DIY: How to Make Your Own CBN

There’s a lot of talk about different cannabinoids, and the growing unregulated cannabinoids market. One of the cannabinoids of interest is CBN, for its possible ability to help with sleep. Unlike many cannabinoids which require synthetization, CBN can be made pretty easily, and not as a synthetic. Read on for tips on how to make your very own CBN.

With a wide-ranging cannabinoids market out there, there are now tons of ways of enjoying cannabis besides standard THC. Whether you’re interested in delta-8 THC which causes less anxiety, CBN which might be good for promoting sleep, THCV which has shown as a possible aid in weight loss, or HHC a minimized version of THC, options abound, and we’ve got plenty for you. Check out all our deals on these compounds, and find the ones that work best for you.


What is CBN

Before getting into how to make CBN, we need to know more about what it is. The cannabis plant is made up of many components including flavonoids, terpenes, chlorophyll, lipids, cannabinoids, and other compounds. In fact, the main association with cannabis, is the cannabinoid delta-9 THC, sometimes erroneously called ‘THC’. This term actually stands for ‘tetrahydrocannabinols’, which can involve more cannabinoids than just delta-9, but somehow that slang term has prevailed, even showing up in medical literature. However, what we are actually speaking of, is delta-9 THC.

Cannabis plants can be split into two general types of plants, though both categories fit under the umbrella of ‘cannabis’. One, which we refer to as ‘hemp’ has lower amounts of delta-9 (which actually shows in a live plant as the acid THCA), and higher amounts of CBD (which shows in a live plant as the acid CBDA). On the other hand, ‘marijuana’ is now the term used for plants higher in THCA than CBDA.

Both THCA and CBDA are ‘phytocannabinoids’ because they appear in the plant. And both convert in the presence of light and heat to their respective cannabinoid counterparts THC (delta-9) and CBD. But this is not the end of the story. Once converted to delta-9 and CBD, these new cannabinoids can eventually degrade further into what we call ‘degradants’. These degradants can be entirely new cannabinoids. And this is where CBN comes in. CBN is the main degradant of delta-9, for which the vast majority of delta-9 will become. This makes CBN a rather prevalent cannabinoid in comparison to others like delta-8 or THCV, which only ever show in miniscule amounts. The chemical formula for CBN is C21H26O2, and it’s considered only minorly intoxicating.

make CBN

While it’s hard to say exactly what CBN is capable of, there is a growing belief that it could be related to properties like the ability to help with sleep and anxiety. This thought came around because of the noticed effect of older cannabis (which is more degraded than a new flower), making people more relaxed and tired. Plenty of research is currently being done into the possible existence of these properties. Apart from a sleep aid, CBN has many other similar benefits to delta-9 THC and other cannabinoids.

The history of CBN

Weirdly enough, CBN was the first cannabinoid of the cannabis plant to be discovered. This was not the goal at all, though, as the goal was to find the intoxicating element of the plant, for which CBN was confused. This research to establish the intoxicating element was already underway in the late 1800’s, being led by different scientists, namely Thomas Easterfield. And it was his discovery that led to the finding of other cannabinoids like CBD and THC.

To find this intoxicating element, cannabis was distilled into what was referred to as a ‘red oil’, and this was the first form to be studied in modern times. This red oil was discovered by Dr. Thomas Easterfield, who was a member of the Cambridge Group, and a lecturer at Cambridge University. When he first wrote about this ‘red oil’, he gave it the name ‘cannabinol’. These days we know that term to specifically mean the compound CBN, but at the time, it was related to the red oil distilled from the plant, as well as what was thought to be the intoxicating factor.

It was thought at that time that cannabinol was a narcotic substance, which was later clarified to be untrue. Easterfield was the first to isolate cannabinol, which, he stated in his late 1800’s writing, as being the intoxicating factor. Perhaps Easterfield would have gotten further, but a couple incidences got in the way of research.

One involved the accidental death of two collaborators in a lab accident. The other is a strange story of the voluntary ingestion of a large dose of CBN by another guy, leading to this guy getting extremely high and somehow catching on fire. Don’t worry, it was extinguished and he was fine, but research stopped upon media reports exaggerating the circumstances for smear campaigns against cannabis (started that early!) Research was halted for decades.

Things didn’t really pick up again until the 1930’s when Dr. Robert S. Cahn began studying CBN again. Cahn started calling the red oil ‘crude cannabinol’, and started using the term ‘cannabinol’ for the actual cannabinoid compound. Through his research he was able to validate that CBN was not the intoxicating factor. Cahn did map the structure of CBN, but many questions were still left unanswered until future scientists finally discovered CBD and THC. Separately, Easterfield and Cahn made the initial discoveries into CBN.

CBN

How to make CBN

When it comes to how to make CBN, the important thing to remember is that it’s a degradant of delta-9 THC, and that means you can make CBN from regular marijuana. Though it can be made from a hemp plant, since a hemp plant has considerably less THCA, it would require synthetization, rather than being made naturally. The best way to make CBN, therefore, is by using high-THC marijuana plants.

So how do you make CBN? It’s actually quite easy. Just add the things that naturally convert THC to CBN, light and/or heat. Both of these options essentially speed up time, allowing for a quicker degradation process that allows for CBN to be made. When made industrially, CBN is often created using solvents and metallic catalysts. However, if you do it yourself, not only do you know you’re getting the right product, but you can actually make a cleaner product. This can go for many cannabis products, where DIY methods can often net a better result when done correctly.

Heating: If you want to use the heating method (and you probably do as its more defined), you need to go through the regular process of decarboxylation that turns THCA into delta-9. However, in this case, you need to go a little further, to degrade the delta-9 in order to make CBN. Regular decarboxylation to convert THCA to delta-9 is usually done for no more than 20-40 minutes at a temperature of 230-250°F. These temperatures are low enough that the further conversion to CBN and degradation of other plant compounds, isn’t a problem. In this case, though, you would decarb at higher than 302º F, for a total of 15 minutes, although some publications say that 300º F for one hour also works. And that’s it. After this, you can go on to use the bud to make oil, butter, or whatever other product you know how to make, or can find instructions for.

UV light: The other option to age the plant in order to make CBN from delta-9, is with UV light. Unfortunately, less has been published about the specifics for this method, apart from the fact that a very intense light would need to be used. How intense, and for how long, is harder to say. Perhaps in the future, as CBN becomes more popular, this topic will get further flushed out.

There is, however, plenty of information about how light effects the cannabis plant, and much can be gleaned from this explanation:

“In cannabis, Δ 9-tetrahydrocannabinol (THC) naturally degrades to cannabinol (CBN) over time. Light exposure supplies energy and speeds up this process. The ratio of THC to CBN in a stored sample of cannabis can actually be used to indicate age and quality of storage.

Lindholst (2010) examined tetrahydrocannabinolic acid (THCa) in cannabis extracts. Samples exposed to daylight degraded at a half-life of 35 days, while those kept in darkness degraded at a half-life of 91 days (an approximate 250% difference).”

Cannabis UV light

While this is not specific, it does indicate that if you leave your weed out in bright sunlight, or put it under a UV light, that the process of converting delta-9 to CBN is much faster. I didn’t see an exact consensus on how to do this online, but several message boards contained different instructions by different people, and interested parties should check through to find more specific information if this is a desirable method to try. Personally, I suggest using the heat method.

How this differs from other minor cannabinoids

The cannabinoids market of today offers tons of options of both naturally occurring and synthetic cannabinoids. What’s the catch? Even the naturally occurring ones (besides THC and CBD) don’t occur in high enough amounts for extraction without synthetization. Meaning if you’re buying a product, even if it’s something like delta-8, which most definitely is naturally occurring (as likely another minor degradant of delta-9), your product will have gone through processing. This likely means the involvement of harsh chemicals or processes that may not be safe, and which aren’t currently being regulated.

Beyond that, the lack of regulation means its hard to know you’re getting the product you’re paying for, and that it’s not a fake, or filled with adulterants. For this reason, this has become a questionable market in terms of safety and product quality. And this goes for any cannabinoid product that fits the category of requiring synthetization. It also goes for many other cannabis products, but minor cannabinoids in particular we already know cannot be easily and directly extracted for use.

