CBD (Cannabidiol) Explained – The Real Benefits of this Trendy Cannabinoid

While a fringe, alternative treatment option only a decade ago, today, CBD is everywhere you look – in wellness supplements, beauty and hygiene products, FDA-approved prescription medications, food and beverages, dental products, and even pillows, mattresses, and other random household goods.

As far as cannabinoids go, CBD, or cannabidiol) is the most widely accepted. Not only is there a growing body of clinical research to support its benefits, but it is non-intoxicating which makes it much more likely for laws to be passed in its favor – as is evidenced by the fact that CBD is federally legal in the US and many other countries, while THC still is not. But when it comes to CBD, what are some actual legitimate uses for this compound, and which ones are just marketing gimmicks? Let’s take a look at some of the real, science-backed benefits of CBD.

CBD is amazing, and so incredibly versatile. To learn more about this compound, and for exclusive deals on CBD flowers, as well as on Delta 8Delta 10 THCTHCVTHC-OTHCPHHC and even on legal Delta-9 THC! , make sure to subscribe to The CBD Flowers Weekly Newsletter, your hub for all things CBD-related.


What is CBD?

CBD, or cannabidiol, is the most prominent, non-intoxicating compound found in cannabis plants. When most people think of cannabis, they’re thinking about marijuana, which is the type so cannabis that is high in THC and associated with feelings of being “stoned”. Some types of cannabis, hemp for example, are high in CBD and contain only trace amounts of THC, meaning these plants can be considered non-intoxicating, by all accounts.

CBD is gaining popularity as a safe, non-toxic, non-addictive, natural treatment option for many different chronic and debilitating ailments; both mental and physical. Not only is CBD itself non-psychoactive, but when taken in combination with compounds that are, like tetrahydrocannabinol for instance, CBD can minimize the likelihood of negative side effects such as paranoia and anxiety that are occasionally associated with THC use.

The reason CBD (or any cannabinoid for that matter) works in the human body at all is because of the Endocannabinoid System (ECS) – a complex signaling system made up of numerous receptors, as well as some naturally produced endocannabinoids, that exists in the bodies of nearly all animals (except insects). Researchers have discovered two different endocannabinoids so far, 2-arachidonoylglycerol (2-AG) and anandamide (AEA), plus the two most studied receptors, CB1 and CB2. This quad makes up the majority of existing cannabis research.

As a whole, the ECS regulates numerous different functions and processes in our bodies and maintains internal balance and homeostasis. Many cannabinoids engage directly with the ECS receptors. Others, like CBD, have indirect connections by activating other receptors that will then interact with the endocannabinoid system. Specifically, CBD activates the TRVP1 receptors, which in turn activate receptors in the ECS and also function as ion channels.

CBD as an Anti-Inflammatory

One of the most common uses for CBD is to treat inflammation, which is the body’s process of fighting against pathogens and other hazards, such as infections, injuries, and toxins. When something damages your cells, your body releases chemicals that trigger a response from your immune system, thus causing inflammation.

The phrase “too much of a good thing” really applies in the case of inflammation. When this inflammatory response lingers after your body is done fighting the infection or whatever it is trying to overcome, this leaves your body in a constant state of stress and unrest. Chronic inflammation can have devastating effects on the tissues and organs and research indicates that it’s the root cause of many ailments including arthritis, contact dermatitis, acne, multiple sclerosis, and type 1 diabetes, asthma, and cancer.

Cannabidiol is becoming a very popular alternative for standard NSAID (Nonsteroidal anti-inflammatory drug) drugs like Aspirin. Long-term use of NSAIDs can lead to various health problems such as heartburn, stomach pain, ulcers, headaches, dizziness, and even damage to the liver and kidneys.

CBD to Manage Anxiety

Anxiety is another condition that’s been researched extensively to determine how well it responds to cannabis therapies. Cannabidiol targets cell receptors in the body and brain that regulate your mood. Many mood disorders, including anxiety and depression, have a few things in common, including a lack of naturally produced endocannabinoids.

Treating mood disorders with CBD is becoming more widespread is among the top-rated treatment options for young adults ages 25-40. According to a study conducted a couple of years ago, thirty-four percent of millennials prefer to manage their mental health with natural and holistic remedies, and 50 percent of millennials believe CBD oil is the best way to do this; and this number continues to grow.

The main reason cited was a fear of being prescribed a medication that is too potent for their level of symptoms. Because CBD doesn’t have the mind-numbing and other unwanted side effects of prescription drugs, nor is it psychoactive like THC, it can be used all day like any other medication or supplement.

CBD for Controlling Seizures

One of the first, medically-accepted, modern-day uses for CBD was to treat epilepsy. There are many studies out there researching its effectiveness. As a matter of fact, there is even an FDA-approved, cannabidiol-based medication, Epidiolex, that’s used to treat two rare and severe forms of childhood epilepsy, Lennox-Gastaut Syndrome (LGS) and Dravet Syndrome (DS).

Epidiolex is currently being prescribed in the United States, many countries in Europe, and Japan. Epilepsy medications can have some very serious side effects, and that’s why more natural alternatives are becoming the go-to ­­way to treat children and younger adult patients who suffer from epilepsy.

CBD for Pain Management

Although not common, many patients turn to a CAM, or complementary alternative medicine approach, to manage chronic pain. CBD is at the top of the list for those looking for natural, yet effective, alternative remedies. Because inflammation is the root cause of so many conditions that cause chronic pain, it makes sense how CBD eliminates pain.

Numerous different studies have found that cannabinoids like CBD can help with chronic pain from multiple sclerosis, cancer, and neuropathy. CBD and CBD topicals help with pain — if you suffer from chronic pain, CBD oil may help, as well. Chronic pain can be the main source of a diminished quality of life — CBD may give you hope for getting pain-free, or at the very least, reduced pain, and anything is worth a try.

CBD for Skin Conditions

Studies have shown that CBD can provide relief for the symptoms of various skin disorders, such as eczema and allergic reactions. Reverting back to ​inflammation, we know that cannabidiol can be used internally inflammatory conditions, and now we also know that it does the same when applied topically.

Topical creams containing CBD have been shown to ​or greatly reduce and sometimes even completely eliminate itching and dryness​ ​in sufferers of eczema. The chemical ‘histamine’, which is largely responsible for the irritating itches we experience, has been shown to react well to topical cannabinoid therapy. One study​ ​found that in almost 59% of its participants, their dry and scaly skin significantly reduced with the regular use of a cannabinoid cream, which reduced itching and as a result lead to less sleep loss.

