Can You Treat COVID-19 With CBD and Reduce Mortality Rates? A New Israeli Research Believes You Can!

Can you treat COVID-19 with CBD?
Can you reduce mortality rates of COVID-19 in patients with sever cases by using cannabinoids? A new Israeli clinical trial, approved recently, believes that a possible treatment for COVID-19 could be a blend of CBD and steroids.

Exciting news coming from Israel suggests that you can treat COVID-19 with CBD! According to this research, the possible treatment for COVID-19 patients might be coming from a special blend of CBD and Steroids. Unlike other cannabinoids-based medicine, aimed to treat but not to cure, the current clinical trial, held in the Rabin Medical Center (Beilinson) is using CBD and steroids to reduce mortality rates among the among COVID-19 patients in the worst states of health. If this clinical trial produces positive results, we might see a new wave of global attention toward CBD, cannabis and cannabinoid-based medicine.

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Can You Treat COVID-19 With CBD?

A new clinical trial, by the Rabin Medical Center, (RMC), is testing a promising CBD (Cannabidiol) based treatment for patients with severe and critical COVID-19 pulmonary infection. The study, which runs in cooperation of Stero Biotechs, an Israel-based company focused on Cannabidiol (CBD) formulation research and Mor Research applications, the TTO arm of Clalit, the largest state-mandated health service organizations in Israel, is trying to establish whether a new formula, based on CBD (infused in pharma grade olive oil) and steroids can reduce COVID-19’s mortality rates.

The clinical trial already received Helsinki Committee approval and is planned for 20 patient treatment as a Proof of Concept (‘POC’), using Stero’s CBD-based treatment, conducted by Dr. Ilya Kagan from the intensive care department with the support of Dr. Moshe Yeshurun, Director of the Bone Marrow Transplantation Unit, at Rabin Medical Center, Israel.

Treat COVID-19 with CBD
Treat COVID-19 with CBD: A New Israeli Research In Rabin Medical Center

The study aims to benefit and help COVID-19 patients in severe states with respiratory failure from acute respiratory distress syndrome (ARDS). The treatment cycle will be for 14-28 days with a subsequent follow-up period of the same length. Pending the success of this POC, Stero plans to expand and scale phase 2a multi-center study, with an additional 40 patients, under FDA clinical trial guidelines and regulations.

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According to David Bassa, Founder & CEO of Stero Biotechs after six years of researching CBD they already gathered alot of data about CBD’s safety, its effectiveness in treating inflammation and its ability to moderate the ammune system when it is becoming over-active.

In addition, the company has already researched the efficacy of CBD for the treatment of acute (Grade 3-4) Graft versus Host Disease (“GvHD”), when combined with steroids. That’s why, after learning from Oxford that steroids are effective in treating COVID-19 they have decided to use their own experience research a blend that uses both CBD and steroids. They believe that a formula that uses both CBD and steroids will be more effective in treating patients in severe states and that by adding CBD they will be enhancing the therapeutic effect of a steroid treatment.

About Stero Biotechs, Ltd.

STERO  Biotechs Ltd., founded in 2017 and headquartered in Israel,  is a clinical-stage company committed to the research and development of novel Cannabidiol (CBD) based treatment solutions that will potentially benefit millions by:
1) Enhancing the therapeutic effect of steroid treatments.
2) Lowering the dosage needed in steroid treatments, thus lowering the treatment’s horrific side effects. 
3) Allowing refractory patients to begin responding to the steroid treatments needed. 

All by using Stero’s CBD-based treatment.

Stero has 2 ongoing phase 2a clinical trials in Crohn’s Disease & in Urticaria (Hives) in Israeli hospitals and is planning to commence more clinical trials in 2020-2021 on various indications.

Stero has established a strong partnership with one of its shareholders- MOR Research Applications, the TTO of CLALIT HEALTH SERVICES. The partnership with MOR allows deep support to Stero’s clinical trials.

About Clalit

CLALIT is the largest HMO in ISRAEL, with:

  • Over 4.5M members
  • 14  full-scale hospitals
  • Over 2000 community clinics
  • Over 9000 physicians.

RESOURCES:
The Endocannabinoid System Explained (Why Cannabis Is Good for Our Bodies)
Control of Inflammation with CBD
Everything You Need To Know About CBD Isolate (a deep look into hemp extracts)
Cannabinoids 101 – Spotlight on CBN (Cannabinol)
Everything You Need To Know About CBG Isolate
Your Complete Guide to EU GMP-Certified CBD Isolate and Distillate – Spotlight on the regulated EU market
Newest Cannabinoid Powerhouse – CBC – What Can It Do for You? What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8 THC)
Synthetic Cannabinoids (Are they safe?)
Cannabinoids 101 – Spotlight on CBN (Cannabinol)
DELTA 8 THC Medical Benefits (The medical background of using DELTA 8 THC products)
Everything You Need To Know About CBD Distillate
Get EU GMP-Certified Cannabinoid Isolates and Distillates
A Complete Guide To CBN Isolate (Cannabinol)
Best Delta-8 THC deals, coupons and discount. How to choose Delta-8 THC vape cartridges.

DELTA 8 THC Business: Risks and Rewards (Read it before opening a DELTA 8 THC business)
CBG Distillate Explained: What It Is, What It’s For, and How It’s Made
Delta-8 THC infused hemp flowers: How to choose Delta-8 THC flowers
The 
CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers)
EU GMP Extracts: CBD Isolate, CBD Distillate and CBG Isolate

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Why is using THC good for the eyes

These days the list of illnesses that cannabis medicines can be used for grows every day, with research studies being done left and right to test its efficacy against different symptoms and disorders. Most attention is focused on CBD because of its lack of psychoactive effects, while THC is often left out. However, it was found early on that THC is good for the eyes, and has been used to treat conditions like glaucoma for decades.

