after the experiment ended, Brown starting sharing her story more publicly which eventually led to a full investigative report conducted by Diana Zlomislic from the Toronto Star in 2013.

Watch The Marijuana Conspiracy – Streaming April 20, 2021!

The film uncovers the motivations of those involved in conducting the experiment such as the funders, designers, and implementers; as well as the experiences and backgrounds of the test subjects. Although some aspects are clearly dramatized and some of the characters’ backstories are fictionalized, the overall narrative stays pretty close to the line of truth.

Most importantly, the film discusses how researchers collected a “mountain of data” but never publicly released a single finding. Even now, the extent of what was uncovered during that 4 month period is still a big mystery. So, if you plan on watching any movies this year for 4/20, make sure to add The Marijuana Conspiracy to your list.

A Bit of Canada’s History with Cannabis

In the 1970s, the entire western world was at odds when it came to cannabis legislation. On one side were conservatives who argued that cannabis was the downfall of society, poisoning our youth and turning them in to lazy, impulsive losers. On the other side, and the side that we all personally align with here, were progressive thinkers who believed the plant was not only harmless, but held medicinal value and should be legalized for all to use.

For the most part, if you were pushing for cannabis legalization back then, you were on the fringe. No mainstream media outlets or politicians were inclined to be very vocal on the subject, unless of course, they were discussing the dangers of cannabis and their various ‘reasons’ for keeping it prohibited. To give you a quick example of what I mean, the Commission of Inquiry into the Non-Medical Use of Drugs released a report in the late 60s finding no evidence of the gateway drug theory that experimentation with soft drugs like pot inevitably leads to harder drug use, like meth and heroin.

The release of these results was met with some serious hostility, with members of some medical and political circles claiming that decriminalization and legalization of marijuana “would be tantamount to legalizing ignorance.”

Ironic how they chose the word “ignorance”, isn’t it?

It’s clear that cannabis was a threat of some sort to the powers that be, and governments were dealing with this plant in different ways. In the U.S., President Nixon dedicated $15 million to hire a small army of lawyers that would prosecute dealers and users nationwide. In Canada, Prime Minister Trudeau (the current prime minister’s father) launched a royal commission to investigate and study the effects of this plant. The thought was that, through enough research, they could definitively prove that this plant was unsafe and thus, should remain illegal.

“To make a sound decision, it is necessary to have valid information respecting the effects of the drug on health and social functioning,” wrote British psychologist C.G. Miles in a preliminary report on cannabis research. Miles is the mastermind behind the experiments that followed. In 1970, he launched his first study by recruiting six unemployed male volunteers to build wooden stools while smoking increasingly potent cannabis strains for 70 days straight – no leaving the facility and no communication with the outside world.

The purpose was to see if cannabis affected productivity. Would the men be motivated to continue building those stools for $2 apiece the more stoned they got? As it turned out, cannabis had very little to do with it. The men remained productive, regardless of weed consumption, until they unexpectedly went on strike and demanded higher wages. Once the pay was increased to $2.75 per stool, their output was right back on track.

“Evidence shows that the inability or unwillingness to earn following high cannabis consumption can be overcome by an economic incentive,” Miles wrote. Interesting findings, but how reliable were they? Miles couldn’t say for sure, but he convinced his superiors to let him investigate this phenomenon further through a series of longer and more in depth research projects.

A Social Taboo: Women and Cannabis

At that time, there was almost no clinical research examining the effects of cannabis on females and even to this day it remains a topic rife with questions and concerns. A 1972 report on cannabis by the Le Dain Commission highlighted the lack of scientific data in this field. The question of how cannabis effects women was also at the top of Miles’ list, as he mentioned in a preliminary report to Ontario’s Ministry of Health.

“The necessity for repeating this experiment with women is occasioned by the almost complete lack of information about the behaviour of females under even acute cannabis intoxication.”

Watch The Marijuana Conspiracy – Streaming April 20, 2021!

The idea of women smoking weed has always been a bit of a social taboo. Even in today’s progressive pro-pot society, men have always dominated and monopolized the cannabis scene. Historically, it has always been more accepted, and even encouraged, for men to take risks. We was women have always faced a much harsher cultural restrictions than men, from the clothes that are deemed “appropriate” for us, to the number of sexual partners we’re allowed to have, and yes, even the things we consume.

Anything even mildly intoxicating was off limits, because our delicate little minds simply couldn’t handle a few puffs a joint without going off the deep end, right? Check out this quote from a British professor of psychiatry at the University of London:

“A young Englishwoman on one occasion smoked two-thirds of a home-made hashish cigarette which had not upset her husband; she promptly developed gross incoordination of the hands, astasia (inability to stand or walk), rapid pulse and dyspnoea (shortness of breath).”

Ouch. She didn’t even finish the joint and completely lost it… but hey, at least she didn’t upset her husband right? Undeniably sexist but unfortunately, a sign of the times. Did marijuana really turn women into fragile, unproductive burdens on society who had absolutely no control over themselves? Miles was about to find out.

The Winter of 1972

On January 31, 1972, Miles and his team recruited 20 young women ages 18-25 to take part in “one of the weirdest experiments in Canada’s history.” For 98 uninterrupted days, the women were held up in a Toronto-area hospital just north of Chinatown. Ten of the women – the experimental group – smoked increasingly potent cannabis strains daily and the other half – the control group – were there simply for observation. The two groups were housed in different parts of the hospital.

Watch The Marijuana Conspiracy – Streaming April 20, 2021!

For the experimental group, their brains, hearts, kidneys, livers, blood and urine were analyzed multiple times per day while a team of nurses kept records of their moods and behavior 24/7. Although the control group was not required to smoke, they were allowed to, and both groups could purchase as many mild joints as they wanted for 50 cents apiece at a store that also sold alcohol, junk food, cigarettes, magazines and some toiletries and accessories.

The basis of this study was a sort of micro-economy in which the women were required to cover all of the expenses (expect bed and water) for the duration of their stay. They earned money the same way the men did in the study two years prior, via the production of small goods.

They worked on Guatemalan back-strap looms, which, if you’re unfamiliar with them, are primitive wooden devices used for weaving textiles and fabrics. The women were weaving colorful, wool belts with knotted tassels that had to meet a couple quality standards – they needed to contain two colors and measure exactly 132 centimeters in length. At first, it could take each woman up to 8 hours to create one belt, but eventually that time was cut down dramatically. The women earned $2.50 per belt that passed inspection.    

Extreme Isolation

“The first month or so was the best part—getting high, having fun, and making friendships with the other women,” recalled Doreen Brown. “There were no worries about ‘normal’ life, like working at a job I didn’t enjoy, paying rent, or supporting myself in general. It was an escape.”

However, as time went on, much of the lighthearted fun quickly faded. As the “experimental government super-weed” continued to get more potent and the isolation started to wear on them, the women’s mental health began to deteriorate. Communication with the outside world was only permitted via writing and they weren’t allowed to step out of the hospital for the entire 98 days. Some equated it to “psychological torture” and a few from the experimental group refused to continue past the halfway mark.

“The isolation, I found it very hard,” Brown recalls in an interview with the Toronto Star. “I’d be looking out the windows thinking, ‘I’d love to go out for a walk just to get out of here.’ It probably — even though I was with these nine other women — increased my loneliness.”

Watch The Marijuana Conspiracy – Streaming April 20, 2021!

“I saw a few people get kind of unhinged,” Purdy says. “It gradually built up in our systems so that your peripheral vision was shot. There were things flashing through the air that weren’t there. It felt like you had an iron lung. Not coughing. I just mean you felt heavy. It definitely had a build-up effect.” The isolation also took its toll on the non-smoking group. Marcia Smith’s roommate, a woman named Misty who was part of the control group, also quit the experiment just before it ended.