Final Thoughts on Cannabidiol Benefits

Simply put, cannabidiol is an incredible compound. It’s non-psychoactive, non-toxic, and non-addictive; and it can be used to treat dozens of different health conditions. The ones covered in this list are the most common uses for CBD, but it can be utilized for many other ailments as well. Do you use CBD? And if so, what do you use it for? Drop us a line in the comment section below!

Thank you for stopping by CBD TESTERS, your hub for all things cannabis-related. To learn more about weed, and for exclusive deals on flowers, vapes, edibles, topicals, and other products, make sure to subscribe to The CBD Flowers Weekly Newsletter.

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The New Entourage Vape Cartridges: Delta 8, THC-O and HHC Carts

Have you tried the new entourage products? Several companies have recently introduced what they call “Entourage Vape Cartridges”, a combination of three new psychoactive cannabinoids: Delta 8 THC, THC-O and HHC with some CBN, CBD & CBG for the final touch.

Simply put, entourage vape cartridges are new blends, that combine different cannabinoids, in-order to reach the most-wanted ‘Entourage Effect‘ (AFA the ‘Family Effect‘ – the way different cannabinoids, terpenes, and flavonoids work together to offer health benefits you can usually only get when consuming the entire plant in its natural state). This is why the best hemp products are usually either full spectrum or broad spectrum and not made from isolate. However, it is much more complicated when you are trying to create hemp-derived psychoactive entourage vape cartridges, as some of the compounds are not naturally occouring, or exist in only small amounts.

That’s why, until recently using psychoacative entourage vape cartridges felt somewhat ‘hollow’, as there were just not enough cannabinoids to create the full-image needed for a deeper experience. All that changed when the new cannabinoids such as Delta 8, THC-O, THCV, THCP and even HHC entered the game. Now, for the first time ever, you can create sophisticated blends that that gives you a much more rewarding experience.

Have You Tried The New HHC Carts?

While these new products are psychoactive, some even very potent, they are sold online, as unlike regular Delta 9 THC, they are hemp-derived and not coming from cannabis. This loophole provides hemp-suppliers a legal way to sell psychoactive products, such as Delta 8 THC, THC-O, HHC, Delta-10, THCP, THCV and starting this month, allowed them to create ‘entourage vape cartridges’ – advanced products with tailor-made blends that effectively takes you to the next level.

A word of caution before looking into the new entourage vape cartridges: these are high-potency carts, so start low and grow slow, as you are among the very first to ever try them and the right dosage haven’t been calculated yet. Always make sure you buy from a company you trust and be patient as some cannabinoids need more time to kick in. Last but not least you should keep in mind that blended products might affect people differently, so be open for an experience, as everything is possible with new blended products.

As always, the subscribers of the Delta 8 Weekly are the first to put their hands on new cannabinoid-based products. Subscribe today, get our 25% discount code and learn more about the exciting entourage vape cartridges, as well as on other new products.

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Best Entourage Vape Cartridges:

Sativa / Indica / Hybrid Entourage Cartridge – 1 Gram

Sativa entourage vape cartridges

Leave it to the creative minds of Utoya to come out with this great product: a THC-O based sativa vape cartridge, blemded with CBG, CBN, Delta 8, CBD and HHC (in that order, see image above). This ‘sky-high sativa’ is the most popular of all three, providing a strong euphoria coming from a very fulfilling smoking experience. If you are looking for a sativa vape cart, this is the product for you!

You might want to know that the sativa entourage vape cartridges, as well as the indica and the hybrid carts, are made with live resin terpenes, which results in a more quality product with better flavor. The vapes taste exactly like the flowers they are name of, simple as that. In addition, there are no cutting agents in the preparation of the products, which meands no PG / VG / MCT or Vitamin E will be inside your carts. 

Choose between Maui Wowie, Blueberry Diesel, Jack and Fire OG

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Hybrid entourage vape cartridges
Hybrid entourage vape cartridges

Another great product is the hybrid entourage cart, featuring three psychoactive cannabinoids: HHC, Delta 8 THC and THC-O, with some CBN, CBD and CBG to flavor things up. This well balanced product is perfect for people who like to see how does it feel to vape a product high in both THC-O, HHC and D8. If you are looking to try a new hybrid psychoactive product, this is the one you should try.

Choose between OG Kush, Sunset Gelato, L’Orange and Mimosa.

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 Indica carts
Indica entourage vape cartridges

No product line is complete without a good Indica product. These indica entourage vape cartridges are using are based on HHC, Delta 8 and CBN, with a small amount of CBD, THC-O and CBG (in that order, see image above). If you are looking to buy a strong indica cartridge, this your best choice, as it allows you to experience the combined effects of HHC, Delta 8 and CBN. You must try it to see how effective they are when working together.

Choose between: Deathstar, GG#4, Pineapple Diesel and Biscoti.

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More Must-Have Deals

HHC Vape Cartridges – Special Bundle

HHC Vape Cartridges - Special Bundle
HHC Vape Cartridges – Special Bundle

Want to save big on HHC vape cartridges? Get 25% discount on the 4 pack and the 8 pack bundles using our special delta25 coupon code!

Both bundles include the following HHC carts: Sunset Sherbert (Indica), Hawaiian Sunrise (Sativa), Cali Gold (Hybrid) and Lucid Blue (Sativa). Choose the 8-pack to get the biggest discount!

Each HHC vape cartridge contains 94% HHC distillate and 6% cannabis based terpenes, resulting in a intense mental and physical buzz.

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VIBIN’ Delta-10 THC Tincture

Because you deserve a long-lasting euphoria…

NEW: Delta-10 THC Tincture
NEW: Delta-10 THC Tincture

Want to try something new? The Delta 10 VIBIN’ Tincture is everything you ever hoped for and even more!

With 300mg Delta 10 and 700mg Delta 8 in every bottle, this best-selling product will let you experience the unique benefits of Delta 10 THC, softly blended with Delta 8, which we all know to love. If you are looking for a ‘mental euphoria‘ and wish to feel ‘happy and motivated‘ this product might be the one for you!

Size: 30ml

Strength: 1000mg/Bottle: 700mg of Delta 8 THC + 300mg Delta 10 THC

Terpenes Used: Sour diesel, Blueberry OG

Current deal: Get it for as-low-as $25/bottle, when buying the 3-pack bundle and using the Delta25 coupon for an additional 25% discount.

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THC-O Vape Cartridges – Special Bundle

Want to save big on THC-O vape cartridges? Get 25% discount on the 4 pack and the 8 pack using our special delta25 coupon code!

Both bundles include the following strains: Maui Wowie (Sativa), Do Si Dos (Indica), Blue Zkittlez (Indica) & White Runtz (Hybrid). Choose the 8-pack to get the bigger discount!

