CBD (Cannabidiol) Explained – The Real Benefits of this Trendy Cannabinoid

While a fringe, alternative treatment option only a decade ago, today, CBD is everywhere you look – in wellness supplements, beauty and hygiene products, FDA-approved prescription medications, food and beverages, dental products, and even pillows, mattresses, and other random household goods.

As far as cannabinoids go, CBD, or cannabidiol) is the most widely accepted. Not only is there a growing body of clinical research to support its benefits, but it is non-intoxicating which makes it much more likely for laws to be passed in its favor – as is evidenced by the fact that CBD is federally legal in the US and many other countries, while THC still is not. But when it comes to CBD, what are some actual legitimate uses for this compound, and which ones are just marketing gimmicks? Let’s take a look at some of the real, science-backed benefits of CBD.

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What is CBD?

CBD, or cannabidiol, is the most prominent, non-intoxicating compound found in cannabis plants. When most people think of cannabis, they’re thinking about marijuana, which is the type so cannabis that is high in THC and associated with feelings of being “stoned”. Some types of cannabis, hemp for example, are high in CBD and contain only trace amounts of THC, meaning these plants can be considered non-intoxicating, by all accounts.

CBD is gaining popularity as a safe, non-toxic, non-addictive, natural treatment option for many different chronic and debilitating ailments; both mental and physical. Not only is CBD itself non-psychoactive, but when taken in combination with compounds that are, like tetrahydrocannabinol for instance, CBD can minimize the likelihood of negative side effects such as paranoia and anxiety that are occasionally associated with THC use.

The reason CBD (or any cannabinoid for that matter) works in the human body at all is because of the Endocannabinoid System (ECS) – a complex signaling system made up of numerous receptors, as well as some naturally produced endocannabinoids, that exists in the bodies of nearly all animals (except insects). Researchers have discovered two different endocannabinoids so far, 2-arachidonoylglycerol (2-AG) and anandamide (AEA), plus the two most studied receptors, CB1 and CB2. This quad makes up the majority of existing cannabis research.

As a whole, the ECS regulates numerous different functions and processes in our bodies and maintains internal balance and homeostasis. Many cannabinoids engage directly with the ECS receptors. Others, like CBD, have indirect connections by activating other receptors that will then interact with the endocannabinoid system. Specifically, CBD activates the TRVP1 receptors, which in turn activate receptors in the ECS and also function as ion channels.

CBD as an Anti-Inflammatory

One of the most common uses for CBD is to treat inflammation, which is the body’s process of fighting against pathogens and other hazards, such as infections, injuries, and toxins. When something damages your cells, your body releases chemicals that trigger a response from your immune system, thus causing inflammation.

The phrase “too much of a good thing” really applies in the case of inflammation. When this inflammatory response lingers after your body is done fighting the infection or whatever it is trying to overcome, this leaves your body in a constant state of stress and unrest. Chronic inflammation can have devastating effects on the tissues and organs and research indicates that it’s the root cause of many ailments including arthritis, contact dermatitis, acne, multiple sclerosis, and type 1 diabetes, asthma, and cancer.

Cannabidiol is becoming a very popular alternative for standard NSAID (Nonsteroidal anti-inflammatory drug) drugs like Aspirin. Long-term use of NSAIDs can lead to various health problems such as heartburn, stomach pain, ulcers, headaches, dizziness, and even damage to the liver and kidneys.

CBD to Manage Anxiety

Anxiety is another condition that’s been researched extensively to determine how well it responds to cannabis therapies. Cannabidiol targets cell receptors in the body and brain that regulate your mood. Many mood disorders, including anxiety and depression, have a few things in common, including a lack of naturally produced endocannabinoids.

Treating mood disorders with CBD is becoming more widespread is among the top-rated treatment options for young adults ages 25-40. According to a study conducted a couple of years ago, thirty-four percent of millennials prefer to manage their mental health with natural and holistic remedies, and 50 percent of millennials believe CBD oil is the best way to do this; and this number continues to grow.

The main reason cited was a fear of being prescribed a medication that is too potent for their level of symptoms. Because CBD doesn’t have the mind-numbing and other unwanted side effects of prescription drugs, nor is it psychoactive like THC, it can be used all day like any other medication or supplement.

CBD for Controlling Seizures

One of the first, medically-accepted, modern-day uses for CBD was to treat epilepsy. There are many studies out there researching its effectiveness. As a matter of fact, there is even an FDA-approved, cannabidiol-based medication, Epidiolex, that’s used to treat two rare and severe forms of childhood epilepsy, Lennox-Gastaut Syndrome (LGS) and Dravet Syndrome (DS).