“She withdrew,” Smith recalls. “She went into a cocoon. She broke down “There were few protections in place for the young test subjects in 1972. Today, researchers who receive government funding must abide by a stricter code of conduct.

“You cannot go and take people and lock them up in an artificial environment and pretend these are real-life conditions,” says Benedikt Fischer, a professor in the faculty of health sciences at B.C.’s Simon Fraser University. “The ethical standards and scrutiny has changed dramatically.”

Everyone and Everything “Seemed to Vanish”

To this day, the extent of what researchers discovered during those 98 days remains unknown because the data from the study was never released – not publicly, and not even to the participants. By the time the women left that facility, they were broken, isolated, confused, and covered in so many track marks from blood testing that doctors had to give them notes to prove they participated in a study and were not drug addicts.

They were paid thousands of dollars to essentially smoke extra strong weed and make accessories for months on end, all funded and controlled by the federal government, but strangely, the results were buried and even many of the people who conducted the research seemed to “vanish”, according to participants and reporters.

 “I want to know, I want to know,” says Brown. “The dosages. What they found psychologically, physically. I feel ripped off, taken advantage of. It’s just like it didn’t happen. I feel like, yeah, you gave three months of your life for what? Were the results that horrible that they didn’t give them to us? You wonder. I think they might have supported legalizing marijuana. That’s why they didn’t come out. I don’t know. It leaves you with a lot of questions.”

She’s not the only one who believes that. According to the Toronto Star, some of the study’s documents eventually landed in the hands of an economist at Texas A&M University. After analyzing the data, he confirmed that “despite smoking a lot of high-grade cannabis under fairly dystopian circumstances the women in the mandatory weed group remained perfectly rational and worked their butts off.” Yes, he actually said, “worked their butts off”.

The results were politically inconvenient because they showed cannabis in a favorable light, and some suggest the study wasn’t a “study” at all, but rather expected to function as some kind of smear campaign against cannabis legalization, masked as clinical research. One of the main themes of the film, The Marijuana Conspiracy, is the idea that the entire project was actually a conspiracy.

Over the next few decades, the women involved in the study made several attempts to get more information from the Addiction Research Foundation on what happened to them during those few months in 1972. Unfortunately, all to no avail. In 2009, C.G. Miles passed away, so that door was shut and locked, but one of the junior researchers on the project, Dr. Galfrid Congreve, confirmed that his team did actually “product mountains of data”, although he also, did not elaborate any further.

Watch The Marijuana Conspiracy – Streaming April 20, 2021!

Final Thoughts

Conspiracy theories and marijuana go hand in hand, but this one is more than just off-the-wall stoner lore… this really happened and because the results of the study didn’t align with the government’s anti-cannabis sentiments at the time, they promptly swept everything under the rug, in hopes that no one would ever find out stoners can be productive members of society.

If you want to watch this movie, you can stream it on Fandango Now or AppleTV, this April 20th. And don’t forget to subscribe to The CBD Flowers Weekly Newsletter for more articles like this one and exclusive deals on flowers and other products.

The post The Marijuana Conspiracy and the Strangest Experiment in Modern History appeared first on CBD Testers.

Precise Cures – How Nanotechnology Enhances Cannabis Products

As the cannabis industry expands, it also gets more technologically advanced. Within the last few years, a new trend has started which will change how we use cannabis for consumption, especially on the medical front. With nanotechnology, cannabis products can be made to fit a precise diagnosis, and delivered to the exact point necessary.

Nanotechnology might be all the rage when it comes to newer cannabis delivery methods, but when it comes to all the rage in newer products, its all about delta-8 THC. If you still haven’t experienced delta-8, and how it gives a less-anxiety-producing, and clear-headed high compared to delta-9, now is a great time to take advantage of our delta-8 THC deals, and give it a shot.

What is nanotechnology?

Nanotechnology is a branch of technology that involves manipulating particles on an atomic level, with sizes under 100 nanometers. Which – to give a frame of reference – is about 1000 times the thinness of a piece of paper. Nanotechnology is similar to nanoscience, which attacks the same topic, but from the physics side. The two topics are very much intertwined.

In physics, different fields investigate how masses of different sizes behave. Astrophysics examines the nature of how large objects behave, whereas particle physics – on the other end – investigates how the very smallest of particles behave. And particles of these two different extreme sets, behave in their own strange ways. In terms of nanotechnology, particles often conduct electricity better, offer more strength, different reactivity to chemicals, and magnetic abilities.

One of the abilities of nanotechnology, is the ability to force together liquids that would ordinarily not go together: think oil and water. This is an emulsion. When done on particles of bigger sizes, it’s called macroemulsion or microemulsion. When it happens to particles at the size of 20-200 nm, it’s called nanoemulsion. Mico and macroemulsions are used in food products, and chemical industries like for pesticides. Nanoemulsions are newer, and used primarily in pharmaceuticals, cosmetics, and by biotech companies.

emulsion

Nanotechnology and medicine application

This process of putting together unlike substances – emulsions, allows for non-water soluble medications to be absorbed by human beings. The process of taking two immiscible liquids and turning them into one liquid, is done with an emulsifying agent like a surfactant (substance that reduces surface tension). By being absorbed into the bloodstream at a very quick rate, nanoparticles can deliver medication more quickly and effectively. Nanoemulsions are also created to increase the effectiveness of medications at their point of interaction.

Nanoparticles can be used as diagnostic tools, to mask the taste of oily liquids, to protect drugs from hydrolysis and oxidation, and to deliver medicine in a targeted fashion. They can also lengthen the time frame of a medication, and increase bioavailability. On top of all this, they can deliver stem cells, create heat, be metallic, or even be radioactive.

To give an idea of what it means to have a targeted drug delivery system, consider that with nanoparticles, instead of a drug being ingested, digested, and then put into the bloodstream where it effects the entire body, the medication can be delivered straight to the necessary site, bypassing the rest of the body. If there are infected cells, nanoparticles can attack them directly, without hurting healthy cells around. Think about how any time you take an antibiotic, it kills all the good bacteria in your stomach and digestive tract leading to all kinds of problems with reflux and superinfections. With targeted applications, these negative effects wouldn’t necessarily have to exist.

How insanely specific can these delivery systems be made? Well, researchers at MIT just created a cancer drug by combining two nanoparticles. The drug, with these two nanoparticles working in conjunction, does two things. It can both target the cancer cells in patients, and deliver a treatment to the infected cells. That’s a pretty cool one-two punch.

Nanotechnology and cannabis

We know that nanoparticles are made by essentially smashing two liquids that don’t actually mix, into one liquid. We know that this is accomplished using a surfactant, or surface tension lessening agent. And we know that once employed, a nanoparticle can provide a couple different services in disease fighting, like the ability to locate a specific site, and the ability to deliver medications to that site. On the website ‘Neurology of Cannabis’, Dr. Daniel Stein published the article Cannabis & Nanotechnology in 2020, which addresses the growing field of nanotechnology and cannabis applications.

Says Stein, when it comes to cannabis, there are several diseases like cancer, Parkinson’s, diabetes, multiple sclerosis, and intense inflammation that are already being looked at in regards to cannabis nanotechnology. Since cannabinoids can be stored within nanoparticles, and delivered to a specific and targeted site, cannabis medicines can be stored, protected, and then delivered for a controlled release without degrading. Nanotechnology can even detect and locate diseases by the first few damaged cells, and deliver a cannabinoid to modify the cell’s behavior before more damage can occur.

cannabis and nanotechnology

One thought is that if a nanoparticle can identify and focus on a specific cannabinoid receptor right when a disease is first starting to grow, it might be able to pull a 180degree turn, and keep the entire inflammatory process at bay. Other researchers are working on nanoparticles of a ‘superclass’ which would have the ability to treat illnesses across a much broader spectrum. Future research into the use of nanotechnology and cannabis will focus on making the physical particles stronger, increasing the bioavailability, and improving on routes of administration via pills, injections, or sublingual drops, according to Stein.