Each THC-O vape cartridge contains 92% Premium THC-O Distillate, 5% Terpenes and 3% Natural Plant Lipids.

TIP: Choose the 8-pack and get an additional 25% discount using the Delta25 coupon code. That’s only $22.5/cart, the lowest price anywhere for THC-O vape cartridges!

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(With ‘Delta25’ coupon code)

Best Delta 8 Deals, Coupons & Discounts

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Affiliate disclaimer: We work hard to find and verify the best products, so we may include affiliate links to support the maintenance and development of this site.

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Artificial High – The History of Cannabis Synthetics

The idea that cannabis exists as a pharmaceutical product, is still strange to people like me who grew up with the plant as the only form of ingestion. Whereas some medications have no natural counterpart, like Tylenol (acetaminophen) or Benadryl (diphenhydramine), some do, like anything based off cannabis. And we know the plant itself works fine, but that hasn’t stopped an immense amount of research into synthetic cannabis, and the production of synthetic cannabis products. Here we’ll take a look at the history of cannabis synthetics, and what can be expected in the future.

The history of cannabis synthetics is important because it’s a large part of today’s current market, including products like delta-8 THC. Though delta-8 is naturally occurring, it does require human synthetization help to provide large quantities, which means the dealt-8 we use in products, is all synthetic. We’re into quality cannabis products, whether naturally occurring or synthetic, and have a nice selection of delta-8 THC, delta 10 THCTHCVTHC-OHHC, THCP and even legal hemp-derived Delta-9 THC products. Subscribe to the Delta 8 Weekly and check ’em out!

What is a synthetic?

First things first, when talking about the history of cannabis synthetics, or simply what the synthetic version of something is, it’s best to know what we’re talking about. According Dictionary.com, the definition of ‘synthetic’ encompasses several principals. Under adjective, the definitions that relate to cannabis are:

  • Of, pertaining to, proceeding by, or involving synthesis (opposed to analytic).
  • Noting or pertaining to compounds formed through a chemical process by human agency, as opposed to those of natural origin: synthetic vitamins; synthetic fiber.
  • Not real or genuine; artificial; feigned: a synthetic chuckle at a poor joke.

Under noun, the following relates to cannabis:

  • Something made by a synthetic, or chemical, process.
  • Substances or products made by chemical synthesis, as plastics or artificial fibers.
  • The science or industry concerned with such products.

A synthetic is something that was created, rather than occurring naturally, although this not does negate that a naturally-occurring compound can also come as a synthetic. A synthetic is something that is not real or genuine, but is instead artificial. Synthetics are made through a process, and studying synthetics, means studying the process of making artificial products. Thus, synthetic cannabis compounds, are compounds that do not exist in nature on their own (or which do, but still require synthetization help outside of nature for products), and are manufactured by human production. This can relate to much more than just cannabis. For example, a lot of clothing uses synthetic plastic fibers rather than natural ones like cotton or hemp.

Have You Tried The New High-Potency THCP Vape Cartridges?

Main points of cannabis research

When talking about the history of cannabis research in general, two of the occurrences that stand out the most are related to the isolation of certain compounds: the two main compounds of the cannabis plant. By isolating a compound, researchers can understand what it is, how it’s made, and are then able to synthesize it, and modify it. The two most spoken about findings in cannabis history are these:

1940 – The funny thing about the solation of CBD, is that it gets way less attention than the isolation of delta-9 THC, even as the current CBD industry booms. In fact, the name Doctor Roger Adams is way less known than Raphael Mechoulam, the guy up next. However, back in 1940, Roger Adams and his team at the University of Illinois, were the first to isolate CBD. In 1940, the team published their findings here: Structure of Cannabidiol, a Product Isolated from the Marihuana Extract of Minnesota Wild Hemp. It should be noted, that while Adams was not the first one to synthesize delta-9 completely, he was the first one to identify it, and he did do a partial synthesis.

1964 – Doctor Raphael Mechoulam, an Israeli researcher from the Hebrew University of Jerusalem, isolated delta-9 THC for the first time in 1964. Mechoulam and team published their findings here: Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish. Since this time, Mechoulam has been a leader in the industry, actively taking part in research, and even discovering this synthetic cannabinoid in 2020, called HB 580, or cannabidiolic acid methyl ester. And this at the ripe old age of 90. Mechoulam is still the president of The Multidisciplinary Center for Cannabinoid Research at the Hebrew University of Jerusalem.

Tons of other research has been done into different compounds within the cannabis plant, its history of use, and how it can be used today. But somehow, the isolation of these two main cannabinoids stands out as beacons in the history of cannabis research. And it’s through the finding of these compounds, that the history of cannabis synthetics began.

History of cannabis synthetics

If you’ll notice from the publication put out by Mechoulam and team in 1964, in the title it directly states that not only did they identify delta-9 THC, but they did a partial synthesis of the compound. What does this mean if delta-9 does appear in nature? It means, the researchers were able to isolate and map the compound, and that they then attempted to re-create it themselves, without help from nature. The ‘isolation’ is the part where the single molecule can be taken and studied, its chemical formula identified, and its chemical structure mapped. The ‘synthesis’ part is when the same molecule is created through human production. This might make it seem like the history of cannabis synthetics started here, but once again, it was really the other guy.

The thing about Roger Adams, is that he didn’t just isolate CBD, he isolated CBN (cannabinol), identified delta-9 THC as well, and was able to show the relationship between CBD, CBN and delta-9, as the three are isomers to each other. Not only that, he was able to synthesize analogues of CBN and delta-9, meaning he was able to create artificial versions of these cannabinoid analogues. He wasn’t, however, the only one doing this at that time!

cannabinoids

Enter Doctor Alexander Todd, the British researcher who was neck and neck with Roger Adams, and who received a Nobel prize for his work with nucleotides. In 1940, while at the University of Manchester, at the age of only 32, and working with a very small research group, Todd was able to isolate CBD from a sample of hashish from India. He published his findings in the journal Nature in 1940. Adams submitted his first notes on CBD in 1939 to the Journal of America Chemical Society, making him technically first over Todd. Todd’s version was without detail originally, with a full detailed version published in March of 1940 in the Journal of Chemical Society

Adams’ early synthetization of cannabinoids can be seen in his published research, which additionally shows a partial synthesis of delta-9 THC. Both Adams and Todd showed the isolation of CBN, which was fully mapped before CBD. Adams takes the win for first providing the structure of CBD, though Todd was right there with him. In fact, the two scientists spent a few years dueling in the scientific press, each publishing their findings as they came to them, in direct competition with each other. Later on, the two scientists became good friends and even worked together. It should be pointed out that the goal of both scientists had been to find the intoxicating agent of cannabis (delta-9), which neither ever established for sure.

