When it comes to learning about the specific effects of a compound, especially a new cannabinoid, most people want cold, hard, science. Concrete facts they can point to. However, due to decades of illogical overregulation, that isn’t always possible in the cannabis world. Take Delta 10 THC, a brand new, synthetic cannabinoid that is already hitting the market, despite how little we know about it. In this case, the only information we have to work with is anecdotal evidence… so in other words, what do the people have to say about Delta 10 THC and how it impacts their minds and bodies?
Like many cannabis trends before it, Delta 10 THC started in the Golden State: California. In this case, however, the discovery was purely accidental. It all began when Adelanto-based company Fusion Farms bought some outdoor flower to manufacture concentrates. Because of the wildfire-prone climate in California, the biomass they purchased had been sprayed with fire retardant, but this was unbeknownst to Fusion Farms as they were under the impression the flower they purchased was clean.
Being unaware of the contamination, they continued with the extraction as planned but a different chemical reaction happened this time and some unusual crystals began to form after the distillation process. These crystals had a completely different structure than previously observed cannabinoid crystals. After conducting some laboratory tests, it was determined that these crystals were most similar to CBC (cannabichromene), but still not an exact match.
For several months, they continued testing this compound against all the existing cannabinoids and no match was found. Eventually, they learned that it was yet another variation of tetrahydrocannabinol, formed because of plant exposure to those fire retardants – dubbed Delta 10 THC. So basically, Delta Ten is a synthetic cannabinoid, formed by converting D9 or other cannabinoids using some type of chemical catalyst. In this case, it was fire retardant, but obviously that’s not something people want in their cannabis products, so companies are looking at various – greener – methods of creating Delta 10 THC.
In chemistry, “Delta” refers to the double bond in a compound’s molecular structure. Delta compounds have more electrons and interact with the body in different ways than single bond cannabinoids do. The variation between the Delta THC analogues comes down to where the double bond is located on their chain of carbon atoms. Delta 8 has this bond on the 8th carbon chain, D9 on the 9th chain, and Delta 10 THC has the double bond on the 10th carbon chain. Although it seems miniscule, it makes a substantial difference.
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Like many of us, my go-to site for public opinions is Reddit. In this case, it was actually the ONLY site that I was able to find anything at all. For the most part, I was just finding a lot of questions; everyone wondering who had tried it and how it feels. A few different sites have reported that it feels similar to Delta 8 THC, but milder. I honestly couldn’t say because I haven’t had the opportunity to try it yet (although that will change in about a week, so stay tuned for product reviews).
On Reddit user gave a very detailed description of their experiences with D10 . “So, I recently had the privilege of receiving some distillate that was supposedly high in Delta-10 THC. This cannabinoid is very novel. I can report that the effects are pretty desirable, on its own it seems that it acts in a similar way to D8 compared to D9, with milder effects, but the effects themselves are totally different.”
He continued: “So far I’ve gotten some strong Sativa like feelings off of it, and it seems to be strong, because this material isn’t even THAT high in D10a, and it’s still yielding these results. In combination with other cannabinoids, I’ve noticed that it seems to amplify the effects greatly. I took a hit of D10a immediately followed by a d9 dab, and I felt a noticeable difference in how fast and strong it hit me. I’m not sure what’s going on there. I still need to test oral consumption (I’ll be making gel caps soon).”
Other people – and this situation seems to ring truer – are experiencing shipping and customer service issues and are still waiting to try it for themselves. Take this reddit user who stated: “They ran into supply issues and had to refund my order, they said once they have complaint samples I’ll be getting one for free to try. It’s been a couple of months but I know how this stuff goes, I’m still holding out that they’ll ship me some. I’ve been in recent contact with them.”
Why It Matters
As delta-9 THC is illegal, D10 gives a bit of a loophole to acquire the medical benefits of THC, but legally, and without as much of the jitteriness, paranoia, or overall anxiety that is often experienced with marijuana. This is great news for those who want the therapeutic benefits without as much of a high, as well as for those who are sensitive to THC, and prefer a formulation that gives them the benefits of the psychoactive effects without the negatives of anxiety.
As of now, products are difficult to find because not a lot of companies are manufacturing D10. Because of this, not a lot of people are very familiar with D10 which makes communicating through these online forums that much more important. Through our newsletter, you can purchase vape carts that utilize a blend of Delta 8 and CBN, enriched with Delta 10 distillate. Lab tests put them at roughly 16% D8, 7% CBN, and 57% Delta 10. Subscribe to The Delta 8 Weekly Newsletter for more information on products and access to exclusive deals.
Cannabis edibles are trending big time. Not only do they offer many advantages that smoking simply does not, such as added discretion and no carcinogens, but for most users, they also provide a much more potent and long-lasting high. Unfortunately for some people, edibles just don’t work… at all.
This can leave a consumer with many questions. Are the edibles bad or is there anther reason why they’re ineffective? Can someone be immune to cannabis edibles? Surprisingly, yes, this is possible; and it relates to the complex way in which our bodies absorb and metabolize cannabinoids.
Are you a cannabis aficionado who would like to learn more this incredible plant, as well as gain access to exclusive deals on flowers and other products? If so, make sure to subscribe to The CBD Flowers Weekly Newsletter for the best of the best that this industry has to offer.
The difference between edibles and other consumption methods
Let’s start with the basics… why do cannabis edibles affect our bodies so differently than smoking or vaping? Just like anything else that goes through our digestive systems, cannabis edibles need to metabolize before the effects can be felt. It’s not an instant sensation like the aforementioned alternatives would be and it can take anywhere from 30 minutes to 2 hours to kick in, but the effects last much longer.
Food and supplements need to be processed by the liver, meaning more of the cannabinoid will be filtered out of your system because of the slower absorption time. There are also some individual factors that impact the onset and intensity of the effects, such as the specific cannabinoid consumed or a person’s metabolism.
Take THC for example; whether you’re consuming Delta 8 or Delta 9, the body processes all tetrahydrocannabinols the same, by converting them to a metabolite known as 11-hydroxy-THC. This process is known as first-pass metabolism. According to neuroscientist and medical cannabis adviser, Dr. Adie Rae, “The liver is responsible for this transformation, and specifically, the drug-metabolizing enzyme known as cytochrome P2C9 or CYP2C9. Even when you smoke, your liver still sees some delta-9 and turns it into 11-hydroxy-THC, but you get way more 11-OH when you eat cannabis.”
When it comes to other cannabinoids, they also produced metabolites as well. Most abundant are hydroxylated 7-COOH metabolites, which are derivatives of CBD/cannabidiol. Like THC, CBD has first-pass effects in the liver. However, our bodies absorb these metabolites differently, and unlike THC, a large portion of CBD is excreted unchanged in the feces. So in other words, when you consumes a CBD edible, a significant portion of the active cannabinoid is going straight to your bowels, waiting to be wasted.
You will still feel the effects of CBD even orally, but it will take a while longer and won’t be anywhere near as noticeable as the effects from a THC edibles, psychotropic activity notwithstanding. However, the effects you do feel will last much longer than if you had inhaled the CBD, and that rings true with any orally administered cannabinoid.
There are numerous benefits to choosing edibles over smokeables. First and foremost is the impact on your health. When you smoke – anything, cannabis included – you’re exposing your body to carcinogens and other harmful chemicals. Another reason people might choose edibles is because of the long-lasting effects. If you’re using cannabis to manage a chronic condition like ongoing pain, anxiety, etc., it makes more sense to eat an edible a few times a day as opposed to finding somewhere that you can smoke or vape every hour or two. They’re also more discreet, making them easier to travel with and use on the go or in the workplace.
