Using Cannabinoids & Fungus For The Development Of Medicine For Cancer

*** THIS IS A PRESS RELEASE ***
Cannabotech is advancing in the development of botanical medicine for cancer: It reports obtaining a worldwide exclusive license to use a unique fungus for the development and commercialization of products for the treatment of pancreatic and colon cancers

The studied fungus was found effective in killing pancreatic cancer cells and reducing the extent of cancerous tumors in animals; Cannabotech estimates it will present a prototype of the drug as early as the first half of 2023;

Using Cannabinoids & Fungus For The Development Of Medicine For Cancer - Credit PR
Using Cannabinoids & Fungus For The Development Of Medicine For Cancer – Credit PR

Herzliya, Israel – 2 January 2022 – Cannabotech, which develops, among other things, medical cannabis-based products and fungal extracts, reports it received exclusive use of a patent for the development of drugs based on the extract of Cyathus striatus fungus. The fungus is being researched in the laboratory of Professor Fouad Fares, an expert in molecular biology and cancer research at the Faculty of Natural Sciences at the University of Haifa.

According to the agreement signed between Cannabotech and Carmel, the economic company of the University of Haifa, Cannabotech will develop a botanical drug for pancreatic and colon cancers, based on a combination of cannabinoids from the cannabis plant with the fungus extract researched in Professor Fares’ laboratory, which has shown promising results and found to be effective in killing pancreatic and colon cancer cells, and reducing the extent of cancerous tumors in animals, without damaging healthy tissues. 

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Dr. Alex Weissman, an expert in organic chemistry and former director of R&D at the Chimagis Active Ingredients Factory (API), and Dr. Isaac Angel, an expert pharmacologist with more than 15 years of experience in leading drug development processes, will assist Cannabotech in the research process.

A few days ago, Cannabotech reported the results of a study according to which its CannaboBreast product for the treatment of breast cancer, based on a unique combination of cannabinoids and terpenes from the cannabis plant, combined with standard chemotherapy, resulted in an improvement of up to 6-fold in the killing of cancer cells compared to existing treatment (from 10% to 60% cancer cell mortality). 

Cannabotech CEO Elhanan Shaked said: “Cannabotech continues to advance according to its business plan. Along with our preventative medicine products that are already available today, we are operating in the medium-long term in a variety of clinical trials, the most significant of which is the development of a botanical drug for cancer-based on a unique combination of cannabinoids with the Cyathus striatus fungus.”

 Cannabotech CEO Elhanan Shaked - Credit: PR
Cannabotech CEO Elhanan Shaked Credit: PR

Professor Fouad Fares said: “We are pleased with the results achieved so far in animals and the critical reduction in the extent of cancerous tumors and with improved cancer cells’ mortality. The collaboration with Cannabotech enables us to accelerate the research and development process.”

 About Cannabotech:  

Cannabotech is an Israeli biomedical company that develops botanical solutions for preventive medicine and integrative medicine.  These solutions are based on combinations of active agents from the cannabis plant and fungi that work on two central systems in the human body: the endocannabinoid system and the immune system.

As part of the concept of integrative medicine, in the last two years, Cannabotech has been developing a series of 8 preparations based on unique combinations of botanicals from medical cannabis and fungus-based products, designed to help patients with cancer and chronic pain.  Upon completion of their development, the company’s goal is to designate the products to be integrated into oncology patients’ existing treatment protocol.   

At the same time, Cannabotech is working to develop a defined treatment protocol made available to physicians and technology for treatment customization. 

*** END OF PRESS RELEASE **

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Meet the Mushrooms – Health Benefits of Various Fungi  

Mushrooms are widely regarded as a superfood because they taste great, add richness and can elevate most meals, and are packed with nutrients, vitamins, and antioxidants that translate to incredible health benefits for consumers. If you’re looking for one type of food to add to your diet that could really make a difference in your overall health, fungus is truly where you get the most bang for your buck.  

From common grocery store types like creminis, to incredibly rare psychedelic varieties, all edible mushrooms are extremely beneficial. Remember that some are poisonous, so don’t go running around the woods eating unidentified fungi. But do try to incorporate more healthy mushrooms into your diet. Whether you’re adding shitakes to dinner once a week or microdosing with liberty caps, you’re sure to experience some positive changes. Remember to subscribe to The Psychedelic Weekly Newsletter to learn more about mushrooms and the psychedelic industry as a whole.  


