Which Cannabis Cannabinoids Will Survive Into the Future?

There are a ton of new cannabis products coming out all the time now, some with more relevance and staying power than others. Which will really survive this stage and go into the next? It’s hard to say. Some cannabis discoveries have caught on better than others. Which cannabinoids will survive the current industry, any new decriminalization or legalizations that might occur, and prosper into the future? This still remains to be seen.

Is delta-8 one of the cannabis cannabinoids that will make it into the future? Of all the alternate cannabinoids on the market, delta-8 is the most popular, and most likely to make it big. We’re ahead of the game with tons of delta-8 THC products and deals for you to look into. But delta-8 isn’t alone in the game, other hemp-derived THC products, such as delta-10 THCTHCVTHCO, THC-PHHC are also selling very well and might survive into the future.

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Cannabis cannabinoids

Everyone knows about delta-9 THC. This is the main psychoactive compound of the cannabis plant, and the part that makes a person feel euphoric. THC was first isolated in 1964 by Raphael Mechoulam, but it was first found by Roger Adams in the early 40’s, around the time that CBD was isolated. CBN was the first cannabinoid to be isolated, in an attempt to find the ‘intoxicating factor’ of cannabis, which it didn’t end up being. CBN was discovered by Thomas Easterfield at the end of the 1800’s.

Everyone also knows about CBD at this point, the other major cannabinoid of the cannabis plant, which is the primary cannabinoid of the low-THC hemp plants. Significantly less CBD is found in high-THC marijuana plants, and vice versa. CBD was discovered in 1940 by Roger Adams, although Alexander Todd discovered it at about the same time in the UK, making for dueling research and discoveries for several years.

The whole reason Roger Adams investigated cannabis at all, was at the behest of the US government. The US government, often through the military and CIA, has done all kinds of drug research and testing, from the Edgewood Arsenal Experiments, where THC-O-Acetate was given to military personnel, to MDMA tests during the Cold War era for use as psychological warfare. There are even various unconfirmed reports of unleashing chemicals like LSD in public places. That compounds like THC-O-Acetate and LSD were found on the streets at the time of such testing even indicates that street use might have been started by these organizations in an attempt to study the compounds further.

cannabis plant

This, of course, is supposition on my part, but in the 1940’s, the government did sponsor research into cannabis, with a main factor being the isolation of the intoxicating agent. In so doing this, and in the follow-up research when THC was isolated, several different cannabinoids were found, including other delta THC’s, like delta-8, delta-7, and delta-6, some naturally occurring, and some entirely synthetic. Other compounds were found around this time including CBL, CBC, and HHC.

Most of what has been mentioned are cannabinoids, but what exists in the actual cannabis plant, before decarboxylation, oxidation, or any other chemical process that changes the chemical structure, are phytocannabinoids. THCA and CBDA are the precursor acids to CBD and THC, and a range of other cannabinoids. These cannabinoid acids also have tons of medical benefits, but are different from their cannabinoid counterparts. THCA, for example, is not psychoactive, and does not cause the same response as its decarboxylated version, delta-9 THC.

Research into the cannabis plant has turned up tons of naturally occurring cananbinoids like delta-8 THC, THCV, CBC, CBG, and 11-hydroxy-THC, what delta-9 becomes after being ingested. There are also a range of purely synthetic compounds that can’t be found in nature. These include delta-10 THC, delta-7 THC, THC-O-Acetate, and HU 580.

How popular are these alternate cannabis cannabinoids?

This is an interesting question, and one without a formal answer, as there isn’t much data out on buying patterns for these products. This might be partly because this is an unregulated market, and a relatively new one, where that kind of information has not been collected as of yet. The best indication for establishing interest, come from individual sales statistics, mentions and conversations online, and overall population know-how about these compounds. Different researchers might turn up different opinions, since even these metrics involve personal research methods, and subjective analysis.

If a person is to blindly believe the marketing hype of an industry, delta-8 is about the biggest thing out there. But marketing campaigns are rarely real life, and looking at real metrics, (and over a period of time), is the better way of establishing where something actually fits into the grand scheme. Maybe delta-8 has raised in popularity, but if it has, will this be a passing fancy, to disappear in a year from now? And how big is this popularity to begin with?

It’s always good to remember that while it’s great to take the plant apart and find new ways to access different aspects of it, we never lose the original cannabis plant itself, which has been doing just fine keeping people happy for millennia. Whether these compounds really become stable market representatives or not, will likely do little to effect a worldwide cannabis industry that has propelled itself along, even under worldwide prohibition. This means, regardless of which currently out cannabis cannabinoids make it to the future, we’ll always have our standby.

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Sales statistics – there aren’t any

When it comes to sales, I don’t see any massive breakthrough reports about any of these compounds. Delta-8 THC gets the most press, but mainly only within the world of weed itself, and as a niche part of the cannabis market. For the most part, even delta-8 goes unnoticed in terms of sales statistics. Even in the articles where delta-8 is mentioned as a growing fad, none of them can offer any backup for this. In fact, an article like this one in Fortune Magazine, show this well. The article refers to delta-8 as the “fastest-growing segment of the market for hemp chemicals for roughly the last year.”

This makes it sound pretty big, right? But then it goes on to state that this happened only after “wholesale CBD prices plummeted amid oversupply and other issues.” This merely implies that with CBD leveling off (or possibly losing value), that delta-8 has taken its place as the top hemp chemical product. Even the comparison is weak, and shows a changing fad, from CBD to delta-8, with the inability to keep that trajectory long-term. Considering delta-8 isn’t likely to produce anything substantially new for users, the expectation of it getting to the point where it could threaten the longstanding regular cannabis industry, is sort of short-sighted.

One of the biggest indicators, which the authors of the Fortune article seemed to gloss over, is that if cannabis cannabinoids like delta-8 THC follow in the footsteps of CBD, they’re not going to make it into the future, especially if they don’t hit the same volume before leveling off. That CBD has lost momentum, is an indication that delta-8 is just a passing fancy too. 2021 numbers for CBD sales (when released) might help us understand how cannabis cannabinoids like delta-8 THC might fair in the future, better.

Mentions and conversations

Without sales statistics, one of the other ways to see how big something is, is simply in how much its mentioned and talked about. The internet is a huge place, so finding mentions of a subject is never that hard. But the questions become, how often is it mentioned, where is it mentioned, and what is being said? When it comes to delta-8 THC, the most popular of the alternate cannabis compounds, there are plenty of mentions online. Many of these mentions come from large scale publications that are non-cannabis related. Most mentions are of the fear variety, talking about the possible detriments, or mentioning new regulatory measures to keep it out. As an untaxed item with any amount of popularity, this makes sense. Delta-8 THC is undesirable for governments that can’t tax it.

But the general conversation is limited. Apart from what seem like pre-emptive fear-marketing campaigns, people aren’t talking about it all over the place. There aren’t a huge number of questions being asked, or reviews being given. Even a site like reddit, has some, but not too much. When I changed my search results to just the last month, only one reddit mention came up, and as a news article about issued warnings. A search for ‘Acapulco Gold’ turned up several mentions on Reddit just from the last month. And that says a lot. Since delta-8 proposes an issue to the government as an unregulated and untaxed product, the issues of legality and regulation are among the bigger talking points, when it does show up on-line.

Realistically, if the stuff is sitting on store shelves, at least some people are bound to buy it. Most of what’s written, however, seems like a reaction to the possibility of an out-of-control market, more than the reaction to an actually out-of-control market. This is also backed up by very few arrests being made, or government intervention beyond these articles.

cannabinoids

Do people know about it?

I find this question to be the most interesting one. It’s possible to get the wrong idea by something being seen online. It’s easy to forget how big the internet is, and how much is necessary to show real engagement with an industry or product. Marketers can fill internet pages with content that isn’t backed up by anything, and governments can put out campaigns in an effort to stop something before it starts. Neither has to indicate mass appeal, though they can be a factor in it. So, one of the best ways of assessing whether something has an influence, is to see if its actively influencing people. And this is where I see the biggest issue.

