A Complete Guide To CBN (Cannabinol) Isolate

Cannabinol (CBN) is a
cannabinoid non-psychoactive compound found in cannabis and hemp plants, and
the methods for harnessing this compound are becoming increasingly technical.

When it comes to products other than flowers, whatever
cannabinoid is being utilized needs to be extracted from the plant matter and
processed. If you’re trying to manufacture a product with a very specific
amount of CBD in it – medication for example that would require accuracy down
to the milligram – you will need isolate.

But not just any CBN isolate or distillate will be acceptable though, you will need it to be made at a EU GMP facility. This applies to anyone in the world, as the industry is moving towards a more regulated entity, but GMP (good manufacturing practice) is especially important in the European cannabis and hemp industries.

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What is CBN?

Cannabinol, or CBN, is a non-psychoactive compound found in the cannabis plant. It’s  becomes prevalent as the cannabis plant ages. It actually originates from THC, so as your flowers are exposed to the elements (oxygen and heat), THC molecules begin converting into CBN.

Freshly cured buds, the ones that are typically more sought
after, are generally very low in cannabinol. Older, dry flower that’s been
sitting around for a while will have much higher levels of this cannabinoid.
That said, letting your buds dry out until they’re barely desirable is not
necessarily the best way to get CBN, although it’s probably the easiest.

CBN can also be manufactured in a lab from THC that’s extracted
from fresh cannabis plants. More and more brands are beginning to utilize this
compound to create tinctures, edibles, and softgels. There are numerous medical
benefits to using CBN, although there is often a lot of false advertising
associated with this cannabinoid (more on that later).

Medical Benefits
of CBN

Cannabinol has many of the same benefits as CBD and THC,
however, it’s believed that CBN might be more effective for treating certain
ailments than the aforementioned cannabinoids. They can also be combined for a
more potent, entourage effect.

Bear in mind
that studies on CBN are very limited, even by industry standards. But since
this cannabinoid is non-intoxicating and can be sourced from old cannabis that
may not have any other valuable use, it’s an important compound to continue
exploring. That said, let’s discuss what the existing research does have to say
about it.

CBN can be a potent antimicrobial. Researchers found that it effectively killed 3 different strains of MRSA – a type of staph bacteria that’s become dangerously resistant to traditional antibiotic medications. In a rodent study, researchers discovered that could also be used to delay the onset of ALS (Lou Gehrig’s disease), as well as treat existing cases. ALS is a nervous system disorder that weakens the muscles.

Rats exposed to CBN increased the amount of food they ate per sitting – AKA, the munchies. The implication here is that CBN can be used to boost appetite in situations where a patient can’t use THC, whether for legal reasons or to avoid intoxication. Another study on rabbits found that CBN reduces ocular pressure, which is the root cause of vision loss from glaucoma. THC has this same effect on the eyes. While CBN hasn’t yet been shown to be more effective than pharmaceutical drugs, it could be a viable natural alternative for those who want to minimize their use of standard medications.

And finally, inflammation. Just like pretty much every other cannabinoid, CBN seems to be a worthwhile anti-inflammatory agent. A study on mice showed that CBN could reduce arthritis, as well as other conditions stemming from inflammation.

Over the next
few years, we can expect to learn a lot more about CBN and what kind of impact
this cannabinoid will have on human medicine.

The Endocannabinoid
System

The reason CBN and other cannabinoids work for such a diverse range of conditions is because of the Endocannabinoid System (ECS). The ECS is a network of receptors that can be found throughout the bodies of all mammals. We naturally create cannabinoids which bond to these receptors to regulate different processes in our bodies and maintain homeostasis. The ECS helps manage things such as immune function, appetite, sleep wake cycles, pain response, and the list goes on.

Get EU GMP-Certified Cannabinoid Isolates and Distillates

On the
other hand, when we are ‘cannabinoid deficient’ our bodies become destabilized and no longer function
optimally. It’s theorized that many illnesses stem from the inability to
produce endocannabinoids. This is where supplementing with plant-based
cannabinoids (phytocannabinoids) comes into play.

What is
Isolate?

The most CBN extract on the market is isolate. As the name
indicates, this product is made by completely isolating the cannabidiol from
all the other plant matter and compounds. That means all other cannabinoids,
terpenes, flavonoids, and inactive compounds are stripped from the extract,
leaving only CBN. The final product is a fine white powder that has over 99% CBN.
Basically, it’s an extra-refined distillate.