Why mushrooms are amazing  

In addition to being considered a gourmet food, mushrooms are one of the most nutritious foods on earth. They’re a low-calorie source of fiber, protein, potassium, and antioxidants, known to have the ability to mitigate (or completely heal in some instances) many serious health conditions. The list of ailments that can benefit from mushroom consumption is vast but includes: diabetes, cancer, heart disease, inflammation, cancer, Alzheimer’s, high blood pressure.  

Not only can fungi help treat existing conditions, but they can make you healthier overall. The anti-inflammatory effect of fungi is proven to greatly improve immune function and efficiency. The anti-inflammatory effect of mushrooms has been shown to greatly improve the efficiency of the immune system. Numerous studies have found that mushrooms help stimulate macrophages in the immune system, amplifying its ability to fight disease.  

In that same vein of general wellness, research indicates that mushrooms, when combined with other healthy lifestyle choices like regular exercise, are key to weight loss and maintenance. Mushrooms have low calories, no cholesterol, and no fat, so they’re a great way to get the recommended amount of dietary protein for building muscle, without all the unnecessary compounds that can make you gain fat.  

Another interesting feature of mushrooms, one that was only recently discovered, and by accident, is that they can produce antibiotic compounds for a huge range of bacteria. If exposed to certain bacterium, mushrooms will create metabolites to kill that pathogen. This discovery could be pivotal in changing the way we treat antibiotic resistant bacterial infections.  

Fungus as a healing superfood is a somewhat new concept in the western world, but they’ve been utilized in eastern medicine and nutrition for centuries. The oldest official record of medicinal compounds from Traditional Chinese Medicine, dating from the 29th century BC, lists several mushroom species. In recent years, they’ve become a popular meat substitute as we’ve seen a steady rise in vegetarianism and veganism across the globe. They’re also being discussed with increased frequency in the realm of mental health, especially psilocybin mushrooms.  

Lion’s Mane  

Hericium erinaceus is an edible mushroom hailing from the tooth fungus group. It’s native to three different continents, North America, Europe, and Asia, and they resemble of clump of long spines growing on various hardwood trees. They can be eaten raw, cooked, dried, or steeped in soup and tea. They have a strong seafood/shellfish flavor, like crab or lobster. Lion’s mane extracts are commonly found in health supplements, and Asian countries like China, India, Japan, and Korea have been using these mushrooms medicinally for ages.  

Research has found that lion’s mane mushrooms contain high levels of two compounds that can aid in brain cell regeneration: hericenones and erinacines. These compounds can also prevent neural damage caused by amyloid-beta plaques, which are abnormal clusters of protein fragments built up between nerve cells; commonly found in the brains of people with Alzeihmer’s.  

Lion’s Mane mushrooms are also known to be extremely effective in fighting cancer. This theory has been tested and proven numerous times over with several different types of human cancer cells in test tubes. Liver, colon, stomach, and blood cancer cells have been studied and Lion’s Mane was successful in destroying them all.  

Cordyceps 

Cordyceps are not quite mushrooms, but rather a genus of parasitic fungi that grows on insect larvae. The fungi attacks the host and replaces its body tissues with stems that grow on the outside of the larva’s body. Over 600 species of cordyceps have been discovered all over the world, although most are concentrated in Asia and medical literature has focused heavily on two types: Cordyceps sinensis and Cordyceps militaris 

The remnants of these infected insects have been harvested, dried, and used in Traditional Chinese Medicine formulations to treat inflammation, fatigue, low sex drive, kidney disease, and many other illnesses. Formal research on this fungus is limited, but anecdotal evidence is abundant.  

Additionally, cordyceps are believed to increase the body’s production of adenosine triphosphate (ATP), source of cellular energy for muscle contractions, nerve impulse propagation, and other physiological functions. In Eastern cultures, cordyceps are often used by the elderly for the anti-aging properties – attributable to their high levels of antioxidants – as well as to battle weakness and fatigue and improve their sex lives.  