The vast majority of people have no idea what delta-8 THC is. Had I not been a writer in the cannabis industry, I probably wouldn’t know about it either. I know a lot of weed smokers, and somehow, not a single one has heard of this compound. First off, it’s only a US product that hasn’t gained popularity anywhere else, and that means we’re only looking at a US audience. On top of that, cannabis – as stated – is a stable industry, and its been there for a while. Even now it exists as bigger black markets than legal ones, which means, we already have a version we can use. It’s not like delta-8 is the answer to not being able to get any weed at all. We can all get it, and this will always be a roadblock to delta-8 sales.

Having said all this, I will point out one countering factor. Governments are making specific legislation to rule out delta-8 THC, even with other legalizations. This could indicate that sales are high enough to cause worry and necessitate these laws. But, it could also be a reactionary measure meant to stifle a possible industry, whether it would actually meet the potential indicated, or not. That it would be singled out by governments does say something for its existence, and ability for at least some popularity. However, even this doesn’t indicate that it’ll stick around.

Cannabinoids Future – Conclusion

None of this article really answers the question of what can be expected for all cannabis cannabinoids in the future. However, the most useful point comes from the fact that delta-8 seems to be following in the footsteps of CBD, which itself has been leveling off after a few years of being the golden product. If this is any indication, none of these products will last it out, not even delta-8 THC. In the end, there realistically isn’t a great reason for it. Does this mean it doesn’t have good or alternate benefits? No, it doesn’t mean that. But it’s also quite possible that the slightly lesser high and clearer head are more important  for medical patients, and might not be as desirable by those looking for a full effect. On top of that, reports of causing less anxiety have never been totally confirmed meaning it might not provide these effects the way we read about them.

Though this doesn’t mean something can’t catch on further, my best bet is that none of the newly released, bottom-feeding (let’s be honest) attempts to capture a greater part of the industry, will work. Alternate cannabis cannabinoids might be fun to try, but if they don’t provide a better answer, and if they come at a higher price, they’re likely to be dropped fast and never see the future. Luckily for us though, we’ll always have our regular weed. And if the last few years is any indication, our black markets for that aren’t going anywhere.

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DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

The post Which Cannabis Cannabinoids Will Survive Into the Future? appeared first on CBD Testers.

Best Hybrid Delta 8 THC Products – With Delta 10, THCV, CBD, CBN, or CBC

In the last few months it has been Delta 8 everywhere. From Delta 8 vape cartridges, to gummies, to tinctures, to moon-rocks and even Delta 8 hash, this new cannabinoid has become the hottest trend of 2021. Now, just in time for the summer, we are looking into the next big thing: Hybrid Delta 8 THC Products.

Hybrid Delta 8 THC products are formulas that are based on a blend of Delta 8 THC with other cannabinoids, usually, Delta 10 THC, CBN, CBD, THCV or CBC. These special formulas have been gaining popularity lately, as people find them to be very effective in reducing their suffering. Whether it is stress, sleep, anxiety or pain, the common problems people use cannabinoids to treat their symptoms, the new hybrid Delta 8 products, offer us new remedy for our suffering.

To help you find the best hybrid Delta 8 THC products we have created a short-list of products that you should try first. Some of of the products below are sold in bundles, perfect for stocking-uo opportunities as the price is very attractive that way.

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Best Hybrid Delta 8 THC Products – Summer 2021

#1 Delta 8 + Delta 10 Hybrid Products

Delta 10 THC is The latest cannabinoid to enter the market. While it is still too-early to say if it will become as popular as Delta 8, we can already see that Delta 8 + Delta 10 THC hybrid products are becoming a best-seller.

With ratio of 2:1 (60% Delta 8, 30% Delta 10 THC and 10% terpenes), these new hybrids allow you to experience the unique benefits of the new THC’s.

Choose between Delta 10 vape cartridges, Delta 10 tinctures and Delta 10 disposables.

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Want to try something new? The Delta 10 VIBIN’ Tincture is everything you ever hoped for and even more!

With 300mg Delta 10 and 700mg Delta 8 in every bottle, this best-selling product will let you experience the unique benefits of Delta 10 THC, softly blended with Delta 8, which we all know to love. If you are looking for a ‘mental euphoria‘ and wish to feel ‘happy and motivated‘ this product might be the one for you!

Size: 30ml

Strength: 1000mg/Bottle: 700mg of Delta 8 THC + 300mg Delta 10 THC

Terpenes Used: Sour diesel, Blueberry OG

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The ‘Euphoria Collection‘ Delta 10 Vape Cartridges

Experience the new high of Delta 10 THC!

The 'Euphoria Collection' Delta 10 Vape Cartridges
The ‘Euphoria Collection‘ Delta 10 Vape Cartridges

Have you ever tried Delta 10 THC vape cartridges?

Experience the benefits coming from the blend of 70% Delta 8, 20% Delta 10, and 10% cannabis terpenes. Thanks to the perfect blend of Delta 8 and Delta 10, these next generation vape carts are proven to take you to a new high

Save big on the ‘Euphoria Collection‘ Delta 10 THC vape cartridges. Use coupon code Delta25 for the additional 25% discount and get a 6 pack or 12 pack bundle for a great price. 

INSTRUCTIONS: Choose between: 6-pack and 12-pack bundle and don’t forget to use Delta25 coupon code.

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Delta 10 THC Disposable Vapes – Premium Bundle

Lightweight, Compact & Easy-to-use

Delta 10 Disposable Vape Bundle
Delta 10 Disposable Vape Bundle

Need a winning product? Take Delta 10 THC on-the-go with these lightweight, compact & easy-to-use disposables, currently on sale! With the prefect blend of Delta 8, Delta 10 THC & terpenes, the new ‘Euphoria Collection‘ disposables offer us an unforgettable vaping experience.

Each bundle includes the following carts: Blue Candy Kush (Indica), Ekto Kooler (Sativa) and Wedding Cake (Hybrid).

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Delta 8 & Delta 10 Hybrid Moon Rocks

Delta 8 & Delta 10 Hybrid Moon Rocks
Delta 8 & Delta 10 Hybrid Moon Rocks

If you are looking for the next-level experience, we have just found the right product for you!

Imaging a high-quality Delta 8 moon-rock, the one that makes you smile for hours. Now, add to it Delta 10 THC, find a good spot, and take the rest of the day off…

If you are looking for the next-level experience, we have just found the right product for you!

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Delta 8 + Delta 10 THC Hash

Hybrid Durban Poison Delta 10 & Delta 8 Hash
Hybrid Durban Poison Delta 10 & Delta 8 Hash

Some people just love hash, their pipe, or both, and for a very good reason…

The new Hybrid Durban Poison Delta 10 & Delta 8 Hash, is both high on CBD, Delta 10 THC, Delta 8 and CBN. In-fact, it is infused with the same potent D10 distillate used for the Moon-Rocks (above). The result is no-less than amazing and if you ever wanted to try Delta 8 or Delta 10 THC hash, now it’s your chance to do so!

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#2: Delta 8 + CBN Hybrid Products

Having sleep problems? You might want to try the new Delta 8 + CBN products.

As stress, anxiety and hyper-alertness disrupt our natural sleep-wake patterns, new cannabinoid-based formulas are offering us a very promising solution. While we still don’t know for sure, looks like CBN (cannabinol) might have unique benefits when treating sleep problems. Blend it with Delta 8, and you will go to sleep with a big smile on your face. Happy and relaxed…

Want to play it safe? Try mixing Delta 8, CBD and CBN. A match made in heaven…

Delta 8, CBD & CBN Tincture

D8+CBD+CBN 1500/100/500 Tincture
Delta 8, CBD & CBN Tincture

If you are looking for a powerful relaxation formula, we have found the best one for you! With three powerful cannabinoids in one convenient bottle, the new Delta 8, CBD & CBN 1500/100/500 tincture, is your best choice!

