Cannabinoid Blends and the Future of Cannabis Wellness 

We have reached a turning point in the cannabis industry, where, as consumers, we now have more choices than we know what to do with. When I was younger, shopping for weed consisted of calling one of the 3 or 4 dealers in my area and picking up whatever flower strain was available from whoever had the best product or lowest price, or a combination of the two. Now, whether you live in a legal state or not, you have options – from classic flowers, to vape products, edibles, topicals, and so much more.  

Obviously, legal markets are rife with product variety, but even in prohibition states you can check out smoke shops, gas stations, or online retailers and find a myriad of alternative cannabinoids, some intoxicating and some not, some safe and some sketchy. The more popular are products containing blends of three or more different cannabinoid compounds; for example, vape carts with delta 8 THC, delta 10 THC, and CBN.  

According to recent surveys, nearly half of all cannabis consumers prefer to use products that contain more than one cannabinoid, and that number is expected to grow. Knowing what we know about the entourage effect and how different plant compounds work together synergistically to provide the highest level of benefits, it’s no surprise that people are excited to try new combinations. But how exactly do these blends work? What are the best combinations? And what different effects can you expect to experience?    

Cannabis science has come a really long way since the initial discovery of individual cannabinoids back in the 1940s. To this day we continue to uncover new and exciting things about this incredible plant. Remember to subscribe to The THC Weekly Newsletter all the latest news and industry stories, as well as exclusive deals on flowers, vapes, edibles, and other products. Also save big on Delta 8Delta 9 THCDelta-10 THCTHCOTHCVTHCP & HHC products by checking out our “Best-of” lists!

What is the entourage effect? 

First noted in 1998 by Professors Raphael Mechoulam and Shimon Ben-Shabat, the entourage effect is a mechanism by which plant compounds work together, often resulting in more noticeable effects compared to when compounds are used individually. With cannabis, the entourage effect refers to the way different cannabinoids, terpenes, and flavonoids offer the best health benefits and psychoactive effects when combined, and only when consuming the entire plant in its natural state. 

It has been attributed to the way the combination of compounds increases the activity of CB receptors one and two. Because these receptors are found throughout the entire body, the human endocannabinoid system plays a critical role in modulating many different physiological functions such as immune response, sleep/wake cycles, appetite, communication between cells, mental health, and more.   

In 2001, two highly notable researchers Ethan Russo (MD, is a board-certified neurologist, psychopharmacology researcher, and author) and John McPartland (DO, MS, University of Vermont, Department of Family Medicine), published a paper titled “Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts.” This research paper revisits the claims of Mechoulam and Ben-Shabat regarding how cannabinoids act with other cannabinoids, as well as their interactions with secondary compounds such as terpenes and flavonoids.  

Their research found supporting evidence that “extracts rich in both cannabinoids and terpenes increased pharmacological activities that strengthened and broadened clinical applications and improved the therapeutic index.” Simply put, the effects all-around are better when these compounds are allowed to do what they do naturally and work together. 

How many cannabinoids and terpenes are there? 

There are 113 cannabinoids and over 150 terpenes in cannabis. Russo explains in this detailed study how every single part of the plant matters, from more dominant cannabinoids to even the trace terpenes. Each compound in the plant has a specific role and they all influence each others’ modes of operation when consumed together. For reference, let’s quickly cover what each of these compounds are. 

  • Cannabinoids: Naturally occurring compounds, such as THC (tetrahydrocannabinol), CBD (cannabidiol), CBN (cannabinol), etc., that interact with the endocannabinoid system in mammals. 
  • Terpenes: A diverse group of organic compounds found in most plants that give them their specific fragrances. 
  • Flavonoids: These are important antioxidants that give plants their pigments and attract pollinator animals. In cannabis they’re referred to as cannaflavins. 

For example, the terpene myrcene can help diminish resistance in the blood-brain barrier which allows other cannabinoids to access the central nervous system with more ease. Linalool and limonene, two terpenes commonly found in citrus fruits, show promise in managing symptoms of MRSA (Methicillin-resistant Staphylococcus aureus) when combined with CBG (cannabigerol). The study covers many more instances of how all these chemicals work together to the patient’s advantage. 

More about terpenes 

Terpenes are compounds found in most plants that produce their aromas and flavors. For example, they give lemon its powerful citrus scent, and they are the reason cinnamon smells so crisp and spicy. Terpenes are also abundant in cannabis, which is it has such a distinct smell with varying undertones. Lesser known is that terpenes are not just a factor in flavor, they also contribute to the effects we feel when we use cannabis. There’s a heavy focus on cannabinoids in consumer products, but if it wasn’t for terpenes, cannabis would not get us as high the way it does, nor would we experience all the numerous health benefits the plant is known for. 