Because
it’s odorless, tasteless, and highly concentrated, it’s a great to use in the
manufacture of many medical, wellness, and retail products. Its purity means
that 1 milligram of isolate equals exactly 1 milligram of CBN, whereas 1
milligram of less potent extract might have 0.5 milligrams of CBN, 0.3
milligrams of CBD,
and 0.2 combination of other terpenes and compounds. This makes isolate very
easy to use for specific dosing.

How is it made?

To make isolate, the CBN must be extracted from the plant – and
there are numerous ways to do this. The industry gold standard and consumer
favorite is CO2 extraction. The equipment is industrial and very pricey, but
this method results in a very pure final product. A closed-loop system is used
to cool CO2 to -56C, as the pressure inside the chamber is hiked up to 75psi.

The CO2 becomes “supercritical” at this stage and sits somewhere
between a liquid and gaseous state. The CO2 is then passed through the closed
chamber and, almost like a solvent, the cannabinoids and terpenes are extracted
and remain intact. This process is called Supercritical CO2 Extraction. There’s
also Subcritical CO2 Extraction which used cheaper equipment, lower pressure,
and results in smaller yields.

A more
cost-efficient but equally effective method is with an ethanol extraction
system. Ethanol extraction involves applying the solvent ethanol directly to
the hemp plant in order to extract the cannabinoids. Ethanol extraction has
gotten a bad reputation as being unsafe, but that’s simply incorrect. Ethanol
extraction is actually an FDA-approved method of extraction compounds from
various plants in order to make food and medicines.

There is one issue with ethanol extraction, however. Certain
compounds easily co-extract with ethanol, and the one of concern here is
chlorophyll. Chlorophyll is a molecule that absorbs sunlight and converts it
into plant energy. It also gives plants their green color. When using ethanol
extraction, the chlorophyll may need to be stripped away in a separate process.

Why is CBN Isolate important?

Isolate can be used to make anything that needs CBN added to it – edibles, topicals, tinctures, softgels, nasal sprays, various pharmaceuticals, and the list goes on. Anything that requires precise dosing will benefit from isolate and distillate.

Cannabinoid isolate in crystal form

Better yet, if the product is manufactured in a GMP-certified
facility. It’s already a requirement in Europe, India, and many other
countries/continents that all medications, supplements, and cosmetics must be
GMP-certified. And while the North American market is currently an unregulated
free-for-all, this is expected to change over the next few years.

Where to Get EU GMP CBN Isolate

We have partnered with some leading suppliers of CBM isolate (and
distillate). Both products are, as you probably guessed, GMP and certified by
the EU, listed in the Eudra database, and available for export globally. We
offer the best pricing and have the ability to accommodate extremely large
orders.

We offer wholesale orders for our subscribers. The pricing for
EU GMP CBN Isolate is as follows:
  • 1 – 25kg – €1,850
  • 25 – 50kg – €1,650
  • 50 – 100kg – €1,550
  • 100kg+ – €1,450

To place an order, or if you need more information, subscribe to the CBD Business Weekly Newsletter. For time-sensitive deals and questions, contact us directly at info@cbdtesters.co.

The post A Complete Guide To CBN (Cannabinol) Isolate appeared first on CBD Testers.

Cannabinoids 101 – Spotlight on CBN (Cannabinol)

If you’ve been following recent updates in cannabis research, you’ve probably noticed there has been a lot of talk about new cannabinoids lately.

Everyone knows about the two major players – CBD (cannabidiol) and THC (tetrahydrocannabinol) – but now it’s time for some of the minor cannabinoids to shine. Today, CBN (cannabinol) is in the spotlight.

Just like every other plant compound, this cannabinoid has unique properties and carries its weight when it comes to medicinal benefits. So let’s take a closer look at CBN.

What is CBN?

CBN is a phytocannabinoid that becomes prevalent as the cannabis plant ages. It actually originates from THC, so as your flowers are exposed to the elements (oxygen and heat), THC molecules begin converting into CBN.

Freshly cured buds, the ones that are typically more sought after, are generally very low in cannabinol. Older, dry flower that’s been sitting around for a while will have much higher levels of this cannabinoid. That said, letting your buds dry out until they’re barely desirable is not necessarily the best way to get CBN, although it’s probably the easiest.

CBN can also be manufactured in a lab from THC that’s extracted from fresh cannabis plants. More and more brands are beginning to utilize this compound to create tinctures, edibles, and softgels. There are numerous medical benefits to using CBN, although there is often a lot of false advertising associated with this cannabinoid (more on that later).