Are some people immune to cannabis edibles?
Technically, yes. Because edibles can be so discreet, potent, and beneficial, many people find themselves seriously disappointment when they take some and realize they don’t work for them. Obviously there is no exact number on this, but even in my personal life I’ve met quite a few people who say they don’t feel anything when they use edibles, myself included.
Ok, to be fair, I wouldn’t say I don’t feel anything… but I definitely don’t experience any type of psychoactive effects. When I use edibles, I feel really tired and nothing more. Estimates indicate that anywhere from 10-15% of cannabis user do NOT experience the desired effects from cannabis edibles, and we can thank our intricate and complicated digestive systems for that.
Research shows that the effectiveness of cannabinoids administered orally can vary based on numerous different factors. Generally speaking, when people are unable to process cannabis edibles it can be narrowed down to one of two complications: digestion/absorption issues or metabolic issues.
Sometimes, using cannabis for Gastrointestinal disorders can be a bit of a catch 22. On one hand, cannabis can be extremely helpful for someone suffering from these conditions; on the other hand, GI issues can often have a negative impact on how the body digests and absorbs cannabinoids. If a person is unable to absorb fats and nutrients, it’s highly likely that they will not be able to absorb cannabinoids either.
Disorders that can affect how your body absorbs and digests cannabis include: Fat malabsorption syndrome, Irritable bowel disease, Irritable bowel syndrome, gallbladder removal surgery, Lipase deficiency, Pancreatic issues, Issues with bile production, Cystic fibrosis, Chronic diarrhea, or history of other GI surgery.
Additionally, several medications are known to affect digestion and absorption as well. Just think about how many medicines you’ve come across in life that list “gas, bloating, constipation, diarrhea, nausea, etc.,” as possible side effects. This applies to both pharmaceuticals and over-the-counter medications.
Another possible scenario is that metabolic issues are hindering your body’s ability to process cannabinoids. When using edibles, the cannabinoids are metabolized in the liver before being dispersed into your bloodstream. To be fully processed, the cannabinoids must pass through the incredibly complex CYP450 metabolic pathway, in which metabolic enzymes are produced to help our bodies further utilize certain compounds.
If a person’s body produces too little or too many CYP enzymes, they won’t be able to properly metabolize cannabis products. Some will metabolize them too quickly or too slowly so they won’t be able to properly take effect, others won’t metabolize them at all.
There are many conditions that can affect metabolic enzyme production. According to research from Prof of Pot, one of the reasons could be genetic. “There is a very strong genetic component that influences cannabis metabolism. These genetic components are the reason each individual responds to cannabis so differently. Some people are considered rapid cannabis metabolizers, while others are ultra-slow metabolizers. How your body processes cannabis could be genetic.”
Other elements that could work against your metabolism include age, muscle mass, diet and medications, age, hormone function and production, level of physical activity, and environmental factors such as temperature.
Could it be something else?
The good news is, aside from the above health conditions, there are some simple issues that could be preventing you from experiencing cannabis edibles to their fullest. One of the most obvious being that the dosage is too low, in which case, just find products with a higher concentration of cannabinoids and if that’s not possible, simply eat a few extra.
Assuming you’ve already taken that into account, then you can consider another common issue – maybe you’re using the wrong type of edible. All edibles are made with different strains, meaning they have a different blend of terpenes, minor cannabinoids and other compounds. If you’ve been trying mostly the same types of products to no avail, it might be time to start looking at some different brands and really learning more about the specific ingredients in each edible you’re trying.
And finally, another common issue I hear about is people trying to take edibles on an empty stomach. This is something I typically run into with recreational users rather than medical ones. It’s a commonly held belief that if you’re drinking to get drunk, the quickest way to achieve that is by drinking on an empty stomach, and many people apply the same principal to cannabis.
However, when it comes to edibles, it doesn’t work quite the same way. Yes, the cannabinoids will be processed faster if you take your edible on an empty stomach, but that’s not necessarily a good thing. Again, with cannabis edibles, absorption time and metabolism are everything. If your body metabolizes cannabinoids too quickly, you won’t get the desired effects. Try eating a nice meal, drink some water, and think of the edibles as an ultra-relaxing dessert.
For some people, edibles simply don’t work no matter what they do. Just like certain types of conventional medications don’t work for everyone – for example, I don’t do well with antibiotics – cannabis edibles don’t work for everyone either. Some patients claim to benefit from dietary supplements (Lipase specifically), or by making sure to accompany their edibles with an additional fat.
If nothing helps, you might want to try a sublingual tincture, nasal spray, or vaping. You could also try speaking to your local dispensary workers or even check out a cannabis helpline to see what options might be more suitable for you.
Whether you’re a cannabis newbie, a longtime stoner, or calling yourself a cannaseur, you should be familiar with the term dry haul. If you don’t, then now is the time to get familiar with dry hauling as it allows you to taste your cannabis’ terpenes completely. So, let’s look into practicing the dry haul and […]
Whenever a new cannabis trend emerges, we tend to get the same reactions every time: excitement from consumers and industry stakeholders, followed by a wave of legislation trying to regulate or prohibit the new product. Typically, by the time a product gets on the radar of the general public, it’s already on its way to becoming illegal.
Why ban the new Delta 10 THC? It happened with many cannabinoids and products already, most recently, Delta 8 THC. Despite the fact that it falls under a legislative loophole that makes it federally legal, technically; many states have completely outlawed its production and sale. And you might be inclined to assume that it’s only the most restrictive states taking these steps, but then you would be completely wrong. For example, some legal states including Colorado and Arizona don’t allow the possession or distribution of any products containing Delta 8 THC.
But we’re not here to talk about D8, today we’re discussing how this same exact dilemma is unfolding in the small but fast-growing Delta 10 THC market – which states are trying to ban this new cannabinoid?
Following in the footsteps of many cannabis trends prior, Delta 10 THC was first noted in California, although in this case, the discovery was purely accidental. It all began when an Adelanto-based company called Fusion Farms bought some outdoor flower to manufacture concentrates. Because of the wildfire-prone climate in California, the biomass they purchased had been sprayed with fire retardant, although Fusion Farms believed the flower they were getting was pure.
Being unaware of the contamination, they continued with the extraction as planned but some unusual crystals began to form after the distillation process. These crystals had a completely different structure than previously observed cannabinoid crystals. After conducting some laboratory tests, it was determined that these crystals were most similar to CBC (cannabichromene), but still not an exact match. For several months, they continued testing this structure against all the known cannabinoids and no match was found.
Eventually, they found out that it was yet another variation of tetrahydrocannabinol, formed because of plant exposure to those fire retardants – dubbed Delta 10 THC. So basically, D10 is an artificial cannabinoid, formed by converting D9 or other cannabinoids using some type of chemical catalyst. In this case, it was fire retardant, but obviously that’s not something people want in their cannabis products, so companies are looking at various – greener – methods of creating Delta 10 THC.
In chemistry, “Delta” refers to the double bond in a compound’s molecular structure. Delta compounds have more electrons and interact with the body in different ways than single bond cannabinoids do. The variation between the Delta THC analogues comes down to where the double bond is located on their chain of carbon atoms. Delta 8 has this bond on the 8th carbon chain, Delta 9 on the 9th chain, and Delta 10 THC has the double bond on the 10th carbon chain. Although it seems miniscule, it makes a substantial difference.
Although all tetrahydrocannabinols are supposed to be on the FDA’s list of Schedule 1 narcotics, some of them remain permissible on technicalities. In short, if the THC (regardless of which Delta) was extracted from legal hemp, or chemically converted from CBD or another legal cannabinoid, then the THC itself is LEGAL.