Reishi  

Ganoderma lucidum, also known as Lingzhi or Reishi, is a reddish-brown colored, polypore fungus with a banded cap and peripheral stem. Fresh reishi look soft and flat, and they grow at the base of deciduous trees, particularly maples. They can be eaten fresh, dried, in tinctures or extracts, or in powdered form that can be added to smoothies or drinks. 

Reishi mushrooms contain a bunch of different compounds that are beneficial to human health, such as triterpenoids, polysaccharides and peptidoglycans. Although many mushrooms lack the scientific literature to back up their benefits, that is not the case with reishi. As a matter of fact, over 3,300 research papers published on these mushrooms in the US National Library of Medicine alone.  

Although all mushrooms are believed to have positive effects on immunity, reishi mushrooms are especially known for this. Studies have found that reishi mushrooms can affect the genetic makeup of white blood cells, making them more effective immune system agents.  

Morels  

Morchella, or true morels, are a genus of edible sac fungi that can be found in temperate regions around the world including North America, Turkey, China, the Himalayas, India, and Pakistan. They are a prized ingredient in many types of cuisine, especially French. Cultivation of these mushrooms can be tricky, so harvesting wild morels has become a multi-billion-dollar industry. 

It’s important not to confuse true morels with false morels, a term loosely applied to describe Gyromitra esculenta, Verpa bohemica, and other species morel lookalikes. Although some false morels can be eaten safely, the ones in my area and many others are extremely poisonous. So toxic in fact that even fumes from cooking the mushrooms can cause dizziness and nausea. When cut down the middle, true morels have a hollow cap and a stem that connects at the bottom of the cap, whereas false morels have a thick fibrous stem that runs through the entire cap and connects at the top. Check the photos on this page to learn more.  

That said, I personally love morels. You can’t really find any in grocery stores but I’m blessed to have them growing in abundance in my yard in Indiana. I live in the woods near some small creeks and a large lake and find them frequently in open fields along the forest edge, near oak, elm, ash, and aspen trees. 

Like all mushrooms, morels have many benefits but one thing that makes them unique is that they have one of the highest amounts of vitamin D out of any edible mushroom species. Only 100 grams of morels (less than 1 cup) will provide you 34% of the daily required levels of vitamin D. They’re also loaded with potassium, vitamins, copper, and antioxidants.  

Turkey tails  

Turkey tails, also known as Coriolus versicolor, Polyporus versicolor, or Trametes versicolor (meaning ‘of several colors’) is a common polypore mushroom that grows in humid areas all over the world. They are technically considered to be inedible, only because they harden when cooked and don’t taste good, but they can be turned into powders, tinctures, and extracts for use in various products.  

Like reishi mushrooms, Turkey tails are also revered for their immune-boosting abilities. Turkey tails contain Polysaccharopeptides, which are protein-bound carbohydrates that block inflammation and activate beneficial immune cells. Because of this, Turkey tail mushrooms are used in combination with pharmaceutical treatments to enhance their efficiency. For example, a review of 13 studies found that chemotherapy patients who were consuming 1-4 grams of Coriolus versicolor had a greater chance of survival than those who did standard treatments alone. Overall, Turkey tails contributed to a 9% reduction in 5-year mortality.  

Another unique benefit of Turkey tails is that they can help regulate your gut bacteria, which plays a pivotal role in overall health. Many health conditions stem from an imbalanced gut microbiome. A study of 24 healthy volunteers found that this strain of mushroom contains prebiotics that suppressed the growth of harmful bacteria like E. coli, Salmonella, and Shigella. Outside the digestive system, Turkey tails can prevent the growth and spread of Staphylococcus aureus.  

Chaga  

Chaga, formally known as Inonotus obiquus, is a parasitic fungus from the Hymenochaetaceae family. They grow on a lot of different trees but have an affinity for birch. Chaga mushrooms have been used medicinally for hundreds of years in Siberia and other parts of Asia. They’re not pretty compared to other mushrooms and resemble an irregularly-shaped clump of burnt charcoal, but they’re one of the more popular species on this list and are becoming better-known in the Western world as well.  

Chaga mushrooms contain a wide variety of different vitamins, minerals, and nutrients such as B-complex vitamins vitamin D potassium rubidium cesium amino acids fiber copper selenium zinc iron manganese magnesium calcium. The extract from this fungus is commonly used to help lower cholesterol and prevent heart disease.  