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Medical cannabis back in the day

Before getting into the restart of medical cannabis in more recent decades, let’s go over some facts about the use of cannabis in medicine. Essentially, it’s been used in medicine for thousands of years, long before it was co-opted by Western medicine in the 1800’s, and then re-introduced once again after a period of enforced illegalization. It’s a part of two of the oldest medicinal traditions, Ayurvedic and Traditional Chinese Medicine, both of which have multiple applications for the use of cannabis to treat tons of different ailments. It has been used in many other lesser-known medical traditions as well.

Prior to it being scheduled as a narcotic by the Single Convention on Narcotic Substances which forced a global illegalization, cannabis was being used in all types of Western medicine applications. In fact, it was listed in the United States Pharmacopoeia for the first time in 1850, but dropped from there in 1937 following the Marijuana Tax act. Before the laws changed, it could be found in tons of products, for almost anything. Most people, of course, had no real understanding of this, but it does show that cannabis was being used very heavily in the world of medicine. Considering how many countries were forced into illegalizing the plant, this was not confined to just the US.

marijuana for the eyes

Cannabis has existed medicinally in essentially three stages. The first was everything up until the 1800’s when it was used in natural medicine traditions. The second stage was the original co-opting of the drug into Western medicine, and the third is the reintroduction back into Western medicine more recently.

It entered Western medicine for the first time in around 1842 when the Irish researcher Dr. William O’Shaughnessy published Bengal Dispensatory and Pharmacopoeia which included an entire 25 pages devoted to cannabis use in medicine. He started studying it back in 1933, when a part of the British East India Company, and saw it as beneficial for use with digestive issues, acute rheumatism, in dealing with pain, and for sedation, among other applications.

The restart of medical cannabis

Over in Israel, Raphael Mechoulam was doing his own thing in the mid-1900’s, publishing a paper on the isolation of THC in 1964, and investigating it for use with a number of illnesses. Research that essentially got pushed underground for decades. There was also Roger Adams, the guy who isolated CBD in 1940, the compound that helped bolster medical cannabis in general by offering a non-psychoactive compound to treat illnesses. Basically, all those things cannabis had already been used for, prior to illegalization, began to be tested through more modern means of medical research. Most of this didn’t make any waves for a long time, until California made the topic an international story.

In the US in 1979, Virginia passed a drug bill to overhaul its system, and this bill allowed for cannabis medications to be prescribed to people with glaucoma and cancer. This was the first modern medical legalization in the US. California pushed harder with a bill solely for cannabis use in medicine in 1996, setting off a flurry of changing regulation in the States with its Proposition 215.

THC is good for the eyes, especially glaucoma

THC and glaucoma

It might not be considered one of its more prevalent uses now, but cannabis use to treat glaucoma was one of the first reasons for its reintroduction into Western medicine. And this because THC has been shown to be good for the eyes. Research into cannabis use for the eyes has been out since the 1970’s, when it was determined that marijuana, and specifically THC, can decrease intraocular pressure, one of the main reasons for glaucoma.

There is more than one type of glaucoma, but the majority of sufferers have POAG – or, primary open-angle glaucoma. It might not be mentioned as much as other disorders, but glaucoma is very widespread, affecting upwards of 60 million people worldwide. Other than age and race, intraocular pressure is the third risk factor for developing the disease, meaning keeping pressures under control is vital, especially as glaucoma is the second leading cause of blindness after cataracts.

The idea that THC can be used to treat glaucoma – AND medically in general! – came about in the mid 70’s when a 26-year-old guy named Robert Randall – who was experiencing advanced glaucoma, which wasn’t being adequately taken care of – noticed the disappearance of halos around lights (caused by his high eye pressures) after smoking marijuana. Randall ended up growing his own marijuana, for which he got caught and arrested, and subsequently faced federal charges.

In the 1976 landmark case The United States vs Randall, Randall successfully argued his case in front of the DC Superior Court, creating “The first successful articulation of the medical necessity defense in the history of the common law, and indeed, the first case to extend the necessity defense to the crimes of possession or cultivation of marijuana.” This made Randall the first legal medical cannabis user since 1937 when the Marijuana Tax Act essentially ended cannabis use in medicine, and in general.

smoking cannabis

How else is THC good for the eyes?

Funny enough, THC has an application that we all technically know about already. And if not necessarily ‘good’, with possible medical purpose, at least. Everyone knows that cannabis dries out the eyes. I can personally attest to the fact that my contacts stick right to my eyes when using marijuana. This, in and of itself, isn’t a benefit, but in this study it was shown that THC is good for regulating the lacrimal gland, and this may have positive benefits for people with epiphora, a condition of over-tearing eyes.

In 2004, a study was published on the effects of cannabis on night vision. The study included very few subjects which means it requires more corroboration, however, it did show a positive outcome. In two double blind studies on subjects who smoked kif (here defined as “sifted cannabis sativa mixed with tobacco”), it was noted that night vision improved after smoking. The belief of the investigators is that this is based on dose, and that the effect is mediated at the retinal level. The study used Marinol as its form of THC, in doses of 0-20mg.

One of the issues with THC is that due to the general ban on it, not as much research has been done into it as could have been. Right now there isn’t much research regarding cannabis and cataracts, but there are some connections that might prove promising. For one thing, THC helps reduce inflammation, which is a major characteristic of cataracts, along with elevated blood pressure which cannabis can help to decrease as well.

Another major eye issue, especially among the aging, is macular degeneration. Cannabis can help treat symptoms in many ways. For one, much like with cataracts, it can help with inflammation. Second, it can also inhibit vascular endothelial growth factor, and without the harsh side effects of pharmaceutical medications for this purpose. Third, it lowers intraocular pressure – which is beneficial for glaucoma sufferers too. And fourth, when looking at the psychological factors of having such an eye condition, and the anxiety and depression that can go along with it, cannabis can be useful here as well, helping to ease these symptoms and relax the patient.