The difference with CBN is that it can be made to appear in large enough amounts, by simple methods that don’t involve synthetic processing. However, for the other reasons mentioned, this doesn’t mean that because you’re buying a CBN product, that it will be real. And that brings us to the other difference with CBN and other minor cannabinoids. Much like delta-9 itself, it can be made DIY style, giving users the ability to make a clean product, and to know for sure what that product is.

Conclusion

CBN likely has plenty of medical benefits, and one seems to be the ability to help with sleep and anxiety, though this is not formally stated. Research has been inconclusive, and is ongoing, but message boards are already filled with people talking up these qualities. Perhaps in the future we’ll know more. Let’s remember one thing. The government never likes when people can make their own products, or buy them outside of regulation, since it means less money in taxes for the government.

The push to say CBN isn’t effective for sleep could be more related to trying to save it for the pharmaceutical market, or simply to keep people from buying it, than trying to help people find a safe method to promote sleep. This is supposition, but something to consider in the whole ongoing cannabis debate, and with the rapid growth of the government backed pharma market.

Hello and Welcome! Thanks for making it to CBDtesters.co, the internet’s preeminent location for the most important and though-provoking cannabis and psychedelics-related news globally. Visit us whenever you can to stay on top of the always-in-flux universe of legal drugs and industrial hemp, and remember to check out The THC Weekly Newsletter, to ensure you always know what’s going on.

DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advice, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

The post DIY: How to Make Your Own CBN appeared first on CBD Testers.

How to Get Supplements to Work? Change Your Life

There are some very intense realities to life, and one is that if you really want change, you need to really make changes. Though the addition of supplements may be useful, if you really want them to work, you might need to change other aspects of your life.

Supplements can improve your health, but if you really want them to work, you might need to change other parts of your life. The cannabis plant provides many compounds that can be used as supplements for sleep, weight loss, stress reduction, and more. Remember to subscribe to The THC Weekly Newsletter for deals on legal cannabis products, as well as all the latest news and industry stories. Also save big on Delta 8Delta 9 THCDelta-10 THCTHCOTHCVTHCP & HHC products by checking out our “Best-of” lists!


Supplements

These days there are supplements for pretty much anything. You don’t eat meat and you’re not getting enough B12? Well, there’s a capsule for that. Not enough fermented foods in your diet and your guts are acting up? Take yourself a probiotic. Eating a diet full of omega-6 and you feel a little swollen, best to swallow down some fish oil. Overweight and trying to deal with it, maybe add some THCV into your diet.

A supplement is something that is added into a diet, generally to make the addition of something that is lacking, or for a particular purpose. Supplements generally contain “minerals, herbs or other botanicals, amino acids, enzymes” as well as other possible ingredients. They can come as tablets, gummies, capsules, tinctures, oils, powders, drinks, energy bars, and pretty much any other way to get something in you.

Dream Job Alert: Get Paid To Try Cannabis Products

A lot of things can be used as supplements in a diet, although the term ‘dietary supplement’ is a specific term made by congress that rules out many compounds. Some supplements are taken specifically to obtain nutrients that aren’t being acquired in a regular diet. These kinds of supplements can be for essential nutrients which are not made by the human body, (and must be taken from the environment around), or non-essential nutrients which the body can produce, even if it can’t produce enough. Examples of essential nutrients are fats like omega-3, amino acids like lysine, vitamins like vitamin A and the vegan-loved B12, and minerals like calcium, magnesium, and zinc.

Nonessential nutrients are those that can be made in large enough quantities by the human body, but for whatever reason are lacking. Nonessential nutrients include amino acids like tyrosine and L-cysteine, and vitamins like vitamin D and biotin. Another thing not produced by the body (though not considered a nutrient) is fiber, which many people also take as a supplement to improve digestive function.

‘Dietary supplement’ is a legal definition for what can be sold in a specific category, so not everything that acts as a supplement, is considered a dietary supplement. Insulin is a good example of this. It is most certainly supplemental, but not considered a supplement by definition. This is also legal, as insulin is in approved medications, and therefore can’t be marketed as a supplement.

Not all supplements were created equally, and this must be remembered. The supplements market is not regulated, and therefore, though the market is legal, what can go into products is not defined. This makes it a ‘know your labels’ industry, as cheaper brands might put in additives, use lesser quality materials, or sell you the wrong thing altogether. There is also the issue of chemicals used.

A supplement will contain several other ingredients not related to the actual purpose of the supplement. Think about the capsule it might be in, something put in it to keep it from spoiling, or whatever makes it that bright blue color. Depending on what you want to stay away from in life, picking the right supplements as per the desired ingredients, is also important.

Do supplements work?

This is a great question in life, and different people will give you different answers. The most honest answer is, sometimes it’s hard to tell. If a person isn’t taking something where they expect to see a direct effect, it might be hard to tell if there is one. There are a lot of factors that can complicate life, and its often hard to tell exactly what is causing each response.

Many supplements fit the bill for ambiguous results. If a vegan is taking B12 to make up for not ingesting animal products, and their energy improves, it will still be hard for them to rule out other factors that could’ve caused the improvement. Maybe they simultaneously also started getting more sleep, or inadvertently upped protein without realizing it, through a dietary change.

When a person takes an antibiotic to kill an infection, an improvement in symptoms will generally be related to that medication. If a person has an infected cut that won’t heal on its own, and then the application of hydrogen peroxide or alcohol decreases infection, the two are likely correlated. Does it mean they have to be related? No, but in general practice, they are.

If a supplement is taken for something that it can help with, it probably will. Think about people with diabetes. Technically, the insulin they take is supplemental because its not the insulin made by their bodies. We consider insulin a medication, not a supplement, because its in approved mediations, but this doesn’t change that its acting as a supplement.

Generally, taking insulin will reverse symptoms by temporarily solving the problem of not enough insulin produced in the body. For a Type I diabetic, insulin is actually an essential supplement, because the body isn’t producing enough. Whereas for Type II, its nonessential because there isn’t a problem with production, but rather with production being enough for an expanded body size (assuming the issue is weight). In the case of diabetes, the user will most certainly know if the supplemental insulin is working.

The above example is very different from a person supplementing with something like probiotics. In this case, the difference can still be incredibly intense, but it won’t necessarily be quite as direct, and can often take a long time for full effects. Probiotics can be very useful, and I personally attest to the difference it can make in the digestive tract when a person consistently takes a quality product.

Best way to make supplements work, is to change your life

This is not a desired headline for many people, but it’s still mostly true. Unless a supplement is always going to work for everyone, there isn’t a guarantee for effectiveness. Realistically, this is also relevant for the standard medical world. Think of how often we speak of antibiotic resistance… well, that denotes people not getting the intended effect of the antibiotic. Supplements might work better in some bodies than in others, but there is still a hard and fast truth to easy answers.

Let’s be honest, most people take supplements to solve a problem, or improve their health in some way. Like taking those probiotics. It’s a great idea, BUT, if a person is going to continue with bad habits, the probiotics might not be very effective. If a person is eating a diet full of chemicals and processed foods, simply taking a probiotic might not be enough to counter or reverse years of internal damage and the continuation of what caused the damage in the first place. If you are concerned enough about your digestive health to take a probiotic regularly, you might want to consider a change to your life in the form of a better actual diet.

Another example is if a person is having problems sleeping, and attempting to remedy the situation by taking a CBN product. Expecting the CBN to work, despite ingesting caffeine and living by a schedule not conducive to good sleep, is a little off base. But if the person in question also takes caffeine out of their diet, gets some exercise, and works their schedule to be more conducive to a natural sleep cycle, that supplement might work way better.

To some, this takes away the idea of the easy answer, but realistically, easy answers don’t exist. The person with sleeping problems might require something more to help sleep, even despite making lifestyle changes. However, this doesn’t mean a certain amount can’t be achieved through those lifestyle changes alone. It also doesn’t mean the supplement absolutely will work if changes are made, but better overall lifestyle habits can influence overall supplement performance.

