The New Entourage Vape Cartridges: Delta 8, THC-O and HHC Carts

Have you tried the new entourage products? Several companies have recently introduced what they call “Entourage Vape Cartridges”, a combination of three new psychoactive cannabinoids: Delta 8 THC, THC-O and HHC with some CBN, CBD & CBG for the final touch.

Simply put, entourage vape cartridges are new blends, that combine different cannabinoids, in-order to reach the most-wanted ‘Entourage Effect‘ (AFA the ‘Family Effect‘ – the way different cannabinoids, terpenes, and flavonoids work together to offer health benefits you can usually only get when consuming the entire plant in its natural state). This is why the best hemp products are usually either full spectrum or broad spectrum and not made from isolate. However, it is much more complicated when you are trying to create hemp-derived psychoactive entourage vape cartridges, as some of the compounds are not naturally occouring, or exist in only small amounts.

That’s why, until recently using psychoacative entourage vape cartridges felt somewhat ‘hollow’, as there were just not enough cannabinoids to create the full-image needed for a deeper experience. All that changed when the new cannabinoids such as Delta 8, THC-O, THCV, THCP and even HHC entered the game. Now, for the first time ever, you can create sophisticated blends that that gives you a much more rewarding experience.

Have You Tried The New HHC Carts?

While these new products are psychoactive, some even very potent, they are sold online, as unlike regular Delta 9 THC, they are hemp-derived and not coming from cannabis. This loophole provides hemp-suppliers a legal way to sell psychoactive products, such as Delta 8 THC, THC-O, HHC, Delta-10, THCP, THCV and starting this month, allowed them to create ‘entourage vape cartridges’ – advanced products with tailor-made blends that effectively takes you to the next level.

A word of caution before looking into the new entourage vape cartridges: these are high-potency carts, so start low and grow slow, as you are among the very first to ever try them and the right dosage haven’t been calculated yet. Always make sure you buy from a company you trust and be patient as some cannabinoids need more time to kick in. Last but not least you should keep in mind that blended products might affect people differently, so be open for an experience, as everything is possible with new blended products.

As always, the subscribers of the Delta 8 Weekly are the first to put their hands on new cannabinoid-based products. Subscribe today, get our 25% discount code and learn more about the exciting entourage vape cartridges, as well as on other new products.

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Best Entourage Vape Cartridges:

Sativa / Indica / Hybrid Entourage Cartridge – 1 Gram

Sativa entourage vape cartridges

Leave it to the creative minds of Utoya to come out with this great product: a THC-O based sativa vape cartridge, blemded with CBG, CBN, Delta 8, CBD and HHC (in that order, see image above). This ‘sky-high sativa’ is the most popular of all three, providing a strong euphoria coming from a very fulfilling smoking experience. If you are looking for a sativa vape cart, this is the product for you!

You might want to know that the sativa entourage vape cartridges, as well as the indica and the hybrid carts, are made with live resin terpenes, which results in a more quality product with better flavor. The vapes taste exactly like the flowers they are name of, simple as that. In addition, there are no cutting agents in the preparation of the products, which meands no PG / VG / MCT or Vitamin E will be inside your carts. 

Choose between Maui Wowie, Blueberry Diesel, Jack and Fire OG

TIP: Use the cbdflowers coupon code for an additional 20% discount.

Click HERE to get the sativa entourage vape cartridges

Hybrid entourage vape cartridges
Hybrid entourage vape cartridges

Another great product is the hybrid entourage cart, featuring three psychoactive cannabinoids: HHC, Delta 8 THC and THC-O, with some CBN, CBD and CBG to flavor things up. This well balanced product is perfect for people who like to see how does it feel to vape a product high in both THC-O, HHC and D8. If you are looking to try a new hybrid psychoactive product, this is the one you should try.

Choose between OG Kush, Sunset Gelato, L’Orange and Mimosa.

Don’t forget to use cbdflowers coupon code for an additional 20% discount.

Click HERE to get the hybrid entourage vape cartridges

 Indica carts
Indica entourage vape cartridges

No product line is complete without a good Indica product. These indica entourage vape cartridges are using are based on HHC, Delta 8 and CBN, with a small amount of CBD, THC-O and CBG (in that order, see image above). If you are looking to buy a strong indica cartridge, this your best choice, as it allows you to experience the combined effects of HHC, Delta 8 and CBN. You must try it to see how effective they are when working together.

Choose between: Deathstar, GG#4, Pineapple Diesel and Biscoti.

Use the cbdflowers coupon code for an additional 20% discount.

Click HERE to get the indica entourage vape cartridges


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More Must-Have Deals

HHC Vape Cartridges – Special Bundle

HHC Vape Cartridges - Special Bundle
HHC Vape Cartridges – Special Bundle

Want to save big on HHC vape cartridges? Get 25% discount on the 4 pack and the 8 pack bundles using our special delta25 coupon code!

Both bundles include the following HHC carts: Sunset Sherbert (Indica), Hawaiian Sunrise (Sativa), Cali Gold (Hybrid) and Lucid Blue (Sativa). Choose the 8-pack to get the biggest discount!

Each HHC vape cartridge contains 94% HHC distillate and 6% cannabis based terpenes, resulting in a intense mental and physical buzz.

TIP: Choose the 8-pack and get an additional 25% discount using the Delta25 coupon code. That’s only $22.5/cart, a great price for these new HHC vape cartridges!

Click HERE to save big on HHC carts

(With ‘Delta25’ coupon code)

VIBIN’ Delta-10 THC Tincture

Because you deserve a long-lasting euphoria…

NEW: Delta-10 THC Tincture
NEW: Delta-10 THC Tincture

Want to try something new? The Delta 10 VIBIN’ Tincture is everything you ever hoped for and even more!

With 300mg Delta 10 and 700mg Delta 8 in every bottle, this best-selling product will let you experience the unique benefits of Delta 10 THC, softly blended with Delta 8, which we all know to love. If you are looking for a ‘mental euphoria‘ and wish to feel ‘happy and motivated‘ this product might be the one for you!

Size: 30ml

Strength: 1000mg/Bottle: 700mg of Delta 8 THC + 300mg Delta 10 THC

Terpenes Used: Sour diesel, Blueberry OG

Current deal: Get it for as-low-as $25/bottle, when buying the 3-pack bundle and using the Delta25 coupon for an additional 25% discount.

Click HERE to buy Delta-10 THC Tinctures

(With DELTA25 coupon code)

Want to sell entourage vape cartridges in your shop?
Click HERE to register a wholesale account


THC-O Vape Cartridges – Special Bundle

Want to save big on THC-O vape cartridges? Get 25% discount on the 4 pack and the 8 pack using our special delta25 coupon code!