Since everything regarding Delta 10 THC specifically is a bit new, let’s once more take a look at Delta 8 for reference. Last year there was some controversy and confusion about whether Delta 8 would be added to the DEA’s list of controlled substances. Many in the industry believed it would be prohibited under the DEA’s Interim Final Ruling over “synthetically-derived” cannabinoids but, fortunately, this turned out not to be the case.
Although a few changes were made, the final result was this: if the end Delta 8 product is derived from hemp and has less than 0.3% Delta 9 THC, then it’s legal. The DEA does include Delta 8 THC on its list of controlled substances which was just updated in August 2020. But since the 2018 Farm Bill expressly exempts “tetrahydrocannabinols in hemp”, this means that any form of THC derived from hemp that falls within the already established limits will remain legal.
So yes, Delta 10 THC is federally legal… however, states can override federal laws if they choose to. It happens all the time with industries like alcohol, tobacco, and gambling. So, while Delta 10 may be federally legal, some states governments are already taking steps to ban the new THC.
What states are working on bans?
The Alabama Senate Judiciary Committee recently approved a measure that would prohibit Delta 8 THC and Delta 10 THC, along with Delta 9 which is already illegal. The original intent of this bill was to regulate a new synthetic opioid, Tianeptine, by adding it to the state’s controlled substances list. The bill was amended by Republican Senator Arthur Orr who added the sections about THC at the very last minute.
The Alabama Cannabis Industry Association starkly criticized the proposal in a blog post: “It’s premature to outlaw these potentially beneficial treatments for very serious conditions until research has been done. What we do know is that there have been no deaths attributed to delta-8-thc and cannabis is generally safer than even some over-the-counter medications. The Alabama Senate has the opportunity to regulate delta-8-thc and delta-10-thc in The Compassion Act so it is controlled but still accessible to people who will benefit from it in reducing suffering and improve quality of life.”
In North Dakota, not only did the Senate quickly shut down a bill that proposed legalizing cannabis, but a new bill that would outright ban the manufacture, sale and possession of ALL tetrahydrocannabinols (specifically Delta 8, 9, and 10) is quickly gaining traction. The governor has 10 days to sign the bill which would then go into effect immediately. If it passes (and it’s expected to), anyone found buying or selling products containing any type of THC could face criminal charges.
Final thoughts – Delta 10 ban
It’s hard to say what exactly will happen with Delta 10 THC on a national scale. So far, these are the only two states that I’ve heard of that are actively trying to ban Delta 10. It seems like a lot of wasted time and effort, considering anything with Delta 10 THC is difficult to find as it is, and all cannabis products will inevitably become legal in the very near future anyway (or at least we hope).
For now, the best thing you can do is stay up to date on your local news and laws, and make sure to stock up on your favorite products if you start hearing talk of new legislation.
Thank you for stopping by CBD TESTERS, your hub for all things cannabis-related. Don’t forget to subscribe to The Delta 8 Weekly Newsletter for more articles and exclusive deals on flowers and other products!
As the cannabis industry expands, it also gets more technologically advanced. Within the last few years, a new trend has started which will change how we use cannabis for consumption, especially on the medical front. With nanotechnology, cannabis products can be made to fit a precise diagnosis, and delivered to the exact point necessary.
Nanotechnology might be all the rage when it comes to newer cannabis delivery methods, but when it comes to all the rage in newer products, its all about delta-8 THC. If you still haven’t experienced delta-8, and how it gives a less-anxiety-producing, and clear-headed highcompared to delta-9, now is a great time to take advantage of our delta-8 THCdeals, and give it a shot.
What is nanotechnology?
Nanotechnology is a branch of technology that involves manipulating particles on an atomic level, with sizes under 100 nanometers. Which – to give a frame of reference – is about 1000 times the thinness of a piece of paper. Nanotechnology is similar to nanoscience, which attacks the same topic, but from the physics side. The two topics are very much intertwined.
In physics, different fields investigate how masses of different sizes behave. Astrophysics examines the nature of how large objects behave, whereas particle physics – on the other end – investigates how the very smallest of particles behave. And particles of these two different extreme sets, behave in their own strange ways. In terms of nanotechnology, particles often conduct electricity better, offer more strength, different reactivity to chemicals, and magnetic abilities.
One of the abilities of nanotechnology, is the ability to force together liquids that would ordinarily not go together: think oil and water. This is an emulsion. When done on particles of bigger sizes, it’s called macroemulsion or microemulsion. When it happens to particles at the size of 20-200 nm, it’s called nanoemulsion. Mico and macroemulsions are used in food products, and chemical industries like for pesticides. Nanoemulsions are newer, and used primarily in pharmaceuticals, cosmetics, and by biotech companies.
Nanotechnology and medicine application
This process of putting together unlike substances – emulsions, allows for non-water soluble medications to be absorbed by human beings. The process of taking two immiscible liquids and turning them into one liquid, is done with an emulsifying agent like a surfactant (substance that reduces surface tension). By being absorbed into the bloodstream at a very quick rate, nanoparticles can deliver medication more quickly and effectively. Nanoemulsions are also created to increase the effectiveness of medications at their point of interaction.
Nanoparticles can be used as diagnostic tools, to mask the taste of oily liquids, to protect drugs from hydrolysis and oxidation, and to deliver medicine in a targeted fashion. They can also lengthen the time frame of a medication, and increase bioavailability. On top of all this, they can deliver stem cells, create heat, be metallic, or even be radioactive.
To give an idea of what it means to have a targeted drug delivery system, consider that with nanoparticles, instead of a drug being ingested, digested, and then put into the bloodstream where it effects the entire body, the medication can be delivered straight to the necessary site, bypassing the rest of the body. If there are infected cells, nanoparticles can attack them directly, without hurting healthy cells around. Think about how any time you take an antibiotic, it kills all the good bacteria in your stomach and digestive tract leading to all kinds of problems with reflux and superinfections. With targeted applications, these negative effects wouldn’t necessarily have to exist.
How insanely specific can these delivery systems be made? Well, researchers at MIT just created a cancer drug by combining two nanoparticles. The drug, with these two nanoparticles working in conjunction, does two things. It can both target the cancer cells in patients, and deliver a treatment to the infected cells. That’s a pretty cool one-two punch.
Nanotechnology and cannabis
We know that nanoparticles are made by essentially smashing two liquids that don’t actually mix, into one liquid. We know that this is accomplished using a surfactant, or surface tension lessening agent. And we know that once employed, a nanoparticle can provide a couple different services in disease fighting, like the ability to locate a specific site, and the ability to deliver medications to that site. On the website ‘Neurology of Cannabis’, Dr. Daniel Stein published the article Cannabis & Nanotechnology in 2020, which addresses the growing field of nanotechnology and cannabis applications.
Says Stein, when it comes to cannabis, there are several diseases like cancer, Parkinson’s, diabetes, multiple sclerosis, and intense inflammation that are already being looked at in regards to cannabis nanotechnology. Since cannabinoids can be stored within nanoparticles, and delivered to a specific and targeted site, cannabis medicines can be stored, protected, and then delivered for a controlled release without degrading. Nanotechnology can even detect and locate diseases by the first few damaged cells, and deliver a cannabinoid to modify the cell’s behavior before more damage can occur.
One thought is that if a nanoparticle can identify and focus on a specific cannabinoid receptor right when a disease is first starting to grow, it might be able to pull a 180degree turn, and keep the entire inflammatory process at bay. Other researchers are working on nanoparticles of a ‘superclass’ which would have the ability to treat illnesses across a much broader spectrum. Future research into the use of nanotechnology and cannabis will focus on making the physical particles stronger, increasing the bioavailability, and improving on routes of administration via pills, injections, or sublingual drops, according to Stein.