During this time, delta-9 THC was not synthesized fully, though it was identified. But other compounds were synthesized, like CBN, CBD, and analogues of these cannabinoids and delta-9. CBN seems to be the very first cannabinoid that was synthesized in the quest to find delta-9, which CBN was assumed to be very closely related to. This makes CBN and CBD the first examples of synthetic cannabinoids, even though they do appear in nature. This reinforces the idea that a naturally occurring compound, can also be produced in synthetic form.

Cannabis synthetics today

We could have a whole debate about why cannabis was illegalized, and the part that pharmaceutical companies played in it, as a way to minimize use of a plant that couldn’t be patented. And while we could go back and forth on that one, the results of it can be seen clearly in today’s world. For example, while the US government likes to talk about how bad synthetics are, it also approved synthetic cannabinoid medications like Dronabinol, Epidiolex, and Sativex, and this in place of allowing the actual plant which has been used for thousands of years. This means, the only cannabis medications approved in the US, are synthetics.

In a great example of how far a government will go to protect pharmaceutical interests, France literally went to court with the EU over the ability to block sales and imports of naturally-occurring CBD. Of course, what the majority of reporters missed in the story, was that while France went on and on about the dangers of CBD (which it failed to back up in court), it was allowing GW Pharmaceuticals’ Epidiolex, a synthetic version of CBD, to be sold. Kind of seems like France wasn’t actually all that against CBD, huh?

At this point, there are about a million synthetic cannabinoids out. From non-naturally occurring like THC-O-Acetate, delta-10 THC, and canabidiolic acid methyl ester, to naturally occurring, like delta-8 THC, Dronabinol (THC), and Epidiolex (cannabidiol). And then, of course, there are the compounds that are generally thought of as synthetic, like Spice and K2, although these are no more or less synthetic than the pharmaceutical versions being sold to patients, and were discovered through the same lines of research. In fact, the compound that led to spice and K2, was none other than HHC, which was created in a lab in a search to find a simplified, yet working, THC compound. THC-O-Acetate was also an early street synthetic, possibly put out by the military, as the military was doing testing on this compound, and it seems to have shown up in public around that time.

legal cannabis synthetics

Some of the first non-naturally occurring cannabinoids to be synthesized were non-naturally occurring delta THCs like delta-7 THC and delta-10 THC, synthesized around the time that Adams first identified delta-9. The very first cannabis medicine to be approved in the US, was Dronabinol, under the name of Marinol, which gained FDA approval in 1985. Marinol, of course, is synthetic, meaning the very first cannabis medicine allowed in current day America, is synthetic. Clearly the US is A-okay with synthetics.

What can be expected in the future should be obvious. Use of the plant will likely not be stopped, but increasing pressure will probably be put on consumers to buy pharmaceutical products. The demonization and smear campaigns for cannabis will in all probability continue since they incite fear, and can be used to push the pharmaceutical ‘better answer’. And though this ‘better answer’ might prove to be true for people fighting ailments like cancer, for many people, nothing more than the plant would ever be necessary.

Conclusion

It might not be very well known, but the history of cannabis synthetics started at around the same time as the first major breakthrough in cannabis research. Adams and Todd led the charge in the early 40’s, identifying isolating, and synthesizing CBD and CBN, making them the first isolated cannabinoids, and the first examples of synthetic cannabis compounds.

Hi there and welcome! Thanks for joining us at CBDtesters.co, the best online location for the most relevant and up-to-date cannabis and psychedelics-related news from around the world. Stop by regularly to stay abreast of the exciting universe of legal drugs and industrial hemp, and sign up to get our newsletter, so you always know what’s going on.

DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

The post Artificial High – The History of Cannabis Synthetics appeared first on CBD Testers.

Nakkia Gold on Weed, Uplifting Youth and Rising in the Hip-Hop World

When we caught up with singer, songwriter and producer Nakkia Gold, she was chilling in her kitchen, smoking a joint and happy to talk about her newly exploding musical career.

From uplifting women and weed to rising in the star-studded ranks (all while staying focused on paying it forward to youth), we talked all things positive with Nakkia Gold. Freshly riding the waves of success from her recent release of “Justice (Get Up, Stand Up)” featuring the powerhouses of Wiz Khalifa and Bob Marley and The Wailers, here’s the conversation.

How did you first get started making music?

I fell in love with music at a very young age. I was always dancing, and when I danced, I would be singing the song instead of doing the dance, or remembering the dance because of the specific words in the songs. And I was always in church. Then, when I figured out I was able to create my own world and write my own songs, and say and do what I want, it made me fall even more deeply in love.

Who helped you along the way, and what all went into your journey of getting into music?

I grew up in South Central Los Angeles, so I got to see a lot of hip-hop and street artists really make it from nothing, just by telling their story. When I found out I was able to create my own world within music and write my story, like Nipsey Hussle, Kendrick Lamar, Snoop Dogg, like everybody from here, I wanted to do that for my community.

I kind of want to do that for my generation as well. There’s an opening for lesbian, gay women, and I want to be the face of LA and show that we can do it, too. So, just getting that confidence and assurance, and coming from where I’ve come from gave me more of a drive to do more for not just myself, but for my community.

How did you get into cannabis activism, and how does it show up in your music?

I dealt with social anxiety for a long time as a kid, so when I was introduced to cannabis, I was able to let everything go, no more stress. Now I don’t have to take medication for pain. When I feel sore after I go to the gym, I use CBD as well, so not just the THC part of it. I use the medicinal part. I use CBD bath bombs and body oil.

Also, cannabis really helps me create well; it opens up my creative space and my mind so that when I’m writing, I’m not concentrating on stress or what I’m going through in my personal life. I’m able to let it all go and really be myself and speak my truth without worrying about anything.

In terms of legalization, what changes do you hope to see, especially when it comes to people of color being incarcerated for cannabis?

I’d like people to be able to see the medical benefits, and finally just have legal use because it’s not hurting anybody. I feel like if the world would just hit a blunt sometimes, or a bowl, everybody would be cool. No one would be stressed out.

I think elderly people should be able to have a little weed sometimes if they want to. It’s not like we have deaths or people doing crazy stuff on it. I feel like everybody needs to be able to smoke up without consequences.

Do you find yourself working that, and other cannabis themes, into your music?

Oh yes, I definitely incorporate those themes. I mean, I did a song with Bob Marley and Wiz Khalifa, so how could I not? I think it’s well-branded that everywhere I go, I have a nice bag with me.

As a queer person in hip-hop, do you feel there is acceptance, or is there still a lot of work the community needs to do?

