Canada Regulators Ease Access to Psychedelic Drugs

Health Canada, the nation’s health department, said that drug regulations were being amended based on new research into the therapeutic benefits of psychedelics.

“There has been emerging scientific evidence supporting potential therapeutic uses for some restricted drugs, most notably psychedelic restricted drugs such as MDMA and psilocybin,” Health Canada noted in the Canada Gazette, an official government publication.

Under the amendment to federal food and drug regulations, physicians will be able to request access to restricted drugs on behalf of their patients through Health Canada’s Special Access Program. Previously, restricted drugs including psychedelics were not available through the program.

The Special Access Program permits health care professionals to request permission to use unapproved treatments for patients with serious or life-threatening medical conditions. The program applies only in cases where conventional therapies have failed, are unsuitable, or not available in Canada. Patients are not permitted to request access to treatment through the program on their own behalf.

Psychedelic Research Continues

Research into psychedelics including psilocybin, MDMA and ketamine has shown that the drugs have potential therapeutic benefits, particularly for serious mental health conditions such as depression, addiction and anxiety. A study published in the journal JAMA Psychiatry in 2020 found that psilocybin-assisted psychotherapy was a quick-acting and effective treatment for a group of 24 participants with major depressive disorder. Separate research published in 2016 determined that psilocybin treatment produced substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer. 

“Given the growing scientific interest in certain restricted drugs, it is expected that Health Canada would eventually encounter a situation where scientific evidence supports the therapeutic use of a restricted drug within the context of the Special Access Program,” regulators wrote in the January 5 announcement. “The regulatory amendments are therefore expected to benefit patients with serious or life-threatening conditions who may be granted access to restricted drugs through the Special Access Program in instances when other therapies have failed, are unsuitable, or are unavailable in Canada.”

Before Wednesday’s announcement, patients could gain access to psychedelic drugs through two legal avenues. The first method would be to participate in a clinical trial, which only accepts patients on a limited basis and are not available nationwide. Patients could also gain access to restricted drugs by personally requesting a special exemption to regulations from Canada’s Health Minister.

Easing Access for Patients

Regulators noted in the announcement that “the regulatory amendments will not create large scale access to restricted drugs and they do not signal an intent towards the decriminalization or legalization of restricted drugs. The Special Access Program is for emergency treatment only.” But the move should make it easier for patients with an exceptional need to access psychedelic drugs.

Dr. John Huber, a clinical forensic psychologist and the CEO of Tripsitter Clinic, a publicly-traded ketamine therapy telemedicine provider that is listed on the Canadian Securities Exchange, applauded the Canadian government for continuing to advance and acknowledge the benefits of psychedelic therapy.

“This breakthrough decision will expand access to MDMA and psilocybin therapy and help save the lives of those with life-threatening mental health conditions,”  Huber wrote in an email to High Times. “We hope Canada’s success pushes the U.S. government to follow a similar pathway while awaiting FDA approval for MDMA and psilocybin.”

Greg Rovner, CEO of Heally, a telemedicine platform for psychedelic clinics and patients looking for alternative medicine treatment, said the decision by Canadian regulators to ease access to psychedelics should spur new research into the drugs.

“Health Canada’s recent decision is a ringing endorsement of MDMA and psilocybin’s therapeutic potential,” Rovner wrote in an email. “It recognizes the growing body of research into the benefits of psychedelics and expands access to psychedelics for patients in serious and life-threatening conditions. We hope to see more studies on the safety and efficacy of psychedelics that will spur further regulatory reform.”

The post Canada Regulators Ease Access to Psychedelic Drugs appeared first on High Times.

Esketamine in the UK

The world of drugs is constantly shifting and changing. It seems like, finally, government’s are beginning to open their minds to the many magical benefits of drugs, and are no longer being blinded by the potential recreational uses. The truth is, almost all drugs that people may buy from street dealers or off the dark web – are also used daily in medical practices.

This is the case with heroin, NOS, cocaine, MDMA and ketamine. What some of these drugs offer are quick relief from mental and physical pains, which usually prescribed medicines do not have the capability for. This is the situation with esketamine. Since 2019, esketamine has been medically legal in the UK due to its proven benefits for treating depression. But how has it been going? How easily accessible is it? And, more importantly, what even is esketamine? The UK isn’t championed by the rest of the world for their open-drug policies, but perhaps this is a start. 

Ketamine and esketamine therapy are all the rage, but they’re still not as easily accessible as cannabis. Fortunately, there has been more focus on these compounds in recent years and the market is poised to explode in the very near future. Remember to subscribe to The Psychedelics Weekly Newsletter for more articles like this one. And save big on Delta 8Delta 9 THCDelta-10THCOTHCVTHCP & HHC products by checking out our “Best-of” lists!


What is Esketamine?

Esketamine is an isomer of ketamine, which essentially means that it has a very similar chemical structure, despite a few certain atoms. For those of you who aren’t aware, ketamine is both a popular recreational and medical drug. Ketamine has been found to be an anesthetic and anti-depressant and was actually used to treat injured Vietnam soldiers. Not only that, but Ketamine is often referred to as a ‘horse tranquiliser’ as it’s often used in veterinary practices to anaesthetize bigger animals. Ketamine has also been found to have euphoric effects, which is why it’s often used as a party drug, and is also why it’s not being further considered as a potential antidepressant. This is why Esketamine has not been created. Esketamine is actually a more potent version of ketamine.

“…blocks N-methyl-D-aspartate (NMDA) receptors and interrupts the association pathways of the brain, resulting in dissociative anaesthesia and analgesia and in restoration of neural pathways regulating mood and emotional behaviour.”

Now, this might sound a little bit scientific, but actually esketamine works quite simply. The drug is believed to act on a brain chemical called glutamate, which is thought to restore connections between brain cells, which supposedly shrink during long periods of depression. This regrowth leads to the production of healthy serotonin, which affects the emotions of a person. 

How It’s Taken

Esketamine, unlike ketamine, is taken in the form of a nasal spray called Spavato. It’s taken alongside an oral anti-depressant. The patient will usually seek a prescription, and if they’re able to get one, they will embark on two key stages of treatment. 

Step 1

Step 1, also known as the induction phase, consists of the user taking two treatments per week, for a full month. The amount of sprays and dosage will be different depending on the patient. 

Step 2

Step 2, also known as the maintenance phase, will consist of the esketamine dosage being slowly reduced to once a week, or even perhaps once a fortnight. This is to see how bad the depression flares up with less of the medication. 