Future versions of nanotechnology might include ways to maximize absorption and minimize side effects to create the most potent products possible. Considering all the different varieties of cannabis, with all their specific properties, companies can use nanotechnology to offer custom-made therapeutic products. General benefits could also be enhanced through bioengineering to create a more effective version of nearly anything.

Nanotechnology and the blood brain barrier

The blood brain barrier is a barrier that exists around the brain, and which keeps particles from being able to penetrate into the brain. Drugs that cause a person to feel different mentally, have crossed the barrier. In fact, the barrier can be thought of as a bouncer that keeps unwanted molecules out of the brain.

So when it comes to taking medications for anything that would effect the brain, like antidepressants, or for treatment of nervous system disorders like Parkinson’s or multiple sclerosis, it’s important to get active compounds into the brain. In answer to this, researchers are currently working to engineer lipid nanocapsules that will contain cannabinoids, that will be able to get through the blood brain barrier, and deliver treatment to areas of the brain.

Nanotechnology and cannabis edibles

Cannabis edibles are becoming more widely used these days with tons of options for food and drink-related products. However, edibles are tricky in that its hard to define how a specific person will absorb them, and how quickly they will actually start working. The company Sunderstorm started manufacturing Kanha Nanotech Gummies, which CEO of the company Cameron Clarke says should kick in within 15 minutes. At the very least this dissuades people from taking a second dose too early, and possibly overdosing on THC.

It seems there is already quite a building competition between brands in the ‘nanotechnology for cannabis edibles’ department. Back in 2019, as Trait Biosciences – a Toronto-based cannabis company, introduced its own product line developed from technology which transforms fat-based cannabinoids to water-soluble ones, it warned consumers against the very technology it was employing, if it was coming from another company.

cannabis nanotechnology

Yup, as the company put out its nanotechnology line of cannabis products, it warned consumers “Nanoparticles can permeate into many different types of tissues and you can’t really control that.” And that comes from Dr. Richard Sayre, the Chief Scientific Officer for Trait.

This, of course, doesn’t make what Sayre is saying untrue, in fact, its quite the opposite. He essentially pointed out possible faults in his own company’s products by pointing this out, as well as mentioning his general concern over the use of emulsifying agents like surfactants, and their ability to accumulate in a human system.

There are also other questions which can’t be accounted for yet, like whether nanoparticles can pass from a mother to her unborn child, and if nanoparticles can accumulate in different parts of the body, like the heart, liver, or lungs. Says Dr. Anubhav Pratap Singh, University of B.C.’s Faculty of Land and Food Systems assistant professor, people should know about risks associated with nanotechnology ingestion, especially when the particle size goes under 100 nm.

Companies that sell nanotechnology cannabis products

There are already plenty of companies using nanotechnology to produce cannabis products. Sunderstorm and Trait have already been mentioned, but there are lots more. One such company to be aware of is Geyser Brands, which reportedly closed a deal with Chinese HMI – Hanma Investment Group, which is China’s biggest hemp conglomerate, and a major global technology innovator. Geyser is a cannabis company that develops health and wellness products. They create CBD and hemp-based preparations for conditions like anxiety, pain, and insomnia, using patented nanotechnology delivery systems to allow for slow release.

When it comes to companies specifically in the CBD field which are using nanotechnology, there’s Pressure BioSciences, Inc, a technology company specializing technology solutions, consumables, and, pressure-based instruments. In 2020, it was reported that Pressure signed a deal with Can B Corp for a CBD oil processing system to create a water-soluble nanoparticle solution.

There’s also CBDLiving, which according to COO Sean McDonald, helps with the problem of bioavailability in edibles. Edibles are known to have a low bioavailability. Sometimes only 4-20%, according to McDonald, is actually taken up by the body. He stated, “By nanosizing the protein down to a molecular level, the protein is more easily absorbed into the body, thus increasing the bioavailability to 90 to 100 percent.”

cannabis edibles

Another is EmbarkNano, formerly Axiomm Technologies, which is coming in from a slightly different direction. Instead of producing a nanoparticle product directly, EmbarkNano produces a precursor to a nanoparticle, in the form of a micro goo, called µGOO. This special goo makes it easy to create nano products, and in that sense acts as a general base for product manufacturing. µGOO is available to other companies, and can help keep R&D budgets in check by offering this service. Companies can then use the goo to build their own individual products. Like a white-label starter kit for nano cannabis products.

Conclusion

A 5-second internet search will tell you that the field of nanotechnology for cannabis use is competitive and growing. By this time next year, there will likely be at least a hundred products out using nanotechnology for cannabis delivery, or other purposes. It should be kept in mind that nanoparticles are like little rebels, doing what they please, and often in an unpredictable way. So perhaps before we get too comfortable in this new nano-sized world, we should make sure that it’s safe, and not doing harm as it gets us our meds.

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Resources

Delta 8 Syringes, the Best Vape Ban Workaround
Delta-8 THC Delivery Methods: Best Way to Get It in You
Are CBD-Infused Beverages The Next Big Thing?
How Vape Mail Ban Will Hurt Kids More
What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8THC)
Will Legal Synthetic Cannabinoids Take Over Cannabis Industry?
Delta-8 THC and Athletics – Why the Two Go Together
The CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers). 11-hydroxy-THC and the Power of Edibles
Why Vaping CBD Oil Is My Preferred Delivery System
The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc) and the Best Delta 8 THC Deals. Chocolate Interferes with THC Testing and Complicates Edibles Dosing
It’s Not Your Parents’ THC – Welcome Cannabidiolic Acid Methyl Ester Delta-8 THC Contaminated Products, or Just Bad Press? Delta 8 Syringes, the Best Vape Ban Workaround
Why the Vape Ban Is Happening, and How It Will Impact Online Vape Sales Are Delta-8 THC Syringes the Most Practical Way to Medicate?
Extra Potent 11-hydroxy-THC and the Power of Cannabis Edibles

Disclaimer: Hi, I’m a researcher and writer. I’m not a medical professional, I have no formal legal education, and I’ve never been to business school. All information in my articles is sourced from other places, which are always referenced, and all opinions stated are mine, and are made clear to be mine. I am not giving anyone advise of any kind, in any capacity. I am more than happy to discuss topics, but should someone have a further question or concern, they should seek guidance from a professional in the relevant field for more information.

The post Precise Cures – How Nanotechnology Enhances Cannabis Products appeared first on CBD Testers.

Delta-8 THC Delivery Methods: Best Way to Get It in You

We know there are a lot of ways to take different drugs, but that not every way works for every drug. When we think of something like a hypodermic needle, chances are, heroin will come to mind, and probably not cannabis. But should it? As we (thankfully) start moving away from smoking these compounds, other ways of ingesting them arise. When it comes to cannabis and compounds like delta-8 THC, here are some of the best delivery methods available today that don’t involve smoking or vaping.

Delta-8 THC is the new answer to the anxiety and paranoia caused by delta-9 THC in standard marijuana. And if you’re looking to try delta-8 THC, there are plenty of delivery methods to get the best possible effects from it. Take a look at our awesome delta-8 THC deals and give this newer version of THC a shot.

Last chance: Get Delta 8 vape cartridges for only $10/cart!

How is it usually done?