Epidiolex is currently being prescribed in the United States, many countries in Europe, and Japan. Epilepsy medications can have some very serious side effects, and that’s why more natural alternatives are becoming the go-to ­­way to treat children and younger adult patients who suffer from epilepsy.

CBD for Pain Management

Although not common, many patients turn to a CAM, or complementary alternative medicine approach, to manage chronic pain. CBD is at the top of the list for those looking for natural, yet effective, alternative remedies. Because inflammation is the root cause of so many conditions that cause chronic pain, it makes sense how CBD eliminates pain.

Numerous different studies have found that cannabinoids like CBD can help with chronic pain from multiple sclerosis, cancer, and neuropathy. CBD and CBD topicals help with pain — if you suffer from chronic pain, CBD oil may help, as well. Chronic pain can be the main source of a diminished quality of life — CBD may give you hope for getting pain-free, or at the very least, reduced pain, and anything is worth a try.

CBD for Skin Conditions

Studies have shown that CBD can provide relief for the symptoms of various skin disorders, such as eczema and allergic reactions. Reverting back to ​inflammation, we know that cannabidiol can be used internally inflammatory conditions, and now we also know that it does the same when applied topically.

Topical creams containing CBD have been shown to ​or greatly reduce and sometimes even completely eliminate itching and dryness​ ​in sufferers of eczema. The chemical ‘histamine’, which is largely responsible for the irritating itches we experience, has been shown to react well to topical cannabinoid therapy. One study​ ​found that in almost 59% of its participants, their dry and scaly skin significantly reduced with the regular use of a cannabinoid cream, which reduced itching and as a result lead to less sleep loss.

Final Thoughts on Cannabidiol Benefits

Simply put, cannabidiol is an incredible compound. It’s non-psychoactive, non-toxic, and non-addictive; and it can be used to treat dozens of different health conditions. The ones covered in this list are the most common uses for CBD, but it can be utilized for many other ailments as well. Do you use CBD? And if so, what do you use it for? Drop us a line in the comment section below!

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Covid-19 causes inflammation by hacking endocannabinoid synthesis

Cannabinoids are fat. Those particular molecules known as cannabinoids are all fatty acids, whether they exist within the cannabis plant or us. Other essential and non-essential fats have differing effects on the endocannabinoid system (ECS), as well. Interestingly, different fats and endocannabinoid metabolites are affected by Covid-19, which may act as a unique fingerprint for […]

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5 Reasons to Smoke CBD Hemp Flower

CBD has become more popular as a natural supplement, and that includes all the different kinds of products you can find. There’s CBD oil drops, capsules, vapes, edibles, drinkables, topicals, pain patches, freeze rollers, protein powder, oral sprays, and more. All of them come with some shared health benefits, but may help in different ways […]

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Orenda Botanicals Review: CBD-infused Products for Pain Relief

For a long time, I had been on the hunt for a natural, high quality product that would help me with pain relief. Recently, I’ve been paying more attention to CBD-infused products, because of the immense benefits that CBD provides. For those who don’t know, CBD can help with anxiety, insomnia, chronic pain, joint pain, […]

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Can You Treat COVID-19 With CBD and Reduce Mortality Rates? A New Israeli Research Believes You Can!

Can you treat COVID-19 with CBD?
Can you reduce mortality rates of COVID-19 in patients with sever cases by using cannabinoids? A new Israeli clinical trial, approved recently, believes that a possible treatment for COVID-19 could be a blend of CBD and steroids.

Exciting news coming from Israel suggests that you can treat COVID-19 with CBD! According to this research, the possible treatment for COVID-19 patients might be coming from a special blend of CBD and Steroids. Unlike other cannabinoids-based medicine, aimed to treat but not to cure, the current clinical trial, held in the Rabin Medical Center (Beilinson) is using CBD and steroids to reduce mortality rates among the among COVID-19 patients in the worst states of health. If this clinical trial produces positive results, we might see a new wave of global attention toward CBD, cannabis and cannabinoid-based medicine.

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Can You Treat COVID-19 With CBD?