Esketamine & Depression

Depression is a mental health problem that can affect 1 in 5 adults in the UK. The symptoms of depression can include: feeling low, suicidal thoughts, anxiety, lack of appetite and a loss of hope. Most doctors prescribe anti-depressant drugs to deal with depression. These drugs are known as SSRIs and they help to keep more serotonin in the brain. Serotonin is a neurotransmitter that carries signals between nerve cells; it’s thought to have a positive influence on mood. SRRIs stop serotonin from being reabsorbed after it carries these signals, which keeps more serotonin in the body. However, esketamine does not work like this. The issue with SSRIs is that they can take quite a long time to take effect – perhaps a few months – and for some people they don’t work at all

“As many as two-thirds of people with depression do not respond to the first medication prescribed and are considered to have TRD. TRD is a term used to describe depression that has failed to respond to at least two different antidepressants.”

This is where esketamine comes in. TRD stands for treatment-resistant depression and essentially means that the usual SSRI treatment is obsolete for them. Esketamine works differently to mainstream antidepressants, it instead increases the levels of glutamate – which has the largest quantity of chemical transmitters in the body. The new drug is thought to be the future of antidepressants as it has robust effects within a few hours and the effects are long lasting. Eskatimine

“…Is one of the first “rapid acting” drugs for depression and the first drug in decades to target a new brain pathway. Unlike conventional antidepressants, which take weeks or months to take effect, ketamine has been shown in some patients to have enduring effects within hours.”

The benefits of Eskatimine is undoubtable, and this has caused many countries to turn their heads towards it as a potential, more mainstream treatment option. That is why the UK, among other countries, have begun this process. 

Is Esketamine Legal in the UK?

Yes. As previously mentioned, esketamine is a more potent, and slightly different version of ketamine. Ketamine is of course one of the most popular party drugs in the UK and in many countries. However, due to ketamine’s street-drug credit, many governments are fearful of using it as a viable antidepressant alternative. Nonetheless, in 2019, things changed. Spravato had been subject to many medical trials with those suffering from treatment-resistant depression and now...

“..It has been deemed a safe treatment and was licensed in the UK for use in late 2019, as well as approved in the USA by the Food and Drug Administration (FDA) for use in early 2019”

The companies that are the creators of the drug were Johnson & Johnson in the US, and Janssen-Cilag in the UK. Eskatmine in the form of a nasal spray is legal and available from specific psychiatric prescribers and pharmacists within the UK. However, like with all legalization, it’s never just as simple as ‘here you go, whoever needs it, come get it’. The truth is that, just like medical cannabis in the UK, esketamine is not an easy substance to get ahold of, and it’s not cheap either. So, let’s take a little look into how the UK is doing since legalizing this substance in 2019. 

How’s It Going Since 2019?

Legalizing esketamine for medical use was a big leap for the UK and highlights a potential but a slow shift in drug policy. Nonetheless, the sad truth is that – whilst the substance could be having huge medical benefits for those suffering with TRD – it’s currently very difficult to get a prescription. Almost all of the limited prescriptions of Spravato come from private institutions, and the prices are not cheap. Supposedly, the current price of a 1 x 28mg nasal spray bottle is £163. In addition, to access esketamine you need a written prescription from a private psychiatrist. Psychiatrists are a luxury and are not something that the majority of people are able to afford. 

The NHS is the UK’s free health care service, and it is perhaps the UK’s pride and joy. However, it’s constantly underfunded by the Conservative government. The NHS do not currently back esketamine in the UK, as they don’t see it as being  a cost effective option for them. Due to the price of it, it’s easier for them to continue prescribing other antidepressant medication than spravato. However, there is one specific case where the NHS has prescribed the drug. And that is in, of course, Scotland. Scotland is known to be the liberal side of the UK. 

“the Scottish Medicines Consortium (SMC) accepted the use of esketamine (Spravato; Janssen) nasal spray for use within NHS Scotland for adults with treatment-resistant major depressive disorder on 8th September 2020.”

Whilst this isn’t massive, it’s still a step in the right direction. The hope is that, going forward, the government will help the NHS to back the spravato medication and finally allow people who need it to have access to it. However, it could still be a long road ahead.

Conclusion – Esketamine in the UK

Esketamine is an example of a drug that has forced itself to be noticed by medical professionals and government officials due to its undoubtable worth. Even the UK, who aren’t the leaders of drug acceptance, have decided to give it esketamine shot. Whilst it is not the cheapest and most accessible antidepressant medication, the hope is that now it’s been accepted for medical use, it’s only a matter of time before more people have access to it. The hope is there. Let’s wait and see.

Hello to all. Welcome to CBDtesters.co, your #1 web source for cannabis and psychedelics-related news, offering the most thought-provoking and current stories going on today. Give us a visit frequently to stay on top of the always-changing world of legal drugs and industrial hemp, and remember to check out  The Psychedelics Weekly Newsletter, so you’re never late on getting a news story.

Disclaimer: Hi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

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Robo-Tripping – The Cough Syrup Psychedelic Answer to Getting High

With all the talk about upcoming psychedelic legalizations, and the beginnings of the medical psychedelics market, it’s easy to forget that some psychedelics are already legal. For years now, people have been robo-tripping off cough syrup, (or at least taking the medication), making it the most commonly used psychedelic in America, and an OTC one at that!

Robo-tripping and cough syrup might represent legal psychedelic use in the US, but that’s not everyone’s cup of tea. Some prefer a good old standby like cannabis, and all the recreational and medicinal compounds within. Not only can you now get hemp-derived delta-9 THC, but compounds like delta-8 THC, THCV, and THCA are all available as well, and come with their own specific benefits. We’ve got great deals for delta-8 THC and more, so check out our stock, and figure out which compounds work best for you. Check out our selection of products in The Delta 8 Weekly Newsletter. And save big on Delta 8Delta 9 THCDelta-10THCOTHCVTHCP & HHC products by checking out our “Best-of” lists!

What is robo-tripping?

You might be familiar with this term, or you might not be. The word ‘robo-tripping’ is based on the name Robitussin, a brand name cold and flu cough syrup, which contains a special ingredient. This ingredient can also be found in Nyquil, and is associated strongly with both of these brand names, among others.

The drug in question is DXM, or dextromethorphan. DXM has been legal in the US since 1958, so while the government was running smear campaigns about LSD and magic mushrooms, it was simultaneously pushing the use of DXM in over-the-counter (OTC) medications, without using the term ‘psychedelic’. Though there may be some confusion over where exactly DXM fits in, most consider it under the general umbrella of psychedelics.

DXM is, in fact, a member of the morphinan class of drugs, which also comprises drugs like codeine and morphine. Morphinans are generally naturally occurring (like the two just mentioned), but as exemplified by DXM, can be synthetic as well. DXM does not have the same effect on receptors as other morphinans, and is not related to pain relief in the same way. In high does, DXM acts as a dissociative hallucinogen. At lower doses, it has sedative, dissociative, and stimulant properties, while also bringing on feelings of euphoria and general well-being. I know this from my own experience.