Each bottle cotains 1500mg of Delta 8 THC, 1000mg CBD and 500mg CBN for maximum effectiveness. Looking for a stronger product, look for the 2500/1000/750 or the mighty 5000/1500/1000 DB/CBD/CBN tinctures.

Choose between: CalmEnergyMintNaturalRecoveryRest flavors.

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Comfortably Numb: D8 + CBN Tincture

Beside having a great name, Comfortably Numb by 3Chi is one of the best Delta 8 tinctures available for you today.

With 1:1 ratio of Delta 8 THC and CBN this is a powerfull relaxation formula. Add to it a few drops of CBC and beta-caryophyllene dominate terpene blend for maximum effects, and you have a winning product.

Choose 1200mg for the best results.

“This product will have you feeling exactly like its name”…

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#3: Delta 8 + THCV Hybrid Products

The new cannabinoid everyone is talking about is THCV, but what exactly is it good for?

While more research is needed, we already can identify a few potential medical benefits using THCV (the statements below are NOT based on research and shouldn’t be taked as medical advise!):

Unlike regulr THC, THCV might be an appetite suppressant and may assist in reaching your weight loss goals. this is probably the most important thing we can say about THCV today.
In addition, THCV may help with treating diabetes, by regulation blood sugar levels and reducing insulin resistance (see research), THCV may reduce panic attacks, THCV may even help with Alzheimer’s and finaly, THCV may stimulates bone growth. 

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THCV + Delta 8 Vape Cartridges – BUNDLE

THCV + Delta 8 Vape Cartridges – BUNDLE

If you are looking for the perfect blend, try the new THCV + Delta 8 + CBD vape cartridges, currently on sale.

While Delta 8 THC gives a great body-buzz and relaxation, THCV is made to help give mental clarity, productivity and focus. Similar to a “super sativa“. Relief made for both your body and mind. 

Each cart use 20% THCV, 30% Delta 8 THC, 45% CBD/CBN/CBC, and 5% Terpenes.

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#4: Delta 8 + CBC Hybrid Products

Although much of the global discourse regarding cannabis is focused on THC and CBD, cannabichromene (CBC) is next in line as the third most prominent compound in the plant, and of equal importance therapeutically. 

While more resrearch is needed, initial findings suggest the CBC (like CBD and THC) might assist in suppressing tumor growth. CBC also showed some very promissing anti-depressant activity and were said to have the a significant mood-elevating properties. Lastly CBC may produce an antinociceptive response that helped control pain, minimize digestive issues, and offered neuroprotective qualities.

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Limitless Delta 8 CBC Vape Cartridge
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The Limitless Delta 8 CBC line is unlike any other Delta 8 product on the market. A potent formulation of Delta 8 and CBC that will give you an incredible entourage effect and homeostasis!

This limited edition exclusive bundle includes one of each of 6 strains below:

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OG Cookies
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Effects: Incredible relief: uplifting yet relaxing, euphoric, clear headed, focus & lucid thinking.

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Limitless Delta 8 CBC Tincture

Providing you all the relief you need

Limitless Delta 8 CBC Tincture
Limitless Delta 8 CBC Tincture

With 1200mg of Delta 8 THC and 500mg CBD, the Limitless Delta 8 CBC Tincture gives you the most incredible entourage effect providing all the relief you need. Choose it if you want a very potent product that will make your life more enjoyable.

Effects: Incredible relief: uplifting yet relaxing, euphoric, clear headed, focus & lucid thinking.

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Cannabichromene – How CBC Interacts With Our Brain’s “Bliss” Molecule to Target Depression

An average of 9.5% of American adults ages 18 and over will suffer from an ongoing depressive illness every year – that’s roughly 17 million people. For many, finding relief is a daily struggle between managing symptoms, avoiding triggers, and trying to find a treatment plan that actually works – the latter often proving to be more difficult than most would expect. The reason for that is simple: pharmaceutical antidepressants just aren’t that effective. Natural compounds that interact with existing receptors in our bodies… that is what really works, and that is what certain cannabinoids like Cannabichromene (CBC) have to offer.

Are you a cannabis aficionado who would like to learn more about cannabichromene, as will as other cannabinoids and all aspects of this incredible plant? If so, make sure to subscribe to The CBD Flowers Weekly Newsletter for the best of the best that this industry has to offer, as well as access to exclusive deals on flowers and other products. Or you can check out the Delta 8 Weekly Newsletter for the best deals on Delta 8 THC.

Wholesales: Click HERE for Delta 8 & Delta 10 THC wholesale opportunities


What is Cannabichromene (CBC)?

Although much of the global discourse regarding cannabis is focused on THC and CBD, cannabichromene (CBC) is next in line as the third most prominent compound in the plant, and of equal importance therapeutically. In most strains (both marijuana and hemp), CBC ranges from 0.3% to 0.9% of the total plant constituents. Just like other cannabinoids, CBC starts out as a plant acid – cannabichromenic acid to be specific – and eventually drops the carboxyl acid group becoming just cannabichromene.

CBC is non-psychoactive and interacts with the endocannabinoid system differently than both THC and CBD. THC binds directly with both the CB1 and CB2 receptors, and CBD interacts indirectly to these receptors via secondary pathways. CBC, however, is an agonist of only the CB2 receptors, which play a vital role in immune function, pain management, inflammation, and overall homeostasis.

Researchers have been looking at CBC for a few decades now, with studies dating back to 1981. In one of the earlier studies, the anti-inflammatory, antibacterial, and antifungal properties of CBC were put to the test. It was discovered that CBC was more powerful than phenylbutazone (an NSAID anti-inflammatory/pain medication) at controlling inflammation. It was also found to be a potent antibacterial and a moderately effective antifungal treatment as well.


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Fast forward to a 2006 study, in which numerous cannabinoids were examined to see if they could be used to shrink tumors. Among the cannabinoids tested was cannabichromene, and it scored equally well as THC and CBD at suppressing tumor growth in the animal subjects. 

And finally, in this 2010 scientific study, the anti-depressant activity of CBC and other cannabinoids was tested on mice. In one part of the study – a forced swim – CBC, CBD and Delta 9 THC all showed significant anti-depressant effects. In the second part of the study – a tail suspension test – CBC and Delta-9-THC were said to have the most significant mood-elevating properties compared to other cannabinoids as well as the pharmaceutical antidepressants they were tested against.

Additional studies over the years echoed these findings, and also found that CBC produced an antinociceptive response that helped control pain, minimize digestive issues, and offered neuroprotective qualities. As with other cannabis compounds, research on the full potential of cannabichromene is still ongoing, but it has shown potential as both a standalone treatment and working synergistically with other cannabinoids.

Anandamide and Homeostasis – The Bliss Molecule

When it comes to happiness, the majority of it is situational; but according to newer global studies, the levels of happiness one feels on a regular basis can have some genetic components as well. If you know any people that seem just naturally happier than others, it might be because they have higher levels of anandamide in their brains.

Anandamide (N-arachidonoylethanolamine) is first endocannabinoid, discovered and isolated by Lumír Hanuš (Israel) and William Devane (United States) in 1992. The name comes from the Sanskrit word “ananda,” translating to “internal bliss, joy, or delight.” Anandamide is a fatty acid neurotransmitter that activates the same receptors as THC.

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Normally, anandamide is broken down by the fatty acid amino hydrolase enzyme (FAAH), at which point it is no longer in the body and thus, no more blissful effects are felt from this compound. Some people and animals produce less FAAH enzymes, and these people report feeling overall happier, experiencing less fear and anxiety than those who produce more FAAH. In addition to mental health, anandamide has been found to positively impact fertility and inhibit the growth of breast cancer tumors.