Terpenes are a very large and diverse class of organic compounds that are produced by a wide variety of plants including herbs, trees, flowers, and fruit. In cannabis, they are secreted by the same glands that produce some of the most prominent cannabinoids including THC and CBD; but their role and effects are vastly different. Terpenes are aromatic plant oils that, when combined with other plant compounds, create a limitless palate of scents and flavors. In nature, terps serve as a defense mechanism by deterring herbivores who are turned away by the smells, and by attracting predators and parasites that attack herbivores. 

Chemically, terpenes are hydrocarbons and they are the major component of rosin, a waxy type of sap that is produced and developed throughout the life cycle of the cannabis plant. There are curing processes that can improve the final quality and content of the terpenes, but other factors that impact their development are climate, weather, age and maturation, fertilizers, soil type, and light cycles. 

As far as cannabis goes, terpenes – not classification (sativa/indica) – are the key to differentiating between effects and flavors of a strain. Some terpenes are relaxing, like those found in lavender, while others are energizing, like the terps abundant in citrus fruit. Some smell fruity, some are piney, and others are musky. The possible variations are endless. So far, over 100 different terpenes have been discovered in cannabis plants alone, and each strain typically has its own unique blend and composition. 

Terpenes have long been known to hold great therapeutic value, and some of the more common ones – like limonene, pinene, and caryophyllene – have been studied more extensively since they’re found in many different types of legal plants. More research is needed to determine the extent of their medicinal effects when combined with other cannabis plant compounds. 

Common combinations  

There are a few different ways that you can utilize cannabinoid blends. First, you could buy products that are premixed with different ratios of various compounds. These products are not hard to find, but regulation of alternative cannabinoids is sketchy at best and non-existent at worst, so some people are choosing to mix compounds at home and formulate their own oil, vape liquids, edible products, and more.  

Honestly the latter is not a process I’m personally familiar with. However, there are a handful of retailers, like Rare Cannabinoid Company, that offer single minor cannabinoid extracts as well as how-to guides to help consumers mix their own oils. Below are some popular combinations, all using some type of broad-spectrum oil as a base.  

  • Energy / Appetite suppression: THCV + 3000mg CBD 
  • Relaxation / Sleep: CBN +  Delta-8 THC + Terpenes  
  • Post-exercise / Relief blend: CBG +  CBDV + Terpenes  
  • For low mood: CBC + THCV + Delta-8-THC  
  • For nausea: CBDA + Delta-8 THC + CBDV  
  • For focus: THCV + Delta-8 THC  

Final thoughts on cannabinoid blends

It’s a well-established fact that, in most cases, cannabinoid and terpene blends work better individual compounds. That’s not to say that isolated cannabinoids serve no purpose, because they do, especially in a clinical setting where precise dosing can be extremely important. But for overall wellness, and recreational aims, mixing cannabinoids or simply using raw flowers and live resin extracts with a combination of compounds is enough to boost your high and provide many therapeutic benefits.

Hello and welcome! Thanks for stopping by, your #1 web source for cannabis and psychedelics-related news, offering the most interesting stories of today. Join us frequently to stay on-top of the quickly-moving world of legal drugs and industrial hemp, and remember to check out The THC Weekly Newsletterto ensure you’re never late on getting a story.

Disclaimer: Hi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advice, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

The post Cannabinoid Blends and the Future of Cannabis Wellness  appeared first on CBD Testers.

Cannabis Wellness Holiday Gift Guide

Cannabis is the single best ingredient to integrate into your daily self-care routine. Looking for a tincture that actually provides results? Maybe a little DIY lotion and bath salts spa treatment is more your jam, or a sleep aid that will actually help you get much needed rest. High Times picked out some of the best wellness items to improve day-to-day life for either yourself or someone you’re gifting to this holiday.

Photo Courtesy of Rare Cannabinoid Company

Rare Cannabinoid Company’s Pure THCV, CBN, CBG, CBD Gummies

Experience the world’s first pure high potency THCV, CBN, CBG and CBD gummies this holiday season. Based on Rare Cannabinoid Company’s apothecary concept, you can mix and match them with each other or the brand’s pure Delta-8-THC oil for an enhanced high.

THCV boosts energy and suppresses appetite, CBN will make you sleepy, and CBG is good for pain and inflammation. Gummies Variety Bundles make the perfect stocking stuffers and let you try all of the gummies! Each packet contains: one 25mg THCV gummy, one 30mg CBN gummy, one 30mg CBG gummy, and three 30mg CBD gummies. They are sold in bundles of 3 packets for $59.85. You’ll receive one FREE Gummies Variety Packet with any $50 purchase through New Year’s Eve! Rare Cannabinoid Company also sells gummies by the bottle and tinctures of pure Delta-8-THC, THCV, CBDV, CBDA, CBC, CBG, CBN, extra strength 3000mg CBD, terpene-only oils, and 1:1 blends with full spectrum Rare Hawaiian CBD. Buy gummies and rare cannabinoids here.