DXM

What does DXM from cough syrup feel like?

As stated, at regular doses, DXM has sedative, dissociative, and stimulant properties. It makes a person feel high and good, even at standard doses, and can go on to cause more extreme dissociation, and hallucinations in higher does. On the other hand, in testing, DXM and psilocybin (of magic mushrooms) were found to produce similar effects, with the biggest difference being that psilocybin causes more extreme hallucinations and mystical experiences.

In my personal experience, I found cough syrup to be the best part of being sick. I mean, no one wants to be sick, but whenever I was, I knew I could jump on the Nyquil train (my preferred brand name DXM remedy). These days I don’t take pharmaceuticals except if necessary, so I stay off the Nyquil train for the most part, but still hop back on at times when I need a sick-time pick-me-up.

It always made me feel great. I never took it above recommended doses, and if I did, it wasn’t by much. I did go as far as buying just the cough syrup to avoid unnecessary acetaminophen (Tylenol) use. If I take it today, it’s strictly without the acetaminophen. DXM has always been a sick-time oasis for me. That one thing that can be taken at a miserable time, to make a badly feeling body, feel a little better. And all the while reaping the benefits of a cough suppressant.

I expect at higher doses I would’ve been more out-of-it, but even with the standard dose, I always felt euphoric, but in a kind of not-totally-there way. I don’t remember experiencing any negative side effects over years of intermittent sick-time use. It should be remembered though, that when a person is ‘robo-tripping’ on cough syrup, they often consume an entire bottle, or more. I’ve never done this.

Where did DXM come from?

Since it’s synthetic, we know it wasn’t found out in the wild, or as part of an existing plant. Which means we know that at some point, someone created DXM in a lab. The parent compound was first described in a patent application by Hoffmann-La Roche in 1946. The patent was granted in 1950. The parent compound underwent testing and was mentioned in published literature in 1952, DXM was first tested in 1954.

Who did this testing? None other than the US Navy and CIA, on research into non-addictive options instead of codeine. It gained approval from the US’s FDA in 1958 as an antitussive – or cough suppressant. While opioids like codeine are generally associated with pain management, such compounds can also serve as cough suppressants. In the 1960’s and 70’s, DXM really took off in the States with the brand Romilar selling it for this purpose. The brand was discontinued in 1973 because of misuse of the medication.

cough medicine

A few years after this (showing the government was actually totally cool with it), new brands emerged like Robitussin and Vicks-44. When the internet emerged in the 1990’s, it allowed for the quick spreading of information, which led to discussions about use and how to get it. By the mid-90’s, wholesale DXM powder could be ordered online, thereby bypassing the need to take a product with other ingredients.

In September of 2010, the FDA shot down an initiative to make DXM prescription, once again showing that the government was cool with people using, and abusing, this psychedelic. Though DXM is federally legal as an OTC medication, some states like California and Oregon have instituted regulation to bar sales to minors.

How does DXM work?

DXM has several mechanisms of action including being a nonselective serotonin reuptake inhibitor, and a sigma-1 receptor agonist. In terms of its function as a cough suppressant, DXM works differently than opioids. Whereas opioids produce an antitussive effect by way of opioid receptors (though how and why is not necessarily understood), DXM actually tricks your brain into not feeling the need to cough. This is because the airways and lungs have tons of nerves attached, and these nerves can detect fluid in the lungs, other irritants, respiratory constriction, and mucous build-up.

DXM works by being a communication disruptor between the brain and the nerves which are responsible for the coughing reflex. It creates a temporary block of this information, so that the brain never receives the signal from the body that it should cough. When enough receptors are blocked, a person no longer feels the need to cough, even if they technically should. For this reason, DXM (much like opioids) is not advised for anything other than a dry cough, as it can stop a person from coughing up fluid from their lungs, which can cause other issues.

Though DXM was supposedly meant to keep prospective chronic coughers from getting addicted to opiates, it ended up being used recreationally, much like opiates. In fact, the term robo-tripping was coined in reference to the high that legal cough syrup can provide users, whether in the correct dosages, or by taking more than the recommended amount.

Psychedelic legality in the US

DXM is strange because it gets treated fundamentally differently than every other psychedelic out there. While everything from LSD to MDMA to psilocybin is a Schedule I Controlled Substance, DXM just slid right through, not just to legality, but to OTC legality. The only other pharmaceuticals that have any legalization status, are ketamine and esketamine.

ketamine

While ketamine has been cleared for use as an anesthetic, it can’t be used or prescribed for anything else. So while it’s not Schedule I, it’s also not accessible legally for anything but anesthesia. Ketamine remains big as an illicit party drug. It’s close cousin esketamine was cleared for medical use with treatment-resistant depression, for which it received authorization by the FDA in 2019. This authorization was updated in 2020 to cover suicidal thoughts as well. This requires a doctor’s prescription, however, making it significantly less accessible than DXM to the average person.

Esketamine does show a new trend arising. The treatment of psychological issues by way of psychedelics over monoamine antidepressants, and this trend looks to be picking up and continuing. Both MDMA and psilocybin have received ‘breakthrough therapy’ designations by the FDA for PTSD and severe depression respectively, for which both are undergoing trials. This means a US federal government agency is pushing for the research and development of compounds with Schedule I listings. And this indicates that laws could be changing very soon.

Conclusion

Robo-tripping from cough syrup is the most common way to experience psychedelics legally in the US. That is, unless you live in a place like Oregon, which has decriminalized their recreational use, and legalized medical use for some compounds like psilocybin.

The idea of DXM certainly stands out as inconsistent when it comes to regulation for psychedelics. Though its nice to know that not everything is banned, there’s a certain strange aspect to the idea that DXM is so openly sold, while comparable compounds are kept off limits. I guess no one says much about it because DXM isn’t advertised as a psychedelic, and the connection is not made by the masses. It truly is astonishing how brilliant well-orchestrated marketing campaigns can be.

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DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

The post Robo-Tripping – The Cough Syrup Psychedelic Answer to Getting High appeared first on CBD Testers.

Mental health is reset by psychedelic therapy — Tripping the switch

A secret once kept in nuanced circles of degenerates and free spirits has recently gained mainstream appeal, fitting in with wider professional crowds. As it turns out, psychedelic therapy can reset mental health — a good trip can flip the switch. A story circulates that Apple Inc. founder, Steve Jobs, learned how to poke at […]

The post Mental health is reset by psychedelic therapy — Tripping the switch appeared first on Latest Cannabis News Today – Headlines, Videos & Stocks.