One of the biggest issues where supplements come into play, is weight loss. Everyone wants an easy answer, and no one wants to do the work. Whether the work means getting to the gym and working out, or establishing a healthy diet that promotes weight loss, (or more likely, both together) it’s incredibly common for people to try to cut corners with bad diets, and supplemental weight loss products. Compounds like ephedra, or the cannabis cannabinoid THCV, are examples of supplements used for dieting. However, if you pay attention to what goes on in the world of weight loss, you already know that if you want to lose weight, its not about the pill, it’s about making a change in your life.

If a person really wants to lose weight, they’ll probably need to start exercising. If a person really wants to improve their sleep, they’ll probably have to cut out caffeine and assess other aspects of their diet and schedule. And if a person with digestive issues really wants to improve them, taking a probiotic is great, but cutting out foods that are bad for the guts, will make those probiotics way more effective.

Conclusion

Very few people will take a supplement without the notion that it’ll do something for them. However, in looking for answers, it’s not uncommon to rely on something like a supplement without considering the realities of every other aspect of life. When looking to improve health, it’ll infrequently be done by simply popping a capsule, though that capsule can still be beneficial. If you want real change, the right supplement can certainly help, but the unfortunate reality is that you’ll probably need to change your life in other ways, if you really want to chase that positive result.

Welcome… Thanks for joining us at CBDtesters.co, the internet’s one-stop-shop for all the best and most pertinent cannabis and psychedelics-related news going on currently. Stop by daily to stay abreast of the quickly-moving landscape of legal drugs and industrial hemp, and sign up for The THC Weekly Newsletter, so you always hear every news story first.

DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

The post How to Get Supplements to Work? Change Your Life appeared first on CBD Testers.

Recent Study Sheds No Real Light on Cannabis and Sleep

The new trend seems to be to put out constant research on cannabis saying it does something or other. As a growing industry, everyone wants their say, even if they don’t have anything to say, or if it means getting news information wrong, or changing stories to have better headlines. Such is the case with articles coming out about a recent study conducted into cannabis and how people sleep. Not only do the articles about it get it wrong, but the study itself is shoddy at best.

Truth is, if cannabis helps you with sleep, then it doesn’t matter what comes out in conflicting studies, just use what works for you. And if delta-9 doesn’t do the job, there are tons of other cannabis compounds to try, like delta-8 THC, THCV, and CBN which is used in many sleep medications. The cannabinoids market is an ever-expanding unregulated offering that can be bought anywhere, making it convenient for those in illegal locations. We’ve got tons of great deals for products to try in time for the holidays, so go ahead and start your shopping today. Make sure to subscribe to The THC Weekly Newsletter. Also save big on Delta 8Delta 9 THCDelta-10 THCTHCOTHCVTHCP & HHC products by checking out our “Best-of” lists!


The study in question

In December 2021, the study Recent cannabis use and nightly sleep duration in adults: a population analysis of the NHANES from 2005 to 2018, was published in the magazine Regional Anesthesia & Pain Medicine. The aim of the study was to “determine the relationship between cannabis use and nightly sleep duration in a nationally representative dataset.” What data set was used? Already collected data that was not collected for this particular study. The information used comes from National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2018.

The reason I make a big deal about where the information came from, is because, what this means is that the researchers pulled data from a survey unrelated to what they were studying. They spoke to none of the respondents in the study, as it was conducted for other purposes, and controlled for literally no information, like prior sleep issues, other drug use, mental health issues, and familial health histories.

What the researchers did was to group survey respondents (covering approximately 146 million US adults) in two categories based on whether they reported cannabis use in the past 30 days, or not. Then, sleep patterns were examined between the two groups, with each being put into the category of short (less than 6 hours), optimal (6-9 hours), and long (9 hours and up). The study did adjust for sociodemographic and some health-related co-variates, although only what could have already been collected. As the health survey taken from was not designed to answer the questions in the cannabis study, it cannot be expected that relevant covariates were accounted for.

cannabis sleep studies

According to the study results, 14.5% of respondents reported cannabis use in the past month. With an adjusted analysis, it was found that recent cannabis users were more likely than non-users to report short sleep times and long sleep times. Those who were considered heavy users (smoked 20 or more days in the past 30), were more likely to be on either end.

Why a study like this is essentially useless

While collected data can often be useful, it can also be the basis for misusing information. For the standard public, it would appear that a study was actually done into cannabis use and sleep, but that’s not the case. The NHANES is survey research collected by the National Center for Health Statistics (NCHS) in order to track health and nutrition issues of adults and children in the US, and to track changes over time. It’s not about cannabis.

It uses interviews, laboratory tests, and physical exams in its collected data set. How much of this is specifically collected by researchers, and how much is taken from existing data sets is hard to say though, meaning even the collection of this information may have been done without speaking to respondents.

The researchers for the cannabis sleep study merely tapped into some of this research, taking the parts they wanted, leaving out anything they didn’t want to account for, and simply not accounting for anything for which data never existed. This is not research where the researchers set up their own study groups, so the researchers have never had anything to do with any respondents in this survey, nor did they design a study to investigate this issue, or perform an experiment.

What if people using cannabis with shorter sleep times were actually elongating a much shorter sleep time by using the cannabis? And what if the majority of long cannabis sleepers actually have some other health issue that relates to their long sleeping time? And what about the kind of cannabis used – was it standard weed, CBD, CBN; was it sativa or indica; what was the method of ingestion; what was the quality of sleep; and specifically were they smoking it? Once smoking enters the picture, all kinds of things can go out of whack because smoking causes so many issues. What about nutritional aspects, what percentage of these respondents were eating a diet that might get in the way of sleep? The US isn’t known for its awesome health, and physical health issues play massively into sleep.

I see so many issues with this study, that it’s hard to imagine it would be taken up by the public. In essence, nothing is learned, because the study is so faulty. Yet, that hasn’t stopped writers from snatching it up for a headline, ready to make statements like “CANNABIS MAY MAKE SLEEP WORSE, STUDY SAYS” which is a) not really what the study said, and b) not technically something that can be gleaned from it based on black holes of information.

sleep studies

The reality of it

In reality, actual sleep studies into cannabis use have turned up mixed results, though a growing industry toward using it for sleep would indicate that people are getting help with it. This is also backed up by sites like reddit, where the majority of answerers relay positive sleep benefits of cannabis. On such sites, its best to keep in mind that people often answer with what they think they know, not their own experience, so it helps to look at what they’re saying to tell if its a personal experience or not, and to disregard know-it-alls over experience-givers. This is probably a good time to remind that not everyone is effected the same way by everything, and that its quite possible cannabis could be beneficial for some, and not for others.

For my part I can say that vaping weed can help me fall asleep as well as go back to sleep in the middle of the night. Though it won’t work all the time. And I say this as one of the worst insomniacs you’ll meet, who has been medicated for this purpose since childhood. In fact, I can use cannabis products for this purpose rather than harder medications, which is a major benefit. As an athlete (running and ballet), taking heavy medications can get in the way of daytime performance, so having an alternative like cannabis is not only useful, its imperative. That’s how it effects me, though, and this may not be relevant to everyone.

While different results exist, this study being written about did not use data collected on a study into cannabis and sleep, it used preexisting data from an unrelated survey, which would not have gotten all the necessary information for any firm and usable results to be made. So though it showed a similar outcome of varying results, these specific results are not based on very good data. They also say very little other than that cannabis users tend to fall on opposite ends of a spectrum, while providing nothing about quality of sleep. A real sleep study will give much more specific and relevant information.

A study being done directly into cannabis and sleep is a study where the study investigators specifically design an experiment to test a related hypothesis, using study participants for that purpose, and collecting direct data on the outcome of the experiment. An experiment could mean giving respondents cannabis and then assessing their sleep after.

Or if done via a survey, for the survey to be directly about the issue of cannabis and sleep, wherein all the relevant questions are asked to ascertain all necessary information. Even a systematic review into a certain topic is more likely to net more correct information since it evaluates multiple pieces of literature designed on the same topic. This study isn’t even like that, literally taking information from an unrelated place.