Both bundles include the following strains: Maui Wowie (Sativa), Do Si Dos (Indica), Blue Zkittlez (Indica) & White Runtz (Hybrid). Choose the 8-pack to get the bigger discount!

Each THC-O vape cartridge contains 92% Premium THC-O Distillate, 5% Terpenes and 3% Natural Plant Lipids.

TIP: Choose the 8-pack and get an additional 25% discount using the Delta25 coupon code. That’s only $22.5/cart, the lowest price anywhere for THC-O vape cartridges!

Click HERE to save big on THC-O carts

(With ‘Delta25’ coupon code)

Best Delta 8 Deals, Coupons & Discounts

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Affiliate disclaimer: We work hard to find and verify the best products, so we may include affiliate links to support the maintenance and development of this site.

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The post The New Entourage Vape Cartridges: Delta 8, THC-O and HHC Carts appeared first on CBD Testers.

Zion Herbals: Pushing the Limits of CBD

Zion Herbals is carrying their motto, “strictly the best,” into all they do. 

Founded in 2010, the Richmond, Virginia-based botanicals and extracts brand offers a wide range of hemp products, all designed to give users clean, effective and consistent results for an improved sense of well-being. 

In order to maintain control over the entire manufacturing process and ensure the highest quality from seed-to-sale, Zion Herbals sources hemp from their Oregon and Virginia hemp farms. Both farms are located on land that has been untouched for over 100 years, and are completely free of chemicals, pesticides and processed fertilizers. Only bat guano and fish emulsion are used for fertilization. Although they don’t have the USDA certification, all farming is organic and follows a a Rastafarian level of purity known as “Ital.” 

Zion Herbals is the flagship brand of parent company BotanaWay, which offers white label manufacturing and branding services for approximately 40 brands and provides hemp cannabinoid extracts for more than 200 brands. For BotanaWay founder and CEO, David Reynolds Derian, Zion Herbals is an outlet where he can showcase the company’s high-quality extractions via in-house formulations in a variety of delivery methods—from tinctures and pressed tablets to pre-rolls and liquid gels.

“We always offer a higher level of purity and lab-verified cleanliness with less residual solvents then can be found anywhere in the industry,” he said. “Strictly the best is our motto, and that is what we’re known for.”

Pushing the Limits of Extraction

Zion Herbals pushes extraction methods to over 99% pure, meaning a complete isolation of the cannabinoids. Their Delta-8 THC is at 95% purity, compared to most competitors on the market, which rank in the high 80s.  Once purity reaches the high nineties, the oil becomes crystal clear, like water. 

“You can visibly see its cleanliness,” Derian said.

The company’s proprietary extraction process uses multiple extraction methods in order to reach this high level of purity with the end-result being a completely solvent-free extract. 

“The final steps to get to the higher stages are super expensive and difficult,” Derian said, explaining that a greater level of knowledge and understanding around safety is required, as well as additional lab equipment. 

A higher level of purity doesn’t necessarily make for a stronger product. However, when cannabinoids are surrounded by fewer impurities, they can bind to the body’s receptors more effectively. This translates to a cleaner, healthier, and more well-rounded experience. 

“Steps of pushing it to the extreme are costly, but these are things we don’t avoid,” Derian said. “I believe we are a couple steps ahead. By the time others get to where we are, we are going to be on another plateau.”

Refined Delivery 

Zion Herbals intentionally stays away from more recreationally inspired consumption methods, such as gummy bear edibles and vaping. Rather, the company aims to create mature delivery methods, like pressed CBD tablets. 

“We’re trying to forge and develop new paths as a dietary supplement manufacturer,” Derian said. “I think CBD tablets, much like a pressed aspirin, is the future.” 

According to Derian, since these kinds of products are more normalized in society, they also appeal to a broader range of consumers seeking the benefits of hemp.

Delta-8 THC 

All Zion Herbals products are health-oriented, including their Delta-8 THC. Derian was initially on the fence about adding Delta-8 THC to the product line, but after a loyal customer shared how the cannabinoid had helped him manage pain without anxiety, Derian decided it supported the Zion Herbals mission. 

“My mission is to provide natural alternatives to pharmaceuticals,” he said. 

Packaged in pharmaceutical-style bottles, the Delta-8 liquid gels are intended for medicinal uses rather than a way for people to get high. The effects are fast-acting and immensely stronger than CBD.  

Five Fan Favorites

Zion Herbals offers a plethora of products to choose from online. A few favorites are the best-selling CBD Soft Chews, Pressed CBD Tablets, Hemp Flower Jars, Delta-8 THC Liquid Gels, and their line of Element C CBD Sparkling Juices. Pushing the limits and staying ahead of the curve is what Zion Herbals is all about. Each of these products exemplifies their mission to improve and perfect delivery systems and flavors as they take CBD products to a new level. 

1) Citrus Mango CBD Soft Chews

Through a partnership with The Apple Rush Company, a leader in the natural beverage industry, Zion Herbals utilizes their access to large-scale food preparation equipment to make these unique CBD Soft Chews, featuring all organic ingredients. Reminiscent of a starburst, each delicious chew has a sweet Citrus Mango flavor and is formulated to offer a relaxing and well-balanced sense of calm. It’s like a little treat and completely masks the bitter taste of CBD. Individually wrapped, each CBD chew contains 30mg of hemp extract and can be taken as needed. This is a great consumption option if you need CBD but haven’t had much to eat, as the organic sugars act as a carrier and help your body absorb the product. 

2) Pressed CBD Tablets 
Zion Herbals Hemp Extract CBD Tablets

Available in jars of ten, these pressed CBD tablets contain 75mg of CBD each. If you are seeking relief for a specific health issue, whether it’s severe pain or epilepsy, these tablets are an easy way to incorporate high levels of CBD into your diet daily. The precise dosing means you can count on every tablet being exactly 75mg. While there are a few other pressed CBD tablets on the market, you’re unlikely to find any with this high of a dosage. 

3) Premium CBD, CBG and Delta-8 Infused Hemp Flower Jars
Zion Herbals Sour Space Candy Hemp Flower

Zion Herbals’ whole hemp flower is available in CBD, CBG and CBD/Delta-8 THC strains. All of these flower offerings give people a way to enjoy the benefits of CBD in a more social and spiritual way. 

Sour Space Candy, Cherry Cirtus, and T1 are CBD-only varietals. The Bubba Kush and Honolulu Haze strains combine both CBD and Delta-8 THC for an immediate calming effect. Whole hemp flower is also available in two CBG strains: White Lion and White Whale. A natural sedative, CBG is a perfect way to wind down before bedtime. White Whale is grown in Oregon and is very frosty with a lot of cannabinoids on the flower, helping clean out your lungs. White Lion is grown on Zion Herbals’ Virginia hemp farm and has an earthier flavor profile. 