A new clinical trial, by the Rabin Medical Center, (RMC), is testing a promising CBD (Cannabidiol) based treatment for patients with severe and critical COVID-19 pulmonary infection. The study, which runs in cooperation of Stero Biotechs, an Israel-based company focused on Cannabidiol (CBD) formulation research and Mor Research applications, the TTO arm of Clalit, the largest state-mandated health service organizations in Israel, is trying to establish whether a new formula, based on CBD (infused in pharma grade olive oil) and steroids can reduce COVID-19’s mortality rates.

The clinical trial already received Helsinki Committee approval and is planned for 20 patient treatment as a Proof of Concept (‘POC’), using Stero’s CBD-based treatment, conducted by Dr. Ilya Kagan from the intensive care department with the support of Dr. Moshe Yeshurun, Director of the Bone Marrow Transplantation Unit, at Rabin Medical Center, Israel.

Treat COVID-19 with CBD
Treat COVID-19 with CBD: A New Israeli Research In Rabin Medical Center

The study aims to benefit and help COVID-19 patients in severe states with respiratory failure from acute respiratory distress syndrome (ARDS). The treatment cycle will be for 14-28 days with a subsequent follow-up period of the same length. Pending the success of this POC, Stero plans to expand and scale phase 2a multi-center study, with an additional 40 patients, under FDA clinical trial guidelines and regulations.

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According to David Bassa, Founder & CEO of Stero Biotechs after six years of researching CBD they already gathered alot of data about CBD’s safety, its effectiveness in treating inflammation and its ability to moderate the ammune system when it is becoming over-active.

In addition, the company has already researched the efficacy of CBD for the treatment of acute (Grade 3-4) Graft versus Host Disease (“GvHD”), when combined with steroids. That’s why, after learning from Oxford that steroids are effective in treating COVID-19 they have decided to use their own experience research a blend that uses both CBD and steroids. They believe that a formula that uses both CBD and steroids will be more effective in treating patients in severe states and that by adding CBD they will be enhancing the therapeutic effect of a steroid treatment.

About Stero Biotechs, Ltd.

STERO  Biotechs Ltd., founded in 2017 and headquartered in Israel,  is a clinical-stage company committed to the research and development of novel Cannabidiol (CBD) based treatment solutions that will potentially benefit millions by:
1) Enhancing the therapeutic effect of steroid treatments.
2) Lowering the dosage needed in steroid treatments, thus lowering the treatment’s horrific side effects. 
3) Allowing refractory patients to begin responding to the steroid treatments needed. 

All by using Stero’s CBD-based treatment.

Stero has 2 ongoing phase 2a clinical trials in Crohn’s Disease & in Urticaria (Hives) in Israeli hospitals and is planning to commence more clinical trials in 2020-2021 on various indications.

Stero has established a strong partnership with one of its shareholders- MOR Research Applications, the TTO of CLALIT HEALTH SERVICES. The partnership with MOR allows deep support to Stero’s clinical trials.

About Clalit

CLALIT is the largest HMO in ISRAEL, with:

  • Over 4.5M members
  • 14  full-scale hospitals
  • Over 2000 community clinics
  • Over 9000 physicians.

RESOURCES:
The Endocannabinoid System Explained (Why Cannabis Is Good for Our Bodies)
Control of Inflammation with CBD
Everything You Need To Know About CBD Isolate (a deep look into hemp extracts)
Cannabinoids 101 – Spotlight on CBN (Cannabinol)
Everything You Need To Know About CBG Isolate
Your Complete Guide to EU GMP-Certified CBD Isolate and Distillate – Spotlight on the regulated EU market
Newest Cannabinoid Powerhouse – CBC – What Can It Do for You? What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8 THC)
Synthetic Cannabinoids (Are they safe?)
Cannabinoids 101 – Spotlight on CBN (Cannabinol)
DELTA 8 THC Medical Benefits (The medical background of using DELTA 8 THC products)
Everything You Need To Know About CBD Distillate
Get EU GMP-Certified Cannabinoid Isolates and Distillates
A Complete Guide To CBN Isolate (Cannabinol)
Best Delta-8 THC deals, coupons and discount. How to choose Delta-8 THC vape cartridges.

DELTA 8 THC Business: Risks and Rewards (Read it before opening a DELTA 8 THC business)
CBG Distillate Explained: What It Is, What It’s For, and How It’s Made
Delta-8 THC infused hemp flowers: How to choose Delta-8 THC flowers
The 
CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers)
EU GMP Extracts: CBD Isolate, CBD Distillate and CBG Isolate

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Why is using THC good for the eyes

These days the list of illnesses that cannabis medicines can be used for grows every day, with research studies being done left and right to test its efficacy against different symptoms and disorders. Most attention is focused on CBD because of its lack of psychoactive effects, while THC is often left out. However, it was found early on that THC is good for the eyes, and has been used to treat conditions like glaucoma for decades.