Future versions of nanotechnology might include ways to maximize absorption and minimize side effects to create the most potent products possible. Considering all the different varieties of cannabis, with all their specific properties, companies can use nanotechnology to offer custom-made therapeutic products. General benefits could also be enhanced through bioengineering to create a more effective version of nearly anything.
Nanotechnology and the blood brain barrier
The blood brain barrier is a barrier that exists around the brain, and which keeps particles from being able to penetrate into the brain. Drugs that cause a person to feel different mentally, have crossed the barrier. In fact, the barrier can be thought of as a bouncer that keeps unwanted molecules out of the brain.
So when it comes to taking medications for anything that would effect the brain, like antidepressants, or for treatment of nervous system disorders like Parkinson’s or multiple sclerosis, it’s important to get active compounds into the brain. In answer to this, researchers are currently working to engineer lipid nanocapsules that will contain cannabinoids, that will be able to get through the blood brain barrier, and deliver treatment to areas of the brain.
Nanotechnology and cannabis edibles
Cannabis edibles are becoming more widely used these days with tons of options for food and drink-related products. However, edibles are tricky in that its hard to define how a specific person will absorb them, and how quickly they will actually start working. The company Sunderstorm started manufacturing Kanha Nanotech Gummies, which CEO of the company Cameron Clarke says should kick in within 15 minutes. At the very least this dissuades people from taking a second dose too early, and possibly overdosing on THC.
It seems there is already quite a building competition between brands in the ‘nanotechnology for cannabis edibles’ department. Back in 2019, as Trait Biosciences – a Toronto-based cannabis company, introduced its own product line developed from technology which transforms fat-based cannabinoids to water-soluble ones, it warned consumers against the very technology it was employing, if it was coming from another company.
Yup, as the company put out its nanotechnology line of cannabis products, it warned consumers “Nanoparticles can permeate into many different types of tissues and you can’t really control that.” And that comes from Dr. Richard Sayre, the Chief Scientific Officer for Trait.
This, of course, doesn’t make what Sayre is saying untrue, in fact, its quite the opposite. He essentially pointed out possible faults in his own company’s products by pointing this out, as well as mentioning his general concern over the use of emulsifying agents like surfactants, and their ability to accumulate in a human system.
There are also other questions which can’t be accounted for yet, like whether nanoparticles can pass from a mother to her unborn child, and if nanoparticles can accumulate in different parts of the body, like the heart, liver, or lungs. Says Dr. Anubhav Pratap Singh, University of B.C.’s Faculty of Land and Food Systems assistant professor, people should know about risks associated with nanotechnology ingestion, especially when the particle size goes under 100 nm.
Companies that sell nanotechnology cannabis products
There are already plenty of companies using nanotechnology to produce cannabis products. Sunderstorm and Trait have already been mentioned, but there are lots more. One such company to be aware of is Geyser Brands, which reportedly closed a deal with Chinese HMI – Hanma Investment Group, which is China’s biggest hemp conglomerate, and a major global technology innovator. Geyser is a cannabis company that develops health and wellness products. They create CBD and hemp-based preparations for conditions like anxiety, pain, and insomnia, using patented nanotechnology delivery systems to allow for slow release.
When it comes to companies specifically in the CBD field which are using nanotechnology, there’s Pressure BioSciences, Inc, a technology company specializing technology solutions, consumables, and, pressure-based instruments. In 2020, it was reported that Pressure signed a deal with Can B Corp for a CBD oil processing system to create a water-soluble nanoparticle solution.
There’s also CBDLiving, which according to COO Sean McDonald, helps with the problem of bioavailability in edibles. Edibles are known to have a low bioavailability. Sometimes only 4-20%, according to McDonald, is actually taken up by the body. He stated, “By nanosizing the protein down to a molecular level, the protein is more easily absorbed into the body, thus increasing the bioavailability to 90 to 100 percent.”
Another is EmbarkNano, formerly Axiomm Technologies, which is coming in from a slightly different direction. Instead of producing a nanoparticle product directly, EmbarkNano produces a precursor to a nanoparticle, in the form of a micro goo, called µGOO. This special goo makes it easy to create nano products, and in that sense acts as a general base for product manufacturing. µGOO is available to other companies, and can help keep R&D budgets in check by offering this service. Companies can then use the goo to build their own individual products. Like a white-label starter kit for nano cannabis products.
A 5-second internet search will tell you that the field of nanotechnology for cannabis use is competitive and growing. By this time next year, there will likely be at least a hundred products out using nanotechnology for cannabis delivery, or other purposes. It should be kept in mind that nanoparticles are like little rebels, doing what they please, and often in an unpredictable way. So perhaps before we get too comfortable in this new nano-sized world, we should make sure that it’s safe, and not doing harm as it gets us our meds.
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Disclaimer: Hi, I’m a researcher and writer. I’m not a medical professional, I have no formal legal education, and I’ve never been to business school. All information in my articles is sourced from other places, which are always referenced, and all opinions stated are mine, and are made clear to be mine. I am not giving anyone advise of any kind, in any capacity. I am more than happy to discuss topics, but should someone have a further question or concern, they should seek guidance from a professional in the relevant field for more information.
For many people, the idea of smoking cannabis and exercising, are not things that go together. However, as cannabis becomes more popular for its medical benefits, how it can be useful for physical activities is becoming more clear. While it might not be beneficial to consume any kind of cannabis prior to exerting oneself physically, something like delta-8 THC and athletics might just be a great combination.
Are you an athlete who is interested in seeing if delta-8 THC can help with your athletic performance? We have some great delta-8 THC deals to get you started. Even if you’re not an athlete, take advantage of our deals to get some of the best delta-8 THC products currently on the market!
Before getting into why delta-8 THC might be good for athletics, let’s take a look at exactly what this compound is we’re talking about. It’s not delta-9 THC, but it’s also not far off. Delta-8 THC is a naturally occurring derivative of delta-9. When delta-9 THC oxidizes upon contact with oxygen, it loses electrons, and the compound changes. The change can be seen specifically in where the double carbon bond occurs. In delta-9 THC, it occurs on the 9th carbon atom in the chain, for delta-8 THC, it happens on the 8th.
It seems this one minor difference, actually causes quite an impact. Delta-8 THC and delta-9 THC have many of the same medical benefits, including help with nausea and vomiting, particularly related to cancer and AIDS treatment cases, as well as appetite stimulation. They both have antimicrobial properties, benefit disorders like epilepsy, and have shown strength in dealing with neurodegenerative diseases.
However, they have important differences as well. Delta-8 THC is known to produce less psychoactive effect, and to cause less anxiety, panic, and paranoia behaviors. Users have reported a more energetic high than associated with most forms of delta-9, and a more clearheaded high, which might help indicate why delta-8 THC is possibly beneficial for athletics.
Is delta-8 legal?
The question of delta-8 legality is its own mess, with no clean-up just yet. The whole reason delta-8 became widely known, is because of the 2018 US Farm Bill which legalized hemp, and products derived from hemp for different purposes. Now, since delta-8 THC can be sourced from any delta-9 THC, it doesn’t matter if it comes from high-THC marijuana plants, or low-THC hemp plants. So, if it’s sourced from low-THC hemp plants, it falls into a legal loophole. THC might be schedule I, but products derived from hemp, are not.