KETAMINE: What Is It?

The world of new drugs and drug fads move quicker than anyone can keep up with. In fact, if you even tried to understand what ‘the kids’ are taking these days, you’d probably end up both confused and intoxicated quite quickly.

There used to be a time where cocaine, cannabis and ecstasy was all anyone spoke about. However, nowadays, the world of drugs has opened up excessively. The likes of GHB, M-CAT, ketamine, mushrooms, acid, crystal meth and unlimited others are all being taken around the world. Each drug has its own story and its own positives and negatives. So what about Ket, K, or Ketamine? The horse tranquillizer that many people have decided to take, despite not being horses. What is it and what does it do? Let’s delve into the world of ket. 

Ketamine is a drug with a very interesting history and reputation, but, like many other mind-altering compounds, it does have a place in both the worlds of the therapeutics and recreation. To learn more about cannabis and psychedelics, make sure to subscribe to The Delta 8 Weekly Newsletter for more articles like this one, as well as exclusive deals Delta 8Delta 10 THCTHCVTHC-OTHCPHHC and even on legal Delta-9 THC!


What is Ketamine?

Ketamine, like most drugs, has many different names: ket, wonk, donkey dust, K, Klein and many others. There are unlimited names for most drugs as often all it takes is for someone to invent a new one whilst they’re high, and usually it will stick. Ketamine, or often shortened to just ‘ket’, is an anesthetic that is used by both doctors and veterinarians. The reason why most people refer to ket as ‘horse tranquillizer’ is because it technically is. However, ketamine is also used as anesthetic for most animals. The reason why it is especially popular with horses is because doctors find ketamine to be a helpful way to deal with larger animals. 

Most people would say that all drugs have to sit in one of two categories: uppers and downers. Whilst ecstasy would be described as a stimulant or upper, alcohol would be considered a depressant or downer. Ketamine is part of the latter category: the downers. That is because it is literally anaesthetizing the user. Whilst there are also feelings of euphoria, the overarching feeling is weighty and thus it is a depressant, not a stimulant. But what does this drug look like? 

What Does It Look Like?

Although Ketamine can be used as a clear fluid by those in the medic world, on the streets – Ketamine is most commonly found as a white powder. It looks very similar to cocaine, but don’t be fooled, they are very different drugs. They are also very different in their potencies. In fact, if you were to take a line of ketamine with a cocaine amount, you’d most definitely be surprised by the strength. It wouldn’t be a good idea, that’s for sure. Ketamine is most commonly sniffed either through a note, or by using a key. Due to its strength, it is often ‘keyed’ because the amount you can place on a key and sniff is usually enough. 

Although Ketamine can resemble cocaine, it’s important to remember that they both smell and taste different. For those who are well versed in the worlds of drugs, the differences are pretty obvious. Plus, cocaine can sometimes be sold in rocks, which means you have to crush it first. Ketamine will never be sold in rocks, always in fine powder. However, the similarity between the two substances is definitely something to keep an eye on. Getting the two mixed up will most likely lead to something not very nice. In fact, it could lead to the infamous ‘K-Hole’. Don’t worry… we’ll get on to that later. 

The History of Ketamine

The history of Ketamine is a surprisingly interesting one. In 1956, a drug called Phencyclidine was found to be a very good anesthetic for monkeys. It was so useful that doctors then began using it on humans. However, there was a problem. The problem was that those using this drug were beginning to experience side effects. With an ideal anesthetic, the patient will wake up and feel normal after. However, with Phencyclidine, patients were waking up with loss of sensations in their limbs and other senses. This was of course an issue. In conclusion, Phencyclidine was considered to be a bad anesthetic, despite the initial successes. It was then that Dr. Calvin Lee Stevens decided to mess about with the substance, with the aim of synthesizing a better alternative. One without the bugs, but with the positives. Reset Ketamine speaks about what happened next: 

“The compounds he synthesized were sent to pharmacological testing in animals, and one compound in particular was found to be a successful, short-acting anesthetic. Selected for human testing, it was titled CI-581 and is what we now call ketamine. Ketamine was named because of the ketone and the amine group in its chemical structure”

After the creation of this new substance, Ketamine took off and was used for a variety of different things. Obviously it was used as an anesthetic on all types of animals and humans. But not only this, Ketamine was found to have euphoric and antidepressant qualities. In fact, Ketamine was used on injured soldiers during the Vietnam War. This is because it was known to help with short-term pain. In addition, Ketamine was being used in small doses to deal with mental health issues like schizophrenia and depression. The use of this drug in dealing with mental issues was seen was a huge breakthrough. However, like all substances, there was of course the recreational side. People were finding ways of making Ketamine and selling it on the black market. This is perhaps where Ketamine gets a negative reputation from. 

Ket: How Does It Make You Feel?

Now you understand the history of Ketamine, what it is, and what it might be used for, the question still remains: what does it feel like? Ketamine is a hugely popular drug both in the medic world and recreationally. When used recreationally, ketamine lasts around 30-60 minutes, and takes about 10 minutes to kick in. 

Positive Effects

  • The feeling of euphoria
  • Positive dissociation
  • Slows down time 
  • Allows you to concentrate
  • Physical pains subside 
  • Mental pains subside 
  • Funny and elaborate thoughts 

Negative Effects

  • Agitation 
  • Panic attacks 
  • Short-term or long-term memory loss 
  • Negative dissociation 
  • Can become addictive 
  • Can feel depressed without it 
  • You can feel invincible, which could lead to harming yourself
  • K-holing 

The K-Hole 

Anyone who knows about ketamine will have heard of the infamous ‘k-hole’. Now some people enjoy the k-hole, whilst others fear it. It’s sort of like the ‘whitey’ in the world of cannabis. A k-hole occurs when someone takes too much Ketamine. Due to the strength of Ketamine powder, it’s very easy to take too much or become unaware of how much you’ve taken due to anesthetic feeling of the drug. Therefore, k-holes are actually a lot more common than you’d think. The feeling of a k-hole is peculiar. All of those feelings of being outside your body, unable to move freely, and feeling slow, all become extremely strong and sort of paralyze you. It usually feels like it’s lasting hours, when actually it only lasts 30 or so minutes. Ultimately, It isn’t a very pleasant feeling. However, if you’ve got someone around you that you can trust then you should be fine. 

Is Ketamine Legal?

Ketamine, much like the majority of drugs, is used in medicines and in doctor’s practices but is illegal to use recreationally. In the UK, it is a Class B drug, which is the same as cannabis. In the US, ketamine is also illegal and is a Schedule III substance under the Controlled Substances Act. 