Conclusion

As with any other topic related to medical marijuana, there are plenty of articles shouting out about possible damage caused by using it. Anyone interested in using cannabis to treat their eye issues should speak to a professional of some kind, preferably one who understands cannabis medicine. However, that THC can be good for the eyes seems to have been understood for quite some time, though its actual application has been much slower with the pick-up. Perhaps in the future this will change.

Thanks for dropping by CBDtesters.co, your #1 spot for all cannabis-related news. Keep up with us every day to know what’s going on in the world of legal marijuana, and sign up to our newsletter so you’re always in the know!

Resources

Interview with Raphael Mechoulam: The Father of Cannabis Research
Cannabis and Schizophrenia – Not a Testable Hypothesis

Cannabis Falling from the Sky in Israel
Germany Leads EU in Cannabis Oil Imports…and Exports

Prop 65 Warning on California Cannabis Products Opens the Floodgates for Next Nobel Prize Winner? Harvey Prize, a Predictor of the Nobel Prize Goes to Raphael Mechoulam
What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8THC)

Cannabis Use in Ancient Times – From Nomadic Warrior Women to Egyptian Pharaohs, and beyond
Can Greece Leverage Medical Cannabis to Save Its Ailing Economy?
The CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers)
The Medical Cannabis Weekly newsletter (International medical cannabis business report)
How Green Is Ireland When It Comes to Cannabis Regulation?

The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc) and the Best Black Friday Delta 8 THC Deals 2020.  The best delta-8 THC deals, coupons and discounts.
Cannabis Election Results Virginia and Cannabis, Setting the Record Straight The World’s First Fully Stable and Genetically Uniform Cannabis Hybrid Seeds
Best Delta-8 Deals, Coupons and Discounts

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Succesful feasibility study for the development of topical medical cannabis products

Cannassure Therapeutics Ltd (TASE: CSURE) (“Cannassure”), an Israel based developer and producer of innovative medical cannabis products, announces today the successful completion of a feasibility study for the development of IP protected, homogeneous, topical medical Cannabis products for the treatment of skin inflammation, including psoriatic lesions. (PRESS RELEASE)

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Product development of such topical medical Cannabis products based on AKVANO® is being conducted under a collaboration between Cannassure and Lipidor AB (“Lipidor”), a Swedish topical drug development company, owner of the proprietary drug delivery platform technology AKVANO, which was signed in December 2019. The development project budget is partially funded by the Israeli Innovation Authority, by a non-dilutive grant.

The product under development is an incorporation of cannabinoids with AKVANO®, a topical drug delivery platform. Successful development of the product will allow localized administration of a precise dosage of cannabinoids using a spray, in a technology that allows for prolonged contact and optimal penetration of the active ingredient into the skin.

As part of the feasibility study, AKVANO® technology and cannabinoids were tested for compatibility, and it was found that the cannabinoids can be successfully combined in the AKVANO® system for a homogeneous, uniform and stable formulation. Cannassure tested the degree of product penetration into the skin by using known and acceptable models and found significant penetration of active ingredients into the skin tissue. This enhanced penetration may increase the therapeutic potential of the product. Based on these results, Cannassure will proceed to accelerated development stages and more advanced testings.

According to the agreement, Cannassure has informed Lipidor on its intention to start negotiating an exclusive global license for the use of Lipidor’s technology for the development of cannabinoids based topical therapeutics products for the treatment of indications to be chosen by Cannassure.  

The main guidelines for the licencing agreement, including royalties to be paid to Lipidor on product sales, were defined in the collaboration agreement.

According to estimates, the global market for products for the treatment of psoriasis is expected to reach 21.1 billion dollars by 2022. The current global market for topical products for the treatment of psoriasis is valued at 7 billion dollars, and the global market for topical pain treatment products is projected to reach 13 billion dollars.

The product development of topical treatments based on cannabinoids is in line with Cannassure’s strategy focused on the development and commercialisation of innovative medical cannabis products based on established drug delivery systems and formulations for enhanced therapeutic value. The product development is performed under the Israeli Medical Cannabis regulation, which allows a short development process.

About Cannassure Therapeutics Ltd.

Cannassure Therapeutics Ltd. (TASE:CSURE) is a leading, world class, trusted developer and provider of top-quality-grade medical cannabis products and pharmaceutical cannabinoid medicines, addressing a broad range of unmet medical needs.

About Lipidor AB

Lipidor AB (www.lipidor.se) is a Swedish, Stockholm-based research and development company with a pipeline of pharmaceutical development projects in preclinical and clinical phases. The Company develops topical medical products for the treatment of diseases such as psoriasis, bacterial skin infections and atopic dermatitis by reformulation of proven pharmaceutical substances.

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Do CBD bath bombs have any benefits toward reducing Inflammation?

I’ve heard people say that CBD has helped them with pain and inflammation. I’m always looking for holistic ways to help with pain, you’ll be surprised to see what I’ve found! What is CBD? CBD is a short form for cannabidiol and it is the second most active ingredient of Cannabis. It’s derived from the […]

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Newest Cannabinoid Powerhouse – CBC – What Can It Do for You?

The ever-increasing cannabinoid family has new members coming in every day, and there’s reason to be excited as new research comes out about CBC.

In the last couple of years, CBD (cannabidiol) – a cannabis cannabinoid, has risen to prominence as an effective treatment for many suffering from medical issues like insomnia, anxiety, pain, depression, seizures, high blood sugars, pathogenic diseases, ADHD etc., and a possible answer to many other issues that still require more research like: different forms of cancer, neurodegenerative diseases, and even prion diseases. It seems like every day a new breakthrough is coming out about the use of CBD as a treatment.