The most common way that cannabis has been used throughout history, is as a smokable product. Long before there were laboratories to create all kinds of high-tech vaping devices, and before there were cookbooks full of edible recipes, or the ability to make tablets, there was smoking. Even back then, vaping was a thing, although vapor would have been created the good old fashion way, by heating a substance over time until it vaporized.

There is plenty of evidence that cannabis was used in other ways through history. For example, as a topical treatment for skin ailments. But none of these other ways would have detracted from lighting the plant on fire as the primary way to consume it. And so, for something like cannabis, the idea of smoking it, goes hand-in-hand with the drug in general. This means that the majority of people using it, are subjecting themselves to the detriments of breathing in smoke, which is bad regardless of the material burning. While vaping is often weirdly demonized, and called unsafe, the sheer injury and death statistics of smoking vs vaping say otherwise.

After all, since the beginning of vaping back in the early 2000’s, right up until early 2020, there were all of 68 confirmed deaths related to vaping, and 2,807 hospitalizations, according to the CDC. The comparative number is the number of cigarette deaths per year, and that in the US is 480,000, also according to the CDC. Somehow, the CDC has turned this comparison into vaping being an ‘epidemic’. It seems the only ‘epidemic’ here, is an ‘epidemic’ of people choosing a safer smoking method, and causing themselves less harm. It’s an epidemic of people doing the generally smarter thing.

In fact, when using words like ‘epidemic’, its best these organizations stick to where the problems actually are. Like opiates, which killed in the neighborhood of 50,000 people in 2019 alone – a trend which was started by our very own pharmaceutical companies and the government regulatory bodies that were supposed to look out for us. Or alcohol, which is essentially the leading cause of preventable death in the world, accounting for as many as three million deaths worldwide each year, and 95,000 deaths in the US alone from excessive alcohol.

Cannabis delivery methods

When thinking of cannabis in general, any relevant delivery method will be viable. However, when dealing with something like delta-8 THC, which is an oxidized version of delta-9 THC, only occurring naturally in very small amounts, the idea of how it can be consumed becomes more relevant. So, let’s check out delivery methods other then smoking and vaping.

Oral methods – pills, oils, edibles, and syringes

Apart from smoking and vaping, oral administration is most popular. However, there is way more than one way to do this. Let’s take a look at the options:

oral delivery methods

Pills/tablets/capsules/soft gel capsules/tinctures – Like with any other medication that’s taken in this way, cannabis, and derivatives like delta-8 THC, can be taken in standard medication form – as a solid pill, or as a capsule containing decarboxylated flower or oil, that can be strain specific, full spectrum, or a specific cannabinoid like delta-8 THC or CBD.

The other option is for sublingual administration. Sublingual administration means putting an oil, tincture, or dissolvable tablet under the tongue for quicker uptake into the blood stream through the massive connection of blood vessels under your tongue and in your cheeks. This also allows a compound to bypass the digestive system, like it will have to do if it is swallowed down as an edible or pill. This digestive process turns it into C21H30O3, which is called 11-hydroxy-THC, whereas allowing it to absorb sublingually means a quicker onset, since it hits the bloodstream faster. Bypassing the digestive system makes it closer to the high obtained through smoking.

EdiblesEdibles are the other form of oral administration, and instead of looking like medicine, they look like food. Edibles can range from a batch of home-made chocolate-chip weed cookies, to well-portioned lab-made gummies. Regardless of what form the food takes, the main aspects of edibles are that they taste good, are easy to get down, and portioned specifically.

With more precise laboratory ways to measure portions, newer cannabis companies are creating edibles with very precise amounts, often segmented within the piece of food. I’ve had chocolate CBD bars where every square was exactly the same, and cannabis gummies that were segmented with each segment being 5mg. Edibles can be candy, liquids, baked goods, sauces, butter, and more. You can find edible products for whatever aspect of the cannabis plant you want most, in whatever form you want it.

Syringes – The idea of cannabis and syringes is a new concept, but it’s not exactly how it sounds. While the term ‘syringe’ might conjure pictures of junkies shooting heroin, cannabis syringes, which are one of the best delta-8 THC delivery methods, are simply large plastic syringes with no needles, in which oil can be put. Why is this method beneficial? Oils are often dense, and it can be hard to know the exact amount being used. The syringes don’t do anything particularly special, but they have a measuring scale so users can be more precise in their usage. Generally speaking, syringes are used for sublingual admiration, and make that process much easier.

Dermal administration

As the word dermal implies, these are methods that have to do with having the compound come into contact with – and be absorbed into the bloodstream through – the skin. Most people probably don’t think of it this way, but you can actually put a cannabis application on your skin, and have it absorb into the bloodstream.

skin delivery methods

Patches – Patches can be seen in medicine for different reasons and for different ailments. One of the predominant reasons is for pain management, though we’ve gotten very used to seeing them in today’s culture for nicotine administration as a way to avoid smoking. Most patches are a piece of plastic with an adhesive coating, which is infused with some amount of medicine in a specific amount. Patches allow slower release for absorption, meaning they can last a long time – all day, or all night. Though cannabis patches are often used for pain in a specific area, they can also be used for any other benefit of the plant.

Topicals – Creams/lotions/oils – Cannabis, and it’s derivatives like delta-8 THC are often used with skin delivery methods, using products like creams and lotions. Many of these products offer relief or benefits that don’t include psychoactive effects, as these products have not necessarily been decarboxylated to turn THCA into delta-9 THC. As with other delivery options mentioned, this is not a hard and fast rule, with some products containing high amounts of THC, and some containing other cannabinoids like CBD, CBN, or delta-8. Topicals can be used for medical benefits like skin rashes or pain, or simply to moisturize, and promote healthy skin.

Injections

Injections – IV and IM – You’ll most likely never do this, or maybe that’s me speaking to the truths of today, without considering the changes of tomorrow. Whether it will actually become a ‘thing’ to do outside of a medical setting, is hard to say, but it certainly gives a good option. To be clear, cannabis injections have been used for around 50 years, so it certainly isn’t anything new.

IV administration has been used mainly for delta-9 THC, and a major benefit of it is that it gets rid of the problem of variation in bioavailability between people. Active compounds are not always available for the body to absorb, even if in the body, and different people will have their own physiological aspects that can lower or raise bioavailability. With IV injections, everything is absorbed, and this is no longer an issue. In that sense, this is the most precise way to dose.

IV injections relate to sticking a needle in a vein. IM, or intramuscular injections, relate to sticking a needle in a large muscle for administration. If you ever had to take a shot in the butt, this is why.

Is it possible for people to do this on their own? Well, maybe, but it would have to become a much better process first. This reddit post was made by a guy who was able to self-inject cannabis kief. It is not a standard process, its not even advisable by the guy who did it, and there are probably better ways to do it. However, it gives an idea of what a person might expect from doing such an activity, and brings up the real possibility of cannabis injections being a more mainstream application measure in the future.

delta-8 THC delivery methods

Nasal sprays, eyedrops, inhalers & inserts

The idea of injections might still be too extreme for the recreational population, but there are already plenty of products for cannabis and delta-8 THC administration through other delivery methods like nasal sprays, eyedrops, and inserts.

Nasal sprays – Starting in 2017, with the release of Vera Wellness’s ‘nasal mist’ spray, it’s been possible to snort your cannabis products as well. It is said to increase bioavailability by being taken in through transmucosal (through the skin of the inner nose) delivery, and that some of the negative products produced from heating, like pyrolytics, wouldn’t be an issue. Dr. David Casarett, the palliative care chief at Duke University, explained how the nasal membrane has a lot of enzymes that can be deactivated by contact with CBD, which can actually halt the body temporarily from metabolizing other drugs like THC. For this reason, users are prompted to start with a low level and up the dose slowly.