According to the DEA, Ketamine is illegal because it has the potential for abuse. But, on the positive side, in 2019 the…

“FDA approved…Ketamine nasal spray for treatment-resistant depression”

This is a potential positive. Whilst Ketamine is illegal in most major countries, research is definitely being done into how it can be used to help people with mental conditions. 

Ket: My Own Experiences

I always like to include my own experiences of the drugs I write about in this series, just so it doesn’t sound like someone who hasn’t himself had his own dealings with Ketamine. I always hate reading about drugs on websites where I know, quite clearly, that that person has never touched a drop in their life. So what do I think about Ketamine? 

Well, university was when I had my first dealings with Ketamine; or ‘Ket’ as everyone called it. I was drunk at a very un-cool club night and someone gave me a bag full of white powder and told me to go take a ‘key’ of it. At the time, I didn’t actually know what a ‘key’ was. I imagined you just placed as much powder on a key as you could. I also didn’t want to risk asking and seeming inexperienced. Oh the wonders of peer pressure! So I snuck into the bathroom, got out the baggy, got out my key, and put the key inside. I placed, what I thought, was the right amount of Ket onto the key (which ended up being far far too much) and tried my best to snort it up my nose. I then went back on the dance floor, unaware that my nose now had a huge amount of white powder quite blatantly stuck to it. 

For about 30 minutes I felt nothing, and continued to drink and dance with my friends. However, as the minutes went past, I began to feel heavier. I felt amazing. The music slowed down, I slowed down, everyone slowed down. My limbs began to feel like warm pillows and all the negative thoughts in my head left me. It wasn’t the same euphoric feeling of ecstasy, but I still felt good.

However, after a while I realized I’d obviously taken too much. Time didn’t just go slow, it basically stopped. That’s when I remember thinking ‘I’m gonna die’. Which, to be fair, was a classic thought I had when I took most drugs at that age. I then don’t really remember much. It felt like I was stuck in time for hours, but it later turned out to only be about 20 minutes. I just remember sort of regaining consciousness outside in the smoking area, with my friend chatting to me about the price of plastic bags. A very odd experience. I then continued my night and just had very elaborate, comical thoughts. It was definitely a mixed first experience. Although I will add, that now I know how much Ketamine to have, I do find it a very amusing drug; and one with the least negative sides. 

What’s Your Opinion?

So, what do you think? Do you think Ketamine is a drug that deserves more research and consideration? Or is its recreational abuse proof that it should be regulated forever? As always, we want to know what you think, drop us a line in the comment section below. Make sure to keep up to date with the rest of the articles in this series as we go through all of the most popular street drugs. Until next time.

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Elon Musk Embraces Potential of Psychedelics at CodeCon

Enter a long, strange trip into the mind of a genius. Elon Musk—who on September 27 became the world’s richest person, surpassing Jeff Bezos—said people should be “open to psychedelics” at a CodeCon event on Tuesday.

Ronan Levy, executive chairman of Field Trip Health hosted conversation with Musk during an interview at CodeCon 21, a celebrated tech development event, confronting him about whether or not he supports psychedelics for therapeutic purposes.

“I think generally people should be open to psychedelics,” said Musk. The session continued. 

“You’ve spent a lot of time talking about outer space, and I want to ask you about inner space. What role do you think psychedelics may have in addressing some of the more destructive tendencies of humanity?” Levy asked Musk.

“A lot of people making laws are kind of from a different era,” Musk replied. “As the new generation gets into political power, I think we will see greater receptivity to the benefits of psychedelics.”

Field Trip Health provides psychedelic-assisted therapies. In an August 31 press release, Field Trip announced new programs, including one that gives eligible therapists the ability to provide ketamine-assisted psychotherapy (KAP) to their patients at Field Trip Health Centers. They will use Field Trip’s medical teams for screening, prescribing and administration of ketamine. 

Field Trip’s programs will also provide both didactic and experiential training to therapists and medical professionals on KAP. Therapists who complete Field Trip’s training programs will automatically become eligible to join the KAP Co-op program.

It’s not the first time that the SpaceX founder and multibillionaire has spoken in favor of psychedelics.

On November 14, 2020, Musk tweeted three statements: “You can’t win; You can’t break even; and You can’t stop playing,” then tweeting in the thread, “Unless you’re on DMT.” Twitter couldn’t handle the statement, and commenters guessed whether it was an admission that the billionaire had tried ayahuasca or DMT.

Why is this important? Because so much weight is often put on Musk’s opinions—given his stratospheric wealth and influence. Musk’s powers are evident in the way his comments significantly influenced and tipped the value of Dogecoin and Bitcoin.

Elon Musk on Cannabis

Cannabis—itself a mild psychedelic—is also a recurring theme in the billionaire’s life. In 2019, Musk smoked a blunt on The Joe Rogan Experience—and High Times’ asked if it was “the most expensive blunt of all time?”

Few people in the world are as scrutinized as deeply as Musk when it comes to personal habits like smoking pot. Smoking a blunt live set off a firestorm.

The U.S. Securities and Exchange Commission sanctioned Musk. There was an active petition to get Twitter to deplatform him—and pop stars even dragged him on Instagram. Even Musk’s SpaceX assets were not safe. NASA investigated Musk also, after his debacle on the podcast. According to three unnamed sources who spoke with the Washington Post, NASA launched a safety review of SpaceX shortly after his spot on The Joe Rogan Experience.

Given the level of investments that NASA pours into SpaceX, to them, smoking a blunt was a big deal. At the time, NASA spokesman Bob Jacobs did not comment on whether Musk smoking a blunt was what triggered the review. But he did mention the importance of SpaceX adhering the rules of a drug-free workplace.

On another episode of The Joe Rogan Experience, Musk suggested that most CBD experiences are “fake” and mostly hype. Rogan immediately schooled him, scolding him for dismissing the compound as a benefit for people around the world.

The post Elon Musk Embraces Potential of Psychedelics at CodeCon appeared first on High Times.

Party Drugs: The Other Side of Psychedelics

Psychedelics drugs are making a major comeback, and attracting mainstream attention, with more than one on the brink of legalization. Psychedelics have shown the ability for mind expansion, in a way that promotes better mental health on many fronts. But while medical psychedelics are the focus of the above-board world, party drugs are still quite popular, representing the other side of psychedelics.

Party drugs like psychedelics are a big thing in the club scene, but they’re not for everyone. Some people prefer a more relaxing drug like cannabis. For the hardcode cannabis aficionados out there, there are more options available than ever. Take delta-8 THC for example, no one knew what this alternate form of THC was a few years ago, and now, this milder version, which doesn’t create the same anxiety, is available all over the place. We’ve got great deals for delta-8 THC along with delta-9 THCTHCVTHCPdelta 10HHCTHC-O, so go ahead, and check out our always-updated selections.