This year, Zion Herbals is also growing Goliath, Abacus 2.0, and Peach Mint Kush on their Oregon hemp farm and will be adding these strains to their lineup in the fall. 

4) Delta 8-THC, 20-mg Liquid Gels
Zion Herbals Delta 8 Liquid Gels

The Delta-8 soft gel is an excellent way to ensure you are taking precisely 20mg at a time. To get standardized exact dosing requires precision—something Zion Herbals can claim, thanks to their experience manufacturing for brands on a large-scale. One capsule is a sufficient serving size and is very effective. You can expect to receive the maximum benefits that Delta 8-THC has to offer through an advanced delivery method that is easy to take with you on-the-go. And last but not least, MCT oil (commonly known as coconut oil) is used for the carrier, making these liquid gels a natural, healthy option.

5) CBD Sparkling Juices
Zion Herbals Element C CBD Sparkling Juice

Zion Herbals teamed up with the beverage company Apple Rush to create their Element C CBD Sparkling Juice line and reach a wider audience by tapping into their impressive distribution network. Available in Black Cherry, Blueberry, and Plain, these sparkling juices contain 25mg of water-soluble CBD. The plain flavor is like a sparkling water while the black cherry and blueberry flavors are similar to Fanta.

With no added sugars and all organic ingredients from real juices, these sparkling juices are a fun and delicious way to ingest CBD. Zion Herbals’ proprietary emulsification process makes for high bioavailability, meaning you will feel the effects faster and stronger too.

Quality Assurance

All of Zion Herbals’ products are third-party lab-tested (typically by Columbia Food Laboratories) in order to give consumers complete peace of mind. Current QR codes are listed on each and every product, taking you directly to the most recent lab results for total transparency. 

The post Zion Herbals: Pushing the Limits of CBD appeared first on Cannabis Now.

Minor cannabinoids: What are they and why are they trending?

Minor cannabinoids have been getting a lot of attention lately, and for good reason. What exactly are minor cannabinoids and why have they been trending? What are minor cannabinoids? When it comes to cannabis, THC and CBD often take the spotlight. But they’re just two of at least 110 different cannabinoids found in the cannabis […]

The post Minor cannabinoids: What are they and why are they trending? appeared first on Latest Cannabis News Today – Headlines, Videos & Stocks.

Meet THC-free: The Latest Innovation from Dosist

Transparency, quality, innovation and trust are four of the most important cornerstones of building brand loyalty. And in the realm of cannabis, this sentiment is paramount. Companies that provide education and innovation with their product portfolios are the brands that see repeat customers and hold on to coveted positions at the top of the game. 

Dosist is one such company. Founded in 2016, the modern wellness company is globally recognized for their dose-controlled cannabis therapy, used to help people manage their health and happiness. According to Gunner Winston, CEO of dosist, the company’s fundamental premise is improving people’s lives. The team works hard to destigmatize the negative stereotypes around cannabis and cannabis consumers, breaking down decades of the ‘reefer madness’ reinforcement around cannabis prohibition.

“Cannabis is such a wonderful plant that we owe it to the world to make it more understood and more trusted. That’s really important,” Winston said.

Trust and Transparency 

Dosist is a lifestyle performance brand, meaning “when you sleep better, you perform better the next day,” said Winston, explaining that when people are able to find time to relax, whether it’s at night or during the day, they can consequently perform better in their endeavors. 

“People need to realize that controlled amounts of cannabis can be very helpful to your life,” he said. “Our goal is to really take cannabis, which is this gift from Mother Nature, and then make it accessible and more powerful to everybody.” 

Dosist focuses on providing customers with education around the benefits of cannabis, rather than marketing its products.  

“Cannabis can be an absolutely wonderful and powerful experience for so many different people. Dosist helps people know that it’s OK to step inside this category. Then, once you’re here, there are a variety of other products in the category.” 

Product Innovation 

For nearly five years, dosist’s proprietary pen has been delivering dose-controlled, THC-powered cannabinoid therapy via disposable vape pens, each one finely tuned to meet customer needs.  

And as cannabis continues to evolve, so too has dosist’s product portfolio. To meet the needs of cannabis consumers, dosist developed an innovative line of consumption verticals including a new range of wellness-focused sublingual drops. The drops, available in sleep, calm, and relief, are offered under their new label, dosist thc-free, marking dosist’s official entry into the CBD marketplace. To provide ease of access to customers, dosist also launched its first e-Commerce platform, which ships the THC-free line nationwide. 

In true dosist style, cannabinoid therapy has been taken one step further with the addition of more isolates, including CBG and CBN, to its hemp-derived thc-free blends. Additionally, a proprietary self-microemulsifying drug delivery system (SMEDDS) enhances the formula’s bioavailability to increase the drops’ efficacy and efficiency.  

“Consumers want different consumption options, and they want different formats,” Winston explained. “Some people appreciate the benefits and fast-acting elements of inhalation. Other people prefer an edible. Some people that prefer not to ingest anything at all will want a topical. We try to bring innovative and differentiated controlled products to the market to give consumers more accessibility and choice.” 

Winston believes fundamental obstacles exist for people who might be interested in cannabis but are “nervous about THC, and who might prefer THC-free products.”  

A range of gummies that utilize the company’s nanotechnology will first be introduced in California in the new year, and then rolled out across the country in both THC and THC-free options. 

Issues around pollution and waste in the cannabis industry need to be addressed by all manufacturers to create a more sustainable sector. Dosist recognized this as an opportunity for innovation and developed a new rechargeable pen — the dose controller – to sit alongside their original disposable pen and other products on dispensary shelves in California, Canada, Nevada and Colorado. 

The Importance of Regulated Products 

It’s no secret that the vape crisis of 2019 made a lot of vape pen enthusiasts nervous about their chosen method of consumption. Black market THC products created a public health problem that resulted in 60 deaths and more than 2,711 hospitalized cases reported from a vaping-related pulmonary illness, which swept across the country. The situation was a tragic reminder that while everyone may not agree with the finer details, regulated markets give consumers access to safer products. 

“These kinds of things happen when governments continue to allow unregulated markets,” said Winston, who believes responsible regulations are important. 

“If you don’t have regulated products, and you’re putting something in your body, it’s very, very risky,” he said. “People are going to find a way to use cannabis. It’s been shown. So, stomping out the illicit market in favor of a regulated market is really, really important.”

The post Meet THC-free: The Latest Innovation from Dosist appeared first on Cannabis Now.

Breeding for Cannabinoids: The CBG Seed

It’s early on a mid-March Friday morning at the Oregon CBD headquarters, outside Corvallis, Oregon. The company’s co-founder, Eric Crawford, is breaking up a piece of intimidatingly frosty cannabis as I watch with apprehension.