Eyedrops – Much like IV and IM injections, eyedrops are not a common form of administration, and might not ever be. But they are great for specific ailments, like glaucoma. As a form of delivery that doesn’t involve inhaling a substance, it also ranks as a safer way to take the drug, so long as the eyes are not damaged. More than needles, this actually could become a popular way to get cannabis in the system.

Delta 8 THC Vape Cartridges - Only $10/cart
Delta 8 THC Vape Cartridges – Only $10/cart

Inserts/Suppositories – What if you had a yeast infection, and wanted to treat it with a cannabis medicine? Or perhaps a herpes outbreak where an anal suppository might be useful? Well, these things are possible to. Cannabis suppositories can be found for the vagina, anus, and penis. And this isn’t anything new. Inserts have been used to combat yeast infections, herpes infections, vaginal infections, and a host of other diseases whether sexually transmitted or not. Now they can be done with cannabis.

Inhalers – Though these can go under oral administration, I’m putting them here. Cannabis inhalers are exactly what they sound like, an inhaler where a metered amount of cannabis, or cannabis derivative, is given per breath. Inhalers actually produce a vapor, which is inhaled, while not producing any other cannabis-related odor.

Conclusion

When it comes to how to get cannabis, or specific cannabinoids like CBD, delta-8 THC, or CBC in your system, there are several different delivery methods that don’t involve any sort of smoking or vaping. Not all of these are popular – though the popularity of all will likely grow. For anyone looking for alternate methods of consumption, these are some of the options to consider.

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Resources

Delta 8 Syringes, the Best Vape Ban Workaround
DIY: How to Make Delta-8 THC at Home

What Are Delta-8 THC Moon Rocks And Where To Get Them?
How Vape Mail Ban Will Hurt Kids More
What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8THC)

Is Delta-8 THC Legal? What Does The Law Says?
Delta-8 THC and Athletics – Why the Two Go Together
The CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers). What is Delta-8 THC? All Your Questions, Answered!
INSIGHT: Delta-8 THC Pricing – The Fair Price for Delta 8 Vapes, Tinctures, Gummies and Flowers

The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc) and the Best Delta 8 THC Deals. How to Get Around Vape Mail Ban – And Get Your Delta-8 THC Carts
How To Choose Delta-8 THC Flowers? Delta-8 THC Contaminated Products, or Just Bad Press? Delta-8 THC and the UK: Is It Legal?
Why the Vape Ban Is Happening, and How It Will Impact Online Vape Sales Are Delta-8 THC Syringes the Most Practical Way to Medicate?
Delta 8 Syringes – Why are they important?

Disclaimer: Hi, I’m a researcher and writer. I’m not a medical professional, I have no formal legal education, and I’ve never been to business school. All information in my articles is sourced from other places, which are always referenced, and all opinions stated are mine, and are made clear to be mine. I am not giving anyone advise of any kind, in any capacity. I am more than happy to discuss topics, but should someone have a further question or concern, they should seek guidance from a professional in the relevant field for more information.

The post Delta-8 THC Delivery Methods: Best Way to Get It in You appeared first on CBD Testers.

Are Delta-8 THC Syringes the Most Practical Way to Medicate?

Dosing is one of the most important considerations when taking any type of product medicinally. With most medications, that’s pretty easy to keep track of, but when it comes to cannabis products, especially oils and some concentrates, product dosing becomes a nearly impossible challenge.

“Pucks” and different types of small jars and containers are most common for storing, transporting, and distributing cannabis oils and concentrates. Sure, you could freeze your shatter, then cut and weigh it into equal doses, but what about products that are more vicious and difficult to work with, like cannabis batter? In this case, Delta-8 THC Syringes would be the perfect option. It’s an all-in-one solution that can be used to store, move, and dispense cannabis products in the same dose every time.

Delta 8 Syringes – Only $10/Dripper!
Delta 8 Syringes – Only $10/Dripper!

Unfortunately, syringes have a very negative reputation in drug culture, because of the obvious connection to intravenous use of harder substances. Much of our society lives with the preconceived notion that syringes either belong in the hands of medical professionals, only to be used for heavily regulated medications, or in the hands of heavy drug users.

Needless to say, if you were to pull a Delta 8 syringe out of your purse or pocket, you’ll probably get some strange looks from people. Despite the fact that Delta-8 THC syringes are used in a completely different manor than intravenous syringes, the illusion of syringes being bad is really hard to shake. Because of this, some users prefer the term applicator in place of the word “syringe.” Another reason to call it an applicator is because of the device at the tip. Although some opt to remove this portion, the term still applies.

Delta-8 THC syringes are one of the best tools for medicating with Delta-8 THC products. They can be used to store and administer oils, pastes, and other products that are difficult to work with by hand. Let’s take a closer look at this innovative new product.

To learn more about Delta-8 THC , and for exclusive deals on Delta 8 flowers, vape carts, gummies, tinctures, and other products, make sure to subscribe to the Delta 8 Weekly newsletter.

Click HERE to get Delta-8 THC Syringes For only $10/Dripper!


Medical Benefits of Cannabis

Before we get deeper into the conveniences of using Delta-8 THC Syringes, it’s important that you have a firm grasp on the many medical benefits of the cannabis plant. The reason cannabinoids are so effective and are able to target such a varied range of conditions is because of the Endocannabinoid System (ECS). The ECS is a network of receptors that can be found throughout the bodies of nearly all living creatures including mammals, birds, reptiles, and fish. We naturally create cannabinoids in our bodies – called endocannabinoids – which bond to these receptors to regulate different processes in our bodies and maintain internal balance and harmony.

So far, researchers have been able to identify two separate endocannabinoids: 2-arachidonoylglycerol (2-AG) and anandamide (AEA), as well as two main receptors: CB1 and CB2. 2-AG is a full agonist of both the CB1 and CB2 receptors but it has a more direct association with the CB2 receptor. Because of this, 2-AG is thought to have a substantial influence over the immune system. Anandamide – The “Bliss” Molecule of the Endocannabinoid System Anandamide – or AEA – is frequently referred to as the “bliss molecule” and it has a major impact on our state of homeostasis.

AEA can help manage things such as appetite, sleep wake cycles, pain response, and then some. Our bodies continuously cycle through anandamide. It breaks down very easily, so it doesn’t stay in the body for long. However, our bodies create it on-demand to maintain homeostasis. There is a condition referred to as ‘cannabinoid deficiency’, characterized by a body’s inability to produce endocannabinoids. Some experts theorize that many illnesses we suffer from, stem from this shortage of endocannabinoids. This is why medicating with phytocannabinoids, or plant-based cannabinoids, can be so effective.

Click HERE to get Delta-8 THC Syringes For only $10/Dripper!

Common medical conditions that cannabis is used for include:

  • Cancer
  • Glaucoma
  • HIV/AIDS
  • Parkinson’s disease
  • Multiple sclerosis
  • Damage to the nervous tissue of the spinal cord
  • Epilepsy
  • Cachexia (wasting syndrome)
  • Crohn’s disease
  • Post-traumatic stress disorder (PTSD)
  • Sickle Cell Disease
  • Post Laminectomy Syndrome with Chronic Radiculopathy
  • Severe Psoriasis and Psoriatic Arthritis
  • Amyotrophic lateral sclerosis/Lou Gehrig’s disease
  • Ulcerative colitis
  • Complex Regional Pain Syndrome
  • Cerebral palsy
  • Cystic fibrosis
  • Irreversible spinal cord injury
  • Terminal illness requiring end of life care
  • Uncontrolled intractable seizure disorder
  • Hydrocephalus with intractable headaches
  • Intractable headache syndromes
  • Neuropathic facial pain
  • Muscular dystrophy
  • Severe rheumatoid arthritis
  • Spasticity or neuropathic pain associated with fibromyalgia
  • Post Herpetic Neuralgia
  • Osteogenesis Imperfecta
  • Cerebral palsy
  • Cystic fibrosis
  • Irreversible spinal cord injury
  • Severe epilepsy
  • Terminal illness requiring end-of-life care
  • Uncontrolled intractable seizure disorder
  • Muscular dystrophy
  • Osteogenesis Imperfecta

Why Delta-8 THC Syringes Make Sense

So now that you know the benefits of medicating with cannabis, let’s look at the benefits of doing so using cannabis syringes. Starting with the obvious, with the cannabis syringe (or applicator), you are able to dispense whatever volume of product that you need. Many have their volume indicated in marks on the body of the syringe, giving you relative measurements for dosage, making it much easier to experiment with dosing. That way and you can more easily keep track of which doses worked for you and at what times.