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Medical cannabis back in the day

Before getting into the restart of medical cannabis in more recent decades, let’s go over some facts about the use of cannabis in medicine. Essentially, it’s been used in medicine for thousands of years, long before it was co-opted by Western medicine in the 1800’s, and then re-introduced once again after a period of enforced illegalization. It’s a part of two of the oldest medicinal traditions, Ayurvedic and Traditional Chinese Medicine, both of which have multiple applications for the use of cannabis to treat tons of different ailments. It has been used in many other lesser-known medical traditions as well.

Prior to it being scheduled as a narcotic by the Single Convention on Narcotic Substances which forced a global illegalization, cannabis was being used in all types of Western medicine applications. In fact, it was listed in the United States Pharmacopoeia for the first time in 1850, but dropped from there in 1937 following the Marijuana Tax act. Before the laws changed, it could be found in tons of products, for almost anything. Most people, of course, had no real understanding of this, but it does show that cannabis was being used very heavily in the world of medicine. Considering how many countries were forced into illegalizing the plant, this was not confined to just the US.

marijuana for the eyes

Cannabis has existed medicinally in essentially three stages. The first was everything up until the 1800’s when it was used in natural medicine traditions. The second stage was the original co-opting of the drug into Western medicine, and the third is the reintroduction back into Western medicine more recently.

It entered Western medicine for the first time in around 1842 when the Irish researcher Dr. William O’Shaughnessy published Bengal Dispensatory and Pharmacopoeia which included an entire 25 pages devoted to cannabis use in medicine. He started studying it back in 1933, when a part of the British East India Company, and saw it as beneficial for use with digestive issues, acute rheumatism, in dealing with pain, and for sedation, among other applications.

The restart of medical cannabis

Over in Israel, Raphael Mechoulam was doing his own thing in the mid-1900’s, publishing a paper on the isolation of THC in 1964, and investigating it for use with a number of illnesses. Research that essentially got pushed underground for decades. There was also Roger Adams, the guy who isolated CBD in 1940, the compound that helped bolster medical cannabis in general by offering a non-psychoactive compound to treat illnesses. Basically, all those things cannabis had already been used for, prior to illegalization, began to be tested through more modern means of medical research. Most of this didn’t make any waves for a long time, until California made the topic an international story.

In the US in 1979, Virginia passed a drug bill to overhaul its system, and this bill allowed for cannabis medications to be prescribed to people with glaucoma and cancer. This was the first modern medical legalization in the US. California pushed harder with a bill solely for cannabis use in medicine in 1996, setting off a flurry of changing regulation in the States with its Proposition 215.

THC is good for the eyes, especially glaucoma

THC and glaucoma

It might not be considered one of its more prevalent uses now, but cannabis use to treat glaucoma was one of the first reasons for its reintroduction into Western medicine. And this because THC has been shown to be good for the eyes. Research into cannabis use for the eyes has been out since the 1970’s, when it was determined that marijuana, and specifically THC, can decrease intraocular pressure, one of the main reasons for glaucoma.

There is more than one type of glaucoma, but the majority of sufferers have POAG – or, primary open-angle glaucoma. It might not be mentioned as much as other disorders, but glaucoma is very widespread, affecting upwards of 60 million people worldwide. Other than age and race, intraocular pressure is the third risk factor for developing the disease, meaning keeping pressures under control is vital, especially as glaucoma is the second leading cause of blindness after cataracts.

The idea that THC can be used to treat glaucoma – AND medically in general! – came about in the mid 70’s when a 26-year-old guy named Robert Randall – who was experiencing advanced glaucoma, which wasn’t being adequately taken care of – noticed the disappearance of halos around lights (caused by his high eye pressures) after smoking marijuana. Randall ended up growing his own marijuana, for which he got caught and arrested, and subsequently faced federal charges.

In the 1976 landmark case The United States vs Randall, Randall successfully argued his case in front of the DC Superior Court, creating “The first successful articulation of the medical necessity defense in the history of the common law, and indeed, the first case to extend the necessity defense to the crimes of possession or cultivation of marijuana.” This made Randall the first legal medical cannabis user since 1937 when the Marijuana Tax Act essentially ended cannabis use in medicine, and in general.

smoking cannabis

How else is THC good for the eyes?