It’s easy to forget that CBD, along with THC (Tetrahydrocannabinol) – the main cannabinoid of cannabis plants – are just two of the possibly hundreds of cannabinoids that are present in cannabis plants. In fact, by now, well over 100 cannabinoids have been identified, and each one – though sometimes only appearing in extremely small concentrations – has its own medicinal benefits. One of these lesser known cannabinoids that is starting to make it into the mainstream is CBC, or Cannabichromene.

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What is CBC?

Cannabichromene, which also goes by the names cannabichrome, pentylcannabichromene, cannabinochromene, and cannanbichromene is a phytocannabinoid that is structurally similar to other cannabinoids like THC, CBD and CBN, and the second most prevalent cannabinoid in cannabis.

Much like other cannabinoids, CBC does not actually start out as CBC, but rather as cannabichromenic acid, and is produced over time through decarboxylation. CBC is non-psychoactive, and interacts with the endocannabinoid system differently than both THC and CBD in that it only poorly binds to the CB1 and CB2 receptors in the brain.

In 2019, a study was done looking into the often misunderstood mechanisms of action of CBC, which found that CBC acts as a selective CB2 receptor agonist. As of yet it has not undergone scheduling by the Convention on Psychotropic Substances meaning it is legal to use as of now.

What does the research say about CBC?

The isolation of new cannabinoids means all new
avenues of medical research to go down. The studies on CBC, in fact, go back as
far as a 1981 study that tested the anti-inflammatory, antibacterial, and
antifungal properties of CBC in rats. According to the research, CBC showed anti-inflammatory
effects superior to phenylbutazone,
an NSAID anti-inflammatory/pain medication. It also showed to be a strong antibacterial
agent and a mild to moderate antifungal.

Then, in a 2006, study into the anti-tumor effects of cannabidiol, cannabigerol, cannabichromene, cannabidiol acid and THC acid, it was found that while CBD had a more expected effect on the inhibition of certain tumor growth in rats, the other cannabinoids tested, including CBC, did as well, leading investigators to point in the direction of further testing of cannabinoids for cancer treatment.

$2 Million Going To Cannabis Cancer Research Led By Professor Mechoulam

In 2010 there was a study investigating how CBD and CBC effect activity of the descending pathway of antinociception in anesthetized rats. It was found that both cannabinoids produce an antinociceptive response by interacting with various targets involved in pain control. A less complicated way of saying this is that both CBD and CBC were found to help alleviate pain caused by nerve damage by the ability to block the detection of pain by sensory neuron cells.

It was looked at again in 2012 as an inhibitor of
inflammation induced hyper motility in rats. The investigators were looking at
CBC as a way to control, or inhibit, the overactive digestive tracts in rats
that was caused as a result of inflammation. The results showed a positive correlation between CBC and the normalization of
intestinal motility.

In the 2013 study, The effect of cannabichromene on adult neural stem/progenitor cells, three different phytocannabinoids were looked at in reference to adult neural stem progenitor cells in rats. These cells are similar to stem cells, but more specified, and play a large role in brain function and overall pathology, making them very important. CBC was found to have a positive effect when looking at the viability of adult neural stem progenitor cells in vitro, indicating neural protective qualities.

An interesting systematic review from 2017 investigated the use of cannabinoids including CBC for the treatment of several different pathogenic diseases. The conclusion was important in that though it showed the use of cannabinoids and the elicitation of the endocannabinoid system to be useful in treating many issues, it also pointed to the idea that simply making the assumption that cannabinoids can help with all issues related to a problem, is quite insufficient.

‘This review was able to point to incidences in research where the application of cannabinoids and the elicitation of the endocannabinoid system was not beneficial, and possibly harmful. While this does not in any way undo, or take away from, the possible positive benefits, it does act as a reminder that it’s important to do thorough investigations that do, indeed, look at everything, and to remember that medications – whether plant-based or pharmaceutical – are often specific to a particular problem, and often times cannot be generalized past that.

CBC
shows similar properties to other cannabinoids in its anti-inflammatory, pain
management, neuroprotectant, pathogenic disease fighting, anti-tumor, and
stomach settling properties. Much like CBD and THC, the research into this
compound is ongoing, with new applications coming out all the time. CBC has
been shown in studies to both work alone as a standalone treatment, and in
conjunction with other cannabinoids.

Cannabichromene and the Entourage Effect

Cannabinoids effect us therapeutically by interacting with the CB receptors in our bodies.

While CBD, and cannabis in general, have risen to mainstream medicine, they are different than standard pharmaceuticals because they fall into the category of plant-based medicine. When dealing with plant-based medicine it is often preferable to take just one part of a plant – for example, a cannabinoid like CBC – isolate it, and magnify it for its specific medicinal properties.

This can often be beneficial when a particular property of a plant has been found to treat a precise ailment. Sometimes that’s the best answer. Sometimes it’s not. When dealing with plant-based medicine, the entourage effect can be a powerful force. When looking up the entourage effect online these days, you’re likely to only see articles about cannabis, when in reality this idea is relevant to all plant medicine.

Plants are complicated structures made up of different substances. These substances can provide benefit on their own, or combine with other substances within to create an even more powerful response, we call this the entourage effect, but what it really is, is a full plant effect. Instead of focusing on one isolated part of the plant, it focuses on the combination of parts and the added benefit that these combinations can bring.

When dealing with cannabinoids like CBC, CBD, CBN, THC, etc., the idea of what they can do in concert is often more appealing than what they can accomplish in isolated form. In this 2019 systematic review, researchers took a look at years of research into cannabinoid isolation versus a cannabinoid entourage effect, and the many different applications of both.

They found when reviewing this research that often times the entourage effect far exceeds the effects of a single compound. In this review are examples of cannabis applications for microbial diseases, cancer treatments, anti-inflammatory treatments, anticonvulsant properties, and so on.