“Don’t worry, it’s only hemp,” Crawford jokes as he packs the flower into the bowl of a glass pipe. “It has no measurable THC or CBD, but about 15 percent CBG and it really helps with staying focused.”

Fridays are usually filled with non-stop meetings at the industrial hemp seed firm, especially as the cannabis growing season approaches. Clients travel from across the nation to sit down and pick the two brains behind the business: Eric Crawford and his co-founder and brother Seth Crawford. The brothers admit that with the barrage of questions visiting clients often lob their way, sometimes a little help with focus can go a long way.

While their innovative early-finishing, CBD-rich strains have brought them success in the past, the duo has spent the last two years working to stabilize the nation’s first production-ready, CBG-dominant varietals in seed form.

CBG, the non-intoxicating cannabis compound whose full name is cannabigerol, has been garnering attention for its promising effects in the treatment of a wide variety of medical conditions.

Morning light on field trials of White Series CBG from Oregon CBD.

According to multiple studies from researchers investigating its potential as a palliative, CBG works to fight inflammation, pain and nausea, and is showing potential in terms of slowing the proliferation of cancer cells. Research has shown it also significantly lowers the intraocular eye pressure caused by glaucoma. Strains high in CBG also could be beneficial for treating conditions such as inflammatory bowel disease, Crohn’s disease and cancer.

In cannabis plants, CBG is essentially the stem cell, or chemical precursor, of many other cannabinoids, and is present in virtually all cannabis plants in their early stages of flower. As the plants mature, CBG morphs into any number of the 113 currently known cannabinoids, such as THC and CBD.

Back at Oregon CBD, I inspect a fragrant nug of the “White Series,” the company’s initial strain offering into the soon-to-be-blossoming CBG market. Out of the four phenotypes of the series, we pass back and forth #103. The flower is coated thick with crystals, speckled with vibrant orange hairs and its terpene profile oozes sweet skunk. It’s hard for me to fathom how something frosted so heavily in trichomes is THC free.

My first hit produces smooth smoke that coats my mouth with sweetness. I’m not drooling high, but I feel an immediate calmness sweep my mind. It slowly gives me a boost of energy, like a cup of coffee without the anxiety.

“It’s a more profound experience than CBD, and while it does not fall under the umbrella of ‘psychoactivity’ like THC does, it does produce a noticeable head change,” Seth says. “It’s perspective-altering.”

Eric Crawford wanders the CBG fields in the evening light at Oregon CBD’s R&D field.

For the Crawford brothers, breeding a CBG-rich flower was only half the challenge. Their company focuses on breeding seeds ready for cannabis farmers looking to cover anywhere from a few to hundreds of acres.

“We conduct rigorous laboratory testing and large-scale field trials on everything we produce,” Seth says. “It takes many years to develop these lines in a way that creates a uniform crop at any scale.”

In recent years, Oregon CBD’s breeding program has sparked national and international attention for a long list of breakthroughs in the industrial hemp industry. In 2018, Seth spoke at the Emerald Cup, as well as at the CannMed conference at UCLA, giving viewers insight as to how they have isolated specific traits and compounds for their seed stock.

“Good breeding is no secret, it’s just a lot of hard work and it takes years of research and development to accomplish,” Seth says.

When asked about the flood of hemp seed stock hitting this year’s market, the brothers both laugh.

“Good breeders are not people to who just take two plants they like and cross them to get some ‘good stuff,’” Eric says. “Good breeders are people who take the time and make a plan, they create specific inbred lines to reach a target. But overall, it’s not rocket science.”

Originally published in the print edition of Cannabis Now. LEARN MORE

The post Breeding for Cannabinoids: The CBG Seed appeared first on Cannabis Now.

Decarboxylation: How Cannabis Becomes Psychoactive

Decarboxylation, which is an essential action in enjoying cannabis flowers and edibles, is a process in which carbon dioxide (CO2) leaves a stable molecule and floats off as a gas. Atoms in a molecule can be thought of like billiard balls, with each one having a size, weight, and exact position. As these atoms float away, the substance left behind will become lighter, like a dry towel being lighter than that same towel soaking wet. The idea is that as the CO2 leaves, the weight left behind is reduced.

Decarboxylation typically occurs by heating, but can also be caused by exposure to certain frequencies of light, and certain substances like molecular oxygen in the air.

If the weight of the molecule before and after its decarboxylation is known, then a percent of mass lost in decarboxylation can be calculated. If the CO2 contributes 10 percent of the weight of a molecule, than 90 percent of the mass remains after decarboxylation. This would mean that continuously heating 100 grams of this substance would eventually yield 90 grams of the decarboxylated substance, as the remaining 10 grams represent the weight of CO2 which gassed off.

How Does Decarboxylation Affect Cannabinoids?

Decarboxylation of cannabinoids and cannabis products is very crucial to understanding the power of cannabis as medicine. The cannabis plant only has the ability to produce cannabinoid acids, like THCA, and THC is only created by decarboxylation outside the plant. This decarboxylation is usually done by fire when smoking, or by baking in edibles. Most cannabinoids lose approximately 87.7 percent of their mass upon decarboxylation. This means that if you had 100 grams of crystalline isolate of a cannabinoid acid, such as THCA, after decarboxylation you would have 87.7 grams left of THC.

This is important for people decarboxylating their cannabinoids themselves, such as producers of cannabis-infused edible products and hash oil producer that wish to sell decarboxylated oil. This is also important for advertisers of raw cannabis products such as cured cannabis flower, who must either report the value of the cannabinoid acid directly observed by the testing lab, use the theoretical conversion, or display both.

This labeling issue with raw flower is not as easy as it seems at first glance. Let’s consider a typical example of THC-dominant cannabis. The lab will test the flower and find 26 percent THCA and 3 percent THC. This is because some of the cannabinoid acids produced by the plant are decarboxylated by air and sun before harvesting and curing. The smaller the amount of THC observed directly by the lab typically indicates that the cultivator has submitted fresh cannabis that has been protected from light and exposure. A very high THC content indicates that the cannabis flower is not as fresh and been more exposed.

Now the dispensary has to either advertise two numbers, 26 percent and 3 percent, or advertise one theoretically calculated number, 25.8 percent, or both. Both allow the patient to access the greatest amount of information and be the best informed, while also reducing liability on the cannabis business involved in label making.

Tetrahydrocannabinol (THC) is a well-known cannabinoid for being the primary intoxicant and euphoriant of cannabis. THC is also one of the most practical and safe treatments for neuropathic, chronic, and other types of pain. THC is effective in addressing both the immunological and symptom component of multiple sclerosis (MS).