Click here or use the sign up form below to subscribe to the Medical Cannabis Weekly Newsletter.

What are the medical benefits of CBN?

Cannabinol has many of the same benefits as CBD and THC, however, it’s believed that CBN might be more effective for treating certain ailments than the aforementioned cannabinoids. They can also be combined for a more potent, entourage effect.

Bear in mind that studies on CBN are very limited, even by industry standards. But since this cannabinoid is non-intoxicating and can be sourced from old cannabis that may not have any other valuable use, it’s an important compound to continue exploring. That said, let’s discuss what the existing research does have to say about it.

  • Antibacterial – CBN can be a potent antimicrobial. Researchers found that it effectively killed 3 different strains of MRSA – a type of staph bacteria that’s become dangerously resistant to traditional antibiotic medications.
  • Neuroprotectant – In a rodent study, researchers discovered that could be used to delay the onset of ALS (Lou Gehrig’s disease), as well as treat existing cases. ALS is a nervous system disorder that weakens the muscles.
  • Appetite Stimulation – Rats exposed to CBN increased the amount of food they ate per sitting – AKA, the munchies. The implication here is that CBN can be used to boost appetite in situations where a patient can’t use THC, whether for legal reasons or to avoid intoxication.
  • Glaucoma – A study on rabbits found that CBN reduces ocular pressure, which is the root cause of vision loss from glaucoma. THC has this same effect on the eyes. While CBN hasn’t yet been shown to be more effective than pharmaceutical drugs, it could be a viable natural alternative for those who want to minimize their use of standard medications.
  • Anti-Inflammatory – Just like pretty much every other cannabinoid, CBN seems to be a worthwhile anti-inflammatory agent. A study on mice showed that CBN could reduce arthritis, as well as other conditions stemming from inflammation.

Over the next few years, we can expect to learn a lot more about CBN and what kind of impact this cannabinoid will have on human medicine.

Sleep Aid.. or not?

If you have heard of CBN already, it’s likely that you’ve seen it promoted as a sleep agent or sedative. I really couldn’t tell you why it’s marketed this way, but research doesn’t seem to fall in line with this particular claim.

What Are The Best CBD Hemp Flowers For Sleep?

“We found that CBN slightly prolongs the sleep time in
barbiturate-induced sleep in mice. There is no current information that I am
aware of that proves CBN is a sedative, even though it is already being
marketed as such,” says Zoe Sigman one of the principal researchers
at Project CBD,
in an interview with Forbes.

Anyone feeling drowsy after smoking older cannabis is likely feeling this way because of residual amounts of THC remaining in the buds. It’s also possible that CBN and THC have synergistic effects when consumed together, meaning the CBN might actually boost the effects of the lower levels of THC.

Will it get you high?

There is some confusion about whether or not cannabinol will have intoxicating effects. The answer is; it depends. If you’re consuming products with CBN that has been completely isolated from the other plant compounds, then no, CBN alone won’t get you high. However, when combined the THC, CBN can actually increase the psychoactive effects, making one feel stoned from flowers that might not actually have that much THC anymore.

This is because of a process known as the Entourage Effect. Simply put, the entourage effect refers to the way different compounds in the cannabis plant interact with each other, and thus, how these combinations have different effects on the body.

Within the cannabis plant you will find:

  • Cannabinoids: Naturally occurring compounds, such as THC (tetrahydrocannabinol), CBD (cannabidiol), CBN (cannabinol), etc., that interact with the endocannabinoid system in mammals.
  • Terpenes: A diverse group of organic compounds found in most plants that give them their specific fragrances.
  • Flavonoids: These are important antioxidants that give plants their pigments and attract pollinator animals. In cannabis they’re referred to as cannaflavins.

Cannabis has hundreds of different therapeutic compounds, most of which are stripped out when using products that contain cannabinoid isolates. This isn’t to imply that individual cannabinoids aren’t beneficial, because they certainly are; and in specific cases it can be advantageous to treat patients with only one compound. Isolated compounds are also required for use in pharmaceuticals and they’re better for research purposes.

However, there are many instances where a patient could  from the synergy of whole plant medicine. The most popular way to reap the benefits of the entourage effect is by simply smoking the buds. However, there are numerous extracts and products on the market thee days that retain a great amount of naturally-occurring compounds.

Where to find CBN products

As a consumer, there are two ways you can get CBN products. First, probably your initial go-to will be to look online for a reliable retailer that sells these kinds of products. There are a few these days, but you’ll have to make sure their products are lab-tested and the company is well-reviewed.