Of course, besides the information source being questionable in terms of how useful it is for this particular study, the results aren’t that enlightening. Without any description or further detail, we’ve learned very little. We don’t know enough about respondents in a group, we don’t know enough about how cannabis was used, we don’t know enough about overall health, and we don’t know enough about sleep issues and histories of respondents. All its saying is ‘cannabis can effect sleep’, which is a broad statement we already knew, and the reason that real research is being done directly into the topic.

Why does this happen?

24 hour news

We’ve had way more intricate and well-defined studies come out on cannabis and sleep, and even they have a hard time making big statements. These are large areas of study that don’t often have hard-fast answers that apply to everyone. In fact, one of the things to be picked up on by the study outcome, is that cannabis users fell into both extremes, and that says something. It says that one outcome cannot be expected, so all that other information…it becomes wildly important.

The problem is that we live in a world where people want hard-fast answers, even when they don’t exist. Couple that with a growing industry that has its own 24-hour news cycle, researchers who want to be published, and writers who want a story, and the end result is a maelstrom of recycled and useless information. For researchers, this is a quick and easy way of putting out a study without essentially having to do a study. A real study can take years of time, this kind of assessment can be done very quickly. The calculations can be made by a computer in minutes, maybe seconds.

And since the public desperately wants clarity in this unclear world, it latches onto what it can to get information, often without seeing the reasons for the information to be put out. Will the average person know to look at methodology to identify a good study from a bad one? Probably not. And they’re not supposed to. So, all they’re left with is headlines meant to pull them in different directions. A lot of headlines based on this study will say all kinds of things about cannabis and sleep. But the reality is that absolutely nothing new was learned, and nothing useful was put out there.

Conclusion

It says way more about research integrity and journalistic integrity that such a study would gain any prominence in news cycles. Is it a bad study? No. It doesn’t look like its meant to be a smear campaign, or misleading apart from the lack of useful information its based on. It looks like an easy, half-assed study that didn’t require any real work. It’s an unnecessary study that doesn’t add anything to our knowledge base. While it definitely means we should be careful in how we weigh research methodology and results in terms of accuracy and helpfulness, the growing muddle of information out there only points to increasing muddiness in the future. More of this should be expected.

Hello and welcome! Thanks for joining us at CBDtesters.co, the internet’s #1 location for all the most relevant and interesting cannabis and psychedelics-related news going on in the world currently. Stop by whenever you can to stay aware of the ever-changing universe of legal drugs and industrial hemp, and remember to sign up for The Delta 8 Weekly Newsletter, so you’re never late on getting a story.

DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

The post Recent Study Sheds No Real Light on Cannabis and Sleep appeared first on CBD Testers.

THCA, THCV, CBN, and Delta-8-THC – A Cannabinoid Crossword

Today, buying weed is like going to Starbucks; Do you have anything made with tropical punch and if not, can I get a one gram, sativa dominant hybrid distillate cartridge? Particularly one with some citrus terpenes and a one-to-one CBD ratio? Thanks to lab testing, today’s cannabis users can afford to be picky. We can […]

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A Guide to Rare Cannabinoids

You’re probably familiar with the two best known cannabinoids produced by the cannabis plant: THC and CBD. THC (tetrahydrocannabinol) is the active ingredient in marijuana, the one that gets you high. CBD (cannabidiol) is THC’s non-intoxicating cousin, legal across the United States and typically sought out for its stress-relieving or sedating properties. But did you know cannabis contains hundreds of other minor cannabinoids, many of which we’ve only just begun to study? Here’s a handy guide to a few of the best known rare and minor cannabinoids—and how one edibles company is harnessing them to enhance their customers’ lives.

What is a Cannabinoid Anyway?

All mammals have what’s called an endocannabinoid system (ECS), which is a complex network of transmitters and receptors that help regulate things like sleep, stress and pain management to keep your body in a state of balance.

Cannabinoids are molecules that activate the ECS’s receptors. Your body produces plenty of cannabinoids on its own (these are called endocannabinoids). Meanwhile, Cannabinoids like THC and CBD are produced by the cannabis plant and are known as phytocannabinoids. It’s also possible to synthesize cannabinoids in a lab, but for the purpose of this article, we’ll stick to those found in nature.

Just like your body’s naturally occurring endocannabinoids, plant-derived phytocannabinoids help send signals throughout your body—signals like, “Hey, we’re safe right now, you don’t have to feel so stressed,” or, “We should probably have a snack,” or, “Don’t you think it’s time to go to sleep?” In other words, they’re messengers that enhance your body’s natural regulatory processes.

What Kind of Rare Cannabinoids Are There?

The cannabis plant produces well over 100 known phytocannabinoids, and science has barely scratched the surface of what they can do. Let’s take a look at three of the best-known rare and minor cannabinoids, and the ones you’re most likely to encounter in commercial cannabis products.

  • CBN (Cannabinol): CBN is probably the third most famous cannabinoid after THC and CBD. That’s because it’s developed a reputation as an effective sleep aid. In point of fact, there’s really only one study that suggests CBN can make you drowsy–and it was conducted in 1975 with just five participants–so the jury is out on whether CBN truly deserves to be known as “the Sleepy Cannabinoid.” That said, some studies do suggest that CBN may have some anti-inflammatory and pain-relieving effects. So, if stiffness or soreness is keeping you up at night, CBN may indeed help you get to sleep – just not in the way most people think it does.
  • CBG (Cannabigerol): In its acidic form (CBGA), CBG is sometimes called “the Mother Cannabinoid” because it’s the first cannabinoid the plant creates, which is eventually converted to THC or CBD. For this reason, CBG is actually pretty rare, but its potential benefits make it worth keeping an eye out for. For one thing, CBG may have some anti-bacterial properties. Some scientists are even hopeful it could aid in cancer treatment! And in terms of everyday usefulness, there’s also evidence that CBG can help make consumers feel less anxious–another important quality in a stress reliever or sleep aid.
  • THCV (Tetrahydrocannabivarin): Even though it’s only one letter off from THC, this fascinating cannabinoid is, in many ways, the total opposite of its more famous counterpart. THCV does not get you high. Rather, it’s believed to sharpen focus. THCV doesn’t stimulate appetite in the way that THC is known to either. In fact, early studies suggest that THCV may actually curb appetite by disrupting the reward patterns in your brain, making you less likely to crave junk food and more able to make thoughtful, controlled choices about what you eat.

Where You Can Find These Cannabinoids

The more we understand about rare and minor cannabinoids, the more we can use them to improve our wellness and quality of life. Wana Brands, North America’s #1 manufacturer of THC and CBD-infused edibles, understands this and is an industry leader when it comes to harnessing cutting-edge cannabis technology.

Wana has recently launched a new first-of-its kind line of daily wellness solutions known as Wana Optimals. These vegan, organically sweetened gummies are infused with both rare and major cannabinoids, terpenes and other plant derived ingredients in order to target problem areas that keep people from living their best lives. In other words, they’re meant to achieve specific results like better sleep and an enhanced fitness routine.

So far, there are two Optimals products currently available in Wana’s home state of Colorado. The first, Fast Asleep Gummies, are powered by a custom sleep blend including CBD, CBN, CBG, a small amount of THC and melatonin, and more than 30 specialized terpenes. This carefully calculated formula doesn’t just induce drowsiness, knocking you out and leaving you groggy the next day. It targets the root causes of sleeplessness, like stress and physical discomfort. Fast Asleep Gummies are also powered by a fast-acting nano-technology that delivers effects in just 5 to 15 minutes.

The second Optimals product, daily Fit Gummies, are infused with THCV to help disrupt unhelpful eating habits and empower consumers to make healthier dietary choices. They’re not diet pills made with jitter-inducing chemicals, and they won’t get you high. They’re simply a plant-based tool to help you feel like the healthiest version of yourself.

Looking to the Future

More Wana Brands Optimals products are on the horizon, and you can sign up on their website to be notified when they launch. Are you ready to start exploring the brave new world of rare cannabinoids?

The post A Guide to Rare Cannabinoids appeared first on Cannabis Now.