A bit about psychedelic drugs

Psychedelic drugs are a subset of hallucinogens, which fall under the category of psychoactive drugs. Unlike other drugs in the ‘psychoactive’ category, hallucinogens cause people to experience things that don’t actually exist, like seeing, hearing, smelling, tasting, or feeling something that isn’t real. Psychedelics are also known for producing other effects, like spiritual experiences, feelings of connectedness between people and the universe, euphoria, and feelings of well-being.

Psychedelics are known for altering mood, perception, and cognitive abilities. They are also known for producing life-changing experiences, in which users have insightful encounters into life and consciousness. These drugs can be found in nature, like with magic mushrooms and DMT, or made in a laboratory like acid, MDMA, or ketamine.

Though psychedelics have been found to be generally safe, and not a factor for death and disability, it is possible to have bad experiences with them. Often called a ‘bad trip’, a user can experience negative hallucinations, as well as physical symptoms like nausea and vomiting, chills, erratic heartbeat, raised blood pressure, dizziness, anxiety, and paranoia. Getting the dose correct is important for these drugs, with proper dosing correcting the majority of these issues. Other factors play in as well, like where the drug is being taken.

psychedelic drugs

Psychedelics have been around for a long time, and researchers have found evidence of psychedelic use in different parts of Mesoamerica, as well as the Near East, among other locations. In Mesoamerica, drugs like ayahuasca, psilocybin from magic mushrooms, and bufotoxins from toad skin, were used among other compounds, by different tribes including the Olmecs, Mayans, Aztecs, and Zapotecs. In the near East, Viper’s Bugloss was found in the Kamid el-Loz Temple in Lebanon, as well as Blue Water Lily extract, which was found in none other than Tutankhamun’s tomb. The former is a potent hallucinogen, and the latter is a narcotic with psychedelic properties.

Party drugs – a different side of psychedelics

The thing about substances that make a person feel good, connected to other people and the universe, spiritual, and with heightened and altered perception, is that it can lead to mind-expanding experiences. But it can also lead to simply wanting to feel good.

This is the case with drugs like MDMA (or its less pure form, ecstasy), and ketamine, among others. In the same way that some people use the drugs to find spiritual or personal clarity in their lives, some people use them to have intense experiences at parties, or with others. Since most of the drugs used for this purpose are synthetic, they’re often dubbed, ‘designer drugs’, or ‘club drugs’. Other drugs like GHB, LSD, cocaine and amphetamine are also included in the category of ‘club drugs’.

The trend of party drugs in the form of psychedelics got big in the rave scene of the 1980s, spurred on by the growing popularity of rave events, EDM parties, and the general dance club scene. Since ‘club drugs’ can encompass different classes of drugs, legalization policies are specific to each drug. While psychedelics don’t pose the same risk as drugs like cocaine or amphetamine, where overdose and death are possible, psychedelics like MDMA have been known to cause dehydration due to all night partying without enough water consumption. This seems to be the biggest complaint.

What is ecstasy?

Ecstasy is interesting because it’s one of the most popular party drugs of the psychedelic variety, but actually denotes nothing more than an impure form of MDMA, one of the up-and-coming medical psychedelics. The names can be interchangeable, including the term ‘molly’, but ecstasy can also mean non-pure versions wherein the MDMA is mixed with other chemicals, leading to lower purity, and possible side effects from the added compounds.

Whether pure or not, and regardless of the name used, the basis for anything with one of those names, is 3,4 methylenedioxymethamphetamine. This compound is not naturally occurring, and was created in a laboratory in 1912 by Merck Pharmaceutical, and patented in 1914, in an attempt to create a medication to stop bleeding. It wasn’t well understood until way later in the 1970’s when chemist Alexander Shulgin found a new way to synthesize the compound, which led to him experimenting on himself along with some close friends.

party drugs psychedelics

Around this time, it started being used the way LSD had, as a part of psychedelic-assisted therapy. Even though it showed usefulness for psychiatric issues back then, it was promptly illegalized in 1985 with Reagan’s Comprehensive Crime Control Act, which ended all therapeutic uses of the drug.

The compound was investigated by the CIA and the US army during the cold war, for use as a psychological weapon. The CIA started the program MK-Ultra to investigate psychedelics like MDMA for mind control purposes. The project was known for experimenting on non-consenting subjects.

Somewhere along the way, it entered the party scene. In a way, it’s similar to THC-O-Acetate, which was also a part of secret military studies, and which also randomly appeared as a street drug around the time of this military testing. Though this doesn’t mean it was put out by the military, (perhaps as a secondary ‘street study’), it certainly implies the possibility, and the same can be said for the appearance of MDMA and other psychedelics.

Somehow these compounds which the government felt the need to do highly secretive, and often non-consenting testing on, all appeared on the street without any kind of information or market behind them. By the 1980’s ecstasy was being called out in a San Francisco Chronicle article as being “the yuppie psychedelic.” It received this name because it was thought of as being slightly less intense and dangerous, as the already popular LSD.

In 2017, MDMA was given the ‘breakthrough therapy’ designation by the FDA, for PTSD treatments. This designation came at the request of the organization MAPS (Multi-Disciplinary Association for Psychedelic Studies), as that is how these designations are assigned. MAPS is currently in phase III of trials using MDMA for PTSD, in which these 3rd trials were planned in conjunction with the FDA, to ensure that study results meet all regulation.

While MDMA is one of the current leading compounds when it comes to medical psychedelics, it’s also one of the most popular party drugs of both psychedelics and other classes, making it popular both for those who want spiritual and mind-enhancing experiences, and those who want to get-down all night.

The legality of psychedelics

Psychedelics are generally illegal in the US, and the rest of the world. They sit in Schedule I of the Convention on Psychotropic Substances, though in many cases when it comes to natural forms, like magic mushrooms, the laws are inconsistent, often illegalizing the compounds inside (psilocybin and psilocin), but leaving the mushrooms themselves as legal. The Convention came into effect in 1971.

party drugs psychedelics

For its part, the US began its smear campaign against psychedelics in the 1960’s, using the drugs as a way to redirect attention from the Vietnam war, and the senseless violence and mounting deaths that came from it. In 1968, the Staggers-Dodd bill was passed which specifically illegalized LSD and psilocybin. This was followed up in 1970 by the inclusion of multiple substances in Schedule I of the DEA’s Controlled Substances list via the Comprehensive Drug Abuse Prevention and Control Act. A year later it was followed up again internationally by the Convention on Psychotropic Substances.