People whose bodies break down anandamide faster, can benefit greatly from supplementing with phytocannabinoids (cannabinoids created by plants); but the key is knowing which ones most closely mimic the bliss molecule’s effects. CBC, CBD, and THC all offer positive effects, but due to CBC’s affinity for the CB2 receptor, it seems to work best for elevating mood without producing any unwanted psychoactive side effects.

CBC’s Effect on Anandamide

The only reason cannabis actually works and has an effect on us at all is because of the Endocannabinoid System (ECS), which is responsible for numerous different psychological and physiological functions. Researchers have discovered two different endocannabinoids so far, 2-arachidonoylglycerol (2-AG) and anandamide (AEA).

In addition to the naturally produced cannabinoids, there is also a large web of receptors that allow AEA and 2-AG to function the way they do. The two receptors that have been studied most extensively are CB1 and CB2. Cannabinoid receptors sit on the surface of cells and monitor conditions on the outside. Once they sense changes and the body begins falling out of a state of homeostasis, they signal the appropriate cellular response to restore balance.

When we don’t produce enough endocannabinoids to complete this cycle, our bodies become unstable and no longer perform optimally, leading to the onset of numerous different diseases and disorders. This is where supplementing with the phytocannabinoids found in cannabis becomes extremely beneficial.

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All of the cannabinoids studied have their place, but cannabichromene was shown to have the strongest antidepressant effects when compared to THC, CBD, and CBG. Because CBC has such strong effects on a group of ion channels located on the plasma membrane, known as the transient receptor potential (TRP) channels, it also has strong effects on anandamide and dopamine. When CBC turns on these receptors, increased levels of the body’s all-natural endocannabinoids like anandamide are released.

One of the greatest medicinal qualities of CBC is that, since it does not interact with the CB1 receptors like THC, it works efficiently at elevating the mood without any intoxicating, psychoactive effects.  

Dangers of Pharmaceutical Antidepressants

Depressive disorders are on the rise, they have been for years, but we’ve seen an even sharper uptick of cases since the COVID-19 pandemic began. By the age of 19, roughly 25% of adolescents have experienced a depressive or major anxious episode, and that number jumps sharply to 53% by 30 years of age. Recent studies show that a growing number of young adults are using antidepressants, which can be beneficial for the mental state but, like all medications, come with a slew of unwanted side effects.

When it comes to the exact figures of how many Americans are taking antidepressant medication on a regular basis, here are the estimates: 4% of children 6-12 years of age, 7% of adolescents 12-18 years of age, and 10-22% of adults (a number that, as explained above, increased with age).  

CBC Distillate 99%

CBC Distillate 99%
CBC Distillate 99%

Common antidepressant side effects:

  • headaches
  • dry mouth
  • blurred vision
  • digestive issues, such as stomach upset, nausea, and constipation
  • dizziness
  • drowsiness
  • trouble sleeping
  • memory problems
  • fatigue
  • weight gain
  • sexual problems such as low sex drive, erectile dysfunction, or ejaculation problems
  • trouble urinating
  • fast heart rate
  • sweating
  • increased risk of suicidal thoughts and actions (especially in users under the age of 25)

To add to the dilemma, newer research and scientific reviews have found that, on average, antidepressants in children and young adults only led to very miniscule psychological improvements when compared to placebo treatments. This was especially true for children and adolescents, who face the greatest risks from taking these medications.

Also keep in mind that physical health is often the catalyst that sets mental health conditions in motion, so it would be a bit of a catch 22 to take antidepressants for depression, and end up with some type of physical ailment that leaves you feeling anxious and depressed all over again.

Final Thoughts

Depression affects millions of people, here in the U.S. and globally. Throughout the world, one in four people suffer from mental and/or neurological disorders at some point in their lives. Wouldn’t it be amazing to have a therapeutic solution that was safe, natural, and actually worked? Cannabis science is still in its infancy but the research we do have shows that it certainly is promising, and in some studies, cannabinoids like cannabichromene performed better than prescription medication (thanks to the presence of anandamide in our endocannabinoid systems). It says a lot and really emphasizes the need for more research and better regulations, especially in the field of mental health.

Hello.. Welcome to CBDtesters.co, the #1 spot for the most relevant cannabis-related news from around the world. Give us a read-thru every day to stay abreast of the quickly-changing world of legal marijuana, and sign up to receive our newsletter, so you always know what’s going on.

The post Cannabichromene – How CBC Interacts With Our Brain’s “Bliss” Molecule to Target Depression appeared first on CBD Testers.

How a Rare Cannabinoid Interacts With Our Brain’s “Bliss” Molecule to Target Depression

An average of 9.5% of American adults ages 18 and over will suffer from an ongoing depressive illness every year – that’s roughly 17 million people. For many, finding relief is a daily struggle between managing symptoms, avoiding triggers, and trying to find a treatment plan that actually works – the latter often proving to be more difficult than most would expect. The reason for that is simple: pharmaceutical antidepressants just aren’t that effective. Natural compounds that interact with existing receptors in our bodies… that is what really works, and that is what certain cannabinoids like Cannabichromene (CBC) have to offer.

Are you a cannabis aficionado who would like to learn more about cannabichromene, as will as other cannabinoids and all aspects of this incredible plant? If so, make sure to subscribe to The CBD Flowers Weekly Newsletter for the best of the best that this industry has to offer, as well as access to exclusive deals on flowers and other products. Or you can check out the Delta 8 Weekly Newsletter for the best deals on Delta 8 THC.


What is Cannabichromene (CBC)?

Although much of the global discourse regarding cannabis is focused on THC and CBD, cannabichromene (CBC) is next in line as the third most prominent compound in the plant, and of equal importance therapeutically. In most strains (both marijuana and hemp), CBC ranges from 0.3% to 0.9% of the total plant constituents. Just like other cannabinoids, CBC starts out as a plant acid – cannabichromenic acid to be specific – and eventually drops the carboxyl acid group becoming just cannabichromene.

CBC is non-psychoactive and interacts with the endocannabinoid system differently than both THC and CBD. THC binds directly with both the CB1 and CB2 receptors, and CBD interacts indirectly to these receptors via secondary pathways. CBC, however, is an agonist of only the CB2 receptors, which play a vital role in immune function, pain management, inflammation, and overall homeostasis.

Researchers have been looking at CBC for a few decades now, with studies dating back to 1981. In one of the earlier studies, the anti-inflammatory, antibacterial, and antifungal properties of CBC were put to the test. It was discovered that CBC was more powerful than phenylbutazone (an NSAID anti-inflammatory/pain medication) at controlling inflammation. It was also found to be a potent antibacterial and a moderately effective antifungal treatment as well.


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Fast forward to a 2006 study, in which numerous cannabinoids were examined to see if they could be used to shrink tumors. Among the cannabinoids tested was cannabichromene, and it scored equally well as THC and CBD at suppressing tumor growth in the animal subjects. 

And finally, in this 2010 scientific study, the anti-depressant activity of CBC and other cannabinoids was tested on mice. In one part of the study – a forced swim – CBC, CBD and Delta 9 THC all showed significant anti-depressant effects. In the second part of the study – a tail suspension test – CBC and Delta-9-THC were said to have the most significant mood-elevating properties compared to other cannabinoids as well as the pharmaceutical antidepressants they were tested against.

Additional studies over the years echoed these findings, and also found that CBC produced an antinociceptive response that helped control pain, minimize digestive issues, and offered neuroprotective qualities. As with other cannabis compounds, research on the full potential of cannabichromene is still ongoing, but it has shown potential as both a standalone treatment and working synergistically with other cannabinoids.

Anandamide and Homeostasis – The Bliss Molecule

When it comes to happiness, the majority of it is situational; but according to newer global studies, the levels of happiness one feels on a regular basis can have some genetic components as well. If you know any people that seem just naturally happier than others, it might be because they have higher levels of anandamide in their brains.