Funny enough, THC has an application that we all technically know about already. And if not necessarily ‘good’, with possible medical purpose, at least. Everyone knows that cannabis dries out the eyes. I can personally attest to the fact that my contacts stick right to my eyes when using marijuana. This, in and of itself, isn’t a benefit, but in this study it was shown that THC is good for regulating the lacrimal gland, and this may have positive benefits for people with epiphora, a condition of over-tearing eyes.

In 2004, a study was published on the effects of cannabis on night vision. The study included very few subjects which means it requires more corroboration, however, it did show a positive outcome. In two double blind studies on subjects who smoked kif (here defined as “sifted cannabis sativa mixed with tobacco”), it was noted that night vision improved after smoking. The belief of the investigators is that this is based on dose, and that the effect is mediated at the retinal level. The study used Marinol as its form of THC, in doses of 0-20mg.

One of the issues with THC is that due to the general ban on it, not as much research has been done into it as could have been. Right now there isn’t much research regarding cannabis and cataracts, but there are some connections that might prove promising. For one thing, THC helps reduce inflammation, which is a major characteristic of cataracts, along with elevated blood pressure which cannabis can help to decrease as well.

Another major eye issue, especially among the aging, is macular degeneration. Cannabis can help treat symptoms in many ways. For one, much like with cataracts, it can help with inflammation. Second, it can also inhibit vascular endothelial growth factor, and without the harsh side effects of pharmaceutical medications for this purpose. Third, it lowers intraocular pressure – which is beneficial for glaucoma sufferers too. And fourth, when looking at the psychological factors of having such an eye condition, and the anxiety and depression that can go along with it, cannabis can be useful here as well, helping to ease these symptoms and relax the patient.

Conclusion

As with any other topic related to medical marijuana, there are plenty of articles shouting out about possible damage caused by using it. Anyone interested in using cannabis to treat their eye issues should speak to a professional of some kind, preferably one who understands cannabis medicine. However, that THC can be good for the eyes seems to have been understood for quite some time, though its actual application has been much slower with the pick-up. Perhaps in the future this will change.

Thanks for dropping by CBDtesters.co, your #1 spot for all cannabis-related news. Keep up with us every day to know what’s going on in the world of legal marijuana, and sign up to our newsletter so you’re always in the know!

Resources

Interview with Raphael Mechoulam: The Father of Cannabis Research
Cannabis and Schizophrenia – Not a Testable Hypothesis

Cannabis Falling from the Sky in Israel
Germany Leads EU in Cannabis Oil Imports…and Exports

Prop 65 Warning on California Cannabis Products Opens the Floodgates for Next Nobel Prize Winner? Harvey Prize, a Predictor of the Nobel Prize Goes to Raphael Mechoulam
What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8THC)

Cannabis Use in Ancient Times – From Nomadic Warrior Women to Egyptian Pharaohs, and beyond
Can Greece Leverage Medical Cannabis to Save Its Ailing Economy?
The CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers)
The Medical Cannabis Weekly newsletter (International medical cannabis business report)
How Green Is Ireland When It Comes to Cannabis Regulation?

The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc) and the Best Black Friday Delta 8 THC Deals 2020.  The best delta-8 THC deals, coupons and discounts.
Cannabis Election Results Virginia and Cannabis, Setting the Record Straight The World’s First Fully Stable and Genetically Uniform Cannabis Hybrid Seeds
Best Delta-8 Deals, Coupons and Discounts

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Succesful feasibility study for the development of topical medical cannabis products

Cannassure Therapeutics Ltd (TASE: CSURE) (“Cannassure”), an Israel based developer and producer of innovative medical cannabis products, announces today the successful completion of a feasibility study for the development of IP protected, homogeneous, topical medical Cannabis products for the treatment of skin inflammation, including psoriatic lesions. (PRESS RELEASE)

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Product development of such topical medical Cannabis products based on AKVANO® is being conducted under a collaboration between Cannassure and Lipidor AB (“Lipidor”), a Swedish topical drug development company, owner of the proprietary drug delivery platform technology AKVANO, which was signed in December 2019. The development project budget is partially funded by the Israeli Innovation Authority, by a non-dilutive grant.

The product under development is an incorporation of cannabinoids with AKVANO®, a topical drug delivery platform. Successful development of the product will allow localized administration of a precise dosage of cannabinoids using a spray, in a technology that allows for prolonged contact and optimal penetration of the active ingredient into the skin.