Second, you can set aside a few buds out of your stash next time you re-up and just let nature take its course. At the moment, there’s no established timeline for when your flowers will become CBN-dominant. If it’s gotten to the point that the buds are dry and powdery, and you don’t feel much of a high anymore, it’s safe to wager that you now have CBN flowers.  

If you’re in the B2B sector, we have partnered with some of the top companies in the world to offer you wholesale deals on kilos of cannabis and hemp extracts. We have CBN distillate and isolate available. It’s EU (European Union) GMP-certified and listed in the Eudra Database. We ship globally. This can be used to make legal, medicinal products, supplements, and cosmetics.

Click here to buy CBN isolate and distillate.

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The post Cannabinoids 101 – Spotlight on CBN (Cannabinol) appeared first on CBD Testers.

New Cannabinoid Said to be 30x Stronger Than THC

Last week, researchers from the University of Salento in Italy discovered two new cannabinoids. The compounds have been deemed tetrahydrocannabiphorol (THCP) and cannabidiphorol (CBDP). What’s interesting about THCP is that it is apparently 30 times stronger than THC. However, nobody is yet to understand what this really means in the grand scheme of cannabis science. The only thing the ganja geeks can say for sure is that this new compound appears to be more prevalent than THC when given to mice. They also believe the presence of THCP could be what provides cannabis strains with varying effects. In other words, we have two new cannabinoids — one that may even be the real rockstar — and we still know very little about their roles or what they are capable of.

Until now, all the scientific sector has really known is that there are hundreds of cannabinoids getting down to business in the cannabis plant. It just so happens, though, that when it comes to how this plant works when providing a buzz, healing, curing or whatever it is a person needs it to do, THC and CBD have been given all the credit. Still, we have known for a long time that the presence of unsung cannabinoids, like cannabinol (CBN) and cannabigerol (CBG), are responsible for helping to produce unique effects. There is also a little something called the entourage effect, whereby all of these compounds work together in harmony to create a certain kind of magic. Yet, we have continued the course in making THC and CBD the focal point of the spiel. Scientists now believe that at least one of the new cannabinoids, THCP, could also prove to have substantial benefits.

“A number of clinical trials and a growing body of literature provide real evidence of the pharmacological potential of cannabis and cannabinoids on a wide range of disorders from sleep to anxiety, multiple sclerosis, autism and neuropathic pain,” researchers said. “In particular, being the most potent psychotropic cannabinoid, THC is the main focus of such studies.”

“THCP is endowed of an even higher binding affinity for CB1 receptor and a greater cannabimimetic activity than THC itself.”

Although the wheels might be turning in the brains of cannabis industry executives curious about whether the discovery of CBDP might provide them with a new revenue stream, scientists argue that it might not be worth it. At least not yet. It seems the compound is wonky (it doesn’t bind well to CB1 or CB2 receptors). Therefore it is not something they are interested in learning more about right away. “In our opinion, this compound should be included in the list of the main phytocannabinoids to be determined for a correct evaluation of the pharmacological effect of the cannabis extracts administered to patients,” researchers explained.

In the end, the discovery of two new cannabinoids means there is still a wealth of opportunity to learn about what makes cannabis tick. But the longer the federal government keeps trying to separate these compounds into good and bad — CBD is medicine, THC is the devil — the longer it’s going to be before anyone of us has a real understanding about what happens when we consume this plant.

TELL US, do you think you could handle a cannabinoid with 30 times of the potency of THC?

The post New Cannabinoid Said to be 30x Stronger Than THC appeared first on Cannabis Now.

The lesser-known cannabis compounds

When most of us think about Cannabis, the two active substances that come to mind are THC and CBD. THC (short for tetrahydrocannabinol) is the prominent mind-altering component that gives cannabis most of its psychological changes. CBD (short for cannabidiol) is the non-psychoactive component that can give its users a calm and relaxing feeling.  The […]

The post The lesser-known cannabis compounds appeared first on Cannabis News | Lifestyle Tips | Expert Opinions | Stocks.

CBN is Another Cannabis Compound With Beneficial Properties

CBD, an abbreviation of cannabidiol, a non-intoxicating compound found in cannabis and hemp plants, is going viral across the globe. Hailed for its natural anecdotal anti-inflammatory and pain-relieving properties, CBD is being added to everything from skincare to food. However, CBD is just one of the hundreds of compounds inherent to the cannabis plant. Even though THC and CBD are garnering all the buzz, there are myriad other cannabis compounds which can help alleviate a…