Anandamide (N-arachidonoylethanolamine) is first endocannabinoid, discovered and isolated by Lumír Hanuš (Israel) and William Devane (United States) in 1992. The name comes from the Sanskrit word “ananda,” translating to “internal bliss, joy, or delight.” Anandamide is a fatty acid neurotransmitter that activates the same receptors as THC.

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Normally, anandamide is broken down by the fatty acid amino hydrolase enzyme (FAAH), at which point it is no longer in the body and thus, no more blissful effects are felt from this compound. Some people and animals produce less FAAH enzymes, and these people report feeling overall happier, experiencing less fear and anxiety than those who produce more FAAH. In addition to mental health, anandamide has been found to positively impact fertility and inhibit the growth of breast cancer tumors.

People whose bodies break down anandamide faster, can benefit greatly from supplementing with phytocannabinoids (cannabinoids created by plants); but the key is knowing which ones most closely mimic the bliss molecule’s effects. CBC, CBD, and THC all offer positive effects, but due to CBC’s affinity for the CB2 receptor, it seems to work best for elevating mood without producing any unwanted psychoactive side effects.

CBC’s Effect on Anandamide

The only reason cannabis actually works and has an effect on us at all is because of the Endocannabinoid System (ECS), which is responsible for numerous different psychological and physiological functions. Researchers have discovered two different endocannabinoids so far, 2-arachidonoylglycerol (2-AG) and anandamide (AEA).

In addition to the naturally produced cannabinoids, there is also a large web of receptors that allow AEA and 2-AG to function the way they do. The two receptors that have been studied most extensively are CB1 and CB2. Cannabinoid receptors sit on the surface of cells and monitor conditions on the outside. Once they sense changes and the body begins falling out of a state of homeostasis, they signal the appropriate cellular response to restore balance.

When we don’t produce enough endocannabinoids to complete this cycle, our bodies become unstable and no longer perform optimally, leading to the onset of numerous different diseases and disorders. This is where supplementing with the phytocannabinoids found in cannabis becomes extremely beneficial.

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All of the cannabinoids studied have their place, but cannabichromene was shown to have the strongest antidepressant effects when compared to THC, CBD, and CBG. Because CBC has such strong effects on a group of ion channels located on the plasma membrane, known as the transient receptor potential (TRP) channels, it also has strong effects on anandamide and dopamine. When CBC turns on these receptors, increased levels of the body’s all-natural endocannabinoids like anandamide are released.

One of the greatest medicinal qualities of CBC is that, since it does not interact with the CB1 receptors like THC, it works efficiently at elevating the mood without any intoxicating, psychoactive effects.  

Dangers of Pharmaceutical Antidepressants

Depressive disorders are on the rise, they have been for years, but we’ve seen an even sharper uptick of cases since the COVID-19 pandemic began. By the age of 19, roughly 25% of adolescents have experienced a depressive or major anxious episode, and that number jumps sharply to 53% by 30 years of age. Recent studies show that a growing number of young adults are using antidepressants, which can be beneficial for the mental state but, like all medications, come with a slew of unwanted side effects.

When it comes to the exact figures of how many Americans are taking antidepressant medication on a regular basis, here are the estimates: 4% of children 6-12 years of age, 7% of adolescents 12-18 years of age, and 10-22% of adults (a number that, as explained above, increased with age).  

CBC Distillate 99%

CBC Distillate 99%
CBC Distillate 99%

Common antidepressant side effects:

  • headaches
  • dry mouth
  • blurred vision
  • digestive issues, such as stomach upset, nausea, and constipation
  • dizziness
  • drowsiness
  • trouble sleeping
  • memory problems
  • fatigue
  • weight gain
  • sexual problems such as low sex drive, erectile dysfunction, or ejaculation problems
  • trouble urinating
  • fast heart rate
  • sweating
  • increased risk of suicidal thoughts and actions (especially in users under the age of 25)

To add to the dilemma, newer research and scientific reviews have found that, on average, antidepressants in children and young adults only led to very miniscule psychological improvements when compared to placebo treatments. This was especially true for children and adolescents, who face the greatest risks from taking these medications.

Also keep in mind that physical health is often the catalyst that sets mental health conditions in motion, so it would be a bit of a catch 22 to take antidepressants for depression, and end up with some type of physical ailment that leaves you feeling anxious and depressed all over again.

Final Thoughts

Depression affects millions of people, here in the U.S. and globally. Throughout the world, one in four people suffer from mental and/or neurological disorders at some point in their lives. Wouldn’t it be amazing to have a therapeutic solution that was safe, natural, and actually worked? Cannabis science is still in its infancy but the research we do have shows that it certainly is promising, and in some studies, cannabinoids like cannabichromene performed better than prescription medication (thanks to the presence of anandamide in our endocannabinoid systems). It says a lot and really emphasizes the need for more research and better regulations, especially in the field of mental health.

Hello.. Welcome to CBDtesters.co, the #1 spot for the most relevant cannabis-related news from around the world. Give us a read-thru every day to stay abreast of the quickly-changing world of legal marijuana, and sign up to receive our newsletter, so you always know what’s going on.

The post How a Rare Cannabinoid Interacts With Our Brain’s “Bliss” Molecule to Target Depression appeared first on CBD Testers.

Minor cannabinoids: What are they and why are they trending?

Minor cannabinoids have been getting a lot of attention lately, and for good reason. What exactly are minor cannabinoids and why have they been trending? What are minor cannabinoids? When it comes to cannabis, THC and CBD often take the spotlight. But they’re just two of at least 110 different cannabinoids found in the cannabis […]

The post Minor cannabinoids: What are they and why are they trending? appeared first on Latest Cannabis News Today – Headlines, Videos & Stocks.

Customize Your Cannabinoids – Now You Can Mix’ N’ Match

Most of what’s gone on in the field of medicinal cannabis has been related to simply isolating and/or replicating a specific cannabinoid to get its benefits. In today’s world of cannabis medicine, the new thing is for a customer to order a premium blend of their favorite compounds, because today, you can actually customize your cannabinoids.

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Isolating cannabinoids

There’s plenty in the worlds of medicinal cannabis and recreational marijuana that have nothing to do with isolating anything. If a person wants to smoke hemp flowers, or buy a few grams of high-THC weed, they’re getting the whole plant, no isolation needed. However, the fields of medical and recreational cannabis have been more and more reliant on the idea of isolated cannabinoids. CBD is the most popular right now, with CBD oil and vape cartridges flying off store shelves all over the world.

Much like with other forms of pharmaceutical medicine, where we often pop a pill without really thinking what that circular, chalky, perfectly-shaped tablet contains, where it came from, and how it got to be in the form we take it in, we don’t often question how our CBD oil came to be.

Cannabinoids don’t start out as cannabinoids, but rather as acids that must be heated – or decarboxylated – in order to form into the cannabinoids we are familiar with like THC, CBD, and even the rarer CGBV, and THCV. Solvents are then used to separate certain parts. These can include, ethanol, hydrocarbon (butane, propane…), chloroform, light petroleum, and CO2 – which doesn’t leave a residue.

personalized cannabis medications

After extraction with one of these solvents, the solution is filtered at least a couple times, generally through something like charcoal. Then it should be made more concentrated, down to about half the volume, using a 2% aqueous sodium sulfate solution. When the solvent is stripped out, and the solution is concentrated, its left as a crude oil. At this point it can even be purified further with redistillation or column chromatography.

After extraction, the oil is put in alcohol, mixed, cooled (to remove unwanted terpenes, chlorophyll and flavonoids), and then heated to burn away the alcohol. Something called short path distillation is used to isolate different compounds using their individual boiling points. A pure powder of a specific cannabinoid is left at the end which can then be used in different ways for different kinds of products. It might not be important to know all the steps of isolating a cannabinoid, but understanding it as a process is important, because this process takes time and money.