As part of the feasibility study, AKVANO® technology and cannabinoids were tested for compatibility, and it was found that the cannabinoids can be successfully combined in the AKVANO® system for a homogeneous, uniform and stable formulation. Cannassure tested the degree of product penetration into the skin by using known and acceptable models and found significant penetration of active ingredients into the skin tissue. This enhanced penetration may increase the therapeutic potential of the product. Based on these results, Cannassure will proceed to accelerated development stages and more advanced testings.

According to the agreement, Cannassure has informed Lipidor on its intention to start negotiating an exclusive global license for the use of Lipidor’s technology for the development of cannabinoids based topical therapeutics products for the treatment of indications to be chosen by Cannassure.  

The main guidelines for the licencing agreement, including royalties to be paid to Lipidor on product sales, were defined in the collaboration agreement.

According to estimates, the global market for products for the treatment of psoriasis is expected to reach 21.1 billion dollars by 2022. The current global market for topical products for the treatment of psoriasis is valued at 7 billion dollars, and the global market for topical pain treatment products is projected to reach 13 billion dollars.

The product development of topical treatments based on cannabinoids is in line with Cannassure’s strategy focused on the development and commercialisation of innovative medical cannabis products based on established drug delivery systems and formulations for enhanced therapeutic value. The product development is performed under the Israeli Medical Cannabis regulation, which allows a short development process.

About Cannassure Therapeutics Ltd.

Cannassure Therapeutics Ltd. (TASE:CSURE) is a leading, world class, trusted developer and provider of top-quality-grade medical cannabis products and pharmaceutical cannabinoid medicines, addressing a broad range of unmet medical needs.

About Lipidor AB

Lipidor AB (www.lipidor.se) is a Swedish, Stockholm-based research and development company with a pipeline of pharmaceutical development projects in preclinical and clinical phases. The Company develops topical medical products for the treatment of diseases such as psoriasis, bacterial skin infections and atopic dermatitis by reformulation of proven pharmaceutical substances.

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Do CBD bath bombs have any benefits toward reducing Inflammation?

I’ve heard people say that CBD has helped them with pain and inflammation. I’m always looking for holistic ways to help with pain, you’ll be surprised to see what I’ve found! What is CBD? CBD is a short form for cannabidiol and it is the second most active ingredient of Cannabis. It’s derived from the […]

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Newest Cannabinoid Powerhouse – CBC – What Can It Do for You?

The ever-increasing cannabinoid family has new members coming in every day, and there’s reason to be excited as new research comes out about CBC.

In the last couple of years, CBD (cannabidiol) – a cannabis cannabinoid, has risen to prominence as an effective treatment for many suffering from medical issues like insomnia, anxiety, pain, depression, seizures, high blood sugars, pathogenic diseases, ADHD etc., and a possible answer to many other issues that still require more research like: different forms of cancer, neurodegenerative diseases, and even prion diseases. It seems like every day a new breakthrough is coming out about the use of CBD as a treatment.

It’s easy to forget that CBD, along with THC (Tetrahydrocannabinol) – the main cannabinoid of cannabis plants – are just two of the possibly hundreds of cannabinoids that are present in cannabis plants. In fact, by now, well over 100 cannabinoids have been identified, and each one – though sometimes only appearing in extremely small concentrations – has its own medicinal benefits. One of these lesser known cannabinoids that is starting to make it into the mainstream is CBC, or Cannabichromene.

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What is CBC?

Cannabichromene, which also goes by the names cannabichrome, pentylcannabichromene, cannabinochromene, and cannanbichromene is a phytocannabinoid that is structurally similar to other cannabinoids like THC, CBD and CBN, and the second most prevalent cannabinoid in cannabis.

Much like other cannabinoids, CBC does not actually start out as CBC, but rather as cannabichromenic acid, and is produced over time through decarboxylation. CBC is non-psychoactive, and interacts with the endocannabinoid system differently than both THC and CBD in that it only poorly binds to the CB1 and CB2 receptors in the brain.

In 2019, a study was done looking into the often misunderstood mechanisms of action of CBC, which found that CBC acts as a selective CB2 receptor agonist. As of yet it has not undergone scheduling by the Convention on Psychotropic Substances meaning it is legal to use as of now.

What does the research say about CBC?