CBC Products

CBC
has yet to gain the overall popularity of THC or CBD. As medical research
continues to uncover useful benefits, more products and flowers are sure to
make it to the marketplace. As of right now, CBC can be found in hemp capsules
from different retailers, as an isolate, in oils, and in hemp flowers.

One of
the more well-known high-CBC flower strains is Three Kings: a sativa dominant
hybrid mixing Headband, OG Kush, and Sour Diesel. It has bright green flowers
with tons of trichomes, and an earthy taste of pine and citrus when smoked or
vaped.

Be sure to search for the newest CBC products on the market. We’ll be sure to hook you up with the best new products as they emerge, while keeping you updated on all groundbreaking CBC news.

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Using Cannabis to Treat Crohn’s Disease – Does it Really Work?

Over the last few years, people have been using cannabis to treat a myriad of diseases, including Crohn’s Disease; but what does science have to say about this?

There are numerous articles going so far as to claim cannabis can actually cure patients who are suffering from Crohn’s Disease. Cannabis and Crohn’s Disease have even appeared together in the mainstream media when a Kansas mother was arrested a few years prior for using the plant for this condition.

It seems like the evidence – anecdotal at least – is promising, but unfortunately the research isn’t so cut and dry. Let’s take a look at what scientists have discovered so far.


What is Crohn’s Disease?

Crohn’s Disease is an autoimmune disorder characterized by inflammation of the bowels. Because it impacts the digestive tract, Crohn’s can lead to abdominal pain, severe diarrhea and/or nausea, anemia, fatigue, weight loss and malnutrition. Severity varies from uncomfortable to life-threatening. In some cases, portions of the colon might be lost and the patient may need a colostomy bag.

There is no cure for Crohn’s Disease but for some people, the symptoms can be manageable. Patients will need regular screening for colorectal cancer due to increased risk and some will require surgery. However, for the bulk of people suffering from Crohn’s Disease, steroid and immunosuppressant drugs are the go-to treatment option.

These drugs aren’t without their negative side, however. Side effects include: Blurred vision, cataracts or glaucoma, easy bruising, difficulty sleeping, high blood pressure, and increased susceptibility to infection.

To mitigate these side effects, many people are turning back to nature and self-medicating with cannabis.

Cannabis and Crohn’s Disease: The Science

A 2018 study conducted by the University of Western Ontario looked at whether or not cannabinoids were capable of inducing and maintaining remission for Crohn’s. Researchers came back with inconclusive results.

A Maine-based physician believes in the treatment, however, and he uses it regularly at his own practice. “We’ve treated maybe 400 people with inflammatory bowel disease, [and] we’ve seen a whole range,” says Dr. Sulak in an interview with Leafly.

“We’ve seen people who are on biologic drugs that have been able to achieve better control when adding cannabis, and then over time get off those drugs and retain their remission. We see people who just don’t tolerate those drugs because they have a lot of side effects and they come here for alternatives, and cannabis works well. And [for some], cannabis doesn’t work.”

“There’s no single approach that can specifically address the symptoms,” he continued. “For example, low dose of CBD isn’t likely to help a chronic patient, whereas THCA is an important cannabinoid that should be included in treatment.”

What is THCA?

THCA (tetrahydrocannabinolic acid) is the precursor compound to the most dominant cannabinoid in cannabis plants, THC (tetrahydrocannabinol). Contrary to popular belief, THC isn’t found in fresh buds; it’s actually THCA until heat is applied, then the THCA loose it’s carboxyl acid group and becomes THC. This process is known as decarboxylation.

So when you buy buds from a dispensary and you see “THC content” on the label, that’s technically inaccurate. It’s listed this way because the cannabis buds must be heated or altered in some way to be consumed, so the consumer will feel the effects of THC. However, when it’s sitting in that jar on the dispensary shelf, it’s still full of THCA.

Looking Forward

There is currently a clinical trial in the works that will assess the effects of cannabis on 500-1,000 patients with Crohn’s Disease. The study will take place at the Ichilov Hospital in Tel Aviv, Israel. This will be led by Dr. Jeffrey Hergenrather, a medical cannabis physician from California.

Aside from that, patients are relying on anecdotal evidence and (hopefully) candid conversations with their healthcare providers to learn more about using cannabis to treat their Crohn’s Disease.

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The Connection Between Cannabis and Lupus

Lupus is a long-term autoimmune disease that’s increasing in prevalence in the United States, and many people are searching for relief in the form of cannabis. 

Lupus is chronic condition, inflammatory-based, in which the body’s immune system becomes too active and begins to attack normal, healthy tissue and organs. The effects of lupus can be widespread, impacting the skin, kidneys, blood, heart, and lungs. Lupus is mainly seen in women between the ages of 15 to 44, although in some rare cases, men and infants can be affected as well. African American women are more likely to suffer from lupus than any other race.

There are 4 different types of lupus; Systemic (most common), Cutaneous (skin only), Drug-induced, and neonatal (to infants of affected mothers). Aside from cutaneous, all the other types of Lupus share similar symptoms which include: Fatigue, fever, joint pain, stiffness and swelling, chest pain, difficulty breathing, headaches, rashes.

There is no cure for lupus and the number of cases continue to rise in most of the developed world, particularly in the United States. Treatment options vary but many patients are turning to cannabis to ease their symptoms, and the results seem promising.


Does Cannabis Actually Work?

At the moment, there are no studies or clinical trials looking specifically at the use of cannabis to treat symptoms of lupus. There is, however, interesting research on how cannabinoids interact with the immune system.

According to the findings of a prominent, 2010 study, “Cannabinoids have been tested in several experimental models of autoimmune disorders such as multiple sclerosis, rheumatoid arthritis, colitis and hepatitis and have been shown to protect the host from the pathogenesis through induction of multiple anti-inflammatory pathways.”