Another benefits regards the packaging aspect of Delta-8 THC Syringes. When using a syringe or applicator, very little oil is lost in the application process. When using other dispensing methods for products with an oil-like consistency, one of the most common complaints is loss of product while it’s in use. There are numerous techniques to get your concentrate or oil out of puck when it starts to get to thin or sticky to manipulate, but with Delta 8 syringes you don’t have to waste your time with any of that. With these applicators you get all of the concentrate in the exact portions you want.

How to Use

Well, a syringe is a syringe, so let’s start with the basics. You have a product in there, you push on the plunger on the back of the syringe, the product comes out. Pretty basic. Many oils are meant to be dispensed into a beverage or directly into the mouth, while concentrates and other products can be dispensed top of a bowl or into some type of dab rig or other device.

Some syringes come with a metal tip applicator but many choose to discard that. Not only does it make the application process slightly easier, it makes the whole set up look just a tad bit less like a syringe and needle. It’s a small victory but a victory no less, especially if you’ll be utilizing your Delta-8 THC Syringes in a public place.

Delta-8 THC Syringes – Final thoughts

By utilizing cannabis syringes, you’re helping to normalize product that can help people achieve more accurate, effective, and safe dosing. A huge part of the legal fight against cannabis comes down to public perception, so if we continue to normalize everything cannabis, we continue to strike back against the ridiculous notions that cannabis is bad, “stoners” are no different than hard drug users, and there are no medical uses for cannabis – because we all know none of that is even close to being truth.

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The post Are Delta-8 THC Syringes the Most Practical Way to Medicate? appeared first on CBD Testers.

Kiss the Psychedelic Toads to Treat Mental Illness

Most people have heard the names LSD, magic mushrooms, and ecstasy before. But not everyone has heard of, say Bufo toads. Yet, even without it being a part of popular culture, or a well-known drug, it is a possible premise for a popular long-running fairy-tale. And perhaps it is this fairytale that helps explain why kissing psychedelic toads, can help treat mental illness.

Medical psychedelics are getting more popular everyday, and the most popular psychedelic drug is still THC! If you’re the kind of person that prefers your THC to be less intense and cause less anxiety, then you’re probably more of a delta-8 THC person. If you haven’t tried this addition to the THC family, check out our awesome delta-8 THC deals to see what it’s all about.

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Fairytales are fun

There are different versions of this story around. The most well-known of which was published in 1812 by the Brothers Grimm, called the Frog Prince. In the story, a princess is playing with a golden ball by a spring. When she misses the ball, it falls into the spring and she cannot retrieve it. She is very sad, stating out loud how she would give up everything to get the ball back. A frog hears her and comes over. He tells her he will get her the ball if she will be his friend, which apparently in this context means living with her, sleeping on her pillow, and eating from her plate.

The princess, of course, agrees, but upon receiving her ball back, she runs off with it, ignoring her promise. The frog follows her home, and the princess runs off to consult her father the king, who tells her to respect her promises in life. So she lets the frog in and allows him to eat off her plate, but when he asks to sleep on her pillow, she refuses. When the frog threatens to tell the king that she is refusing, she picks up the frog and throws him against the wall, thus turning him back into a prince and breaking the witch’s spell he was under.

the frog prince

This version seems to be standard, however, in another standard version, the princess kisses the frog in order to change it into the prince. In yet another version, the princess simply allows the frog to be her friend, thereby ending the spell. It’s a kind of trippy story no matter how you look at it. Talking frogs, witch’s spells, and animal/human transformations. Even without considering the possible link between the story, and actual psychedelics, it’s kind of psychedelic anyway.

However, it just so happens, that because a popular version of the story entails the princess kissing the frog in order to break the spell, it brings up a possible tie between the story, and a species of toad that might actually make a person think another person has changed species.

What are psychedelic toads?

Well, for one thing, they’re toads and not frogs, so if there is a tie between the story and the animal, a general mistake was made in categorization. However, it’s the same as confusing a rabbit and a hare, and does little to change the idea of the connection.

In short, psychedelic toads, are toads that contain psychoactive compounds within their skin known as bufotoxins, or a compound called 5-MeO-DMT, that when smoked, or eaten, can cause a psychoactive experience, complete with hallucinations, feelings of connection, euphoria, and so on. Psychedelic drugs are themselves a subset of hallucinogens, which are a class of psychoactive drugs. Psychedelics are known for producing these effects, as well as increasing feelings of spirituality, overall wellbeing, and increasing or distorting perception.

Most well-known psychedelics come from plants like peyote or magic mushrooms, or are made in a lab like LSD. However, the compounds 5-MeO-DMT, and/or bufotoxins like Bufotenin – 5-HO-DMT, can be found in the skin of a living animal. When looking at the chemical structure, you can see that DMT is involved, and in fact, is a related cousin to these compounds, with 5-HO-DMT being 4-6 times stronger than DMT.  

5-HO-DMT is a schedule I compound. So are both MDMA and psilocybin, both of which have been earmarked by the FDA as ‘breakthrough therapies’ for different forms of mental illness. This designation essentially means the drugs are being fast-tracked through medical research trials, so as to get products onto shelves. This implies that scheduling of such compounds will likely change quickly when products are available, and this could include 5-HO-DMT and other psychedelics, as well.

psychedelic toads

There are several different species of toads that have these compounds, with the most well-known species being the Incilius alvarius, or Bufo alvarius (Colorado River Toad/Sonoran Desert Toad). Usage of toads in this way dates back to the Olmec period in pre-Columbian Mesoamerica, from around 1,200 BCE to approximately 400 BCE.

5-MeO-DMT, or 5-Methoxy- N,N-dimethyltryptamine, is a compound found in different plants, as well as the Bufo variety of toads. It has been used since ancient times, and it more recent scientific investigation it was found that it can assist with spiritual exploration, that it’s not addictive, and that it might be good psychotherapeutically. Effects of 5-MeO-DMT can be felt within a second of inhalation, and trips last anywhere from as short as seven minutes, to as long as 90 minutes.

Psychedelic toads and mental illness

If you thought psychedelic toads weren’t studied for mental illness, you’d be mistaken. In 2018, a study came out about the unintended anxiety-reducing and depression-reducing effects of 5-MeO-DMT. The study examined people using the drug for spiritual or recreational reasons, and found self-reported improvements on both fronts. Respondents completed an anonymous survey, which found that 80% of those who responded who had been diagnosed with depression, felt improvement, and 79% of respondents who had been diagnosed with anxiety, also saw improvement in how they felt. Few felt unchanged, and a small amount felt worse than before by a very small margin.