Rare cannabinoids

We’re all familiar with THC at this point, as it is the most prevalent cannabinoid of the cannabis plant (for high-THC marijuana). Most of us now know a good bit about CBD too, which also can be found in plentiful amounts, particularly in low-THC hemp.  We also know there are more than 100 cannabinoids in the cannabis plant, even if some of them appear in only trace amounts. The ability to isolate some of these rarer cannabinoids through the process above, gives users that much more choice in terms of products, and the ability to now formulate different mixtures of cannabinoids. Some rarer cannabinoids, and cannabinoid acids, that are now becoming more popular due to the ability to isolate them, are the following:

  • CBG – Cannabigerol – Comes from acidic precursor CBGA and makes up less than 1% of a cannabis plant.
  • CBN – Cannabinol – A phytocannabinoid with THC as a precursor.
  • CBC – Cannabichromene – The second most prevalent cannabinoid in cannabis.
  • CBCA – Cannabichromenic Acid – The acidic precursor to CBC.
  • CBGA – Cannabigerolic Acid – The precursor acid that transforms into acids THCA, CBDA, and CBCA, which in turn produce other cannabinoids.
  • CGBV – cannabigerivarin – A cannabinoid acid with CBG as a precursor.
  • CBNA – Cannabinolic acid – The parent compound that transforms to CBN through decarboxylation.
  • CBCV – Cannabichromevarin – Closely related to CBC, with the difference of a propyl chain.
  • CBDV – Cannabidivarin – Closely related to CBD, and mainly found in cannabis indica landrace strains, generally from Asia and Africa.
  • THCV – Tetrahydrocannabivarin – Similar to THC, and does produce a psychoactive effect.
  • CBDA – Cannabidiolic acid – The precursor to CBD that exists in acid form.
  • THCA – Tetrahydrocannabinolic acid. The precursor to THC that exists in acid form.

And many more, most of which have gotten so little attention as of yet, that there isn’t much written about them, or studies yet performed on them. Whereas major cannabinoids like THC and CBD can take up about 2-20% of a plant’s biomass, these lesser cannabinoids generally make up less than 1%.

medicinal cannabis

One of the interesting things about cannabinoids, though, is that they each have their own medicinal profile, as they are all unique compounds unto themselves. Sometimes you might want something pure, like CBD oil. Maybe other times you want the whole plant, and the synergistic effect of all parts working together. And on other occasions, you might want to mix and match the different parts and pieces available, to customize your cannabinoids to create medicines very specific to your particular wants and needs.

Mix n match

This new industry of customizing cannabinoids is only just beginning, but it does seem to be taking off. The companies that offer this service are offering a way to create custom medicines, while also introducing customers to lesser known cannabinoids, and cannabinoid acids. The idea of personalized medication is conceptually new to Western medicine. While different people are given different medications to take, in different quantities, pharmaceutical medications are not formulated with a specific person in mind, or tweaked to meet that specific person’s needs. Natural medicine traditions are much more likely to create specialized medication for patients, and this new movement towards the ability to customize your cannabinoids is a mirror of this concept. Instead of the standard ‘trial and error’ in standard medicine, where a person might be cycled through tons of different medications to find something that works specifically with their genetics, the idea is now to tweak the meds to meet the person’s needs.

Companies getting in on it

Global Cannabinoids is a Las Vegas based CBD oil company that now offers something else. CBD oil, and other private label products, that can be customized by the buyer to have an exact profile of cannabinoids – rare and not rare – to meet their needs. This is twofold in that it exposes people to more rare options than the standard CBD, while also giving a level of personalization.

Global Cannabinoids is already one of the biggest white label and private label suppliers of CBD, as well as a leading ingredient supplier for brands that use hemp-derived cannabinoids for their product lines. The company is one of the biggest suppliers for wholesale and bulk cannabinoids, even rarer ones. Customers can purchase CBN, CBC, CBG, and CBDV in the ratios of their choosing. Obviously, there are plenty more rare cannabinoids, as mentioned above, but this opens the door, and gets the ball rolling for using rare cannabinoids at all.

Another company moving in the same direction, is Socati, a company based out of Houston, Texas with a Montana-based facility for manufacturing cannabinoid ingredients, that is known for producing USDA certified organic hemp products. Now, they’re opening up their offering a bit more, just like Global Cannabinoids. Socati recently launched a line of private label products offering the ability to customize your cannabinoids. Custom ratios of CBD, CBG, CBN, and other rare cannabinoids can be made per personal desire in the following products: gummies, tinctures, crystalized flavor powder, pressed tablets, softgels, and capsules.

medicinal cannabis

Precision Plant Molecules is another company now offering a tailored cannabinoid experience. The company is a specialty cannabinoid-based ingredient supplier. It extracts and processes hemp to create distillates, oils, concentrates, extracts, and isolates. While there isn’t much press about the company’s ability to customize your cannabinoid experience, it is explained on their website. PPM uses several minor cannabinoids along with CBD, like: CBN, CBC, CBG, CBT, CBDV, THCV, CBGA, CBDA, and others. According to its website: “Fully customizable ratios of cannabinoids afford more effective health and wellness products. Enriching to achieve a specified ratio of cannabinoids smooths the variability in even Mother Nature’s most stable chemovars.” I expect we’ll be hearing more about this company in the news soon.

The same can be said for Trait, which also hasn’t quite made big news, but which now with Trait Tailored, is also offering customized cannabinoid combinations. According to its website, “Trait Tailored’sTM patent pending technology enables growers to perfectly customize the cannabinoid profiles of their hemp or cannabis strains with ground-breaking precision.” It goes on to say, “With TailoredTM, growers are able to produce strains with greater volumes of CBD, CBG, CBC and other less common cannabinoids to make more refined and desirable products for consumers.”

Conclusion

Customizable medicine is certainly a new thing for most people. As the field of medicinal cannabis grows bigger and bigger, more options are being made available that were never a part of standard Western medicine before. Now, instead of cycling through tons of meds to find the one that works, you can customize your cannabinoids to create the perfect combination for all your health needs.

Thank you for stopping by CBDtesters.co, your hub for all cannabis-related news. Stop by regularly to stay up-to-date, and sign up to our newsletter so you’re always in the loop.

Resources

What are THCV Flowers, and How Are They Different from What You’ve Been Smoking? (Why THCV flowers are unique)
Everything You Need To Know About CBD Isolate (a deep look into hemp extracts)

German Cannabis Flower Market is Ready to Explode
Delta-8 THC Contaminated Products, or Just Bad Press?

Everything You Need To Know About CBG Isolate
Newest Cannabinoid Powerhouse – CBC – What Can It Do for You?
What is DELTA 8 THC (FAQ: Great resource to learn about DELTA 8THC)

Cannabis Cosmetics: What’s Allowed, What’s Not, and Where to Find Them (What is the latest regulations in Europe and which products are allowed)
CBG Study Shows Antimicrobial Properties of Cannabis
The CBD Flowers Weekly newsletter (your top resource for all things smokable hemp flowers)
The Medical Cannabis Weekly newsletter (International medical cannabis business report)
The Legal Landscape Of CBD Hemp Flower In Europe

The Delta 8 Weekly Newsletter (All you need to know about Delta 8 thc)Regulators Go After Smokable Hemp Flower – What Does The Future Hold?
Investing in Delta 8 THC Flowers – Is It The Right Move For Your Business? (All you need to know about the latest hot trend: Delta-8 THC)

The post Customize Your Cannabinoids – Now You Can Mix’ N’ Match appeared first on CBD Testers.

The Rise of CBD Strains

In the southern Oregon town of Takilma — a longtime hippie enclave just above the California border in the foothills of the Siskiyou Mountains — one farm is focused on developing new strains of cannabis. Their mission is not to breed for maximum THC or any particularly trendy flavor expression, but to create strains with an optimal balance between CBD, THC and various terpenes to achieve tailored effects.