To attempt to clear it up, the DEA issued an Interim Final Rule, which was meant to shed further light on the topic. It didn’t really do that at all, making it even more complicated. The Interim Final Rule states that THC and all synthetic derivatives are still federally illegal, regardless of sourcing. However, delta-8 THC does not require being made in a lab, as it is naturally occurring, and this would leave it as an exception to this rule. On the other hand, since it occurs at such a low rate, it is often produced in a lab in order to speed up the process and attain a greater amount of the compound. Some might see this process as producing a synthetic. And so, delta-8 THC remains in gray area, with no further explanation or definition that would help explain legality.
And though it hasn’t yet spread that much outside of the US, delta-8 THC businesses are flourishing within the US, with little – if anything – being done to stop them. In fact, the best the government could recently do, was institute a vape ban, in the form of a tobacco vaping ban which affects all tobacco and cannabis vape products, as cannabis falls under the category of tobacco products according to the Tobacco Control Act of 2009. The ban – Preventing Online Sales of E-Cigarettes to Children Act, isn’t a ban at all, as nothing was outlawed including buying, selling, or producing the products.
It’s actually just a set of more intense-than-necessary regulations that make the shipping of such products so legally complicated, that the cost of shipping them goes up exponentially. The US government is using this premise to keep USPS from making vape shipments, and UPS, FedEx, and DHL opted in, as a way to not have to deal with the complicated legal and taxation issues. None of this pushes any kind of illegalization measure for products like delta-8 THC, however, it merely works as a barrier from obtaining certain products. Luckily, with cannabis, there are other ways to gain its benefits without vaping…or smoking.
Delta-8 THC and athletics
One of the things about delta-8, which separates it from delta-9, is the clarity of mind. Regular marijuana is not usually known to help a person focus harder, although there is a large range when looking at indicas and sativas. So, consider that even compared to a sativa, which is less likely to make a person tired and spacey, delta-8 THC is reported to produce more clarity of mind and focus overall, as well as helping some athletes enjoy intense exercise more.
It’s not a subject that has been specifically medically investigated, so there aren’t a bunch of reviews to substantiate anything. However, there are ways to hear personal experiences. I don’t consider Reddit – for example – to be the beacon of truth in life, but it is a good source when looking for answers to questions or basic opinions or experiences. And this does exist for delta-8 THC and working out, or athletics in general. Here you can see people directly answering the question of how it is to work out with delta-8. If you’ll notice, the grand majority point to a good experience, can say how it helped them, and yet didn’t sound to be made more-than-human in the process.
Cannabis and athletics
One important thing to know about delta-8 THC and cannabis in general when it comes to athletics, is that as of 2004, cannabis was added to the list of prohibited substances for sports competitions by the World Anti-Doping Agency (WADA – established 1999), the group set up to police what substances can and cannot be used in official sporting competitions. The World Anti-Doping Code lists three criteria in order for a drug to be banned from competitive sports.
If it can enhance performance
If it poses a risk to the athlete’s health
If it violates the spirit of sport
I haven’t found much to give meaning to that last measure. To me it sounds like one of those blanket statements that can be molded to fit any cause…in this case, banning cannabis from sporting competitions. If you’re wondering what the ‘spirit of sport’ means, I was too. According to WADA:
“The spirit of sport is the celebration of the human spirit, body and mind, and is reflected in values we find in and through sport, including Ethics, fairplay and honesty; health; excellence in performance; character and education; fun and joy; teamwork; dedication and commitment; respect for rules and laws; respect for self and other Participants; courage; community and solidarity.”
Breaking it down
The only thing I can pull out of this that might apply to cannabis, is the ‘respect for rules and laws’ part, since if its used where illegal, this would constitute breaking a law…I guess. But in that same vein, any athlete with an unpaid parking ticket is just as guilty. Yet somehow, unpaid parking tickets have never been the reason for exemption from major sporting competitions, so perhaps the logic isn’t so great on this one.
When it comes to the 2nd provision, there are some things to consider, and the main one is that when this was put together, vaping wasn’t a thing, and neither was cannabis oil, or patches, or any other method of ingestion. At least, not outside of a laboratory. So the only ways to consume it, were to smoke it, or to use it as an edible, with the former being the much more popular and widely used method.
In fact, world-wide, it still is. In that sense, regardless of whether it actually enhances performance like a steroid, it does pose a risk to health through actively smoking it. That would go for any substance – tobacco, cannabis, and other herbal remedies, as well as wood, paint, or plastic. Anything that gets lit on fire and inhaled. For this reason, I can understand why it would be on this list, since at the time, it would have been advocating for smoking, which is never a good idea, and certainly not for athletes.
However, with the inclusion of vaping, using oils, availability of patches, and more edible options, the idea of why it might have caused a risk to health, essentially disappears. Let’s remember, that since the inception of vaping until early 2020, the total number of associated deaths was 68, while 480,000 people die a year from smoking. Considering all the medical benefits now being associated with cannabis (which have technically been known about for thousands of years), and that the death rate can be cut so substantially by simply not burning it anymore, it makes it hard to see how #2 on the list has any value at this point.
If we back up to that first reason, let’s remember that smoking itself is a hindrance to performance if something burning is inhaled. But even considering that cannabis can be taken without lighting it on fire, it has turned up in investigation to not be a performance enhancer according to this study from 2018. I suppose it could be argued that simply allowing a person to think more clearly might make delta-8 THC a problem for athletics, but then any supplement would have to be banned, as well as eating a healthy diet.
No one is going around saying everyone should use cannabis before exercising, but there is definitely something to be said for the use of cannabis – and specifically delta-8 THC and athletics. While smoking it might detract from health, the multitude of other ways it can be consumed make the ability to use it while working out, seem generally healthy, or at least, not unhealthy. Every interested individual will have to see how it works specifically for them.
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Disclaimer: Hi, I’m a researcher and writer. I’m not a medical professional, I have no formal legal education, and I’ve never been to business school. All information in my articles is sourced from other places, which are always referenced, and all opinions stated are mine, and are made clear to be mine. I am not giving anyone advise of any kind, in any capacity. I am more than happy to discuss topics, but should someone have a further question or concern, they should seek guidance from a professional in the relevant field for more information.
Dosing is one of the most important considerations when taking any type of product medicinally. With most medications, that’s pretty easy to keep track of, but when it comes to cannabis products, especially oils and some concentrates, product dosing becomes a nearly impossible challenge.
“Pucks” and different types of small jars and containers are most common for storing, transporting, and distributing cannabis oils and concentrates. Sure, you could freeze your shatter, then cut and weigh it into equal doses, but what about products that are more vicious and difficult to work with, like cannabis batter? In this case, Delta-8 THC Syringes would be the perfect option. It’s an all-in-one solution that can be used to store, move, and dispense cannabis products in the same dose every time.
Unfortunately, syringes have a very negative reputation in drug culture, because of the obvious connection to intravenous use of harder substances. Much of our society lives with the preconceived notion that syringes either belong in the hands of medical professionals, only to be used for heavily regulated medications, or in the hands of heavy drug users.
Needless to say, if you were to pull a Delta 8 syringe out of your purse or pocket, you’ll probably get some strange looks from people. Despite the fact that Delta-8 THC syringes are used in a completely different manor than intravenous syringes, the illusion of syringes being bad is really hard to shake. Because of this, some users prefer the term applicator in place of the word “syringe.” Another reason to call it an applicator is because of the device at the tip. Although some opt to remove this portion, the term still applies.
Delta-8 THC syringes are one of the best tools for medicating with Delta-8 THC products. They can be used to store and administer oils, pastes, and other products that are difficult to work with by hand. Let’s take a closer look at this innovative new product.