Despite the fact that THCA is not an intoxicant, it is a powerful medicine. THCA is one of the strongest anti-inflammatory agents in cannabis. Smokers receive very little to none of this cannabinoid, due to its decomposition in the smoking process. THCA is an anti-inflammatory agent, and according to one study, a more powerful neuroprotective agent than THC. THCA is a powerful COX-1 and COX-2 antagonist, similar to aspirin and ibuprofen, but with far less toxicity to the liver.

The effects of THCA and THC reflect the diversity of action on the human body a cannabinoid and its precursor acid can have. The other cannabinoids, CBD, CBG, CBC, and THCV all have acid forms which have distinct effects on human health.

Cannabidiol (CBD) has been shown to be an effective medicine for people suffering from anxiety. What CBD has also been shown to be effective at fighting is breast cancer cells. Many of these studies find that CBD promotes apoptosis, or cell suicide, in breast cancer cells while leaving the healthy cells unaffected.

Cannabidiolic acid (CBDA) is CBD’s acid precursor from raw cannabis flower. CBDA has also been shown to fight human breast cancer, but in a different way. Whereas CBD causes apoptosis in breast cancer cells, CBDA has been shown to slow or stop metastasis of breast cancer cells by arresting their motility, or ability to move throughout the body. This evidence would indicate that a breast cancer patient may want to talk to their doctor about dual CBD/CBDA therapy, taking both decarboxylated CBD and raw CBDA together.

Cannabigerol (CBG) has been shown to have some potent anti-inflammatory properties that are particularly applicable in inflammatory bowel disease (IBS). Additionally, CBG has been shown to have some properties not known among many other cannabinoids, such as an ability to interact with human adrenal receptors and serotonin receptors. Currently, more studies need to be done on cannabigerolic acid (CBGA) in isolation from CBG to get an understanding what, if any, difference there are between the cannabinoid and its precursor acid on human health.

It is important to note that the mass loss is not a conversion rate. Mass loss assumes that all of a substance will decarboxylate and calculates how the mass will change. An accurate answer must account for how much of the cannabinoid will decarboxylate. Studies indicate that 30-70 percent of cannabinoids undergo decarboxylation under standard smoking conditions. This is why our calculations are only a theoretical maximum, and are not a result with the same standing as those directly observed in the plant. This is also why it can be very important to label your theoretical calculations as such, and provide all original values provided by lab results, as a means of reducing liability upon your business.

TELL US, have you ever heard of decarboxylation?

The post Decarboxylation: How Cannabis Becomes Psychoactive appeared first on Cannabis Now.

Customize Your Cannabinoids – Now You Can Mix’ N’ Match

Most of what’s gone on in the field of medicinal cannabis has been related to simply isolating and/or replicating a specific cannabinoid to get its benefits. In today’s world of cannabis medicine, the new thing is for a customer to order a premium blend of their favorite compounds, because today, you can actually customize your cannabinoids.

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Isolating cannabinoids

There’s plenty in the worlds of medicinal cannabis and recreational marijuana that have nothing to do with isolating anything. If a person wants to smoke hemp flowers, or buy a few grams of high-THC weed, they’re getting the whole plant, no isolation needed. However, the fields of medical and recreational cannabis have been more and more reliant on the idea of isolated cannabinoids. CBD is the most popular right now, with CBD oil and vape cartridges flying off store shelves all over the world.

Much like with other forms of pharmaceutical medicine, where we often pop a pill without really thinking what that circular, chalky, perfectly-shaped tablet contains, where it came from, and how it got to be in the form we take it in, we don’t often question how our CBD oil came to be.

Cannabinoids don’t start out as cannabinoids, but rather as acids that must be heated – or decarboxylated – in order to form into the cannabinoids we are familiar with like THC, CBD, and even the rarer CGBV, and THCV. Solvents are then used to separate certain parts. These can include, ethanol, hydrocarbon (butane, propane…), chloroform, light petroleum, and CO2 – which doesn’t leave a residue.

personalized cannabis medications

After extraction with one of these solvents, the solution is filtered at least a couple times, generally through something like charcoal. Then it should be made more concentrated, down to about half the volume, using a 2% aqueous sodium sulfate solution. When the solvent is stripped out, and the solution is concentrated, its left as a crude oil. At this point it can even be purified further with redistillation or column chromatography.

After extraction, the oil is put in alcohol, mixed, cooled (to remove unwanted terpenes, chlorophyll and flavonoids), and then heated to burn away the alcohol. Something called short path distillation is used to isolate different compounds using their individual boiling points. A pure powder of a specific cannabinoid is left at the end which can then be used in different ways for different kinds of products. It might not be important to know all the steps of isolating a cannabinoid, but understanding it as a process is important, because this process takes time and money.

Rare cannabinoids

We’re all familiar with THC at this point, as it is the most prevalent cannabinoid of the cannabis plant (for high-THC marijuana). Most of us now know a good bit about CBD too, which also can be found in plentiful amounts, particularly in low-THC hemp.  We also know there are more than 100 cannabinoids in the cannabis plant, even if some of them appear in only trace amounts. The ability to isolate some of these rarer cannabinoids through the process above, gives users that much more choice in terms of products, and the ability to now formulate different mixtures of cannabinoids. Some rarer cannabinoids, and cannabinoid acids, that are now becoming more popular due to the ability to isolate them, are the following:

  • CBG – Cannabigerol – Comes from acidic precursor CBGA and makes up less than 1% of a cannabis plant.
  • CBN – Cannabinol – A phytocannabinoid with THC as a precursor.
  • CBC – Cannabichromene – The second most prevalent cannabinoid in cannabis.
  • CBCA – Cannabichromenic Acid – The acidic precursor to CBC.
  • CBGA – Cannabigerolic Acid – The precursor acid that transforms into acids THCA, CBDA, and CBCA, which in turn produce other cannabinoids.
  • CGBV – cannabigerivarin – A cannabinoid acid with CBG as a precursor.
  • CBNA – Cannabinolic acid – The parent compound that transforms to CBN through decarboxylation.
  • CBCV – Cannabichromevarin – Closely related to CBC, with the difference of a propyl chain.
  • CBDV – Cannabidivarin – Closely related to CBD, and mainly found in cannabis indica landrace strains, generally from Asia and Africa.
  • THCV – Tetrahydrocannabivarin – Similar to THC, and does produce a psychoactive effect.
  • CBDA – Cannabidiolic acid – The precursor to CBD that exists in acid form.
  • THCA – Tetrahydrocannabinolic acid. The precursor to THC that exists in acid form.