During a 2-month study of lab rats on chaga, the extract was found to reduce levels of LDL cholesterol (bad cholesterol) and increase levels of HDL cholesterol (good cholesterol). Experts believe the high antioxidant content in chagas are responsible for this. Additionally, studies have demonstrated that eating chaga mushrooms regularly can reduce oxidative stress and lower blood pressure and greatly reduce the risk of having a heart attack or stroke.   

Maitake  

Grifola frondosa, also known as Hen-of-the-woods or Maitake (not to be confused with shiitake) is a polypore mushroom found in Japan, China, Europe, and North America. It grows at the base of trees, mainly oaks, and can be found in late summer to early fall. The word “maitake” means dancing mushroom in Japanese. As the story goes, people were so elated when they found this mushroom in the wild that they ‘danced for joy’… and no, it’s not psychedelic.  

Although Maitakes are sometimes used in recipes, they are considered a medicinal mushroom and more often utilized in therapeutic settings. Maitake mushrooms are what’s known as adaptogens, or non-toxic plants that can be used to regulate body systems, both physical and mental. They’re one of the best mushrooms to use for ‘resetting’ the body and creating homeostasis. Maitakes have shown more promising results in treating and preventing various health conditions than other mushrooms.  

A 2015 study also discovered that maitake mushrooms can be effective in treating type 2 diabetes, which is on the rise. Statistics show that lifestyle choices (like diet, lack of exercise, and obesity) are responsible for up to 85% of new type 2 diabetes cases. In the study, maitake mushrooms had a positive impact on rats with this disease.  

Psilocybin  

Psilocybin mushrooms, commonly known as magic mushrooms, mushrooms or shrooms, are a polyphyletic, informal group of fungi that includes Copelandia, Gymnopilus, Inocybe, Panaeolus, Pholiotina, Pluteus, and Psilocybe. Psilocybin, the main psychoactive compound in these mushrooms, is actually found in over 100 species around the world.  

Psilocybin is a classic hallucinogenic compound produced by over 100 species of mushrooms across the world. It has a strong effect on serotonin receptors in the brain, including some in the cerebral cortex and thalamus regions. Although mushroom use – casually referred to as “shrooming” – is commonly associated with hippies, artists and others that tend to live a more alternative lifestyle, their consumption actually dates back thousands of years. Historically, they’ve been used to aid in religious ceremonies and are still considered a gateway to some very profound spiritual experiences.  

Psilocybin mushrooms also have some powerful therapeutic benefits, and have already been decriminalized in a few locations around the world as researchers dive into their potential to treat numerous disorders. Areas of interest include conditions such as mood disorders, anxiety, OCD (obsessive compulsive disorder), and substance addiction. 

Unlike other mushrooms on this list, there is an issue of legality with psilocybin mushrooms, meaning that they are still illegal in most countries. In the United States, their active ingredient is listed as a schedule 1 narcotic, and so they are illegal. A few pockets of the world are changing these laws though, as the public becomes increasingly aware of their health benefits.  

Final thoughts 

The mushrooms listed above are just some of my personal favorites, but you can benefit from even the most common species out there. Adding some baby bellas or white buttons to your meal plan a couple times a week can have amazing wellness benefits, while microdosing with magic mushrooms on a regular basis could be a game changer for your mental health. As long as what you’re eating isn’t poisonous, you really can’t go wrong with any type of mushroom, they’re all incredible!   

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DisclaimerHi, I’m a researcher and writer. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

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How do magic mushrooms grow in a man’s blood – or cow patties?

Magic mushrooms began to sprout in a man’s veins in the USA after taking an infused tea. Most of us drink our tea, which has not caused a case of organ failure. But, that cannot be said in this circumstance. But, how do magic mushrooms grow in a man’s blood – or cow patties? Magic […]

The post How do magic mushrooms grow in a man’s blood – or cow patties? appeared first on Latest Cannabis News Today – Headlines, Videos & Stocks.