Price: $59-$109

Photo Courtesy of Flora CBD

Flora CBD—CBDips

Kick off your New Year resolutions to quit tobacco with Flora’s CBDips. Our signature CBD dip is made with non-GMO full-spectrum hemp flower for a healthier, tobacco-free dip alternative. Each can of our dip contains long cut CBD-rich flowers, providing users with a convenient and fast-acting consumption method. Available in a variety of naturally-derived flavors, including Southern Peach and Bourbon, our non-tobacco dip delivers all the natural benefits of CBD while stimulating all your senses. Also, you can buy CBDIP Bundle which includes packs with different flavors. Visit to learn more.

Price: $11.99

Photo Courtesy of Sagely Naturals

Sagely Naturals Rewind & Renew CBD Face Cream

Sagely Naturals’ Rewind & Renew CBD Face Cream is what everyone needs to have in their daily skincare routine. It contains a nutrient-rich formula with ingredients such as CBD with Hyaluronic Acid (100mg), Vitamin C and peptides to nourish your skin and keep it looking healthy. Sagely Naturals also other facial products in their Rewind & Renew line, including an eye cream and face serum, alongside a host of other CBD products focused on Relief & Recovery, Calm & Centered and Drift & Dream.

Price: $34.99

Photo Courtesy of Fleur Marché

Fleur Marché Wellness Patches

The best part about transdermal patches are that you can simply apply them directly to the skin and completely forget that they’re there. Fleur Marché wellness patches are loaded with great benefits in four different CBD offerings: “Energy, Plz” (with B12), “Sex, Plz” (with L-Arginine, Maca and Tribulus), “Sleep, Plz” (with melatonin) and “Relief, Plz” (with peppermint oil). Each patch contains 20mg hemp CBD per serving, and it lasts for up to 12 hours. Plus they’re the perfect size for a stocking stuffer too.

Price: $6

Photo Courtesy of Spruce

Spruce CBD Salve

Founded in 2018 and based in North Carolina, Spruce’s unique nature-packaging honors nature in a beautiful way, but its products are even more impressive. The company’s CBD salve is strong, containing 1,000mg full spectrum CBD in an 0.87 ounce jar, and is perfect for those seeking a potent topical with natural ingredients such as olive oil, shea butter, beeswax and coconut MCT oil.

Price: $89

Photo Courtesy of Vertly

Vertly Bath Salts

Few gifts are as refreshing as a high-quality bath salt to use in a much needed bath. With the addition of hemp extracts grown in Colorado to reduce inflammation and tension in the body, Vertly’s Bath Salts are the way to go. This particular mixture contains arnica flower, Epsom salts, dead sea salts, magnesium, MSM, lavender and clary sage to work a variety of wonders in the realm of soreness, exfoliation and circulation.

Price: $24-$65

Photo Courtesy of Sunday Scaries

Sunday Scaries Big Spoon CBD Sleep Oil

Let’s face it—we ALL get the Sunday Scaries from time to time, if not on a weekly basis. Combat that stress and anxiety with a good night of sleep using Sunday Scaries’ Big Spoon CBD Sleep Oil. With its 750mg of CBD and CBN, and added vanilla cream scent, it will have you experiencing the Zzz’s in no time. All it takes is ½ of a dropper to calm your thoughts about work in the morning and lull yourself into a comfortable sleep for the night.

Price: $59

Photo Courtesy of Quim

Quim Smooth Operator

Sexual wellness isn’t something to be overlooked in a world that’s embracing daily self-care rituals. Quim is one of the strongest proponents for healthy sex lives for everyone: “A self-care line for humans with vaginas and humans without vaginas who love vaginas™” they write in huge lettering on their website. That being said, their products are highly praised for their effectiveness, such as the brand’s Smooth Operator™, which contains CBD and a variety of other herbal ingredients that promote blood flow, pelvic relaxation and a reduction in inflammation and pain.

Price: $49

Photo Courtesy of Mana Artisan Botanics

Mana Artisan Botanics Hawaiian Hemp Massage Oil

It’s always refreshing to find a brand that isn’t just focused on sales, but also the sustainability of their product production, as well as conscious of their environmental footprint and the well being of their customers. Hawaii-based Mana Artisan Botanics embraces all of this and more, with a variety of hemp products. One that might be ideal for a gift this year is their Hawaiian Hemp Massage Oil, which combines coconut MCT oil with organic hemp and vitamin E for a truly relaxing experience.

Price: $80

Photo Courtesy of Moon Mother

Moon Mother Cinnamon Tincture

It’s ideal to have a full spectrum CBD tincture on hand at all times, such as like Moon Mother’s Cinnamon Tincture. Infused with hemp grown in Colorado and the highest quality cinnamon flavor, this delightful tincture is the perfect stocking stuffer in the amounts of 500mg, 1,000mg, 1,500mg or 2,500mg, depending on your personal needs.

Price: $50-$180

The post Cannabis Wellness Holiday Gift Guide appeared first on High Times.