This was stepped up a notch in 1984 when then-president Ronald Reagan, signed into legislation the Comprehensive Crime Control Act which allowed for the emergency banning of drugs by the government. What did this do? The following year, when the topic of MDMA came up, it was able to be immediately illegalized, without medical research, or anything else. When this happened, it went against a judicial decision to allow MDMA as a Schedule II substance. Funny enough, MDMA is one of the drugs getting close to a medical legalization today.

To give an idea of the real nature of why these illegalizations happened, in 1994, the following statement came from John Ehrlichman, the guy who had served as the Assistant to the President for Domestic Affairs under former president Nixon. He said this about the war on drugs and why it was being fought:

“The Nixon campaign in 1968, and the Nixon White House after that, had two enemies: the antiwar left and black people. You understand what I’m saying? We knew we couldn’t make it illegal to be either against the war or black, but by getting the public to associate the hippies with marijuana and blacks with heroin, and then criminalizing both heavily, we could disrupt those communities. We could arrest their leaders, raid their homes, break up their meetings, and vilify them night after night on the evening news. Did we know we were lying about the drugs? Of course we did.”

Things do change however, and esketamine was legalized in 2019 as the first non-monoamine anti-depressant, which works so quickly, it was even cleared for suicidal thoughts in 2020, a diagnosis that would require a very fast-acting medication. Along with that, the compound DXM can be found in cough medicines all over the country, requiring nothing at all to buy, not even being 18 years old, (or at least not in any kind of enforced way). Both Psilocybin from magic mushrooms and MDMA have been identified with the aforementioned ‘breakthrough therapy’ title by the FDA, a designation given to compounds being studied by companies, that present a possibly better alternative to current treatments. This designation is meant specifically to speed up products to market.

Conclusion

When we talk about the possible legalization of MDMA, this only covers medical use. The idea that party drugs would be legalized just because medical psychedelics are, is unfortunately, not the case. The party drugs scene will almost certainly continue, likely spurred on by any legalization that might occur, but it will remain below-board, as part of the black market scene. Will this change in the future? Perhaps. Some places like Denver, and the state of Oregon, have decriminalized psychedelic use. Other states like Michigan and California, are already introducing recreational policies. These laws may not go though, but with esketamine legal medically, and psilocybin and MDMA on the way, the world is definitely becoming a way more psychedelic place.

club drugs

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DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

The post Party Drugs: The Other Side of Psychedelics appeared first on CBD Testers.

New Psychedelic Anti-Depressant Esketamine: What the Patients Have to Say

Psychedelic-assisted therapy, and the legalization pf psychedelic drugs, is most definitely a thing. We know this, because the psychedelic drug esketamine is already legal for use, with MDMA and psilocybin on the way, and being pushed by the FDA. Is esketamine an effective treatment, here’s what the patients have to say.

Esketamine therapy is a real thing with plenty of patients letting us know what they have to say. If you’re not quite ready for psychedelics, there’s always cannabis, and plenty of different options. Like delta-8 THC, an alternate form of THC which leaves users with more energy, less cloudiness in the head, and no anxiety. There are so many compounds to choose from, that there’s something for everyone. Take a look at our selection of THCV, THC-O, Delta 10 THC and Delta-8 THC deals, and figure out your best option.

What is esketamine?

Before getting into esketamine treatment and what patients say about it, let’s cover what it is. If the name ‘esketamine’ sounds incredibly similar to a popular party drug, that’s because it is. The drug ketamine has been a staple of the party circuit since the 80’s and 90’s, and esketamine is its close cousin. Ketamine was discovered in 1962 by scientists at Parke-Davis. They were in search of a strong anesthetic, and after creating, testing, and ultimately rejecting PCP, and other closely related compounds, ketamine was discovered. It was described as a compound with “cataleptic, analgesic and anesthetic action but without hypnotic properties.”

It became known as a dissociative anesthetic, because of how it seemed to disconnect parts of the brain. This was subsequently described as “electrophysiological and functional dissociation between thalamocortical and limbic systems.” Since that time, ketamine has been used as an anesthetic in both animals and humans, as well as being used as a recreational party drug. Essentially it doe three things, provides pain relief, anesthetic affect, and sedation. The chemical formula for ketamine is C13H16ClNO.

Of course, we’re not talking about ketamine, we’re talking about esketamine. Esketamine hasn’t been around as long, making its first appearances in Germany in 1997 as an anesthetic. While it was being used as an anesthetic, it was noticed that the compound had very fast-acting antidepressant effects, and began being investigated for this purpose. In 2017 the drug finished trials in the US for treatment-resistant depression, and in 2018, Johnson & Johnson filed an application with the FDA for a new medication – Spravato. It was approved on March 5th, 2019.

It was technically approved in conjunction with standard antidepressants for the treatment of depression in adults. In 2020, this was updated to include prescription for suicidal thoughts on account of how fast-acting it works. It is already being prescribed for use in psychedelic-assisted therapy.

Esketamine

Esketamine therapy, what the patients say

Pharmaceutical companies put out all kinds of medications, and they promote them all like they’ll save your life, even when going through litigation because of lies. Though psychedelics do seem to have good efficacy for helping people, this does not mean that any psychedelic medication will be okay. So, it suffices to say that hearing directly about esketamine from patients, and what they have to say, is the best thing for understanding the current situation. In the first few years of something being out, it can be hard to find the stories. These are the stories around right now.

One test subject, Amelia D., started receiving esketamine in 2017 at the Rochester Center for Behavioral Medicine. As she explains, she began taking anti-depressants shortly after she finished college, and had been given a range of diagnoses ranging from dysthymia to ADHD to anxiety to major depressive disorder. She explained how after the intake for the study, she was required to take the drug twice a week for at least a month, each time under supervision in the doctor’s office.

She explained how those taking part were not allowed to drive for 24 hours following administration. She says it started with four hours of supervision, but was brought down to between one and two hours over time. This makes sense for shorter acting drugs like ketamine.

By the time a Time article was written about her in 2019, she was going every two weeks for treatment, in which she was administered three nasal doses at five minute intervals, and then watched for an hour or two. She also stated fears of not being able to continue the medication when the trials were over due to insurance not covering it, and not being able to find a therapist. Though she had plenty good to say about the treatment, she highlighted the fact that she had gone from being unemployed for quite some time, to holding a job steadily, and being generally okay. She said she always knows when she’s ready for another dose.

It doesn’t seem like this particular trial included the therapy aspect of it, and was likely more to establish effects of the drug. She did not mention negative side effects, and spoke generally of an improvement in her life.