How To Battle Animal & Mold Infestations in Outdoor Cannabis Grows

All outdoor marijuana crops have the potential to be destroyed by one or two of the various problems lurking in the wilderness, unlike indoor growing where plants are protected. In checking on the crop, make sure to keep an eye on the little details that will spell trouble later. There are a few different things to look for:

Aphids

An aphid infestation is a hard infestation to get rid of. For most of us, using chemical insecticide is the no-brainer solution, and they’re right. Aphids are very hard to kill. Chemicals can be used if the plant is still in the green foliage growth stage. If the scheduled harvest is just 2 or 3 weeks away, don’t use chemical insecticides, as the chemicals will still be present in the finished product. No one wants to risk the dangerous side effects of smoking chemicals.

The natural way to get rid of an aphid infestation on a marijuana plant involves a few steps and a bit of work. Go out and buy a few geraniums. Geraniums exude hormones that pests don’t like. Make a few palm sized cloth bags full of the geranium leaves and hang them on each plant. The hormones the geraniums exude will keep the aphids away. Now the aphid eggs left behind have to be dealt with.

Find a good thick soft cloth and some antibacterial / insecticide soap. The aphid’s eggs will be found mostly on the underside of the leaves of the plant. Using some care, just run the soapy cloth under each leaf, just once. You don’t want to scrub the leaves; just one pass over them will do if the cloth is good and soapy. You’ll feel a slight tug on the washcloth with every aphid egg that you’re displacing.

Depending on the degree of infestation, if you’re using a growing medium such as a peat and perlite mixture, the top coat might have to be replaced. The peat and perlite growing medium gives the aphids many crooks and crevasses to lay eggs in. Dig out the first inch or two and replace it with pH balanced peat and perlite mixture. Be sure to be careful around the roots and everything will be okay.

Since antibacterial / insecticide soap was used, be sure to mist the underside of the leaves for about a week to remove any traces of the chemicals in question. If there are buds present, try not to spray the pH balanced water on them. A happy nug is a dry nug.

Molds & Fungus

Since every grow operation requires standing water of some kind, one must at all times be vigilant when it comes to mold and fungal infestations. They both like to grow in standing water or on surfaces that are wet most of the time. Both molds and fungus can be made of some very nasty substances that can harm humans. If you suspect an infestation of mold or fungus, wear rubber gloves while checking things out.

The first sign of mold or fungus is the smell. It’s hard to not take a good sniff of each plant, as most stoners enjoy the scent of a marijuana plant. If you smell a damp and rotted scent while sniffing, you’ve got a problem. It might be time to break out the chemicals.

The first place to look for mold is on the part of the main stem that sticks out from the roots. Check to see if there is a slimy residue on it. If there is, then it’s time for the chemicals to come out. There is just no way around spraying the stalk with fungicide if it is moldy. This is because the base of the stem is where the plant supports itself and is the first part of the plant that allows the nutrients from the root to spread within the rest of the plant.

There might be the urge to wipe the now dead mold off of the stem. Try not to, because the mold might have punctured the stem all the way to the hollow core of the plant. Wiping away the dead mold will also wipe away the stem if it is dead. This will cause a stop in growth and possibly the loss of the plant as a whole. Leaving the stalk and the dead mold intact will keep the stem sealed – exposing the hollow inner core is a death sentence for the plant.

Marijuana is a very hearty and strong plant. It can live through some pretty major damage. While a mold and fungus infection may kill other plants, if the procedures outlined here are adhered to, the plant will live to maturity. It may have smaller buds than those plants without an infection, but it will still be greedily harvested once the buds have matured.

Mammals & Rodents

Animals love to nibble on marijuana. Whether it’s just the smell or taste or if they know that they can get high is unknown. The culprit most of the time is deer, as the first sign of having a foraging visitor nipping your buds will show on the top of the plant.

The only way to stop this foraging is to push a light mesh cover over your plants or to hang geranium bags on your plants. Animals hate the scent of geraniums, so they stay away from your plants. Another scent-based solution is mothballs. Most animals will shy away from mothballs, as the scent isn’t comparable to anything they eat in the wild.

In growing in the wild, there are bound to be a few deaths in the crop. Whether this is due to male culling or animals or mold or fungus, plant a few extra plants to make up for the future losses and the crop will turn out fine.

How do you combat pests? Tell us your grow tips below.

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