Before we get deeper into the conveniences of using Delta-8 THC Syringes, it’s important that you have a firm grasp on the many medical benefits of the cannabis plant. The reason cannabinoids are so effective and are able to target such a varied range of conditions is because of the Endocannabinoid System (ECS). The ECS is a network of receptors that can be found throughout the bodies of nearly all living creatures including mammals, birds, reptiles, and fish. We naturally create cannabinoids in our bodies – called endocannabinoids – which bond to these receptors to regulate different processes in our bodies and maintain internal balance and harmony.
So far, researchers have been able to identify two separate endocannabinoids: 2-arachidonoylglycerol (2-AG) and anandamide (AEA), as well as two main receptors: CB1 and CB2. 2-AG is a full agonist of both the CB1 and CB2 receptors but it has a more direct association with the CB2 receptor. Because of this, 2-AG is thought to have a substantial influence over the immune system. Anandamide – The “Bliss” Molecule of the Endocannabinoid System Anandamide – or AEA – is frequently referred to as the “bliss molecule” and it has a major impact on our state of homeostasis.
AEA can help manage things such as appetite, sleep wake cycles, pain response, and then some. Our bodies continuously cycle through anandamide. It breaks down very easily, so it doesn’t stay in the body for long. However, our bodies create it on-demand to maintain homeostasis. There is a condition referred to as ‘cannabinoid deficiency’, characterized by a body’s inability to produce endocannabinoids. Some experts theorize that many illnesses we suffer from, stem from this shortage of endocannabinoids. This is why medicating with phytocannabinoids, or plant-based cannabinoids, can be so effective.
Spasticity or neuropathic pain associated with fibromyalgia
Post Herpetic Neuralgia
Irreversible spinal cord injury
Terminal illness requiring end-of-life care
Uncontrolled intractable seizure disorder
Why Delta-8 THC Syringes Make Sense
So now that you know the benefits of medicating with cannabis, let’s look at the benefits of doing so using cannabis syringes. Starting with the obvious, with the cannabis syringe (or applicator), you are able to dispense whatever volume of product that you need. Many have their volume indicated in marks on the body of the syringe, giving you relative measurements for dosage, making it much easier to experiment with dosing. That way and you can more easily keep track of which doses worked for you and at what times.
Another benefits regards the packaging aspect of Delta-8 THC Syringes. When using a syringe or applicator, very little oil is lost in the application process. When using other dispensing methods for products with an oil-like consistency, one of the most common complaints is loss of product while it’s in use. There are numerous techniques to get your concentrate or oil out of puck when it starts to get to thin or sticky to manipulate, but with Delta 8 syringes you don’t have to waste your time with any of that. With these applicators you get all of the concentrate in the exact portions you want.
How to Use
Well, a syringe is a syringe, so let’s start with the basics. You have a product in there, you push on the plunger on the back of the syringe, the product comes out. Pretty basic. Many oils are meant to be dispensed into a beverage or directly into the mouth, while concentrates and other products can be dispensed top of a bowl or into some type of dab rig or other device.
Some syringes come with a metal tip applicator but many choose to discard that. Not only does it make the application process slightly easier, it makes the whole set up look just a tad bit less like a syringe and needle. It’s a small victory but a victory no less, especially if you’ll be utilizing your Delta-8 THC Syringes in a public place.
Delta-8 THC Syringes – Final thoughts
By utilizing cannabis syringes, you’re helping to normalize product that can help people achieve more accurate, effective, and safe dosing. A huge part of the legal fight against cannabis comes down to public perception, so if we continue to normalize everything cannabis, we continue to strike back against the ridiculous notions that cannabis is bad, “stoners” are no different than hard drug users, and there are no medical uses for cannabis – because we all know none of that is even close to being truth.
With so many options in today’s market, it’s no surprise that a large number of medical cannabis patients have questions about the benefits, drawbacks, and differences between the two most popular consumption methods: smoking and vaping. But how do these differences come into play when we’re talking about smoking or vaping delta 8 THC flowers?
In chemistry, “delta” refers to the double bond on a molecule’s carbon chain. In the case of THC, we have a few different variations. With delta 8 THC, the double bond is on the 8th carbon chain, whereas with the more common Delta 9 THC, the double bond is on the 9th chain. In cannabis plants, delta 8 is only present in trace amounts. As delta 9 ages, a small portion oxidizes (loses electrons) and converts to delta 8. As a result of this chemical process, Delta 8 THC remains stable when exposed to air, meaning it could have more potential medical applications than delta 9, although Delta 8 is less potent.
The high you get from Delta 8 THC can vary based on tolerance, personal body chemistry, or strength and type of the product used. For example, if you smoke Delta 8 flowers, the high will be different than delta 9 flowers, but if you eat edibles, all of them will have a similar effect in the body because of the way our digestive system processes cannabinoids. Typically, a Delta 8 THC high is said to be clear-headed, energetic, and uplifted than D9.
Because of the milder head high, Delta 8 THC is great for helping people deal with anxiety, depression, post traumatic stress disorder, and other mental health disorders. And while studies remain limited on this particular cannabinoid, it has been determined to have a few health benefits of its own such has neuroprotective, antioxidant, and analgesic properties.
What are Delta 8 Flowers?
When you hear THC, you probably thinking marijuana (cannabis high in Delta 9 THC), but that would be incorrect in this case. Although Delta 8 can be extracted from marijuana in some cases, typically CBD is converted into this cannabinoid instead, because it exists in such trace amounts that A LOT of cannabis would be needed in order to extract the large quantities of delta 8 required to make quality products.
The way Delta 8 THC Flowers are made is simple yet very innovative – they are simply CBD flowers infused (or sprayed with) Delta-8 THC distillate. First the hemp flower needs to be prepped, meaning it needs to be properly trimmed with as much of the stem removed as possible.
Next, the distillate needs to be prepped so it can be sprayed over the buds. The distillate needs to be less viscous, which is the measure of a fluid’s resistance to flow. There are a variety of ways to do this, but the most common method is to add terpenes. Then the flower is put into a tumbler on a speed low enough to evenly distribute the distillate without breaking up the buds. And the last step, the Delta-8 THC is misted over the flowers.
Whether you’re talking about medical or recreational cannabis users, most of the time, consumers or all varieties are trying to get the most bang for their buck… and by that I mean, they’re looking for the strongest flower strains and products. When it comes to this aspect of the smoking vs vaping debate, typically vaporizing your Delta 8 THC flowers is the way to go.
The reason for this is because vaporizers heat your buds up to a specific temperature, which is much lower than when you burn your flower by smoking it. These lower temperatures allow you to get all effects of smoking and then some because all the natural plant terpenes are not getting burnt.
Contrary to popular beliefs, cannabinoids are not the only compound in cannabis that contribute to the medical benefits and psychoactive effects. Terpenes play a very important role in that as well, in addition to being the main compounds the store the plants flavor and aroma. When you smoke Delta 8 THC flowers instead of vaping, the high temperatures from the fire instantly combust and destroy some of the terpenes.
Honestly, this is hard to say because it depends a lot on personal preference. Logically, it would make sense to say that you get improved flavor when vaping Delta 8 THC flowers because the terpenes aren’t being destroyed, but that’s not always the case. Me personally, I’m old school and prefer to smoke a joint or bowl or vaping dry herb (although I do love dabs too), and I know many people who feel the same way.
Now again, conventional wisdom would say that if you’re looking to get the most flavor out of your flowers, vaping them will be your best bet. Since the vaporizer is utilizing these safe, lower temperatures, you’ll be able to experience each strains unique blend of terpenes on a whole different level.
Another notable difference between smoking and vaping – and perhaps the most important one – is the impact these two consumption methods have on our lungs. Although cannabis is generally regarded as being safer than cigarettes, it is common knowledge that smoking anything can lead to negative health outcomes. All forms of smoke are known to irritate the lungs and cause inflammation.