And many more, most of which have gotten so little attention as of yet, that there isn’t much written about them, or studies yet performed on them. Whereas major cannabinoids like THC and CBD can take up about 2-20% of a plant’s biomass, these lesser cannabinoids generally make up less than 1%.

medicinal cannabis

One of the interesting things about cannabinoids, though, is that they each have their own medicinal profile, as they are all unique compounds unto themselves. Sometimes you might want something pure, like CBD oil. Maybe other times you want the whole plant, and the synergistic effect of all parts working together. And on other occasions, you might want to mix and match the different parts and pieces available, to customize your cannabinoids to create medicines very specific to your particular wants and needs.

Mix n match

This new industry of customizing cannabinoids is only just beginning, but it does seem to be taking off. The companies that offer this service are offering a way to create custom medicines, while also introducing customers to lesser known cannabinoids, and cannabinoid acids. The idea of personalized medication is conceptually new to Western medicine. While different people are given different medications to take, in different quantities, pharmaceutical medications are not formulated with a specific person in mind, or tweaked to meet that specific person’s needs. Natural medicine traditions are much more likely to create specialized medication for patients, and this new movement towards the ability to customize your cannabinoids is a mirror of this concept. Instead of the standard ‘trial and error’ in standard medicine, where a person might be cycled through tons of different medications to find something that works specifically with their genetics, the idea is now to tweak the meds to meet the person’s needs.

Companies getting in on it

Global Cannabinoids is a Las Vegas based CBD oil company that now offers something else. CBD oil, and other private label products, that can be customized by the buyer to have an exact profile of cannabinoids – rare and not rare – to meet their needs. This is twofold in that it exposes people to more rare options than the standard CBD, while also giving a level of personalization.

Global Cannabinoids is already one of the biggest white label and private label suppliers of CBD, as well as a leading ingredient supplier for brands that use hemp-derived cannabinoids for their product lines. The company is one of the biggest suppliers for wholesale and bulk cannabinoids, even rarer ones. Customers can purchase CBN, CBC, CBG, and CBDV in the ratios of their choosing. Obviously, there are plenty more rare cannabinoids, as mentioned above, but this opens the door, and gets the ball rolling for using rare cannabinoids at all.

Another company moving in the same direction, is Socati, a company based out of Houston, Texas with a Montana-based facility for manufacturing cannabinoid ingredients, that is known for producing USDA certified organic hemp products. Now, they’re opening up their offering a bit more, just like Global Cannabinoids. Socati recently launched a line of private label products offering the ability to customize your cannabinoids. Custom ratios of CBD, CBG, CBN, and other rare cannabinoids can be made per personal desire in the following products: gummies, tinctures, crystalized flavor powder, pressed tablets, softgels, and capsules.

medicinal cannabis

Precision Plant Molecules is another company now offering a tailored cannabinoid experience. The company is a specialty cannabinoid-based ingredient supplier. It extracts and processes hemp to create distillates, oils, concentrates, extracts, and isolates. While there isn’t much press about the company’s ability to customize your cannabinoid experience, it is explained on their website. PPM uses several minor cannabinoids along with CBD, like: CBN, CBC, CBG, CBT, CBDV, THCV, CBGA, CBDA, and others. According to its website: “Fully customizable ratios of cannabinoids afford more effective health and wellness products. Enriching to achieve a specified ratio of cannabinoids smooths the variability in even Mother Nature’s most stable chemovars.” I expect we’ll be hearing more about this company in the news soon.

The same can be said for Trait, which also hasn’t quite made big news, but which now with Trait Tailored, is also offering customized cannabinoid combinations. According to its website, “Trait Tailored’sTM patent pending technology enables growers to perfectly customize the cannabinoid profiles of their hemp or cannabis strains with ground-breaking precision.” It goes on to say, “With TailoredTM, growers are able to produce strains with greater volumes of CBD, CBG, CBC and other less common cannabinoids to make more refined and desirable products for consumers.”

Conclusion

Customizable medicine is certainly a new thing for most people. As the field of medicinal cannabis grows bigger and bigger, more options are being made available that were never a part of standard Western medicine before. Now, instead of cycling through tons of meds to find the one that works, you can customize your cannabinoids to create the perfect combination for all your health needs.

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Resources

What are THCV Flowers, and How Are They Different from What You’ve Been Smoking? (Why THCV flowers are unique)
Everything You Need To Know About CBD Isolate (a deep look into hemp extracts)

German Cannabis Flower Market is Ready to Explode
Delta-8 THC Contaminated Products, or Just Bad Press?

Everything You Need To Know About CBG Isolate
Newest Cannabinoid Powerhouse – CBC – What Can It Do for You?
What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8THC)

Cannabis Cosmetics: What’s Allowed, What’s Not, and Where to Find Them (What is the latest regulations in Europe and which products are allowed)
CBG Study Shows Antimicrobial Properties of Cannabis
The CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers)
The Medical Cannabis Weekly newsletter (International medical cannabis business report)
The Legal Landscape Of CBD Hemp Flower In Europe

The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc)Regulators Go After Smokable Hemp Flower – What Does The Future Hold?
Investing in Delta 8 THC Flowers – Is It The Right Move For Your Business? (All you need to know about the latest hot trend: Delta-8 THC)

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Everything You Need to Know About the Science Behind Cannabinoids

The cannabis plant produces literally hundreds of specialized molecules — cannabinoids, terpenes and flavonoids — that have been shown to deliver medicinal efficacy, lifestyle enhancement and even performance enhancement to human beings. For those afflicted with disease, medical cannabis has been found to offer a wide range of health benefits, from killing cancerous tumors to alleviating the pain of arthritis to reducing the number of seizures experienced by epileptic children.

Of these molecules, cannabinoids are the most cited and understood. The most infamous cannabinoid is tetrahydrocannabinol (THC), the molecule responsible for most of the psychoactive (psychotropic) and euphoric effects of cannabis, but that also has been found to successfully treat serious conditions, such as PTSD and cancer. Another notable cannabinoid is cannabidiol (CBD), a mostly non-psychoactive chemical that has been found to provide a wide range of medicinal benefits, including reductions in pain, anxiety and depression.

Endocannabinoids vs. Phytocannabinoids

First discovered in 1964 by Israeli researcher Raphael Mechoulam, phytocannabinoids from the cannabis plant interact with the human body by mimicking the molecular characteristics of chemicals produced internally. Called endocannabinoids, these internally manufactured molecules include anandamide and 2-AG.

Anandamide has been dubbed the “bliss molecule” because of its ability to decrease depression in humans. It plays a central role in the regulation and modulation of critical bodily functions such as mood, appetite, sleep, immune system efficiency and one’s ability to deal with stress and anxiety.

Synthetic Cannabinoids

Synthetic cannabinoids emerged in the 1970s and are created in a laboratory. An example of it would be dronabinol (Δ9-THC synthetic), which is the active compound of Marinol, a medicine that comes in capsules and has been consumed in the US since 1985 to prevent nausea, vomiting, loss of appetite and loss of weight.