The farm is called East Fork Cultivars, and its CEO Mason Walker is a former journalist and editor at the Portland Business Journal who himself uses medical marijuana to control his pain from a serious neck injury in his youth.

“Our roots are in the medical approach to cannabis breeding,” Walker says. “We started selecting varieties high in CBD for therapeutic effect.”

Pineapple Tsu: 13.7% CBD / 0.5% THC

In order to create strains that can best address specific ailments, East Fork Cultivars has focused on cultivating under three broad categories. First, they’re growing out “CBD-dominant” varieties to find phenotypes that typically have less than 1 percent THC and subtle effects, including with Ringo’s Gift, Sour Tsunami and Cenarius. Second, they’re cultivating “CBD-rich” varieties have high CBD content but also around 5 percent THC, including Bubba Kush and an East Fork original strain, Pineapple Jager. Third, they’re growing “THC-dominant” varieties that are the more typically potent strains that outlaw growers long strove for, including Strawberry Satori.

With this spectrum of cannabinoid concentrations, Walker says their selections appeal to “new cannabis consumers who are curious,” but not necessarily looking to get high.

Each fall, the team at East Fork Cultivars harvests one acre of CBD-rich cannabis from its farm in Southern Oregon’s Illinois River Valley.

Through their work developing a wide range of CBD-rich phenotypes and breeding new strains, East Fork is at the forefront of the larger CBD trend, trying to ensure that the increasing crowds of cannabis consumers looking for CBD strains have more options to choose from than the handful currently on the market.

“We’re still early on in our breeding work,” Walker says. “Of our 15 top-selling varieties, three of them we bred ourselves and the other 12 are well-established varieties that someone else bred — but we expect that number to basically flip in the next two years.”

From Llamas to Cannabis

Flowers grow between the rows at East Fork Cultivars.

East Fork was started by the brothers Nathan and Aaron Howard. Aaron, now the company’s chief operations officer, moved from his native Portland to southern Oregon about 10 years ago to grow cannabis under the state’s medical program. (Oregon voted to legalize medical marijuana in 1998, the second state to do so after California.) He initially cultivated as caregiver for a third brother, Wesley, who suffered from neurofibromatosis and epilepsy.

In 2015, Aaron was among the first cultivators in the country to start growing high-CBD strains, and the following year, purchased the 9-acre property in Takilma. At the time, the property was a llama ranch, so the East Fork team inherited three llamas along with the land. The animals have since passed on, but the company’s logo is still a llama — and the laser focus on CBD has not wavered.

Bubba Kush: 13.3 % CBD / 5.9 % THC

“We supply CBD-rich cannabis to other companies who turn it into infused products,” Walker says. “We extract oils for chocolate bars, topical salves, tinctures and beverages.”

Walker says that East Fork is shying away from selling cannabis flowers to consumers, because he thinks the end of cannabis prohibition is changing the way people want to ingest the plant.

“Back during Prohibition [in the 1920s and ’30s], people wanted high-potency moonshine,” says Walker. “With cannabis prohibition, there was the same secretiveness and incentive for high-potency stuff. Now that we’re moving out of prohibition, people are demanding more types of cannabis that are more nuanced. The same way we’re consuming more wine and beer as opposed to moonshine. Nowadays, you don’t hear people say, ‘What’s your strongest stuff?’”

Breeding for CBD

In 2017, the team at East Fork Cultivars harvested 3,300 lbs of cannabis uses garden carts and bicycles.

East Fork’s most cutting-edge work is its on-site breeding program. When selecting and testing new strains, Walker says the farm is focused on creating strains with high levels of “chemical diversity.”

“The beauty of cannabis is it’s one of the most chemically complex plants on the planet,” Walker says. “We focus a lot of time and energy and money on developing the largest diversity we can, in terms of combinations of CBD and terpenes.”

He notes that the linalool terpene, which smells like lavender, is often used to reduce anxiety, while the citrus-smelling terpene limonene is said to have an energizing effect.

“Multiple terpenes have synergistic interactions with each other, creating yet new effects,” he says. “That’s what makes cannabis really fascinating.”

One of East Fork’s original strains with notable limonene content is Wesley’s Wish, named for Wesley Howard, who found the strain gave him relief from his neurofibromatosis and epilepsy before he passed away last year. It is a cross between Pineapple Tsu and Purple Hindu Kush, which Walker describes as “one of the most popular THC-heavy strains in Oregon.” But while Purple Hindu Kush is typically more than 20 percent THC, Wesley’s Wish is only some 5 percent THC and 15 percent CBD.

Wesley’s Wish: 12.7% CBD / 4.5% THC

Another emphasis of East Fork’s breeding program is to broaden the genetic pool of high-CBD strains, especially given the problem that high-CBD strains generally have smaller yields than high-THC strains.

“There’s not a lot of genetics available that are both high-CBD and high-yield, so we’re making them ourselves,” says Walker. “We’ve had a couple of hits — varieties that are high-CBD but also high-yield, and are promising in terms of appearance and other standards cannabis is generally judged by.”

East Fork has sourced their high-CBD genetics over the past five years from California, Oregon and Europe. The farm is currently expanding their genetic library by sourcing high-THC plants from Oregon growers and collaborating on breeding projects with other farms in the adult-use system, splitting the seeds at the end of the project.

ACDC: 17.9% CBD / 0.5% THC

Walker says East Fork is headed in the direction of growing entirely from seed rather than clone. This year, their ratio is about 50/50.

“Plants grown from seed have more vigor, more pest-resistance,” Walker says. “A lot of people call them a truer expression of the plant.”

East Fork is also bred with an eye on cannabinoids besides CBD and THC. Walker mentions tetrahydrocannabivarin (THCV), which is believed to have appetite-suppressing qualities. He also names cannabichromene (CBC), which has shown potential to inhibit tumor growth, and cannabigerol (CBG), which research suggests may help with vision problems such as glaucoma and intraocular pressure.

Business in the Gray Zone

Under Oregon cannabis regulations, the largest licensed cannabis grow can only cultivate up to 40,000 square feet of canopy, which is an area of just under 1 acre.

In Takilma, East Fork Cultivars has reached that 40,000 square feet canopy limit on a section of their original 9-acre plot of land. On the new 24 acres, Walker says they’re planning to grow hemp.

East Fork Cultivars Co-Founder and COO Aaron Haward prepares a cannabis bouquet, combining a fresh cannabis cola with dried straw flowers.

While CBD can also be extracted from hemp, this plant — legally defined as having less than 0.3 percent THC — falls under a different legal classification than cannabis. The cannabis strains grown on the original plot are overseen by the Oregon Liquor and Cannabis Commission, but the hemp plants on the new land will be overseen by the Oregon Department of Agriculture.

The cannabis farm is grown in a fenced-in area with a security camera system, as mandated by state law.

“The state figures the best way to keep feds at bay is to regulate the heck out of the industry,” Walker says.

The Rise of CBD Strains

Canna Tsu: 10.6% CBD / 3.3% THC

But the gray area of difference between the cannabis and hemp regulations on the federal and state levels is clearly not interfering with business. Walker says the farm brought in $830,000 in revenue last year, and is expecting $1.2 million this year.

“We sold just over 1,200 pounds of cannabis last year, and we’re on pace to sell 3,400 pounds this year—nearly triple,” he says. “About 98 percent of our sales are high-CBD strains.”

“We’re just barely starting to scratch the surface of interest in CBD,” he says. “It is having a fad moment, but I think it will have more staying power than the acai berry, for instance. I think our research over the next years will uncover extensive uses both therapeutically and in terms of just enhancing peoples’ lives.”

TELL US, what is your favorite CBD strain?

Originally published in the print edition of Cannabis Now. LEARN MORE

The post The Rise of CBD Strains appeared first on Cannabis Now.