The study went on to explain that “Cannabinoids suppress inflammatory response and subsequently attenuate disease symptoms. This property of cannabinoids is mediated through multiple pathways such as induction of apoptosis in activated immune cells, suppression of cytokines and chemokines at inflammatory sites and upregulation of FoxP3+ regulatory T cells.”

Based on these discoveries alone, lupus-focused research is certainly warranted, but legal hurdles and issues with product consistency remain barriers to overcome.

What Kind Of Numbers?

A survey conducted by LupusCorner discovered that 36 percent of the 781 people interviewed use cannabis in some capacity. Out of those, 83% said it helped their symptoms and they would recommend it to others. 71 percent report smoking it, while a total of 40 percent use some type of CBD-only product like oil, hemp flowers, or softgels.

Something else noteworthy about this study is that 96% of people say they had no discussion with their primary care provider about the use of cannabis for treating Lupus. Briana Smith, 27-year-old from Texas says that she’s been using CBD oil for a long time to treat her symptoms once they started becoming frighteningly severe. She did this without any advice from a medical professional.

“To this day, it’s still a question that I’m too afraid to ask my doctor.”

This disconnect between doctors and patients indicates that people are relying on their own research and recommendations from people they know. Self-medicating can be empowering, but also complicated when dealing with an unregulated industry.

For more stories like this one, subscribe to the Medical Cannabis Weekly Newsletter. 

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Is CBD a Viable Treatment for Muscle Pain?

Do you suffer from intense muscle pain? Are you looking for a natural solution to help heal it? If so, you might want to consider using CBD oil.

While many sometimes are a bit skeptical toward using this new health treatment, it has undergone many studies which have proven it provides relief for many issues, especially muscle pain. This article will explore more behind what exactly CBD oil is and how it can be used as a muscle pain treatment.

What is CBD Oil?

CBD (cannabidiol) oil is made is extracted from cannabis and hemp plants. This oil is usually taken from the resin of cannabis flowers which contains trichomes. Trichomes have the highest concentration of cannabinoids. 

Because its main job is to protect the buds of the plant from diseases it’s
high in antibacterial properties which can help human health quite a bit. Unlike other parts of the plant, CBD oil doesn’t contain THC in it which is the main culprit behind hallucinations.

How is CBD Oil Made?

Once the resin from the flowers is taken, it must go through an extraction process (preferrably CO2) which helps to separate the different compounds from each other. Once this extraction is done, it will leave behind a sticky residue which is then usually diluted or mixed with a base, like olive oil. It is then bottled up or mixed into a type of cream.

Is CBD Oil Legal?

CBD oil is legal almost everywhere as long as it’s extracted from hemp plants and not cannabis. This ensures that the levels of THC will be 0.3% or less. Because of it’s popularity and newly found legal status, you’ll find CBD products sold in many different places and can purchase them without fear of breaking some law.

 

 

What Causes Muscle Pain?

Muscle pain can be caused by many things. Some of which include:

● Stress
● Tension
● Injuries
● Infections
● Lyme disease
● Arthritis
● Muscle cramps

This pain is usually caused by intense tension in a specific area or severe inflammation. When these things are formed in the body, it can result in pain ranging from mild to severe.

The Benefits of CBD Oil

CBD oil comes with many different benefits which can help with quite a few health problems such as:

● It can provide anxiety relief.
● It can help with side effects from cancer.
● It can help skin health.
● It works to help protect the brain and keep it healthy.
● It has properties which can encourage your heart to stay healthy.
● It releases tension and helps heal muscle and joint pain.

These are just a few of the many benefits that have been found when using CBD oil. There is still more research being done on the benefits of CBD oil, but so far, many have come to conclude that CBD oil works well to heal many medical side effects and problems.

How it Can Help with Muscle Pain

You’ll find that CBD oil can help significantly with muscle pain. Below are some ways it does.

● It Calms the Nervous System

The cannabinoids from the oil work to help calm the nervous system. This can help to relieve muscle pain which can be increased due to an overworked nervous system. In fact, a study done for the health journal Frontiers in Neurology showed how cannabidiols work to help the mobility
of those suffering with multiple sclerosis. This makes it perfect for those who have painful nerves to use as it will help to eliminate the pain created.

● It Reduces Inflammation

When you have muscle pain it could be caused due to severe inflammation in one part of your body. CBD oil works to calm inflammation down by balancing your body’s endocannabinoid receptor which is what your brain uses to interpret pain.

● It Keeps Your Muscles and Joints Flexible

Because it reduces inflammation in your muscles and joints, it can keep them flexible. This is because it helps them to recover quickly and prevent future strain and pain from causing harm to them. In fact, in the scientific journal Pain, research showed that CBD oil helps to reduce joint
pain when applied topically.

● It Can Help You Sleep Better

When your muscles tense up, it can make it very difficult for you to sleep soundly. However, CBD oil can work as a muscle relaxant which ultimately can help you sleep better. It also works to calm the brain which can encourage you to sleep.

How to Use CBD Oil for Muscles

One of the best ways to use CBD oil for muscles is to use a CBD oil lotion or diluted oil formula and massage it into the painful area. You want to massage it very gently where your muscles are bothering you. By doing it slowly, it will help to awaken the muscles and warm them up so they better absorb the oil. You should re-apply the oil a few times per day to ensure you get the full benefits of it.

If you use CBD oil for your muscles you can usually find directions on the back that indicate how much you should use. It’s important to use this as it will help make sure that you apply the correct amount for your needs.

CBD oil is a very beneficial thing to use for many health issues, especially muscle pain. It works to reduce inflammation and keep your muscles healthy and flexible. For these reasons, it’s perfect as a natural muscle pain treatment. So, if you’re looking for a way to help treat your muscle pain, definitely consider giving CBD oil a try.