I feel like we have overcome a lot of hurdles, and I feel like there’s still a lot of teaching and a lot of learning out there for people to do as far as the people who don’t accept it. They have to understand, love is love, and we can’t fight who we love; we just can’t.

Where do you hope to see your career in five to 10 years?

In the stars, amongst those who are excelling. I want to drop a few albums; I want to go on tour. I want to do a lot of collaboration. I want to see more of people building their communities, and I want to see change in where I live. I want to help the homeless and make different foundations and organizations to help people. I want to create spaces for kids who don’t have money and benefits.

Can you tell us more about what inspired you to create those spaces for youth?

I was a teacher for a while, so I’ve seen the effect that music can have on kids in education, so that’s really, really deep in me. I’m going to create a foundation that’s like an after school program, but not one where you just give a kid a ball and let them go in the yard.

I want to incorporate and give them a trade, teach them something that they can do afterwords and carry on with their life so they can have skills that can make them money later on, whether it be music, dance, acting, plumbing or construction. I can give them a couple hours after school, and instead of sitting there just bouncing a ball, let’s do something physical.

Do you have anything in the works in terms of touring plans?

Nothing official yet, but when I tour, I want to head straight for Atlanta. I want to go to Atlanta first, and then back home and just go crazy all over again.

So you’d love to just play in those cities where hip-hop shows really pop off so that it’s a crazy time?

Yes, absolutely. That’s what it’s all about.

To stay up-to-date with Nakkia Gold, check her out on Instagram or her official website.

The post Nakkia Gold on Weed, Uplifting Youth and Rising in the Hip-Hop World appeared first on High Times.

Fakkuappu: Japan Struggles with Cannabis Reform

Every country that creates new laws for a not-to-be stopped global cannabis revolution has faced problems when trying to implement “new” regulations—and so far, the Japanese are no exception.

This year, indeed, has seen repeated flubs and embarrassing false starts that so far, have run into significant problems when it gets to the nitty gritty details. 

This begins with the fact that despite increased liberalization just about everywhere else, the Japanese appear to be going backwards in terms of cannabis reform.

Namely, as of June 11, a health ministry panel stated that (high THC) cannabis use will be criminalized (due to concerns about “young people’s ‘abuse’” of the drug). 

In the meantime, cannabis-derived medications (which are currently restricted in Japan), will be permitted, including by import.

Beyond this, however, even legal hemp farmers are not entirely out of the woods.

A History of Cannabis Reform in Japan 

The current Japanese law on cannabis was enacted right after WWII, in 1948. 

Up until this time, cannabis was a valued part of culture and religion of the country. After 1948, thanks to the American occupation, the Cannabis Control Act essentially copied American legal attitudes of the time.

It was only thanks to the direct intervention of the Emperor that the hemp industry was saved from complete extinction. Namely, the hemp industry was allowed to flourish as a permitted industry.

Sadly, however, hemp farmer numbers have steadily dwindled since the 1950s thanks to the expense of obtaining a license and, until now at least, a receding demand for natural fibres.

Beyond limited commercial production, the current law prohibits the possession and cultivation of “cannabis.” Paul McCartney, the former Beatle, was banned from entering Japan for 11 years after being busted for bringing just under eight ounces of marijuana with him on a visit in 1980. National companies like Toshiba have removed sponsorship of athletes caught with the drug.

Yet, while there is a considerable criminal penalty for both (five and seven years of working prison terms, respectively), with additional fines that can range from two to three million yen, there is no criminal punishment for its actual use.

If this were Holland, such grey areas of the law might be enough to spark a whole industry. For the Japanese, however, no such luck. Indeed, in 2018, when Canada legalized recreational use, the Japanese government issued warnings that it was still illegal for Japanese nationals living abroad to use cannabis, even if they lived in a place like Canada where recreational cannabis use became legal.

However, one of the largest reasons for this lack of clear-cut regulation is the fact that hemp in fact has been used for centuries in the country—including to make special “shimenawa” ropes for Shinto shrines. Commercial sale of CBD has been permitted in Japan since 2016.

Yet, it is not as if the stigma about use has not grown up through the weeds. Of late, this suspicion has even fallen on cultivators. Indeed, recent debate about changing the law here to criminalize use began with a discussion about farmers who cultivate and handle the plant (namely, that it is obvious that they are in a position to accidentally inhale cannabinoids as they work).

As of February of this year, the Japanese health ministry presented test results showing that cannabinoids had not ended up in said farmers’ urine. As a result, the panel decided to move forward on setting out penalties for unauthorized, non-medical use, despite objections from three of the panel’s 12 members.

Last year, in 2020, 5,273 people were involved in cannabis-related cases logged by the police and the health ministry’s Narcotics Control Department. These numbers have doubled in just the last five years. Individuals under 30 accounted for 65 percent of the total.

However, despite the current focus on prosecuting “users,” the current regulations for hemp farmers are still causing problems on the agricultural side of the equation too. 

As of September, the Ministry of Health, Labor and Welfare will release a new report setting out clearer guidelines for the hemp cultivation industry. One change will be to allow farmers to sell hemp nationally—in other words outside of their local prefecture (or state). Another will be to reduce the amount of time that surveillance camera footage is required to be stored (it is currently five years).

If this is reform, Japanese style, it leaves a lot to be desired.

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8 Reasons to Try Delta-8 THC Before it’s Too Late

Delta-8 THC’s popularity has skyrocketed, but its days appear to be numbered. Although Delta-8 THC is legal at the federal level, more and more states are banning or restricting its sale across the United States. If you can still buy Delta-8 THC where you live, we recommend trying it before it’s too late. 

Delta-8 is not just THC for those who can’t get “regular” Delta-9-THC (hereafter called “THC”). It has its own, unique benefits, including offering a happy, clear-headed high with less risk of anxiety or paranoia than THC. It offers health benefits for pain, inflammation, nausea and more. Amazingly, scientific research even shows that Delta-8 THC could help you lose weight while making you eat more! (A 50-day experiment found that mice given Delta-8 THC ate 22 percent more than usual but lost 20 percent of their original body weight.) Have we convinced you yet?!

Unfortunately, there’s a lot of sketchy Delta-8 THC online and in gas stations and shops. For the highest quality Delta-8 THC, as well as other rare cannabinoids and full-spectrum Hawaiian CBD, we recommend Rare Cannabinoid Company’s products. They were the first to create a pure THCV (tetrahydrocannabivarin) tincture and are about to launch the world’s first pure CBDV (cannabidivarin) oil. 