The isolation of new cannabinoids means all new
avenues of medical research to go down. The studies on CBC, in fact, go back as
far as a 1981 study that tested the anti-inflammatory, antibacterial, and
antifungal properties of CBC in rats. According to the research, CBC showed anti-inflammatory
effects superior to phenylbutazone,
an NSAID anti-inflammatory/pain medication. It also showed to be a strong antibacterial
agent and a mild to moderate antifungal.

Then, in a 2006, study into the anti-tumor effects of cannabidiol, cannabigerol, cannabichromene, cannabidiol acid and THC acid, it was found that while CBD had a more expected effect on the inhibition of certain tumor growth in rats, the other cannabinoids tested, including CBC, did as well, leading investigators to point in the direction of further testing of cannabinoids for cancer treatment.

$2 Million Going To Cannabis Cancer Research Led By Professor Mechoulam

In 2010 there was a study investigating how CBD and CBC effect activity of the descending pathway of antinociception in anesthetized rats. It was found that both cannabinoids produce an antinociceptive response by interacting with various targets involved in pain control. A less complicated way of saying this is that both CBD and CBC were found to help alleviate pain caused by nerve damage by the ability to block the detection of pain by sensory neuron cells.

It was looked at again in 2012 as an inhibitor of
inflammation induced hyper motility in rats. The investigators were looking at
CBC as a way to control, or inhibit, the overactive digestive tracts in rats
that was caused as a result of inflammation. The results showed a positive correlation between CBC and the normalization of
intestinal motility.

In the 2013 study, The effect of cannabichromene on adult neural stem/progenitor cells, three different phytocannabinoids were looked at in reference to adult neural stem progenitor cells in rats. These cells are similar to stem cells, but more specified, and play a large role in brain function and overall pathology, making them very important. CBC was found to have a positive effect when looking at the viability of adult neural stem progenitor cells in vitro, indicating neural protective qualities.

An interesting systematic review from 2017 investigated the use of cannabinoids including CBC for the treatment of several different pathogenic diseases. The conclusion was important in that though it showed the use of cannabinoids and the elicitation of the endocannabinoid system to be useful in treating many issues, it also pointed to the idea that simply making the assumption that cannabinoids can help with all issues related to a problem, is quite insufficient.

‘This review was able to point to incidences in research where the application of cannabinoids and the elicitation of the endocannabinoid system was not beneficial, and possibly harmful. While this does not in any way undo, or take away from, the possible positive benefits, it does act as a reminder that it’s important to do thorough investigations that do, indeed, look at everything, and to remember that medications – whether plant-based or pharmaceutical – are often specific to a particular problem, and often times cannot be generalized past that.

CBC
shows similar properties to other cannabinoids in its anti-inflammatory, pain
management, neuroprotectant, pathogenic disease fighting, anti-tumor, and
stomach settling properties. Much like CBD and THC, the research into this
compound is ongoing, with new applications coming out all the time. CBC has
been shown in studies to both work alone as a standalone treatment, and in
conjunction with other cannabinoids.

Cannabichromene and the Entourage Effect

Cannabinoids effect us therapeutically by interacting with the CB receptors in our bodies.

While CBD, and cannabis in general, have risen to mainstream medicine, they are different than standard pharmaceuticals because they fall into the category of plant-based medicine. When dealing with plant-based medicine it is often preferable to take just one part of a plant – for example, a cannabinoid like CBC – isolate it, and magnify it for its specific medicinal properties.

This can often be beneficial when a particular property of a plant has been found to treat a precise ailment. Sometimes that’s the best answer. Sometimes it’s not. When dealing with plant-based medicine, the entourage effect can be a powerful force. When looking up the entourage effect online these days, you’re likely to only see articles about cannabis, when in reality this idea is relevant to all plant medicine.

Plants are complicated structures made up of different substances. These substances can provide benefit on their own, or combine with other substances within to create an even more powerful response, we call this the entourage effect, but what it really is, is a full plant effect. Instead of focusing on one isolated part of the plant, it focuses on the combination of parts and the added benefit that these combinations can bring.

When dealing with cannabinoids like CBC, CBD, CBN, THC, etc., the idea of what they can do in concert is often more appealing than what they can accomplish in isolated form. In this 2019 systematic review, researchers took a look at years of research into cannabinoid isolation versus a cannabinoid entourage effect, and the many different applications of both.

They found when reviewing this research that often times the entourage effect far exceeds the effects of a single compound. In this review are examples of cannabis applications for microbial diseases, cancer treatments, anti-inflammatory treatments, anticonvulsant properties, and so on.