In another study from 2019 about psychedelic toads and mental illness, the effects of inhaling 5-MeO-DMT vapor on affect and cognition, were measured. 5-MeO-DMT comes from the parotoid glands of the Bufo alvarius toad. The goal of the study was to investigate the semi-immediate and long-term effects of inhaling this secretion. The study participants were measured before the inhalation to establish a baseline measurement, within 24 hours of it, and again a month later. Trials were conducted in different parts of Europe, and participants were given just a single inhalation of the secretion.

medical psychedelics

The results of the study showed an increase in life satisfaction ratings and convergent thinking within 24 hours after inhalation, and was maintained a full month later. Mindfulness ratings actually went up over time, and at four weeks reached a statistically significant level. Depression, anxiety, and stress ratings all went down immediately after inhalation, and also reached a statistically significant level at four weeks. Those who experienced ego dissolution or ‘oceanic boundlessness’ – a measure of the spirituality aspect experienced, reported higher levels of satisfaction, and lower levels of depression, stress, and anxiety.

In a comparison study concerning spiritual intensity, between 5-MeO-DMT and psilocybin – the psychoactive compound in magic mushrooms, it was found that the two substances produce spiritual experiences that are comparable. 5-MeO-DMT was administered to 20 participants who received 50 mg vaporized of the compound. The results of this were compared to a previously conducted psilocybin study, where participants received 30 mg of that compound, and the general spiritual intensity was found to be the same.

Issues

The main issue with extracting a drug from an actual living being, is that you generally kill, or harm, that actual living being. For the same reason its often frowned on for elephants to be killed for their tusks, the same can be said for indigenous toad populations, which have been affected by their capture and use as a psychedelic drug. This is one place in life where a synthetic answer is most definitely preferable to the killing of a whole species.

Conclusion

As research into different psychedelic compounds continues, psychedelic toads will likely come to the forefront of mental illness treatment, especially synthetic versions. Given the shorter duration time (much like DMT), and the reported positive benefits, something as strange to think of as a psychedelic toad, might actually be one of the best weapons against anxiety, depression, and other forms of mental illness.

Hello! Thanks for stopping by CBDtesters.co, your best spot for the most current cannabis-related news from all around the world. Join us regularly so you’re always on top of the exciting world of legal cannabis, and sign up to our newsletter so you never miss a story.

Resources

How to Invest in Multi-Billion Dollar Medical Psychedelics Industry
The New Rise of Medical Psychedelics

Welcome to the World’s 1st DMT Trials into Depression
Germany Leads EU in Cannabis Oil Imports…and Exports
What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8THC)

Florida Bill Aims to Legalize Medical Magic Mushrooms
Desert Tripping – A Closer Look at Peyote: Spiritual, Medicinal, & Controversial
The CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers). German Cannabis Flower Market is Ready to Explode
Psychedelic-Assisted Therapy, and How It Works

The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc) and the Best Delta 8 THC Deals. Can LSD Treat Your Mental Illness?
DIY: How to Make Delta-8 THC at Home MDMA – The New Way to Treat PTSD Delta-8 THC and the UK: Is It Legal?
Ayahuasca In the Fight Against Drug Addiction German Medical Cannabis – A Model For Europe, As Prices Fall
Delta 8 Syringes – Why are they important?

Disclaimer: Hi, I’m a researcher and writer. I’m not a medical professional, I have no formal legal education, and I’ve never been to business school. All information in my articles is sourced from other places, which are always referenced, and all opinions stated are mine, and are made clear to be mine. I am not giving anyone advise of any kind, in any capacity. I am more than happy to discuss topics, but should someone have a further question or concern, they should seek guidance from a professional in the relevant field for more information.

The post Kiss the Psychedelic Toads to Treat Mental Illness appeared first on CBD Testers.

How to Invest in Multi-Billion Dollar Medical Psychedelics Industry

As the legal cannabis market booms, another class of drugs on the horizon is getting closer to legalization, with its own impending boom coming. And that means a whole new place for investment. So as MDMA, psilocybin, and DMT work their way through medical trials, here’s how to invest in this new medical psychedelics field.

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What are psychedelics?

Psychedelics are a subset of hallucinogenic drugs, which themselves are a subset of psychoactive drugs. Whether made in a lab like LSD, or found in nature like psilocybin or peyote, psychedelics are known for causing ‘trips’. When a person is tripping, they may have altered perceptions of the world around, experience/feel/taste/see/hear things that are not real (hallucinations), feel a heightened sense of connection to those around them, experience euphoria, feel a sense of spirituality and connectedness with the universe, and a greater sense of self-introspection. A large percentage of psychedelics are serotonergic, meaning they effect serotonin receptors in the brain, though they can do this in different ways.

Some drugs like DMT produce short trips of less than an hour in duration. While other drugs like LSD, psilocybin, and mescaline can cause trips that last for many hours, as many as eight or ten. Sometimes people experience bad trips in which negative, or even scary, hallucinations are experienced, and/or a rapid heartbeat, sweating, nausea, disorientation, and fatigue occur. There is indication that the majority of these symptoms can be controlled through proper dosing. In fact, many therapeutic psychedelic users consume the drugs in micro-doses.

All psychedelics are Schedule I in the Convention on Psychotropic Substances, a drug scheduling treaty which defines the legality of different compounds globally. Starting with the Staggers-Dodd bill in 1968 which illegalized LSD and psilocybin, and finishing with the placement in the Convention, making all such substances illegal to buy, sell, or consume, with no purported medical value.

psychedelics

Psychedelics have been used for thousands of years, all throughout the world, though their uses in medicine in the mid-1900’s, and proposed uses today, are generally different than the shamanistic/ritualistic way they were primarily used in history, although this is not to say that there were not traditions that did use psychedelics therapeutically. Technically, if a shaman is consuming ayahuasca to get rid of demons, I suppose that could be thought of as therapeutic anyway.

Medical psychedelics research

Psychedelics, particularly, LSD, were introduced to modern medicine around the 1950’s after Albert Hoffman synthesized the compound in Switzerland in 1938. Several psychotherapists at the time, like Humphry Osmond and Ronald Sandison caught onto the idea, bringing these treatments to England and America. Hoffman conducted, among other research and therapy, the Saskatchewan trials, and ultimately came up with the idea of ‘psychedelic therapy’ in which a single large dose of LSD was given along with therapy sessions.

‘Psycholytic therapy’ is what Ronald Sandison’s version became known as in the UK, with the difference being that Sandison’s treatment style was to do multiple sessions with smaller amounts of the drug that increased through the process. Both doctors found great success particularly with alcohol addiction. How much success? According to the Saskatchewan trials, as many as 40-45% of drinkers were still not drinking a full year after the therapy session.

Unfortunately, when the drugs were made illegal, all ability to continue such treatments ended, and the ability for research into the field was completely stymied, and did not pick up again until much more recently. However, to give an idea of the massive turnaround that has been going on when it comes to psychedelics, consider that the US’s Food & Drug Administration (FDA), singled out both psylocibin in 2019 and MDMA in 2017 as ‘breakthrough therapies’ for depression and PTSD respectively. Such a designation by the FDA is meant to speed up research and development for products deemed necessary for health.

This indicates a desire by a US government agency to not only test these drugs, but to get them to market. And they’re all schedule I right now. One exception to psychedelics all being schedule I, however, is magic mushrooms. Though its psychoactive components like psilocybin are Schedule I, and therefore illegal, the plants themselves are not outlawed, creating a bit of gray area in terms of mushroom use, cultivation, and production. This gray area could prove useful in the future.

What can be expected?