The Endocannabinoid System

All mammals, not merely humans, have evolved with a network of specialized cellular receptors throughout their bodies that are designed to bind with cannabinoids — both endocannabinoids such as anandamide and phytocannabinoids from cannabis — that is called the endocannabinoid system (ECS).

The fact that the ECS is present in all mammals is why companies and product lines dedicated to the health and wellness of household pets are beginning to emerge in legal cannabis markets. Dogs and cats suffering conditions such as arthritis, digestive issues, anxiety and pain can gain significant benefit from the cannabinoids in cannabis and hemp.

Anandamide production has been found to increase and temporarily spike in those who engage in endurance exercise on a regular basis. However, it metabolizes quickly, exhibiting a relatively short duration of effect. Anandamide hints at the chemical underpinnings of the significant health benefits of frequent and intense exercise—and the fact that the mere consumption of cannabinoids is not enough to establish and sustain optimal health of the ECS (a condition called homeostasis that means “balance”).

Both internally produced endocannabinoids and plant-based phytocannabinoids interface with the ECS via specialized cellular receptors that were discovered in the 1990s and called CB1 and CB2. CB1 receptors are found mostly in the brain and central nervous system, whereas CB2 receptors are located primarily in the organs and tissues of the immune system—including the thymus, skin, bone marrow, lymph nodes, spleen, bowel and the mucous membranes of the bladder, genitals, nose and throat.

Major Cannabinoids + Acidic Precursors

More than 113 cannabinoids have been isolated and identified within the cannabis plant — which is, technically, also a vegetable. Beyond the two major cannabis-derived molecules, THC and CBD, are a plethora of healthful cannabinoids that deliver a slew of desirable and beneficial efficacies for lifestyle consumers and patients alike. Among these are cannabichromene (CBC), cannabigerol (CBG), cannabinol (CBN) and tetrahydrocannabivarin (THCV).

Additional healthful cannabinoids include tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA). These chemicals represent a class of cannabinoids dubbed acidic precursors. Think of acidic precursors as the larval caterpillar stage of what becomes the butterflies of THC and CBD.

While they provide significant benefits in terms of health and wellness, the exact effects of these molecules differ from their non-acidic versions. For example, while strains of cannabis that are potent in THC can exact a significant toll in terms of psychoactivity and euphoria, THCA delivers no such psychotropic effect. THCA does, however, offer anti-inflammatory and neuroprotective effects, making it helpful for conditions as wide-ranging as Alzheimer’s disease, arthritis, cancer, Crohn’s disease, fibromyalgia, multiple sclerosis and Parkinson’s.

Understanding Decarboxylation

The process by which the transmogrification from the chemical state of acidic precursor (THCA) to its child molecule (THC) occurs is significant (and can be accurately controlled by anyone). A process called decarboxylation, this conversion involves the application of heat (via flame, as in combustion, or from a hot surface or airstream, as in vaporization) to catalyze a chemical reaction in which the THCA molecule drops a carbon and two oxygen atoms (called a carboxyl ring, or COOH) to become THC — and gain its euphoric effects based on its newfound binding affinity with the CB1 receptors of the ECS.

Technically, maximum decarboxylation for a sample of cannabis flowers occurs most effectively when exposed to 220 degrees F (104 degrees C) for a period of 30 to 45 minutes. Decarboxylation is easy and convenient because it can be accomplished using a standard consumer oven.

Thus, one who eats the raw flowers of cannabis will gain significant medicinal benefits, but no euphoria. The simple application of a flame or hot air, however, leads to the nearly instantaneous transformation of these molecules into their chemical cousins, delivering beneficial — but sometimes very different — effects.

The Research

2017 research study entitled “Medicinal Cannabis: History, Pharmacology and Implications for the Acute Care Setting” that was published in the journal Pharmacy & Therapeutics found the cannabinoids of cannabis, such as THC and CBD, to be effective in the treatment of a wide range of diseases and conditions.

The study’s researchers stated, the “Beneficial cannabinoids exist, as evidenced by single-entity agents derived from cannabis containing the compounds THC and CBD.” The study concluded that “cannabis is relatively safe; therapy is self-titratable by the patient; and…therapy is relatively inexpensive compared with pharmaceutical agents.”

CBC is a powerful cannabinoid first isolated in 1964 by Israeli researcher Raphael Mechoulam. It is considered one of the “big six” cannabinoids that, according to Steep Hill Labs in Berkeley, California, is ten times more effective than CBD in treating anxiety and stress.

In a 2011 study conducted by cannabis research pioneer Ethan Russo entitled “Taming THC: Potential Cannabis Synergy and Phytocannabinoid-terpenoid Entourage Effects” and published in the British Journal of Pharmacology, Russo found that a CBC-extract displayed “pronounced antidepressant effect,” meaning it may be helpful for humans suffering from anxiety and depression.

Additional evidence of the medical benefits of cannabinoids derived from cannabis — this time for an ocular disease — was revealed in a 2008 study entitled “Possibilities of Applying Cannabinoids in the Treatment of Glaucoma” that was published in the journal Klinika Oczna. The study concluded that cannabinoids like CBG are “able to decrease intraocular pressure. These compounds are characterized by neuroprotection and vasodilatation properties that additionally substantiate their therapeutic utility in conservative treatment of glaucoma.”

Originally published on cannabisaficionado.com.

The post Everything You Need to Know About the Science Behind Cannabinoids appeared first on Cannabis Now.

The Rise of CBD Strains

In the southern Oregon town of Takilma — a longtime hippie enclave just above the California border in the foothills of the Siskiyou Mountains — one farm is focused on developing new strains of cannabis. Their mission is not to breed for maximum THC or any particularly trendy flavor expression, but to create strains with an optimal balance between CBD, THC and various terpenes to achieve tailored effects.

The farm is called East Fork Cultivars, and its CEO Mason Walker is a former journalist and editor at the Portland Business Journal who himself uses medical marijuana to control his pain from a serious neck injury in his youth.

“Our roots are in the medical approach to cannabis breeding,” Walker says. “We started selecting varieties high in CBD for therapeutic effect.”

Pineapple Tsu: 13.7% CBD / 0.5% THC

In order to create strains that can best address specific ailments, East Fork Cultivars has focused on cultivating under three broad categories. First, they’re growing out “CBD-dominant” varieties to find phenotypes that typically have less than 1 percent THC and subtle effects, including with Ringo’s Gift, Sour Tsunami and Cenarius. Second, they’re cultivating “CBD-rich” varieties have high CBD content but also around 5 percent THC, including Bubba Kush and an East Fork original strain, Pineapple Jager. Third, they’re growing “THC-dominant” varieties that are the more typically potent strains that outlaw growers long strove for, including Strawberry Satori.