New ReCreate Products Highlight Minor Cannabinoids

ReCreate is redefining the cannabis experience with their new product line, which features the addition of minor cannabinoids for a highly targeted, more effective experience. Founded in 2020, The brand is focused on unlocking the cannabis plant’s many wellness properties—a goal that remains clear with their newly reformulated products. With six main effects to choose from (Boost, Immunity, Relax, Relief, Sleep and Microdose), the new gummies and tinctures are intended to help consumers enhance their wellness goals while easily fitting into existing daily routines. 

While ReCreate products are designed for the health-conscious consumer, there’s no need to sacrifice flavor. Boost mind and body while having a little fun with their colorful and delicious gummies, available in flavors like Watermelon Lemonade, Strawberry Kiwi, and Tart Cherry. Cannabis wellness doesn’t have to be boring, and ReCreate is proving itself to be one of the most innovative brands on the market.

Minor (But Mighty) Cannabinoids:

All ReCreate products are formulated with their full-spectrum extract and fast-acting nanotechnology to provide one of the most efficacious products available in the market. Categorizing products by effect rather than strain helps those who are new to cannabis more easily understand how the products work, and which one is best suited to meet their needs. When utilized correctly, THC and CBD can play a big role in any wellness routine. These products are designed to help enhance any aspect of daily life, harmoniously blending your routine with the medicinal benefits of THC, CBD and adaptogenic botanicals.

Now, let’s look a closer look at the effects of these new products, and how each minor cannabinoid works to provide more targeted results. We’ll also touch on each product’s infused functional botanicals which have natural properties, intended to amplify and augment your ReCreate experience. 

  • THCv: This cannabinoid helps cut down on insulin resistance and regulate blood sugar levels making it perfect for those looking for an uplifting boost throughout the day.
  • CBG: Look no further than CBG for an immunity boost and powerful effect. Coined the “Mother of all Cannabinoids,” CBG is the original compound from which other cannabinoids were created. It is currently being evaluated in numerous studies to determine the full extent of its wellness benefits.
  • CBN: This cannabinoid touts powerful anti-inflammatory results, as well as sedative effects. CBN has been shown to help calm the mind and support sleep cycles within the body, making it a great addition in products designed for relaxation and sleep.

THE EFFECTS

BOOST Gummies

  • 1:1 with THCv: These Watermelon Lemonade Gummies are jam-packed with cannabinoids and beneficial botanicals specially formulated to help uplift your spirits. Recommended for those needing an extra lift in no time.
  • Botanical Booster: Yerba Mate. Popular across South America, Yerba Mate is a traditional drink well known for its energy-boosting properties and support in reducing fatigue.

IMMUNITY Tincture

  • 3:1 with CBG: Naturally flavored with mocha, the 3:1 oil Immunity tincture is packed with Echinacea and 30mg of CBG to help support your immune system.
  • Botanical Booster: Echinacea. Also known as coneflower, Echinacea is a flowering plant found in the daisy family. Native to North America, these plants have been widely used to support the immune system.

RELAX Gummies and Tincture

  • 2:1 with CBN: The 2:1 Relax oil tincture and Strawberry Kiwi Gummies are packed with 10MG of CBN and beneficial botanicals specially formulated to help support a sense of calm. Recommended for those searching for sweet, sweet relaxation. Ashwagandha and 10mg of CBN to help support your sense of calm.
  • Botanical Booster: Ashwagandha. This Ayurvedic herb that has been cultivated in India for generations. Classified as an adaptogen, it’s used to help support a sense of calm and manage everyday stresses.

RELIEF Gummies & Tincture

  • 2:1 with CBG. The Relief oil tincture and Tangerine Gummies are formulated to help your body recover from exercise-induced inflammation. Perfect for those who need that extra bit of recovery after an intense workout.
  • Botanical Booster: Cordyceps Mushrooms. Originally used by Tibetans, Cordyceps has powerful compounds that help protect and support joint health and mobility.

SLEEP Gummies & Tincture

  • 1:2 with CBN. Tart Cherry Gummies are jam-packed with cannabinoids and beneficial botanicals specially formulated to help support healthy sleep cycles. These Sleep Gummies are perfect for those who want to fall asleep easily while developing healthy sleep cycles.
  • Botanical Booster: Passionflower. Used across native populations worldwide, Passionflower is known for its calming and soothing effects. Research from the National Institute of Health shows that Passionflower may help adults who suffer from mild sleep irregularities.

MICRODOSE Gummies & Tincture

  • 6:1 with THCv: These Peach Dragonfruit Gummies are specially formulated to help provide daily support for your endocannabinoid system. By combining full-spectrum CBD with low levels of THC, these gummies are designed for microdosing and formulated to release the benefits of the entourage effect. These fast-acting gummies are formulated to help you find your daily balance and feature a variety of vitamins for additional support. Both the gummies and tincture are designed to be easy to microdose and incorporate into your daily wellness practice.
  • Heightened CBD: Increased levels of CBD for a balanced, well-rounded experience
  • Vitamin Blend: ReCreate’s proprietary superfood vitamin blend is made from whole foods like banana, papaya, oranges, and shitake mushrooms, and includes folate for maximum benefits.

Providing specific results that you can count on, there is no guesswork involved when it comes to ReCreate’s products. Reliability is important when it comes to integrating cannabis and wellness, and the brand prides itself on consistent results. By breaking down the focused advantages of individual cannabinoids, ReCreate was able to improve the reliability and effectiveness of their product. Not to mention, every product is non-GMO and ethically sourced.

The Brains Behind the Operation

Founded by the Stanley Brothers in an effort to incorporate cannabis seamlessly into the world of wellness, ReCreate has gained recognition for its innovative botanical blends. By combining the benefits of cannabinoids with adaptogens like Yerba Mate, Ashwagandha, Cordyceps and Passionflower, the brothers were able to create formulas that break free from traditional cannabis expectations.

As the world of cannabis continues to grow and expand, so does the demand for products that go above and beyond. Recognizing that THC and CBD are a powerful tool in treating a plethora of ailments, the Stanley Brothers created the well-known CBD brand, Charlotte’s Web, setting the stage for the brothers’ goals in the healthy and mindful segment of the cannabis industry.

Wellness, Meet Weed

Cannabis as a market has evolved greatly since we first saw California legalize medical marijuana in 1996. Since then, the work to destigmatize cannabis continues, and the plant is much more widely utilized for its recreational and medicinal properties. Historically, integrating marijuana into your daily routine was frowned upon. But the desire for a product that merges the worlds of wellness and cannabis is rapidly growing. By merging two booming industries, ReCreate is helping new and veteran cannabis users find a holistic alternative for enhancing body and mind.

The post New ReCreate Products Highlight Minor Cannabinoids appeared first on Cannabis Now.

Roger Adams and the Unexpected Discovery of CBD

The name Raphael Mechoulam has gained prominence in the last several years, as he is the man who first isolated delta-9 THC. Not as many people are familiar with the scientist Roger Adams, though he was just as important in the early research on cannabis. The story of Roger Adams and the unexpected discovery of CBD marks one of the biggest milestones in today’s cannabis research. Here’s how it happened.

Not everyone knows the name Roger Adams, or that he made the unexpected discovery of CBD. Just like not everyone knows what delta-8 THC is, or how it relates to marijuana. Both are very important. Roger Adams made some of the biggest discoveries related to identifying cannabinoids; and delta-8 THC represents what that research provided – an alternate form of THC which causes less psychoactive high, less anxiety, and less cloudy head. We support cannabis research, and all the great stuff that comes out of it. Check out our deals for delta-9 THCdelta-8 THC, and for a range of other minor cannabinoids like THCVTHCPdelta 10HHCTHC-O and more, to experience the outcome of decades of research!

Who is this Roger Adams?

Born in 1889, Roger Adams was an organic chemist from Boston, Massachusetts. Adams is from the same family as former presidents John Adams and John Quincy Adams, and is a direct descendent of John Adam’s grandfather. Adams attended Harvard University starting in 1903, and completed his undergraduate degree in three years. He went on to earn his PhD at Radcliffe College in 1912. He was such an outstanding student that he won the Parker Traveling Scholarship for 1912-1913, and used the money to work in laboratories in and around Berlin for that time period.