With Rare Cannabinoid Company’s vast apothecary (all produced in a cGMP facility and third-party lab tested), you can also mix and match Delta-8 THC with stimulating THCV for an energy and appetite suppression, combine it with CBN (cannabinol) for a dreamy night’s sleep, with CBC (cannabichromene) for depression, CBG (cannabigerol) for pain and inflammation, or CBDA (cannabidiolic acid) for nausea.

We’ll explain the eight reasons you should try Delta-8 THC before it’s too late, but first, let’s dive into what Delta-8 THC really is. 

Float away with Delta-8 THC and CBN, or try Rare Cannabinoid Company’s THCV for energy and appetite control. Photo courtesy of Rare Cannabinoid Company.

What is Delta-8 THC?

Delta-8 THC is a hemp-derived cannabinoid that is very similar to the THC found in cannabis. Delta-8 THC can promote euphoria, elation and relieve symptoms. Scroll down for scientific studies on chemotherapy-related nausea, pain, inflammation, weight control and more. 

Does Delta-8 THC get you high?

Yes, Delta-8 THC is intoxicating, with most users saying it feels about half to two-thirds as strong as THC. Many say it offers a positive, uplifting experience where they feel more in control and sociable than with THC. 

What’s the difference between Delta-8 THC and THC? 

The two cannabinoids are chemically and functionally nearly identical. They both have a double bond, but Delta-8 has it on the eighth carbon, while Delta-9 has it on the ninth. This difference slightly alters the way they affect the human endocannabinoid system (ECS). 

Is Delta-8 THC legal?

Most Delta-8 THC is derived from hemp. Thanks to the 2018 Farm Bill, hemp (cannabis containing less than 0.3 percent THC) can be grown and used for extraction across the United States. This means that Delta-8 THC is federally legal even in states where THC is illegal. However, as new legislation comes into place, this loophole could be closed. More and more states are banning Delta-8 THC due to its intoxicating properties.

Can Delta-8 THC be shipped to me?

It depends where you live. Delta-8 THC is federally legal in the United States However, some states are banning it. Brands such as Rare Cannabinoid Company offer free U.S. shipping on orders over $49. However, if your particular state has banned Delta-8 THC, it cannot be shipped to you—just like it can’t be sold in stores there. 

Can I buy Delta-8 THC in a cannabis dispensary?

Again, it depends where you live. Some states require that each dispensary grows and produces all of the products it sells. Since dispensaries normally sell THC from cannabis, it is unlikely that they would grow a field of hemp specifically for making Delta-8 THC. 

Delta-8
Enjoy the happy, mellow high of Delta-8 THC before it’s too late with Rare Cannabinoid Company’s Delta-8 THC oil tincture. Photo courtesy of Rare Cannabinoid Company.

What are the benefits of Delta-8 THC?

1. Eat more and lose weight with Delta-8 THC
Can you really eat more and lose weight with Delta-8 THC? We listed this benefit first, as it’s so extraordinary. Unlike THCV, which is known for suppressing appetite, Delta-8 THC will definitely give you the munchies. In fact, this scientific experiment found that mice who were given Delta-8 THC ate significantly more than those given THC. 

Over 50 days, the mice given Delta-8 THC ate 22 percent more than usual. However, amazingly, they lost 20 percent of their original body weight! In addition to weight loss, their activity levels and cognitive function also improved. The scientists who ran the experiment concluded that the cannabinoid could be a “therapeutic agent in the treatment of weight disorders.” 

In general, cannabis users have lower body mass indexes and are less prone to obesity than non-cannabis users, according to this research. Scientists believe this is because cannabis use speeds up metabolism, and Delta-8 THC appears to have a key role in helping people burn more calories faster. 

If you want to increase your chances of weight loss with cannabis even further, we’d recommend taking THCV. This cannabinoid decreases hunger, making it easier for people to attain a calorie deficit and lose weight faster. Buy THCV here.

2. Delta-8 THC offers a happy, controllable high.

While some seek out the strongest cannabis flower, dabs and shatter to get obliterated, many prefer a happy, more controllable, high—at least for some activities or daytime use. Delta-8 THC is intoxicating but in a mellower, more functional way, with users’ descriptions ranging from uplifting and energizing to calming and relaxing. 

This makes it easier to take it in the morning, on a long flight, at family get-togethers or other occasions where you’d like to take the edge off without being too high to talk or move. Delta-8 THC’s lower level of psychoactivity also makes it more tolerable for those using hemp/cannabis for health and wellness benefits. (Warning: Do not drive a vehicle or operate machinery while using Delta-8 THC.)

3. Delta-8 THC may lower anxiety and improve mood.

Feeling anxious or depressed? Delta-8 THC may be able to help. Compounds in hemp and cannabis can increase levels of the brain’s “bliss” chemical, anandamide. While a little THC can often improve mood, too much can do the opposite and increase mental and emotional instability. Delta-8 THC’s mellower high appears more likely to improve mood with less risk of triggering anxiety, paranoia or depression. 

Microdosing Delta-8 THC could also help one’s mental state without being as intoxicating. It may also be helpful to combine Delta-8 THC with CBC (cannabichromene) and/or CBD (cannabidiol). This is because CBC has been found to be the best non-psychoactive cannabinoid for raising anandamide and CBD positively affects dopamine and serotonin levels. See studies on CBC, CBD and THC for depression here. 

Each cannabinoid offers unique health and wellness properties. Combine them with each other or add them to Rare Cannabinoid Company’s full-spectrum Hawaiian CBD, or your favorite full- or broad-spectrum THC or CBD oil, for an enhanced entourage effect. Photo courtesy of Rare Cannabinoid Company.

4. Delta-8 THC is 200 percent more effective than THC for nausea.

Delta-8 THC appears hugely successful at reducing nausea and vomiting. This scientific experiment—”An efficient new cannabinoid antiemetic in pediatric oncology”—was carried out on child cancer patients undergoing chemotherapy to see if Delta-8 THC could prevent nausea and vomiting. Amazingly, vomiting was prevented in all 480 treatment sessions. 

The United States government also has a patent for Delta-8 THC which states that it is 200 percent more effective at treating nausea than THC. 

CBDA (cannabidiolic acid) is also well-known for reducing nausea and preventing anticipatory nausea (which occurs when people begin vomiting at the sight of a chemotherapy treatment center or place where they have experienced extreme nausea in the past.) Delta-8 THC and CBDA can be combined for even more nausea relief.

5. Best for combining with THCV or CBN

Want to recreate your favorite cannabis sativa or indica? THCV offers a stimulating boost of energy and suppresses appetite. A 1:1 combo of THCV with Delta-8 THC closely mimics the feel of Durban Poison or Doug’s Varin. Meanwhile, CBN (cannabinol) is the best cannabinoid for deep relaxation and improved sleep. A 1:1 combo of CBN and Delta-8 THC feels akin to Hindu Kush or Grandaddy Purple. 