With this spectrum of cannabinoid concentrations, Walker says their selections appeal to “new cannabis consumers who are curious,” but not necessarily looking to get high.

Each fall, the team at East Fork Cultivars harvests one acre of CBD-rich cannabis from its farm in Southern Oregon’s Illinois River Valley.

Through their work developing a wide range of CBD-rich phenotypes and breeding new strains, East Fork is at the forefront of the larger CBD trend, trying to ensure that the increasing crowds of cannabis consumers looking for CBD strains have more options to choose from than the handful currently on the market.

“We’re still early on in our breeding work,” Walker says. “Of our 15 top-selling varieties, three of them we bred ourselves and the other 12 are well-established varieties that someone else bred — but we expect that number to basically flip in the next two years.”

From Llamas to Cannabis

Flowers grow between the rows at East Fork Cultivars.

East Fork was started by the brothers Nathan and Aaron Howard. Aaron, now the company’s chief operations officer, moved from his native Portland to southern Oregon about 10 years ago to grow cannabis under the state’s medical program. (Oregon voted to legalize medical marijuana in 1998, the second state to do so after California.) He initially cultivated as caregiver for a third brother, Wesley, who suffered from neurofibromatosis and epilepsy.

In 2015, Aaron was among the first cultivators in the country to start growing high-CBD strains, and the following year, purchased the 9-acre property in Takilma. At the time, the property was a llama ranch, so the East Fork team inherited three llamas along with the land. The animals have since passed on, but the company’s logo is still a llama — and the laser focus on CBD has not wavered.

Bubba Kush: 13.3 % CBD / 5.9 % THC

“We supply CBD-rich cannabis to other companies who turn it into infused products,” Walker says. “We extract oils for chocolate bars, topical salves, tinctures and beverages.”

Walker says that East Fork is shying away from selling cannabis flowers to consumers, because he thinks the end of cannabis prohibition is changing the way people want to ingest the plant.

“Back during Prohibition [in the 1920s and ’30s], people wanted high-potency moonshine,” says Walker. “With cannabis prohibition, there was the same secretiveness and incentive for high-potency stuff. Now that we’re moving out of prohibition, people are demanding more types of cannabis that are more nuanced. The same way we’re consuming more wine and beer as opposed to moonshine. Nowadays, you don’t hear people say, ‘What’s your strongest stuff?’”

Breeding for CBD

In 2017, the team at East Fork Cultivars harvested 3,300 lbs of cannabis uses garden carts and bicycles.

East Fork’s most cutting-edge work is its on-site breeding program. When selecting and testing new strains, Walker says the farm is focused on creating strains with high levels of “chemical diversity.”

“The beauty of cannabis is it’s one of the most chemically complex plants on the planet,” Walker says. “We focus a lot of time and energy and money on developing the largest diversity we can, in terms of combinations of CBD and terpenes.”

He notes that the linalool terpene, which smells like lavender, is often used to reduce anxiety, while the citrus-smelling terpene limonene is said to have an energizing effect.

“Multiple terpenes have synergistic interactions with each other, creating yet new effects,” he says. “That’s what makes cannabis really fascinating.”

One of East Fork’s original strains with notable limonene content is Wesley’s Wish, named for Wesley Howard, who found the strain gave him relief from his neurofibromatosis and epilepsy before he passed away last year. It is a cross between Pineapple Tsu and Purple Hindu Kush, which Walker describes as “one of the most popular THC-heavy strains in Oregon.” But while Purple Hindu Kush is typically more than 20 percent THC, Wesley’s Wish is only some 5 percent THC and 15 percent CBD.

Wesley’s Wish: 12.7% CBD / 4.5% THC

Another emphasis of East Fork’s breeding program is to broaden the genetic pool of high-CBD strains, especially given the problem that high-CBD strains generally have smaller yields than high-THC strains.

“There’s not a lot of genetics available that are both high-CBD and high-yield, so we’re making them ourselves,” says Walker. “We’ve had a couple of hits — varieties that are high-CBD but also high-yield, and are promising in terms of appearance and other standards cannabis is generally judged by.”

East Fork has sourced their high-CBD genetics over the past five years from California, Oregon and Europe. The farm is currently expanding their genetic library by sourcing high-THC plants from Oregon growers and collaborating on breeding projects with other farms in the adult-use system, splitting the seeds at the end of the project.

ACDC: 17.9% CBD / 0.5% THC

Walker says East Fork is headed in the direction of growing entirely from seed rather than clone. This year, their ratio is about 50/50.

“Plants grown from seed have more vigor, more pest-resistance,” Walker says. “A lot of people call them a truer expression of the plant.”

East Fork is also bred with an eye on cannabinoids besides CBD and THC. Walker mentions tetrahydrocannabivarin (THCV), which is believed to have appetite-suppressing qualities. He also names cannabichromene (CBC), which has shown potential to inhibit tumor growth, and cannabigerol (CBG), which research suggests may help with vision problems such as glaucoma and intraocular pressure.

Business in the Gray Zone

Under Oregon cannabis regulations, the largest licensed cannabis grow can only cultivate up to 40,000 square feet of canopy, which is an area of just under 1 acre.

In Takilma, East Fork Cultivars has reached that 40,000 square feet canopy limit on a section of their original 9-acre plot of land. On the new 24 acres, Walker says they’re planning to grow hemp.

East Fork Cultivars Co-Founder and COO Aaron Haward prepares a cannabis bouquet, combining a fresh cannabis cola with dried straw flowers.

While CBD can also be extracted from hemp, this plant — legally defined as having less than 0.3 percent THC — falls under a different legal classification than cannabis. The cannabis strains grown on the original plot are overseen by the Oregon Liquor and Cannabis Commission, but the hemp plants on the new land will be overseen by the Oregon Department of Agriculture.

The cannabis farm is grown in a fenced-in area with a security camera system, as mandated by state law.

“The state figures the best way to keep feds at bay is to regulate the heck out of the industry,” Walker says.

The Rise of CBD Strains

Canna Tsu: 10.6% CBD / 3.3% THC

But the gray area of difference between the cannabis and hemp regulations on the federal and state levels is clearly not interfering with business. Walker says the farm brought in $830,000 in revenue last year, and is expecting $1.2 million this year.

“We sold just over 1,200 pounds of cannabis last year, and we’re on pace to sell 3,400 pounds this year—nearly triple,” he says. “About 98 percent of our sales are high-CBD strains.”

“We’re just barely starting to scratch the surface of interest in CBD,” he says. “It is having a fad moment, but I think it will have more staying power than the acai berry, for instance. I think our research over the next years will uncover extensive uses both therapeutically and in terms of just enhancing peoples’ lives.”

TELL US, what is your favorite CBD strain?

Originally published in the print edition of Cannabis Now. LEARN MORE

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