In 1913, Adams returned to the US, and began working as a research assistant, teaching organic chemistry at both Harvard and Radcliffe. He left the world of Harvard in 1916, upon accepting an assistant professor position at the University of Illinois, Urbana-Champaign. He remained at this university for 56 years. Adams spent the majority of this time as the department head for chemistry, taking the role from his predecessor William A. Noyes.

While working in this position, Adams accomplished several things. Together with students he created the Adam’s Catalyst, something used in hydrogenation reactions along with an apparatus for using this catalyst. He also elucidated the composition of complex vegetable oils and plant alkaloids. In the late 1930’s he began research into the cannabis plant and isolated the cannabinoids CBN and CBD, synthesized both, found delta-9 THC, and did a partial synthesis of that as well. He also synthesized analogues of these compounds. In this way, Roger Adams was the first guy to create a synthetic cannabinoid.

discovery of cannabinoids

Thomas Easterfield & Robert S. Cahn, the guys before Roger Adams

Before getting into Roger Adams, and his discovery of CBD, there’re two other guys who need to be mentioned, Thomas Easterfield and Robert S. Cahn. As science builds on itself over time, Easterfield’s and Cahn’s discoveries were what led into some of the bigger milestones in cannabis research. It all started with the desire to find what ended up being THC. In the search for the compound that caused intoxication, cannabis was first distilled into a ‘red oil’, which was the first form of it to be studied in modern times.

This red oil was discovered in the late 1800s by Doctor Thomas Hill Easterfield, a member of the Cambridge Group, who had been lecturing at Cambridge University at that time. In the late 1800s when he wrote about the red oil, he called ‘cannabinol’ a narcotic, which it was later clarified not to be by Cahn. At that time cannabinol was the main focus of the cannabis plant, first thought to be the intoxicating factor, but there was intense confusion around it.

Both the red oil, and the compound within, were given the name cannabinol. Though deeper questions were not answered at that time, cannabinol was the first cannabinoid to be isolated, and this was done by Easterfield.

All research was stopped, and Easterfield moved to New Zealand, following a couple incidents. One that involved the death of two collaborators in a lab accident, and one that involved the voluntary ingestion of a large dose of cannabinol by another collaborator, which led to the guy being out of his mind, and wondering around the lab as it caught fire around him. The fire was put out, and he returned to normal, but the news of these accidents was exaggerated and used in smear campaigns against cannabis, with claims that it was causing death and injury to researchers. This stymied research at the time, and it took about three decades for the next major breakthrough, brought by Robert Cahn.

In the 1930s, Doctor Robert S. Cahn began studying the structure and bioactivity of CBN. Cahn called the red oil ‘crude cannabinol’. He used the name ‘cannabinol’ specifically for the pure compound within the oil which he was able to show did not have intoxicating properties, ending the idea that CBN was the psychoactive constituent of the plant. Cahn was able to map the structure of CBN, using the relative position of specific atoms and groups of atoms within the compound, but there were still several questions that didn’t get ironed out until Roger Adams and Alexander Todd began studying the compounds later that decade.

Roger Adams and the unexpected discovery of CBD

The whole idea with the research previous to Adams, was to locate the intoxicating element of cannabis, which was first thought to be cannabinol. Roger Adams began his research into cannabis after the Marihuana Tax Act was passed in 1937, meaning he couldn’t legally study the plant anymore, and had to receive authorization to do so. Prior to getting into cannabis research, Adams had been studying biphenyls and their atropisomerism. What this means is less important for our purposes, than the understanding that cannabinol is a biphenyl derivative, meaning Adams was already well versed in compounds similar to cannabinol, and this made him a great choice to study it.

Hemp-derived Delta 9 THC

It was actually the Bureau of Narcotics of the US Treasury Department which requested Adams do the research into cannabinol, in an effort to locate and isolate the intoxicating element. Funny enough, it was the general misunderstanding about cannabis at the time, that led to the confused discovery of CBD.

You see, cannabis was not well understood, and instead of providing Adams with high-THC cannabis (marijuana), he was provided with high-CBD cannabis (hemp). Using hemp to study THC is much harder, as there is considerably less of it there. THCA is the precursor to CBN, and it only exists in small amounts in hemp, whereas CBDA is more prevalent, but is the precursor to CBD, not CBN. This made it very difficult for Adams to isolate the already-known-about CBN from the plant.

It was this attempt to isolate CBN from the red oil which led Adams to try different methods of isolation. He could not get a direct crystallization of CBN by acetylation (a specific kind of chemical reaction). He instead tried other reagents, eventually finding himself with a previously unidentified crystalline substance. This substance ended up being CBD. In order to isolate the CBN, Adams had to go through a process of purification from the crystalline CBD, which means Adams had to identify a new cannabinoid, in order to isolate the one already found.

What about Alexander Todd?

The story of the discovery of CBD, is twofold. Though Roger Adams is the one who gets credit, there was a parallel discovery around the same time, and that was made by British chemist Doctor Alexander Todd. The two scientists were rather competitive in the late 1930’s and early 1940’s, each publishing their discoveries as they came across them, and likely spurring each other on to work harder and do more.

There was even some contention between them as they both raced to find the same thing – THC, and though neither did find it, they did identify the other major component of the plant. In later years they actually became friends and formed a partnership, but I expect the competitive nature between them is what sped up the discoveries they made.

Anyway, Alexander Todd is more notorious for his winning of a Nobel prize for his work with nucleotides, but before this happened, he got into studying cannabis at the relatively young age of 32. He worked out of the University of Manchester with a very small research group, but was still able to isolate CBD from a sample of Indian hash. The hash had to be carefully gotten to him, as cannabis was illegal in Britain starting in 1928. When he published his paper in 1940, Todd was required to register at the Home Office for holding 2.5kg of hash.

Indian Hash

Part of what was interesting about the rivalry between Todd and Adams, is that they both made great discoveries, but were a generation apart in age and training, and used different means to make their discoveries. Todd identified CBD in an entirely different way, which was more in line with the principals of Cahn. Todd found he could take all the CBN out of the red oil using a type of chloride, and that in so doing, he could isolate a different cannabinoid – CBD.

In terms of who was technically first to make the discovery of CBD, it’s hard to say. In terms of published work, Todd had his first discoveries published in the journal Nature on March 2nd, 1940, but without any detail. Later that month, he published a full, detailed, version in the Journal of Chemical Society. On the other hand, Adams submit his first notes about CBD to the Journal of America Chemical Society in 1939, technically giving him the win, though the discoveries were essentially made in tandem.

These two scientists exemplify the often meandering line it takes to get from point A to point B in scientific research. And though neither reached the goal of finding the intoxicating agent, in attempting to do it, they both became pioneers in the world of cannabis research. Together, yet separately, they discovered one of the main aspects of the cannabis plant.

Conclusion

It’s quite possible that Roger Adams and the unexpected discovery of CBD was very much helped along by his rivalry with Alexander Todd. Either way, neither scientist reached the goal of isolating THC, though Roger Adams was able to identify it. It took another 25 years until Raphael Mechoulam finally did the job in 1964.

In a way, CBD was found completely accidentally. Though it would likely have been discovered at some point, it wasn’t even conceived of at the time it came to light. Roger Adams and Alexander Todd were trailblazers when it came to cannabis research, paving the way for Mechoulam, and the industry as we know it today.

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DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

The post Roger Adams and the Unexpected Discovery of CBD appeared first on CBD Testers.

The New Entourage Vape Cartridges: Delta 8, THC-O and HHC Carts

Have you tried the new entourage products? Several companies have recently introduced what they call “Entourage Vape Cartridges”, a combination of three new psychoactive cannabinoids: Delta 8 THC, THC-O and HHC with some CBN, CBD & CBG for the final touch.

Simply put, entourage vape cartridges are new blends, that combine different cannabinoids, in-order to reach the most-wanted ‘Entourage Effect‘ (AFA the ‘Family Effect‘ – the way different cannabinoids, terpenes, and flavonoids work together to offer health benefits you can usually only get when consuming the entire plant in its natural state). This is why the best hemp products are usually either full spectrum or broad spectrum and not made from isolate. However, it is much more complicated when you are trying to create hemp-derived psychoactive entourage vape cartridges, as some of the compounds are not naturally occouring, or exist in only small amounts.