Rare Cannabinoid Company’s 500mg purified tinctures make it extremely easy to mix and match according to your needs or desires. Delta-8 THC’s mellow high is ideal for fun and easy dosing. Buy Delta-8 THC, THCV and CBN here.

6. Delta-8 THC is helpful for pain and inflammation relief.

Cannabis patients have long reported relief from pain and inflammation and scientific studies show that Delta-8 THC may be especially useful.  This 2018 study showed that Delta-8 THC reduced corneal pain and inflammation. This separate 2020 study also found Delta-8 THC effective at reducing ocular pain and inflammation. Delta-8 THC may also be helpful for patients suffering from painful gastrointestinal (GI) problems including irritable bowel syndrome (IBS) as seen in this medical review

Rare cannabinoid CBG (cannabigerol) could also be combined with Delta-8 THC, as it is being studied for use against many diseases, as you can see in this Leafly article: “Is CBG better than CBD and THC for pain, inflammation, and aging?” 

7. Delta-8 THC may improve cognitive function.

Dementias, including Alzheimer’s disease, take a huge toll on patients and their families. Research shows that Delta-8 THC shows potential for treating these devastating illnesses. This study on mice found that even very low doses of Delta-8 THC altered neurotransmitter levels and improved cognitive function. 

This separate study found that Delta-8 THC increased acetylcholine levels (ACH) in the brain, which is important, as Alzheimer’s disease is linked to declining levels of Ach.

There is also a lot of research on CBC showing it may be helpful in the treatment of cognitive decline. 

8. Delta-8 THC may fight cancer tumors.

Scientific studies suggest that Delta-8 THC might influence the growth of cancer cells and tumors. In this study, mice who were given Delta-8 THC for 20 days showed a significant reduction in tumor size and increase in survival time. 

Many of Delta-8 THC’s benefits are interlinked. It’s mellower high makes it easier for users to take advantage of its health and wellness properties. From first-time users to those trying to take the edge off an important event, Delta-8 THC is worth giving a try. Oh, and don’t forget you might be able to eat more and lose weight too! 

Different cannabinoids each have different benefits and can be added to your THC or CBD regime to enhance particular effects. To learn more and buy Delta-8 THC you can visit Rare Cannabinoid Company. They also have a sister brand, Hawaiian Choice, which specializes in broad spectrum Hawaiian CBD tinctures infused with terpenes, topicals and edibles that are all infused with real Hawaiian fruits, essential oils or Big Island honey. After all, a real Hawaiian CBD gummy may be just what you need when Delta-8 THC gives you the munchies!

Transport yourself to paradise with products from Hawaiian Choice, Rare Cannabinoid Company’s sister brand. Photo courtesy of Rare Cannabinoid Company.

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The UK MS Society Launches #ApprovedButDenied Cannabis Campaign

A report released by the MS Society states that not nearly enough medical cannabis patients have been able to obtain medical cannabis through the National Health Service (NHS), despite research and firsthand accounts of its effectiveness as a medicine for MS patients.

The MS Society is taking a stand on the lack of progress and access to cannabis in the UK, especially since medical cannabis has been legal there for almost three years. The organization has created the #ApprovedButDenied campaign to bring attention to the lack of proper access, in addition to a 30-page report filled with data regarding MS patients in the UK.

“Sativex, a cannabis-based spray, was approved in England in 2019 for use in moderate to severe spasticity when other treatments haven’t worked,” the organization wrote on its website. “Despite this, many people with MS are still being denied access to Sativex, because their local health bodies, called Clinical Commissioning Groups (CCGs), are not prescribing it. This has resulted in an unacceptable postcode lottery, with Sativex only funded in 49 out of 106 CCGs. This must change—everyone with MS deserves access to effective treatments.” 

The organization’s report states that Sativex is only supported by 49 out of 106 CCGs. The National Institute for Health and Care Excellence (NICE) estimates that 4,800 people are currently eligible for a four-week Sativex trial to see if the medicine works for them, but only 630 people had access to Sativex in May 2021 (which is the most current data that was available at the time the report was written).

MS Society’s Policy Manager Fredi Cavander-Attwood expressed her disappointment at the lack of progress for MS patients in England. “It’s completely unacceptable that two years after receiving NICE approval, Sativex is only available in 49 out of 106 health areas in England,” Cavander-Attwood stated. “MS can be relentless, painful and disabling, and getting the treatment you need shouldn’t be a game of chance.”


#ApprovedButDenied

The #ApprovedButDenied campaign also puts a spotlight on the unfair status of the “postcode lottery” that determines which MS patients can gain access to medical cannabis. Some people are being forced to choose between living in pain or paying up to £500 per month for a prescription to Sativex (under the NHS, it costs £300). Cavander-Attwood says that often enough, patients are resorting to buying medicine on the black market.

The MS Society also interviewed a few MS patients and published their responses in the report. One patient, cited as Neil, found relief in obtaining proper sleep with Sativex.

“After starting on the Sativex, I had the first good night’s sleep in 10 years. I didn’t suffer with MS fatigue, but I hadn’t realized how much I was running on fumes due to a lack of sleep until I had some sleep. I didn’t realize how tough it was until it stopped.”

Likewise, another patient named Sheila’s symptoms lightened thanks to medical cannabis. “After Sativex, I can exercise my arms and legs with no problems,” she said. “There hasn’t been any deterioration of my MS symptoms. I no longer get any spasms. After Sativex, I can move my limbs without fear that it will set off painful spasms. I can do more, as there isn’t the fear that it will set spasms off. And I had such a lot of pain with the spasms.”

The MS Society’s report includes list of action which calls for CCGs/prescribers, the UK government, the NHS and the manufacturer of Sativex all to take positive steps forward to help the current situation for MS patients.

“Sativex is not a ‘wonder drug’—it doesn’t work for everyone with spasticity,” the organization stated. “But when it does work, the impact can be life changing. People with MS—like Neil and Sheila, who share their stories in this report—tell us their spasms and related pain have disappeared, meaning they and their families are able to live their lives, not just exist.”

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How Topical CBD Products Work, and Why You Should Use Them

Since cannabis legislation passed in Canada in 2018, an increasing number of people have begun experimenting with its non-psychoactive products. Many Canadians are now accepting the idea that cannabis is not only a means to get you high but can bring relief in a multitude of ways. Topical cannabis creams, balms, and oils are a […]

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FDA Rejects Filing of Charlotte’s Web Hemp as a Dietary Extract

FDA released a letter that questioned how safe Charlotte’s Web is, and if it should be labeled as a dietary supplement. 