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Researchers Unlock What Gives Cannabis its Anti-Inflammatory Qualities

A new study deciphers for the first time the cannabis plant’s biological blueprint for producing two molecules thought to have anti-inflammatory properties, a discovery that could pave the way for expanded use of cannabis as medicine.

That study, which is published in the August 2019 issue of the journal Phytochemistry delineates for the first time the biosynthesis pathway outside of the actual cannabis sativa plant that allows reproduction of the molecules cannflavin A and cannflavin B.

Those cannflavins belong to the class of plant flavonoids, plant chemicals found in almost all fruits and vegetables, known as flavones, which occur in several plant lineages.

The study shows the medicinal versatility of the cannabis plant: Beyond the intoxicating ingredient THC and therapeutic oils that often contain cannabidiol (CBD), there exist many other specialized metabolites requiring further research. 

The researchers at Guelph University in Ontario, Canada, unlocked the blueprint for producing the cannflavins, which were discovered in a 1985 study and were found to display “potent anti-inflammatory activity in various animal cell models.”

The new information in the Phytochemistry study opens a pathway to figure how to engineer plant metabolism to make medicine from the cannflavin A and B enzymes. 

Tariq Ahktar, lead author and assistant professor of plant biochemistry at Guelph’s Department of Molecular and Cellular Biology, told Weedmaps News that “for almost 30 years nobody touched these molecules or worked extensively on them. We thought it was a good time to look at these very promising molecules more closely.”

Ahktar said his laboratory utilizes plant chemistry and genomics to determine how plants produce certain molecules and compounds that have medicinal or industrial uses.

He said the cannaflavins A and B were discovered in the United Kingdom more than 30 years ago by researcher Marilyn Barrett. Her study also introduced the name cannflavin. Barrett’s research also showed that cannflavins A and B have nearly 30 times the power of aspirin to inhibit inflammation in cells.

Yet that discovery is just the beginning. Ahktar explained that the two cannflavins are present in cannabis in very low amounts.

“So if you want to gain the anti-inflammatory benefits, you would have to consume copious amounts of cannabis, which is both unlikely and impractical,” he said, necessitating the need to reproduce the molecules outside of the cannabis plant.

He said cannflavins are “definitely encouraging news” for people suffering from acute and chronic pain, who have few effective alternatives to opioids, which work by blocking the brain’s pain receptors. These cannflavins appear to take a different path by attacking cells that encourage inflammation, a primary cause of much pain.

Ahktar said that for decades American and Canadian researchers have been unable to research the medicinal properties of cannabis because of prohibitions against the cultivation and sale of the plant, still considered illegal by the U.S. federal government. Ahktar said his team has demonstrated a biochemical pathway for commercial producers to allow the production of cannflavins A and B from yeast, bacteria, plants, or other means.

“That way you don’t have to grow huge fields of cannabis to obtain the benefits,” he said, noting that the Guelph researchers have patented the genes and licensed their research to Toronto-based Anahit International Corp., to biosynthesize those molecules.

The ability to “hack” other plants or microorganisms to produce their medicinal compounds offers great potential benefits to science and industry. Dr. Jeff Chen, Director of the University of California, Los Angeles (UCLA) Cannabis Research Initiative, spoke at the July 2019 Microscopes and Machines conference in Los Angeles about using biosynthesis as an alternative that is more scalable, consistent and continuous than plant farming to produce cannabinoids and other beneficial compounds. 

Chen cautioned that science has a long way to go to find the most efficient method of producing the cannabinoids and other beneficial compounds. Patients, however, haven’t been waiting.

Ahktar said he spoke with many patients who used cannabis successfully to treat a range of conditions and swore it improved their pain levels and reduced inflammation.

“That got me thinking that there is something else besides CBD contributing to these benefits and it didn’t take me long to find Barrett’s research,” he said. “My primary focus is to help people with pain.”

Ahktar cautioned that “we are a long way from being able to offer cannflavin products on store shelves. This is not my business or interest. I don’t know if this would be marketed as a natural product or undergo clinical trials for drug testing.”

As researchers focus on how cannabis can be used to relieve pain, they’re also gaining new insights about the process of inflammation. (Gina Coleman/Weedmaps News)

He said today neither researchers nor consumers can purchase pure cannflavins A and B.

“Now that we have a mechanism for reproducing this, we can start producing it and performing side by side comparisons with existing pain relievers and test their relative efficacy.”

The study comes amid an ongoing opioid crisis in the United States. According to the U.S. Centers for Disease Control and Prevention (CDC), U.S. healthcare providers prescribed more than 214 million prescriptions for opioid pain in 2016, with an estimated 11 million people misusing prescription opioids that year. More than two-thirds of the 63,632 drug overdose deaths in 2016 involved prescription or illicit opioids. From 1999 to 2017, almost 218,000 people died in the United States from overdoses related to prescription opioids.

Gregory Gerdeman, chief scientific officer for the St. Petersburg, Florida-based medicinal cannabis cultivator 3 Boys Farm and a neuroscientist who has studied the effects of cannabis on the brain for 22 years, said the takeaway from the study is that herbal cannabis takes a multifaceted approach to combating inflammation and that it may offer a greater therapeutic value than the THC or CBD alone.

“It also may point to potential drug development,” Gerdeman said. “I believe in herbal cannabis as a medicine. I think it already offers a very promising strategy for replacing opioids. We now know how the plant synthesizes cannflavins A and B and we’re living in an age in which pharmaceutical companies are creating genetically modified cannabis that could allow drug factories to reproduce these molecules outside of the cannabis plant. This study shows how the science of cannabis as a medicine is being taken seriously today in the medical and pharmaceutical worlds. It was not that way in 1997 or even in 2007.”

This study shows how the science of cannabis as a medicine is being taken seriously today in the medical and pharmaceutical worlds. It was not that way in 1997 or even in 2007.