If you’re wondering why this matters, consider how massive – and growing – the legal cannabis markets are. Well, psychedelics offer many of the same medical benefits, especially psychologically, with possibly added abilities in other departments. And they’ve proven to be very safe. As an industry in which much of it is pharmaceutical to begin with, it’s a safe bet that these drugs are going to pick up quickly. Because the pharma world is sure to take a massive interest, it gives even more reason to invest in medical psychedelics now, before everything explodes.

psychedelic-assisted therapy

So how much is it worth? I’m not the kind of writer who generally likes to get into these numbers. Every publication makes its own predictions, off its own information, and very rarely do these predictions seem to consider world changes. Whatever the size of the CBD industry was originally predicted to grow to a few years ago, that number would be invalid by now because it didn’t account for THC-based medicines growing in popularity, or legal markets, or psychedelics.

Imagine how much psychedelics could eat away at cannabis revenue. And not only that, any predictions of the future market size for psychedelics would have to take into account the still expanding cannabis markets (with more countries constantly legalizing in some form or another), and the question mark of what currently unforeseen factors could upend the trend a few years down the line. So, I’m not concerned with too many predictor numbers, but here’s just one, in order to get an idea what we’re dealing with.

PRNewswire, citing an analysis by Data Bridge Market Research, explained the forecast for 2020-2027, in which the field is expected to grow to $6.8 billion by 2027. It was worth just over $2 billion in 2019.

Best ways to invest in growing medical psychedelics field

Now that a certain barrier seems to be broken, more companies are conducting clinical trials, getting patents, and starting to get clearances for products. In fact, if you thought the psychedelics market was off limits, you’d be very much mistaken. Not only is this a growing market with a lot of possibility, but companies are already staking their claim, leaving room for you to start investing. So, if you like the idea of getting in on something before it explodes, consider investigating the following companies, and invest in the medical psychedelics field.

Much like with cannabis, Canada is quickly establishing itself as a leader in medical psychedelics, with the top companies coming out of this country. In the first half of 2020, $150 million USD was raised by six different companies: Mind Medicine, COMPASS Pathways, Field Trip Psychedelics, ATAI Life Sciences, Orthogonol Thinker, and Numinous Wellness. Mindmed and Numinous are already publicly listed companies. This is an early stage entry for investors. In fact, to give an idea of how seriously Canada is taking this, the first exchange traded fund – The Horizons Psychedelic Stock Index ETF, made its debut in January. ETF’s are like regular asset exchanges, except that they include a mix of stocks, commodities, and bonds. This exchange is solely for psychedelics.

The CEO of the fund, Steve Hawkins, said that while larger pharmaceutical companies have been admitted to the fund, the idea is to keep it mainly for smaller psychedelics companies. Companies can be added to the fund if they can tick the following boxes: be a part of a regular US or Canada-based stock exchange, be a biotechnology company focusing on medical psychedelic research, be a producer and/or supplier of psychedelic medicines, and be a company that works within the general supply chain for psychedelic medications.

medical psychedelics

Biggest names so far

When it comes to emerging fields and investing, the majority of people will never get there preemptively, and will instead act by reaction. For anyone who wants to get in on it before the top blows off, the following companies currently provide the best prospect for future growth, expansion, approval, and ability for revenue. These names should be noted, they will likely be bringing you the first approved medical psychedelic products, and for anyone looking to invest in this rapidly growing field of medical psychedelics, they stand out as the best options so far.

Mind Medicine is one of the furthest along when it comes to getting a product out there. It’s a pharmaceutical company that specifically works to develop psychedelic medications. The company is currently in the middle of six different trials on drugs like MDMA, LSD and DMT. In January of 2021, MindMed announced the first ever clinical trials to involve a combination of MDMA and LSD, with company president Dr. Miri Halperin Wernli stating:

“I believe that when LSD and MDMA are taken together they have exceptional potential to open a window into our mind which will awaken it to new levels of awareness by changing the fluidity of the ‌state‌ ‌of‌ ‌consciousness, amplifying‌ ‌changed‌ ‌perceptions,‌ ‌intensifying ‌emotions‌, ‌and‌ stimulating ‌novel‌ ‌thoughts. It is like a gateway to a multidimensional universe.”

When it comes to MDMA trials, MAPS – Multidisciplinary Association for Psychedelic Studies,  is also making its way to approval. MAPS entered phase III of its trials into MDMA for PTSD, and aligned this phase with the FDA according to a Special Protocol Assessment made directly with the FDA. This means that so long as the trials show clinically significant results, the study will already check all FDA regulatory boxes, and make it that much easier for approval.

However, a psychedelic drug has technically already been approved by the FDA. In March of 2019, Johnson & Johnson’s Spravato got approval. The spray treatment is considered for those who have not received a benefit from at least two separate anti-depressants. Spravato is a drug that’s a chemical cousin of the drug ketamine, which is classified as a dissociative drug, but also as a psychedelic. The medication is meant for severe depression.

There are tons of companies popping up. Apart from the companies already listed, prospective investors should check out Champignon Brands, Hollister Biosciences, Better Plant Sciences, Captiva Verde Land, Core One Labs, Cybin, Empower Clinics, Ehave, Jazz pharmaceuticals and EGF Theramed Health. All of these companies are associated in some way or other with the production of psychedelic medications. And while I have yet to see it mentioned in an article, it seems to me that what might upend everything I just said, is the ability to cultivate magic mushrooms.

LSD

Something to consider

Much like cannabis, mushrooms come with the ability for easy self-cultivation, as well as large scale cultivation. People who invest in today’s cannabis cultivation already know the value of having growing fields. Imagine the same thing, but with mushrooms. I personally believe that the biggest way in the future to invest in medical psychedelics, will be through the growing of mushrooms.

As stated, this is my opinion, and has not been discussed much as far as I can tell. This is not shocking though, and really doesn’t mean much, as this topic is also an undesirable one for any biotech or pharmaceutical company that – much like with cannabis – would much prefer you know nothing about how to do this on your own. And much like cannabis, it’s easy enough to learn how for anyone who needs some help getting started. Plus, since cultivation and sale of the mushrooms themselves is actually legal in many places, it’s way more legal to grow a field of mushrooms in much of the world, than to grow a field of cannabis.

How to invest in Medical Psychedelics – Conclusion

That the medical psychedelics field is coming is not as much up for debate as many would believe. It might be growing in the shadow of the cannabis market, and being kept quiet until the ability for large scale monetization is possible, but it’s coming, and it will be big. For those who want to invest in the growing medical psychedelics field, getting in now is probably the best idea, and with all the new companies popping up every day, it’s sure to become a heated race very soon.

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References

Why the Vape Ban Is Happening, and How It Will Impact Delta-8 THC
Florida Bill Aims to Legalize Medical Magic Mushrooms

DIY: How to Make Delta-8 THC at Home
Here is everything wrong with Biden’s “forced rehab” plan for drug reform
What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8THC)

Can LSD Treat Your Mental Illness?
Welcome to the World’s 1st DMT Trials into Depression
The CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers). Delta 8 / 9 / 10 / 11… How Many THCs Are Out There?
The New Rise of Medical Psychedelics

The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc) and the Best Delta 8 THC Deals. How To Choose Delta-8 THC Flowers?
Ayahuasca In the Fight Against Drug Addiction The Many Faces of Tetrahydrocannabinol – Different Types of THC and Their Benefits Psychedelic-Assisted Therapy, and How It Works
Desert Tripping – A Closer Look at Peyote: Spiritual, Medicinal, & Controversial Nature’s Magic – The Health Benefits of Psilocybin Mushrooms

Disclaimer: Hi, I’m a researcher and writer. I’m not a medical professional, I have no formal legal education, and I’ve never been to business school. All information in my articles is sourced from other places, which are always referenced, and all opinions stated are mine, and are made clear to be mine. I am not giving anyone advise of any kind, in any capacity. I am more than happy to discuss topics, but should someone have a further question or concern, they should seek guidance from a professional in the relevant field for more information.

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