The FDA letter was sent out on August 11 with an explanation regarding why it felt it was necessary to address the uncertainty of CBD products. “FDA has concluded that CBD products are excluded from the dietary supplement definition.” The letter was in response to Charlotte’s Web’s initial filing of a New Dietary Ingredient notification (NDI) that was originally submitted on March 31, 2021.

After concluding that CBD products are excluded from being listed under the definition of a dietary supplement, Cara Welch, Acting Director of the Office of Dietary Supplement Programs elaborated on the issue. “FDA has also determined that CBD was not marketed as a dietary supplement or conventional food before it was authorized for investigation as a new drug. FDA has concluded based on the record that your NDI 1202 is carefully designed to ensure consistent levels of CBD, and that it is produced from your proprietary that provide robust levels of CBD. In addition, your NDI 1202 contains a significant amount of CBD per mL and you also appear to market ‘full-spectrum hemp extract’-containing products as CBD products.”

Charlotte’s Web responded to the FDA’s letter with a public press release on August 11 that was signed by Tim Orr, Senior Vice President of Charlotte’s Web, Inc. “Today the U.S. Food & Drug Administration (FDA) published an ‘objection’ to Charlotte’s Web’s New Dietary Ingredient notification (NDI) submitted for our full spectrum hemp extract (FSHE), due largely to its drug preclusion provision. This response from the FDA indicates to Charlotte’s Web that without legislation by Congress, this market will remain unregulated.”

Orr further wrote that the company has been working with the FDA for 18 months and has provided more than enough information about their “cultivation, extraction, manufacturing, use and safety” of their proprietary FSHE. 

“The FDA letter asserts that a FSHE cannot be used in dietary supplements because it is precluded and expresses safety concerns. Regarding safety, the conclusions drawn by the FDA do not appear to be based on the data provided in our NDI application.” The company also published a document that it sent to the FDA, dated August 3, stating that they “are disappointed in, and strongly disagree with, not just the FDA’s conclusion and reasoning but in the fact that FDA’s letter contains significant factual inaccuracies.” 

Charlotte’s Web released a 48-page document addressing each and every concern that includes trade secrets and commercial, confidential information that has been redacted for the sake of the public response, with the hope to address FDA’s inaccurate concerns. This includes correcting the FDA’s claim that Charlotte’s Web did not provide data on a study that the company submitted (Dziwenka et al. 2020), which was published in the journal Toxicology Reports, among other corrections.

The situation is evidence toward the desperate need for the cannabis industry to have a reliable and solid regulatory foundation. “We have been working with FDA to develop a clear and strong regulatory framework for full spectrum hemp products that protects consumers while offering them access to these important products,” Charlotte’s Web’s statement concluded. “We will continue to do so. We are, however, puzzled about how the agency intends to move forward to develop this framework.”

Legislation has been introduced in both the House of Representatives as well as the Senate to address the need for hemp CBD as a dietary supplement, which would help address the current uncertainties that companies such as Charlotte’s Web continue to experience. “The need for a clear regulatory framework—soon—is clear and we will continue to work for that outcome.”

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MAPS Organization Granted $12.9 Million to Study Cannabis and PTSD

MAPS, The Multidisciplinary Association for Psychedelic Substances, was awarded a $12,979,050 million grant from the state of Michigan to fund a study on PTSD and cannabis on August 10.

According to Dr. Sue Sisley, President of the Scottsdale Research Institute and longtime cannabis researcher, this new study is sorely needed in the community. “Suicide among veterans is an urgent public health crisis, but it’s solvable if we invest in researching new treatments for pain, depression, and PTSD,” said Sisley in a press statement. “This grant enables more rigorous study, overseen by the FDA, which may lead to cannabis flower becoming prescribable medicine someday. Veterans are demanding objective cannabis drug development research, and the state of Michigan is fulfilling our collective obligation to our beloved Veteran community.”

The grant comes from Michigan’s 2021 Veteran Marijuana Research Grant Program, and is funded by the state’s recreational cannabis taxes. With a goal of determining the “the efficacy of marijuana in treating the medical conditions of United States armed services veterans and preventing veteran suicide.”

MAPS Makes History

This will be the second clinical trial to give cannabis medicine or placebos to participating military veterans, and according to the Chief Science Officer of the MAPS Public Benefit Corporation, Berra Yazar-Klosinki, PhD, the first trial was a great success. “We overcame significant regulatory obstacles obstructing cannabis research to conduct the first clinical trial of inhaled cannabis for PTSD,” said Yazar-Klosinki. 

“This grant funding provides the resources needed to leverage the results from the first trial, conduct a fully-powered clinical trial, and align the body of scientific evidence with cannabis that more closely mirrors what is available within state-regulated cannabis programs.” This trial will be the second of its kind to be conducted so far, and one that is an FDA- and DEA-regulated double-blind, placebo-controlled study.

The study will enlist 320 eligible veterans who have been diagnosed with either moderate or severe PTSD, and also includes those who suffer from major depressive disorder or substance abuse disorders. Four trial sites will be set up, two of which will be located in Michigan. Once participants pass a three-week enrollment period, they will be given five weeks for “self-administering inhaled, self-titrated doses of high-quality botanical cannabis.” This second trial will also use higher quality cannabis to better determine the effects of those who receive medicine versus a placebo.

The Founder and Director of MAPS, Rick Doblin, PhD, expresses the significance of this amount of money from cannabis taxes being used for research efforts. “Michiganders are granting non-profit researchers the opportunity to establish whether marijuana is helpful for Veterans with PTSD. If so, we will seek to return that generosity by developing a public-benefit cannabis pharmaceutical product that would be eligible for insurance coverage, just like any other pharmaceutical drug.”

The first trial was funded by MAPS Public Benefit Corporation (a MAPS subsidiary) which was also responsible for the only FDA-regulated controlled study for PTSD. The study was funded with $2.2 million from the Colorado Department of Public Health and Environment, and was led by the Scottsdale Research Institute. Results of this study showed evidence of the pros and cons to cannabis as a treatment for PTSD patients. According to the MAPS press release, all participating patients showed improvements in their symptoms after three weeks.

PTSD affects a large number of military veterans. According to data from the Veterans Association (VA), about 11-20 percent of veterans who served in Operations Iraqi Freedom and Enduring Freedom suffer from PTSD. Twelve percent of veterans who participated in the Gulf War are diagnosed with PTSD every year. Finally, 15 percent of veterans who served in the Vietnam war are sufferers of PTSD (but the VA also estimates that 30 percent of all Vietnam veterans will be diagnosed with PTSD in their lifetimes).

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