Additionally, smoke produces carcinogens, which are substances known to damage living cells and even cause cancer. All this damage to the lung tissues will eventually decrease overall oxygen intake, making it difficult to breath and engage in physical activity. Despite being one of the most popular ways of using cannabis, as you can see, it smoking does come with a certain level of risk.
Alternatively, vaping Delta 8 THC flower is a much safer option when compared to smoking it. Because to the substantially lower temperatures used by vaporizers, vapor instead of smoke. Vaping isn’t completely risk-free, as studies have known that tiny particles released while vaping may still irritate the lungs, but it does seem to be a healthier alternative based on the information we have available so far.
As you can see, we have a pretty clear winner here when it comes to finding the best way to consume your delta 8 THC flowers: vaping. When vaping delta 8 THC flowers, you’ll get to experience better flavor, less risks to your health, and a more potent high… which is pretty much meets all the main criteria for the modern day cannabis user.
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Delta 8 THC is a shelf-stable, mildly psychoactive, minor cannabinoid that has been quickly gaining popularity over the last couple years. Also climbing into the mainstream are products made with cannabis distillates, which allow for incredibly potent products with accurate dosing. When combined – Delta 8 THC Distillate – we have a powerhouse product that’s full of therapeutic benefits and steadily flying off the shelves.
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What is Delta 8 THC?
Before we talk about the medical benefits of this cannabinoid, let’s talk about what exactly Delta 8 THC is, and how it’s different from the more well-known, Delta 9 THC. Delta 8 THC (tetrahydrocannabinol) is a naturally occurring, minor cannabinoid found in the cannabis plant. Although it’s structurally similar to Delta 9 THC, there are some major differences as well.
For example, Delta 9 THC is the cannabis plant’s most abundant psychoactive compound, whereas Delta 8 is only found in trace amounts. As a matter of fact, Delta 8 is not even produced by the enzymes in cannabis, rather, it is created when Delta 9 THC oxidizes and slowly degrades into Delta 8. Further degradation of Delta 9 would create the cannabinoid CBN (cannabinol).
When it comes to the chemical difference between Delta 8 and Delta 9, it all comes down to one molecule. In chemistry, “Delta” refers to the double bond in a compound’s molecular structure. Delta compounds have more electrons and will interact with the body in a different way than single bond cannabinoids. The difference between the Delta THC analogues comes down to where the double bond is located on their chain of carbon atoms. Delta 9 has this bond on the 9th carbon chain, and Delta 8 THC has the double bond on the 8th carbon chain. It seems like a small difference, but it can be significant.
Similar to its more dominant counterpart, Delta 8 THC is a partial agonist for both the CB1 and CB2 receptors, although it seems to have a stronger affinity for CB1. This means there are effects to be felt in numerous different parts of the body, despite having weaker psychotropic potency. The National Center for Biological Information (NCBI) describes delta-8 THC as follows: “An analogue of tetrahydrocannabinol (THC) with antiemetic, anxiolytic, appetite-stimulating, analgesic, and neuroprotective properties.”
What Medical Conditions Could Be Treated With Delta 8 THC
Inadequate sleep can have a profound impact on one’s health. In the short-term, it can affect mood and judgement, the ability to learn and retain information, and it can increase the possibility of an immediate accident or injury. Over a longer period of time, lack of sleep can lead to diabetes, obesity, cardiovascular disease, and even early death.
Extensive research tells us that activation of the CB1 receptor leads to better, longer, and more restful sleep, and keeping in mind that Delta 8 THC directly stimulates the CB1 receptor, one can easily come to the conclusion that Delta 8 is good for sleep. REM sleep is an important part of our circadian cycles because it stimulates parts of the brain that are essential for learning new things and forming memories.
Anecdotal evidence leads to the same conclusion with many users claiming that Delta 8 THC helps them fall asleep more easily and stay asleep longer. They also report feeling more refreshed and well-rested when waking up.
It’s believed that Delta 8 THC’s analgesic and anti-inflammatory properties play a major role in its ability to function as a sleep aid. There is a strong connection between pain and sleep. Obviously, someone who is experiencing a lot of pain will have trouble getting comfortable and thus, have difficulty falling asleep. But the relationship goes even deeper – as lack of sleep increases the perception of pain. Breaking the pain/lack of sleep cycle is incredibly difficult, and having a good night’s sleep with both REM and deep sleep stages is key to making improvements.
While I’m not saying that smoking some delta 8 flowers or popping a few gummies will cure cancer, studies have proven that pharmaceutical products with highly concentrated doses of certain cannabinoids will do the trick.
This was first observed in 1974, in none other than Israel, where a study meant to focus on the immune system inadvertently found that Delta 8 THC alone significantly slowed tumor growth in mice. When combined with CBN (cannabinol), tumors actually began to shrink in as little as 3 weeks.
“Mice treated for 20 consecutive days with delta8-THC and CBN had reduced primary tumor size. CBD showed no inhibitory effect on tumor growth at 14, 21, or 28 days. Delta9-THC, delta8-THC, and CBN increased the mean survival time.” Antineoplastic activity of cannabinoids – PubMed (nih.gov)
Another study in 1995 on children with leukemia, showed a high rate of efficacy for treating the cancer, while also controlling side effects like nausea and vomiting caused by more conventional forms of treatment. The study was conducted at Shaare Zedek Hospital, Bikur Holim Hospital and the Hebrew University located in Jerusalem. The creators of the study, led by Raphael Mechulam, noted that “at the same this research was occurring, there had been 480 successful treatments of cancer with delta-8 THC.”
If you’re prone to anxiety, the mild and uplifting high you get from Delta 8 THC might be just what you need. Delta 8 THC offers all the medicinal effects of THC, and even some minor psychoactive effects, without the paranoia that often comes with Delta 9. The carefree high that comes with weed is often dampened by the anxious, nervous high some people experience.
Studies show that the endocannabinoid system, mainly the CB1 receptor, is centrally involved in regulating anxiety and depression. When the CB1 receptor is blocked, increased anxiety often occurs. Many people successfully utilize CBD (cannabidiol) to relieve their anxiety, but for many others it’s just not strong enough.
According to the National Cancer Institute, “this phytocannabinoid displays anxiolytic (anti-anxiety) qualities similar to delta-9 THC.” There is little in the way clinical research investing delta-8 THC’s potential to reduce anxiety, however, anecdotal evidence suggests that delta 8 products provide a nice, calm, focused, and stress-free high.
What is Delta 8 THC Distillate?
The scientific definition of distillation is that it is the act of purifying a substance usually through a collection of heating and cooling methods. The end result of a distillation process is known as a distillate.
Delta 8 THC distillate is a highly concentrated extract derived from hemp and cannabis plants, although the latter is not very common. Delta 8 THC distillate typically has upwards of D8 and it’s considered one of the purest and cleanest extracts available on the market.
Distillate retains a minimal amount of other compounds like plant waxes, vitamins, antioxidants, terpenes, and some minor cannabinoids. Whether it contains trace or illegal levels of Delta 9 THC depends on whether it was extracted from cannabis or hemp, although most of the time, hemp is preferred. This makes it great for anyone who needs accurate dosing but also needs the medicinal benefits the come from the entourage effect.
Another reason to choose distillates is that, because of their purity, patients often don’t need as much product to feel the effects. This can be economically advantageous for anyone who needs to use CBG daily but has been roadblocked by the fluctuating but generally high costs of purchasing these products.
How Distillation Works
Delta 8 distillation is a complex refinement procedure that separates the cannabinoid from raw plant material. The process is broken down into a few different steps.