Esketamine, what more patients have to say

patients say

Esketamine therapy has begun to find its way into the mainstream, and has been spoken about openly by American comedian Theo Von. Von, known for his stand up and podcast work, among other projects, runs a podcast called This Past Weekend with Theo Von. In Episode 341, called Ketamine Therapy, Von talks about his own experiences with depression and ketamine therapy, as well as interviews with founder and medical director of the Chattanooga Ketamine Center, Dr. Jason Pooler.

Von talks about the hallucinations he had while taking esketamine (it is often called ketamine by users, but the drug they are prescribed is esketamine). Theo’s father died when he was young, and through the ketamine therapy, he was able to deal with the subconscious pain of not having his father, and he said that using esketamine allowed him to complete the grieving process.

Yet another public personality, albeit on a smaller scale, is podcaster Ariel Kashanchi who runs the show Mad Genius. In her June 16th episode ‘Ketamine Touchup’, she goes into specifics about getting ketamine therapy. She starts by talking about her 7th infusion. She did six consecutively, followed by the 7th touch-up. She explains how touch-ups can be done per person needs, and that for her it’s every eight weeks or so.

However, before this, she had an April 8th, segment called Ketamine, TMS & My New Brain in which she describes more about the actual process. At the time of the recording she was one week into her esketamine and TMS (Transcranial magnetic stimulation) therapies, having had two ketamine sessions at that time. She talks about her longstanding issues with depression, PTSD and childhood trauma. She said more than once in the episode that she feels like a different person since treatment began.

She explains that in her case its administered via IV. She talks about being in a comfortable setting, with a comfortable chair and blankets, eye mask, and noise canceling headphones. She talks about being hooked to the IV for about 40 minutes, with a doctor checking on her every so often (not the standard format for psychedelic-assisted therapy). She was told she had to have an intention the fist time she went in, and hers was to feel valuable and lovable. She said the experience felt a bit like virtual reality…but her overall sentiment was that prior to this she didn’t think she’d ever feel okay, and now she does. She also – like Von, spoke about hallucinations of dead loved ones, and how it created a positive situation to experience them like that.

What is psychedelic-assisted therapy?

When we talk about the new rise in medical psychedelics, it’s not about a doctor blindly giving out a prescription for a drug and saying ‘go take a trip’. In fact, quite the opposite. Perhaps in the future this will be less restrictive, but for now, the only legalization for psychedelics is for medical use, and this goes for Oregon, the first state to legalize for use in this way (although that state, and others like Denver do have decriminalization policies for drugs like psilocybin from magic mushrooms).

magic mushrooms

If you’ll notice, esketamine only has an approval at the moment for use in conjunction with other antidepressants. I don’t expect this will last forever, but this is the first one to get a legalization like this, so it’s not shocking that there are several caveats attached that don’t make a lot of sense. If this stuff works better than standard antidepressants, which actually come with a lot of warnings, why not just use it? In the future, this stipulation will probably be cleared, but for now, that’s the way it’s been legalized.

So, if standard treatments are not working, the doctor can prescribe esketamine to be taken under the supervision of the doctor. There are a few different steps in the process of psychedelic-assisted therapy, and it goes something like this, though the process could certainly be tweaked as the industry progresses. This model may also be more relevant for psychedelic trips on drugs like ayahuasca, LSD, or psilocybin, which create much longer experiences.

  • Preparation – These are initial sessions in which the psychiatrist gets to know the patient, and the issues the patient has. In this phase it’s important to build repour between the two in order to facilitate a meaningful psychedelic session. In this phase, the doctor provides instructions for the psychedelic phase, that include things like not running away from something scary, but approaching it and asking a question instead, or opening a door if one is there. These instructions are meant to help the patient face their issues when they encounter them in the next phase.
  • Psychedelic session – This phase is done in a comfortable setting, which is important, because the setting can affect the patient’s mindset. Two doctors are generally present, likely as safety since the patient is being put in an altered state. The drug is given to the patient, and the doctor guides them through the experience, but does not perform any analysis at this time.
  • Integration – This phase takes place soon after the psychedelic phase, and is meant to help the patient make sense of their experience. This is where the doctor can help the patient analyze their experience to gain meaning out of it.

To be clear, it does not sound like the esketamine therapy model matches this one exactly, but that could be on account of it being very short acting.

Into the future

mdma

Esketamine might be the only legalized psychedelic at the moment, but that should change soon. In 2017 the FDA granted a ‘breakthrough drug’ designation for MDMA for the treatment of PTSD, and in 2019, the FDA granted not one, but two ‘breakthrough drug’ designations for psilocybin from magic mushrooms, also for the treatment of severe depression.

These designations are granted when a drug company finds in testing that a new compound might work better than existing alternatives, and is meant to quicken research and production to get products to market. In this way, the FDA is outwardly pushing for the approvals of these two psychedelic compounds.

To give an idea of how much the FDA seems to want this to happen… the organization running the MDMA studies, MAPS (Multidisciplinary Association for Psychedelic Studies), actually planned its third MDMA trials in conjunction with the FDA to ensure that the results would fall in line with existing regulation. I’m not sure there’s a better indication of what’s to come, than an actual government agency helping to design drug trials. With all this going on, it becomes that much more important to get first hand descriptions of esketamine from patients, who are right now the only people who can say anything about it.

Conclusion

Psychedelic-assisted therapy is a real thing, and esketamine in the first drug to get approval. In understanding how esketamine works, it helps to hear what patients themselves have to say. It should never be assumed that every medication will be an answer for everyone, but the information trickling in shows esketamine to be a very promising drug.

Hello and welcome to CBDtesters.co! This is your #1 spot for the most thought provoking and up-to-date psychedelics and cannabis-related news from around the world. Read through the site daily to stay on top of the quickly moving world of legal marijuana, and sign up to get our newsletter, so you always know what’s going on.

DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

The post New Psychedelic Anti-Depressant Esketamine: What the Patients Have to Say appeared first on CBD Testers.

How is Delic creating a legal psychedelic ecosystem

In 2019, a new kind of wellness business sprouted – a legal psychedelic drug company. We spoke with Matt Stang, the co-founder and CEO of Delic Corp to learn more about their mission as well as any strategies they utilized to build a publicly traded, legal psychedelic ecosystem. Matt Stang spent twenty years pioneering the […]

The post How is Delic creating a legal psychedelic ecosystem appeared first on Latest Cannabis News Today – Headlines, Videos & Stocks.

Ketamine: Leading the Race of Psychedelic-Based Therapy

With psilocybin on the rise as a natural option to traditional therapy, Ketamine is now leading the race of psychedelic-based therapy. Approved by the FDA as an anesthetic in 1970, it is used for pain control during surgeries and to decrease postoperative pain in human and veterinary medicine. Make no mistake – these are not […]

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