He called cannabis the “queen of medicinal plants,” adding, “We have many secrets yet to learn from her.”

Gerdeman cautioned, however, that the Canadian study did not explore the precise role of cannflavins A and B in fighting inflammation or the molecules’ potential therapeutic effects.

“The assertion from a 30-year-old study that these cannflavins offer anti-inflammatory effects 30 times the strength of aspirin requires much more research and study to validate. It would be premature to say that using isolated cannflavins as a drug would be desirable or without safety concerns.”


Feature image: Patients haven’t waited for science to catch up to what they’ve learned about cannabis: It can be an effective pain reliever. (Gina Coleman/Weedmaps News)

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Is CBD An Effective Treatment For Gout?

While roughly 4% of Americans suffer from Gout in one form or another, many get no relief from conventional pharmaceutical drugs given by their doctors. That could be why some Gout sufferers are turning to CBD instead.

Healthy lifestyle, eating foods that aren’t too fatty, doing regular exercise. All of these measures are useful when it comes to treating the pain from Gout. However, Gout is an excruciating condition, and sometimes there’s no choice other than to use prescription medications.

The problem with these medications though is that many drugs are toxic, addictive, and come with other nasty side effects. We’re taking a closer look at Gout and how CBD is being used by many people to treat it.

Gout Explained

Gout is a specific type of inflammatory arthritis which is triggered by abnormal levels of uric acid in the bloodstream. Gout’s medical name is Arthrothapy, and it affects people who overeat red meat, seafood, fructose, and alcohol. Over time, the excess uric acid in the blood forms into crystals which build up between the joints.

In turn, those sharp-edged crystals cause inflammation, which leads to periodic attacks of Gout. As any Gout victim will tell you, life is no picnic, and the pain that comes from these accumulated crystals is often severe. Characterized by pain, swelling, tenderness, redness, and heat, some people are left bedridden by Gout for days at a time.

Even though Gout can hit any joint in the body, the most common place for it is in the big toe. Intense pain follows weeks of recovery, and most of those experiencing Gout will have more attacks as the years go by. While some people are more prone to Gout genetically, it is a condition which is heavily influenced by diet in particular.

Another factor is that Gout affects more men than it does women, and usually affects people with a family history of the condition. Obesity, diabetes, and kidney issues also play a role in Gout, and at least 8 million Americans suffer from it at some time in their lives.

Conventional Gout Treatments

Unfortunately, Gout is a “chronic condition” meaning that there’s no known cure for it. It can be appropriately managed in some patients, but that’s often a case of trial and error more than anything else. The right balance of lifestyle changes and drugs can help many people with Gout.

 

However, prescription medications for gout often come at a price, and that’s not just in terms of money. Pain killers and corticosteroids can alleviate Gout when it’s at its worst, but those drugs have side effects, primarily if used long-term or in high doses.

Gout patients are told as a matter of course, not to drink too much alcohol and to stay away from fruit packed with sugar, red meat, and other fatty foods. Remaining hydrated and keeping in shape also helps greatly when it comes to Gout.

Sure, these medications and lifestyle changes help to manage the symptoms of the Gout for a while, but they are seldom a long-term solution. That could be the reason why so many people suffering from Gout are turning to CBD as their go-to remedy, in favor of visits to the doctor and prescription medications.

CBD For Gout

CBD is a compound inside cannabis and hemp, known for its medicinal and therapeutic properties. Some people use CBD to treat anxiety, others to treat insomnia. However, as CBD is a known, natural anti-inflammatory, it’s also successful in treating Gout for many patients.

While scientific studies and medical research are yet to delve into the connection between CBD and Gout in any substantial way, there’s plenty of studies showing that CBD can be useful in the treatment of arthritic conditions. Being a type of arthritis, Gout can also be treated by the right amount of concentrated CBD for some sufferers.

Cannabis and specifically the CBD compound, influence something called the endocannabinoid system found in the body. This system operates by an intricate network of receptors located in the organs and brain. These receptors, called CB1 and CB2 receptors, are responsible for managing daily human processes such as mood, appetite, and memory.

This system also plays a role in regulating pain and inflammation. Furthermore, CBD works to increase levels of anandamide in the body effectively. This compound binds with the CB1 receptors and blocks pain signals from the brain.

Best CBD For Gout

CBD comes in a variety of different forms and delivery systems. However, not all delivery systems are equal, and that principle also applies to CBD (depending on how it was extracted and other factors). CBD oil tinctures are a great way of taking CBD for conditions like Gout.

This is down to the fact that when CBD is taken in the right dosage, via the stomach, it offers slow-release and well-rounded effects. For immediatte relief from acute pain from inflammation, vaping CBD E-liquid or smoking CBD flowers is a good option. This surrounds the fact that when CBD is taken via the lungs, the effects are felt immediately and potently.

When taking CBD for Gout, it’s best to start low and take it slow. Some experts recommend a starting dose of 20-30mg of CBD per day, but some CBD products come with dosing recommendations on the bottle. CBD also comes in topical cream form, and that is much-loved by some arthritis and Gout sufferers. CBD topicals can locally relieve the area affected by the inflammation, while the CBD oil has a chance to work its way through the stomach and into the bloodstream.

Final Thoughts

For Gout sufferers, life can be a daily struggle. When the inflammation starts and the pain sets in, many people resign themselves to weeks or even months of ongoing and debilitating pain. Eating healthily, staying away from red meat, lobster and beer is advisable, as is regular exercise. However, sometimes people have no choice but to go to their doctor to get some pain killers when the inflammation gets too much to handle.

Fortunately, CBD is becoming an increasingly popular way for Gout sufferers to treat their condition and is also safer and often more cost-effective than prescription medications. When buying CBD for Gout, always ensure you purchase products from reputable CBD vendors only, and check for any third-party lab results carried out on the product you’re interested in.

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