Initial Extraction: The first step in the process of creating CBG distillate is to extract the cannabidiol from the hemp plant matter. There are a few different ways to do this including CO2 supercritical extraction, solvent extraction, or the rinsing and sifting method (physical) method.
Winterization – This step removes the unwanted impurities that are inadvertently extracted from the hemp plants during step one. During winterization, the extracted solution is placed into an extremely cold (winterized) environment for 24 to 48 hours. At this point, any impurities congeal and separate from the rest of the solution. The impurities are thrown out and the remaining product is filtered.
Decarboxylation – Before being exposed to heat or oxygen, cannabinoids exist in an acidic state (CBDA, THCA, etc.). To convert the plant cannabinoids into their active state, the extracted solution is heated thoroughly.
Distillation – The final process of distillation, the solution is vaporized and collected in a distillation cooling system. Each compound in the plant can be separated because of the variations in volatility, or boiling point, so the result is a relatively clean product.
The final product is a golden, thick solid product with a consistency that’s similar to honey.
Cannabinoid Distillate: The Future of Medical Cannabis
Distillation allows users to decide how much they want an oil to stray from the original plant extract. So, if you’re making edibles for example, you would want an oil with little to no flavor, so that your edible tastes like food and not cannabis. If you’re creating a vape oil that is supposed to mimic the smell and taste of cannabis, you can reintroduce some of the terpenes that have been removed using a method known as mass spectrometry. Basically, products using distillate are highly customizable.
Not only that, but in the case of medicinal products, reliable, consistent results are extremely important. “If you’re a doctor recommending a treatment, you’re not inclined to suggest something that has a lot of non-medicinal dissolved plant matter in it,” says Summit Research founder Elliot Kremmerman. “Medications have proven, tested chemical profiles, and distillation is letting us create them for cannabis products.”
He continued: “The purity, potency, and long shelf life of distilled cannabis oils mean they have some of the best margins to be found on the modern cannabis marketplace. In the coming years, there are a lot of consumers who aren’t going to be looking for the best flower, but for the best profile that you can put together mathematically.”
There are many more medical ailments that Delta 8 THC can be used for, and distillate can allow manufacturers to make products with very high and accurate doses of any cannabinoid that can be chemically extracted from the plant. If you want to learn more about Delta 8, make sure to subscribe to the Delta 8 Weekly Newsletter where you will find more interesting articles and exclusive deals on flowers and other products.
Lately we’ve been seeing quite a few new cannabinoids popping up, especially new forms of THC. Most are naturally occurring in cannabis, but some, like 11-hydroxy-THC, aren’t found in the plant at all. Let’s take a closer look at this ultra-potent psychoactive compound and what it has to do with the human digestive system.
11-hydroxy-THC, sometimes written 11-OH-THC, is one of our naturally occurring endocannabinoids; meaning it’s made in the body. After delta-8 or delta-9 THC has been swallowed, the body breaks it down and metabolizes it via the liver. 11-hydroxy-THC is a metabolize of the other tetrahydrocannabinols and is regarded as being much more potent than its precursors. This is why delta-8 THC edibles are just as potent as delta-9 edibles, but the same can’t be said for flowers or vape products.
According to neuroscientist and medical cannabis adviser, Dr. Adie Rae, “The liver is responsible for this transformation, and specifically, the drug-metabolizing enzyme known as cytochrome P2C9 or CYP2C9. Even when you smoke, your liver still sees some delta-9 and turns it into 11-hydroxy-THC, but you get way more 11-OH when you eat cannabis.”
A phenomenon known as “first pass metabolism” is the reason why 11-hyrdoxy-THC has such powerful effects on the brain. Oral administration leads to much more potent and long-lasting effects, compared to inhalation. So if you’ve been wondering why edibles get you beyond baked, this why.
As with other cannabinoids, 11-hydroxy-THC binds to the CB1 receptor; but in this case, it mimics all the known effects of delta-9 THC, but tenfold. The peak concentration of 11-OH-THC is about 1.5 hours after consumption. Effects can last anywhere from one hour to six (and some have reported more) depending on the dose and individual’s tolerance level.
The research on 11-hydroxy-THC
Although limited, the research we do have indicates that 11-hydroxy-THC is considerably stronger than delta-9 THC, the compound in cannabis known for inducing a high. One study in particular published in the Journal of Clinical Investigation found that 11-OH-THC is “much more potent at producing a subjective high and racing heart than delta-9.” This was observed in both animal studies and human surveys, which placed hydroxy-11-THC somewhere between 1.5 and 7 times more potent than delta-9 THC.
Dr. Rae claims the reason for this much higher potency “is partially attributable to the metabolite’s higher binding affinity for the CB1 receptor which physically binds more tightly to the receptor than delta-9. Basically, the better it binds, the better it activates the receptor.”
Back in the 1970s is when this cannabinoid was initially noted, in radiolabled THC was utilized in labs to allow researchers to better study these compounds. Radiolabled THC (which yes, is radioactive) behaves just like regular THC but it allows scientists to see where all the metabolites go once it’s broken down within the body. This is how 11-hydroxy-THC was discovered.
At the time, very little 11-OH-THC was available, for obvious reasons, so for a very long time only small animal studies could be conducted. Once they had the ability create this compound on a larger scale, in a lab, seminal studies were launched to characterize the effects of 11-OH-THC in humans.
Numerous studies of delta 11 taken intravenously showed it was not only more potent, but onset of effects was much quicker than other forms of THC also administered the same way.
Smoking vs eating cannabis
If you’re anything like me and many other cannabis users I’ve spoken to, edibles hit different than smoking. Even though it takes a while to feel anything, once they kick in, I’m laid out on the couch almost every time. I feel more stoned, I’m laughing at everything, and eventually, I get super tired. This seems to be commonplace when it comes to edibles; but why exactly do they differ so much from smoking, from a scientific standpoint?
It comes down to two factors: the drug-metabolizing enzymes in your GI tract, and blood flow to the liver. When you first eat a cannabis edible, various enzymes in the GI tract begin digesting the food. From that point, blood flow from the GI tract goes through the liver where all these enzymes are metabolized, then the blood continues to general circulation. When the metabolites are formed, that’s when you get the effects of 11-hydroxy-THC.
However, when you smoke cannabis, THC is absorbed through the lungs and distributed directly into the bloodstream. The active compounds make their way to the brain where they interact with the CB receptors that are part of the endocannabinoid system. In this scenario, you are feeling the effects of the phytocannabinoids (plant-cannabinoids) themselves, rather than the compound formed during metabolism.
How to avoid consuming too much 11-hydroxy-THC
When it comes to edibles, it’s easy to go overboard. Because it takes so much longer to notice the effects, a lot of people end up eating more than they should, thinking that the edibles aren’t working, then get surprised when all that THC finally kicks in. According to statistical surveys, the overwhelming majority of ER visits associated with cannabis are because of edibles, and this explains why.
Whether you make them yourself or buy them at the dispensary, if you want to avoid having any of these issues yourself, remember the adjunct “less is more”. That’s very true when it comes to cannabis edibles, especially if you’re a novice user.
It’s also important to remember that not everyone feels edibles the same way. Some people are more sensitive to 11-hydroxy-THC than others. Those people will feel edibles in a much more powerful way than people whose bodies are more resistant to the compound.
“Because 11-hydroxy-THC is made by the liver, and we all have different liver enzymes and genetic mutations in those enzymes, cannabis edibles can affect people very differently. There is a huge range in how individuals metabolize delta-9 into 11-hydroxy-THC, with age, sex, historical cannabis use, concurrent medications, and other factors contributing to variability,” Dr. Rae concluded.