That’s why, until recently using psychoacative entourage vape cartridges felt somewhat ‘hollow’, as there were just not enough cannabinoids to create the full-image needed for a deeper experience. All that changed when the new cannabinoids such as Delta 8, THC-O, THCV, THCP and even HHC entered the game. Now, for the first time ever, you can create sophisticated blends that that gives you a much more rewarding experience.

Have You Tried The New HHC Carts?

While these new products are psychoactive, some even very potent, they are sold online, as unlike regular Delta 9 THC, they are hemp-derived and not coming from cannabis. This loophole provides hemp-suppliers a legal way to sell psychoactive products, such as Delta 8 THC, THC-O, HHC, Delta-10, THCP, THCV and starting this month, allowed them to create ‘entourage vape cartridges’ – advanced products with tailor-made blends that effectively takes you to the next level.

A word of caution before looking into the new entourage vape cartridges: these are high-potency carts, so start low and grow slow, as you are among the very first to ever try them and the right dosage haven’t been calculated yet. Always make sure you buy from a company you trust and be patient as some cannabinoids need more time to kick in. Last but not least you should keep in mind that blended products might affect people differently, so be open for an experience, as everything is possible with new blended products.

As always, the subscribers of the Delta 8 Weekly are the first to put their hands on new cannabinoid-based products. Subscribe today, get our 25% discount code and learn more about the exciting entourage vape cartridges, as well as on other new products.

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Best Entourage Vape Cartridges:

Sativa / Indica / Hybrid Entourage Cartridge – 1 Gram

Sativa entourage vape cartridges

Leave it to the creative minds of Utoya to come out with this great product: a THC-O based sativa vape cartridge, blemded with CBG, CBN, Delta 8, CBD and HHC (in that order, see image above). This ‘sky-high sativa’ is the most popular of all three, providing a strong euphoria coming from a very fulfilling smoking experience. If you are looking for a sativa vape cart, this is the product for you!

You might want to know that the sativa entourage vape cartridges, as well as the indica and the hybrid carts, are made with live resin terpenes, which results in a more quality product with better flavor. The vapes taste exactly like the flowers they are name of, simple as that. In addition, there are no cutting agents in the preparation of the products, which meands no PG / VG / MCT or Vitamin E will be inside your carts. 

Choose between Maui Wowie, Blueberry Diesel, Jack and Fire OG

TIP: Use the cbdflowers coupon code for an additional 20% discount.

Click HERE to get the sativa entourage vape cartridges

Hybrid entourage vape cartridges
Hybrid entourage vape cartridges

Another great product is the hybrid entourage cart, featuring three psychoactive cannabinoids: HHC, Delta 8 THC and THC-O, with some CBN, CBD and CBG to flavor things up. This well balanced product is perfect for people who like to see how does it feel to vape a product high in both THC-O, HHC and D8. If you are looking to try a new hybrid psychoactive product, this is the one you should try.

Choose between OG Kush, Sunset Gelato, L’Orange and Mimosa.

Don’t forget to use cbdflowers coupon code for an additional 20% discount.

Click HERE to get the hybrid entourage vape cartridges

 Indica carts
Indica entourage vape cartridges

No product line is complete without a good Indica product. These indica entourage vape cartridges are using are based on HHC, Delta 8 and CBN, with a small amount of CBD, THC-O and CBG (in that order, see image above). If you are looking to buy a strong indica cartridge, this your best choice, as it allows you to experience the combined effects of HHC, Delta 8 and CBN. You must try it to see how effective they are when working together.

Choose between: Deathstar, GG#4, Pineapple Diesel and Biscoti.

Use the cbdflowers coupon code for an additional 20% discount.

Click HERE to get the indica entourage vape cartridges


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Click HERE to register a wholesale account


More Must-Have Deals

HHC Vape Cartridges – Special Bundle

HHC Vape Cartridges - Special Bundle
HHC Vape Cartridges – Special Bundle

Want to save big on HHC vape cartridges? Get 25% discount on the 4 pack and the 8 pack bundles using our special delta25 coupon code!

Both bundles include the following HHC carts: Sunset Sherbert (Indica), Hawaiian Sunrise (Sativa), Cali Gold (Hybrid) and Lucid Blue (Sativa). Choose the 8-pack to get the biggest discount!

Each HHC vape cartridge contains 94% HHC distillate and 6% cannabis based terpenes, resulting in a intense mental and physical buzz.

TIP: Choose the 8-pack and get an additional 25% discount using the Delta25 coupon code. That’s only $22.5/cart, a great price for these new HHC vape cartridges!

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(With ‘Delta25’ coupon code)

VIBIN’ Delta-10 THC Tincture

Because you deserve a long-lasting euphoria…

NEW: Delta-10 THC Tincture
NEW: Delta-10 THC Tincture

Want to try something new? The Delta 10 VIBIN’ Tincture is everything you ever hoped for and even more!

With 300mg Delta 10 and 700mg Delta 8 in every bottle, this best-selling product will let you experience the unique benefits of Delta 10 THC, softly blended with Delta 8, which we all know to love. If you are looking for a ‘mental euphoria‘ and wish to feel ‘happy and motivated‘ this product might be the one for you!

Size: 30ml

Strength: 1000mg/Bottle: 700mg of Delta 8 THC + 300mg Delta 10 THC

Terpenes Used: Sour diesel, Blueberry OG

Current deal: Get it for as-low-as $25/bottle, when buying the 3-pack bundle and using the Delta25 coupon for an additional 25% discount.

Click HERE to buy Delta-10 THC Tinctures

(With DELTA25 coupon code)

Want to sell entourage vape cartridges in your shop?
Click HERE to register a wholesale account


THC-O Vape Cartridges – Special Bundle

Want to save big on THC-O vape cartridges? Get 25% discount on the 4 pack and the 8 pack using our special delta25 coupon code!

Both bundles include the following strains: Maui Wowie (Sativa), Do Si Dos (Indica), Blue Zkittlez (Indica) & White Runtz (Hybrid). Choose the 8-pack to get the bigger discount!

Each THC-O vape cartridge contains 92% Premium THC-O Distillate, 5% Terpenes and 3% Natural Plant Lipids.

TIP: Choose the 8-pack and get an additional 25% discount using the Delta25 coupon code. That’s only $22.5/cart, the lowest price anywhere for THC-O vape cartridges!

Click HERE to save big on THC-O carts

(With ‘Delta25’ coupon code)

Best Delta 8 Deals, Coupons & Discounts

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Affiliate disclaimer: We work hard to find and verify the best products, so we may include affiliate links to support the maintenance and development of this site.

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The post The New Entourage Vape Cartridges: Delta 8, THC-O and HHC Carts appeared first on CBD Testers.

Artificial High – The History of Cannabis Synthetics

The idea that cannabis exists as a pharmaceutical product, is still strange to people like me who grew up with the plant as the only form of ingestion. Whereas some medications have no natural counterpart, like Tylenol (acetaminophen) or Benadryl (diphenhydramine), some do, like anything based off cannabis. And we know the plant itself works fine, but that hasn’t stopped an immense amount of research into synthetic cannabis, and the production of synthetic cannabis products. Here we’ll take a look at the history of cannabis synthetics, and what can be expected in the future.

The history of cannabis synthetics is important because it’s a large part of today’s current market, including products like delta-8 THC. Though delta-8 is naturally occurring, it does require human synthetization help to provide large quantities, which means the dealt-8 we use in products, is all synthetic. We’re into quality cannabis products, whether naturally occurring or synthetic, and have a nice selection of delta-8 THC, delta 10 THCTHCVTHC-OHHC, THCP and even legal hemp-derived Delta-9 THC products. Subscribe to the Delta 8 Weekly and check ’em out!

What is a synthetic?