Federal and provincial agencies continue to stick up for Canadian LPs

In the most recent example of a close relationship between government agencies and cannabis companies, CBC reported Thursday that New Brunswick’s health department had in fact coordinated with Moncton, NB, LP Organigram (TSX:OGI)(NASDAQ:OGI) following a 2019 outbreak of legionnaire’s disease – an outbreak that was pinpointed to “cooling towers on the roof of a section […]

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Fighting cancer with cannabinoids

Cannabics Pharmeceuticals (OTCQB: CNBX) has conducted research focusing on the effect of certain cannabinoids fighting against cancer. The company, which pursues personalized cannabis-based medicines, found promising effects with two cannabinoids, CBC (Cannabichromene) and CBG (Cannabigerol.) When testing these cannabis compounds at their High Throughput Screening (HTS) facility in Israel, they found them to display anti-tumor […]

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Newest Cannabinoid Powerhouse – CBC – What Can It Do for You?

The ever-increasing cannabinoid family has new members coming in every day, and there’s reason to be excited as new research comes out about CBC.

In the last couple of years, CBD (cannabidiol) – a cannabis cannabinoid, has risen to prominence as an effective treatment for many suffering from medical issues like insomnia, anxiety, pain, depression, seizures, high blood sugars, pathogenic diseases, ADHD etc., and a possible answer to many other issues that still require more research like: different forms of cancer, neurodegenerative diseases, and even prion diseases. It seems like every day a new breakthrough is coming out about the use of CBD as a treatment.

It’s easy to forget that CBD, along with THC (Tetrahydrocannabinol) – the main cannabinoid of cannabis plants – are just two of the possibly hundreds of cannabinoids that are present in cannabis plants. In fact, by now, well over 100 cannabinoids have been identified, and each one – though sometimes only appearing in extremely small concentrations – has its own medicinal benefits. One of these lesser known cannabinoids that is starting to make it into the mainstream is CBC, or Cannabichromene.

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What is CBC?

Cannabichromene, which also goes by the names cannabichrome, pentylcannabichromene, cannabinochromene, and cannanbichromene is a phytocannabinoid that is structurally similar to other cannabinoids like THC, CBD and CBN, and the second most prevalent cannabinoid in cannabis.

Much like other cannabinoids, CBC does not actually start out as CBC, but rather as cannabichromenic acid, and is produced over time through decarboxylation. CBC is non-psychoactive, and interacts with the endocannabinoid system differently than both THC and CBD in that it only poorly binds to the CB1 and CB2 receptors in the brain.

In 2019, a study was done looking into the often misunderstood mechanisms of action of CBC, which found that CBC acts as a selective CB2 receptor agonist. As of yet it has not undergone scheduling by the Convention on Psychotropic Substances meaning it is legal to use as of now.

What does the research say about CBC?

The isolation of new cannabinoids means all new
avenues of medical research to go down. The studies on CBC, in fact, go back as
far as a 1981 study that tested the anti-inflammatory, antibacterial, and
antifungal properties of CBC in rats. According to the research, CBC showed anti-inflammatory
effects superior to phenylbutazone,
an NSAID anti-inflammatory/pain medication. It also showed to be a strong antibacterial
agent and a mild to moderate antifungal.

Then, in a 2006, study into the anti-tumor effects of cannabidiol, cannabigerol, cannabichromene, cannabidiol acid and THC acid, it was found that while CBD had a more expected effect on the inhibition of certain tumor growth in rats, the other cannabinoids tested, including CBC, did as well, leading investigators to point in the direction of further testing of cannabinoids for cancer treatment.

$2 Million Going To Cannabis Cancer Research Led By Professor Mechoulam

In 2010 there was a study investigating how CBD and CBC effect activity of the descending pathway of antinociception in anesthetized rats. It was found that both cannabinoids produce an antinociceptive response by interacting with various targets involved in pain control. A less complicated way of saying this is that both CBD and CBC were found to help alleviate pain caused by nerve damage by the ability to block the detection of pain by sensory neuron cells.

It was looked at again in 2012 as an inhibitor of
inflammation induced hyper motility in rats. The investigators were looking at
CBC as a way to control, or inhibit, the overactive digestive tracts in rats
that was caused as a result of inflammation. The results showed a positive correlation between CBC and the normalization of
intestinal motility.

In the 2013 study, The effect of cannabichromene on adult neural stem/progenitor cells, three different phytocannabinoids were looked at in reference to adult neural stem progenitor cells in rats. These cells are similar to stem cells, but more specified, and play a large role in brain function and overall pathology, making them very important. CBC was found to have a positive effect when looking at the viability of adult neural stem progenitor cells in vitro, indicating neural protective qualities.

An interesting systematic review from 2017 investigated the use of cannabinoids including CBC for the treatment of several different pathogenic diseases. The conclusion was important in that though it showed the use of cannabinoids and the elicitation of the endocannabinoid system to be useful in treating many issues, it also pointed to the idea that simply making the assumption that cannabinoids can help with all issues related to a problem, is quite insufficient.

‘This review was able to point to incidences in research where the application of cannabinoids and the elicitation of the endocannabinoid system was not beneficial, and possibly harmful. While this does not in any way undo, or take away from, the possible positive benefits, it does act as a reminder that it’s important to do thorough investigations that do, indeed, look at everything, and to remember that medications – whether plant-based or pharmaceutical – are often specific to a particular problem, and often times cannot be generalized past that.

CBC
shows similar properties to other cannabinoids in its anti-inflammatory, pain
management, neuroprotectant, pathogenic disease fighting, anti-tumor, and
stomach settling properties. Much like CBD and THC, the research into this
compound is ongoing, with new applications coming out all the time. CBC has
been shown in studies to both work alone as a standalone treatment, and in
conjunction with other cannabinoids.

Cannabichromene and the Entourage Effect

Cannabinoids effect us therapeutically by interacting with the CB receptors in our bodies.

While CBD, and cannabis in general, have risen to mainstream medicine, they are different than standard pharmaceuticals because they fall into the category of plant-based medicine. When dealing with plant-based medicine it is often preferable to take just one part of a plant – for example, a cannabinoid like CBC – isolate it, and magnify it for its specific medicinal properties.

This can often be beneficial when a particular property of a plant has been found to treat a precise ailment. Sometimes that’s the best answer. Sometimes it’s not. When dealing with plant-based medicine, the entourage effect can be a powerful force. When looking up the entourage effect online these days, you’re likely to only see articles about cannabis, when in reality this idea is relevant to all plant medicine.

Plants are complicated structures made up of different substances. These substances can provide benefit on their own, or combine with other substances within to create an even more powerful response, we call this the entourage effect, but what it really is, is a full plant effect. Instead of focusing on one isolated part of the plant, it focuses on the combination of parts and the added benefit that these combinations can bring.

When dealing with cannabinoids like CBC, CBD, CBN, THC, etc., the idea of what they can do in concert is often more appealing than what they can accomplish in isolated form. In this 2019 systematic review, researchers took a look at years of research into cannabinoid isolation versus a cannabinoid entourage effect, and the many different applications of both.

They found when reviewing this research that often times the entourage effect far exceeds the effects of a single compound. In this review are examples of cannabis applications for microbial diseases, cancer treatments, anti-inflammatory treatments, anticonvulsant properties, and so on.

CBC Products

CBC
has yet to gain the overall popularity of THC or CBD. As medical research
continues to uncover useful benefits, more products and flowers are sure to
make it to the marketplace. As of right now, CBC can be found in hemp capsules
from different retailers, as an isolate, in oils, and in hemp flowers.

One of
the more well-known high-CBC flower strains is Three Kings: a sativa dominant
hybrid mixing Headband, OG Kush, and Sour Diesel. It has bright green flowers
with tons of trichomes, and an earthy taste of pine and citrus when smoked or
vaped.

Be sure to search for the newest CBC products on the market. We’ll be sure to hook you up with the best new products as they emerge, while keeping you updated on all groundbreaking CBC news.

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