CBC Products

CBC
has yet to gain the overall popularity of THC or CBD. As medical research
continues to uncover useful benefits, more products and flowers are sure to
make it to the marketplace. As of right now, CBC can be found in hemp capsules
from different retailers, as an isolate, in oils, and in hemp flowers.

One of
the more well-known high-CBC flower strains is Three Kings: a sativa dominant
hybrid mixing Headband, OG Kush, and Sour Diesel. It has bright green flowers
with tons of trichomes, and an earthy taste of pine and citrus when smoked or
vaped.

Be sure to search for the newest CBC products on the market. We’ll be sure to hook you up with the best new products as they emerge, while keeping you updated on all groundbreaking CBC news.

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The post Newest Cannabinoid Powerhouse – CBC – What Can It Do for You? appeared first on CBD Testers.

Using Cannabis to Treat Crohn’s Disease – Does it Really Work?

Over the last few years, people have been using cannabis to treat a myriad of diseases, including Crohn’s Disease; but what does science have to say about this?

There are numerous articles going so far as to claim cannabis can actually cure patients who are suffering from Crohn’s Disease. Cannabis and Crohn’s Disease have even appeared together in the mainstream media when a Kansas mother was arrested a few years prior for using the plant for this condition.

It seems like the evidence – anecdotal at least – is promising, but unfortunately the research isn’t so cut and dry. Let’s take a look at what scientists have discovered so far.


What is Crohn’s Disease?

Crohn’s Disease is an autoimmune disorder characterized by inflammation of the bowels. Because it impacts the digestive tract, Crohn’s can lead to abdominal pain, severe diarrhea and/or nausea, anemia, fatigue, weight loss and malnutrition. Severity varies from uncomfortable to life-threatening. In some cases, portions of the colon might be lost and the patient may need a colostomy bag.

There is no cure for Crohn’s Disease but for some people, the symptoms can be manageable. Patients will need regular screening for colorectal cancer due to increased risk and some will require surgery. However, for the bulk of people suffering from Crohn’s Disease, steroid and immunosuppressant drugs are the go-to treatment option.

These drugs aren’t without their negative side, however. Side effects include: Blurred vision, cataracts or glaucoma, easy bruising, difficulty sleeping, high blood pressure, and increased susceptibility to infection.

To mitigate these side effects, many people are turning back to nature and self-medicating with cannabis.

Cannabis and Crohn’s Disease: The Science

A 2018 study conducted by the University of Western Ontario looked at whether or not cannabinoids were capable of inducing and maintaining remission for Crohn’s. Researchers came back with inconclusive results.

A Maine-based physician believes in the treatment, however, and he uses it regularly at his own practice. “We’ve treated maybe 400 people with inflammatory bowel disease, [and] we’ve seen a whole range,” says Dr. Sulak in an interview with Leafly.

“We’ve seen people who are on biologic drugs that have been able to achieve better control when adding cannabis, and then over time get off those drugs and retain their remission. We see people who just don’t tolerate those drugs because they have a lot of side effects and they come here for alternatives, and cannabis works well. And [for some], cannabis doesn’t work.”

“There’s no single approach that can specifically address the symptoms,” he continued. “For example, low dose of CBD isn’t likely to help a chronic patient, whereas THCA is an important cannabinoid that should be included in treatment.”

What is THCA?

THCA (tetrahydrocannabinolic acid) is the precursor compound to the most dominant cannabinoid in cannabis plants, THC (tetrahydrocannabinol). Contrary to popular belief, THC isn’t found in fresh buds; it’s actually THCA until heat is applied, then the THCA loose it’s carboxyl acid group and becomes THC. This process is known as decarboxylation.

So when you buy buds from a dispensary and you see “THC content” on the label, that’s technically inaccurate. It’s listed this way because the cannabis buds must be heated or altered in some way to be consumed, so the consumer will feel the effects of THC. However, when it’s sitting in that jar on the dispensary shelf, it’s still full of THCA.

Looking Forward

There is currently a clinical trial in the works that will assess the effects of cannabis on 500-1,000 patients with Crohn’s Disease. The study will take place at the Ichilov Hospital in Tel Aviv, Israel. This will be led by Dr. Jeffrey Hergenrather, a medical cannabis physician from California.

Aside from that, patients are relying on anecdotal evidence and (hopefully) candid conversations with their healthcare providers to learn more about using cannabis to treat their Crohn’s Disease.

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