First things first, when talking about the history of cannabis synthetics, or simply what the synthetic version of something is, it’s best to know what we’re talking about. According Dictionary.com, the definition of ‘synthetic’ encompasses several principals. Under adjective, the definitions that relate to cannabis are:

  • Of, pertaining to, proceeding by, or involving synthesis (opposed to analytic).
  • Noting or pertaining to compounds formed through a chemical process by human agency, as opposed to those of natural origin: synthetic vitamins; synthetic fiber.
  • Not real or genuine; artificial; feigned: a synthetic chuckle at a poor joke.

Under noun, the following relates to cannabis:

  • Something made by a synthetic, or chemical, process.
  • Substances or products made by chemical synthesis, as plastics or artificial fibers.
  • The science or industry concerned with such products.

A synthetic is something that was created, rather than occurring naturally, although this not does negate that a naturally-occurring compound can also come as a synthetic. A synthetic is something that is not real or genuine, but is instead artificial. Synthetics are made through a process, and studying synthetics, means studying the process of making artificial products. Thus, synthetic cannabis compounds, are compounds that do not exist in nature on their own (or which do, but still require synthetization help outside of nature for products), and are manufactured by human production. This can relate to much more than just cannabis. For example, a lot of clothing uses synthetic plastic fibers rather than natural ones like cotton or hemp.

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Main points of cannabis research

When talking about the history of cannabis research in general, two of the occurrences that stand out the most are related to the isolation of certain compounds: the two main compounds of the cannabis plant. By isolating a compound, researchers can understand what it is, how it’s made, and are then able to synthesize it, and modify it. The two most spoken about findings in cannabis history are these:

1940 – The funny thing about the solation of CBD, is that it gets way less attention than the isolation of delta-9 THC, even as the current CBD industry booms. In fact, the name Doctor Roger Adams is way less known than Raphael Mechoulam, the guy up next. However, back in 1940, Roger Adams and his team at the University of Illinois, were the first to isolate CBD. In 1940, the team published their findings here: Structure of Cannabidiol, a Product Isolated from the Marihuana Extract of Minnesota Wild Hemp. It should be noted, that while Adams was not the first one to synthesize delta-9 completely, he was the first one to identify it, and he did do a partial synthesis.

1964 – Doctor Raphael Mechoulam, an Israeli researcher from the Hebrew University of Jerusalem, isolated delta-9 THC for the first time in 1964. Mechoulam and team published their findings here: Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish. Since this time, Mechoulam has been a leader in the industry, actively taking part in research, and even discovering this synthetic cannabinoid in 2020, called HB 580, or cannabidiolic acid methyl ester. And this at the ripe old age of 90. Mechoulam is still the president of The Multidisciplinary Center for Cannabinoid Research at the Hebrew University of Jerusalem.

Tons of other research has been done into different compounds within the cannabis plant, its history of use, and how it can be used today. But somehow, the isolation of these two main cannabinoids stands out as beacons in the history of cannabis research. And it’s through the finding of these compounds, that the history of cannabis synthetics began.

History of cannabis synthetics

If you’ll notice from the publication put out by Mechoulam and team in 1964, in the title it directly states that not only did they identify delta-9 THC, but they did a partial synthesis of the compound. What does this mean if delta-9 does appear in nature? It means, the researchers were able to isolate and map the compound, and that they then attempted to re-create it themselves, without help from nature. The ‘isolation’ is the part where the single molecule can be taken and studied, its chemical formula identified, and its chemical structure mapped. The ‘synthesis’ part is when the same molecule is created through human production. This might make it seem like the history of cannabis synthetics started here, but once again, it was really the other guy.

The thing about Roger Adams, is that he didn’t just isolate CBD, he isolated CBN (cannabinol), identified delta-9 THC as well, and was able to show the relationship between CBD, CBN and delta-9, as the three are isomers to each other. Not only that, he was able to synthesize analogues of CBN and delta-9, meaning he was able to create artificial versions of these cannabinoid analogues. He wasn’t, however, the only one doing this at that time!

cannabinoids

Enter Doctor Alexander Todd, the British researcher who was neck and neck with Roger Adams, and who received a Nobel prize for his work with nucleotides. In 1940, while at the University of Manchester, at the age of only 32, and working with a very small research group, Todd was able to isolate CBD from a sample of hashish from India. He published his findings in the journal Nature in 1940. Adams submitted his first notes on CBD in 1939 to the Journal of America Chemical Society, making him technically first over Todd. Todd’s version was without detail originally, with a full detailed version published in March of 1940 in the Journal of Chemical Society

Adams’ early synthetization of cannabinoids can be seen in his published research, which additionally shows a partial synthesis of delta-9 THC. Both Adams and Todd showed the isolation of CBN, which was fully mapped before CBD. Adams takes the win for first providing the structure of CBD, though Todd was right there with him. In fact, the two scientists spent a few years dueling in the scientific press, each publishing their findings as they came to them, in direct competition with each other. Later on, the two scientists became good friends and even worked together. It should be pointed out that the goal of both scientists had been to find the intoxicating agent of cannabis (delta-9), which neither ever established for sure.

During this time, delta-9 THC was not synthesized fully, though it was identified. But other compounds were synthesized, like CBN, CBD, and analogues of these cannabinoids and delta-9. CBN seems to be the very first cannabinoid that was synthesized in the quest to find delta-9, which CBN was assumed to be very closely related to. This makes CBN and CBD the first examples of synthetic cannabinoids, even though they do appear in nature. This reinforces the idea that a naturally occurring compound, can also be produced in synthetic form.

Cannabis synthetics today

We could have a whole debate about why cannabis was illegalized, and the part that pharmaceutical companies played in it, as a way to minimize use of a plant that couldn’t be patented. And while we could go back and forth on that one, the results of it can be seen clearly in today’s world. For example, while the US government likes to talk about how bad synthetics are, it also approved synthetic cannabinoid medications like Dronabinol, Epidiolex, and Sativex, and this in place of allowing the actual plant which has been used for thousands of years. This means, the only cannabis medications approved in the US, are synthetics.

In a great example of how far a government will go to protect pharmaceutical interests, France literally went to court with the EU over the ability to block sales and imports of naturally-occurring CBD. Of course, what the majority of reporters missed in the story, was that while France went on and on about the dangers of CBD (which it failed to back up in court), it was allowing GW Pharmaceuticals’ Epidiolex, a synthetic version of CBD, to be sold. Kind of seems like France wasn’t actually all that against CBD, huh?

At this point, there are about a million synthetic cannabinoids out. From non-naturally occurring like THC-O-Acetate, delta-10 THC, and canabidiolic acid methyl ester, to naturally occurring, like delta-8 THC, Dronabinol (THC), and Epidiolex (cannabidiol). And then, of course, there are the compounds that are generally thought of as synthetic, like Spice and K2, although these are no more or less synthetic than the pharmaceutical versions being sold to patients, and were discovered through the same lines of research. In fact, the compound that led to spice and K2, was none other than HHC, which was created in a lab in a search to find a simplified, yet working, THC compound. THC-O-Acetate was also an early street synthetic, possibly put out by the military, as the military was doing testing on this compound, and it seems to have shown up in public around that time.

legal cannabis synthetics

Some of the first non-naturally occurring cannabinoids to be synthesized were non-naturally occurring delta THCs like delta-7 THC and delta-10 THC, synthesized around the time that Adams first identified delta-9. The very first cannabis medicine to be approved in the US, was Dronabinol, under the name of Marinol, which gained FDA approval in 1985. Marinol, of course, is synthetic, meaning the very first cannabis medicine allowed in current day America, is synthetic. Clearly the US is A-okay with synthetics.

What can be expected in the future should be obvious. Use of the plant will likely not be stopped, but increasing pressure will probably be put on consumers to buy pharmaceutical products. The demonization and smear campaigns for cannabis will in all probability continue since they incite fear, and can be used to push the pharmaceutical ‘better answer’. And though this ‘better answer’ might prove to be true for people fighting ailments like cancer, for many people, nothing more than the plant would ever be necessary.

Conclusion

It might not be very well known, but the history of cannabis synthetics started at around the same time as the first major breakthrough in cannabis research. Adams and Todd led the charge in the early 40’s, identifying isolating, and synthesizing CBD and CBN, making them the first isolated cannabinoids, and the first examples of synthetic cannabis compounds.

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DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

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