How Binoid Does HHC Right

HHC is a federally legal cannabinoid and has some pretty distinctive qualities—mainly, it’s a hydrogenated version of THC (meaning it has a hydrogen atom attached), which adds greatly to its chemical stability while offering all of the properties that we associate with Delta 9 THC, including its absolutely beloved psychoactive effects.

This means that HHC gets you high like Delta 9, but is not actually a THC compound. It is its own category, and a unique high that you should explore. HHC has quickly become one of the most sought-after cannabinoids in the hemp plant, and that’s saying something as there are tons of cannabinoids that are grabbing our attention on today’s market.

It’s clear that HHC consistently satisfies its users, and if you’re looking for the absolute best HHC possible, Binoid is the obvious choice. Binoid’s HHC products such as their vapes, tinctures, and capsules have gained a reputation for their effectiveness, lack of additives, potency, and exceptional variety of product types, strains and more.

Try these products using the code HIGHTIMES25 for 25% off your order with fast and free shipping from Binoid.

To buy HHC Products Click Here

What to Look for in a Quality HHC Product
It goes without saying that not all HHC products are created equally. As the cannabinoid grows in demand, so do the instances of low-reputation companies releasing subpar products to capitalize on its popularity. So, how do you know you’re getting the cream of the crop, for a product that’s as safe as it is effective? Here’s why so many hemp enthusiasts choose Binoid as their supplier for HHC vapes, gummies, and more.

#1: Third-Party Lab Reports
You should always, always, always look at third-party lab reports before buying an HHC product, which are also referred to as a CoA (certificate of analysis). These lab reports are provided through a company’s website, and also show the reports that result from having each batch of an HHC product thoroughly analyzed by a state-authorized third-party laboratory. 

Here is where you can verify the safety, purity, and legality of a product, while learning more about the levels of cannabinoids and terpenes present in the product as well. Binoid’s third-party lab reports are easy to find on their website, giving customers the assurance that they need.

Courtesy of Binoid

#2: A Top-Notch Company Reputation
In such a competitive industry, reputation is everything. To really stand out, a company must go above and beyond to keep customers totally satisfied.  That’s where Binoid really succeeds. Thanks to their honesty, their fast and free shipping, their refreshingly fair prices, and the excellent consistency in HHC product quality and effectiveness, customers keep coming back, not having to worry about ending up with a dud product. With over 35,000 total five star reviews, and over 1,000 five star reviews for HHC itself, Binoid is one of the most trusted brands in the Hemp space.

#3: Clean, Fresh, and Carefully Sourced Ingredients
When it comes to crafting a high-quality product, one of the most overlooked aspects is the ingredients that are combined with the HHC distillate. Ideally, an HHC product should contain as few ingredients as possible to avoid fillers, and stick to ingredients that are as clean, natural, and ethically sourced as possible. 

We love that Binoid strives to deliver only vegan products, and makes their ingredient lists as easy to find as possible so that customers can know that they’re getting nothing but top-tier formulas without the use of chemical additives found in so many hemp products on today’s market.

#4: Seed-to-Sale Transparency
Companies should always aim to offer as much transparency as possible about how their products are made, from “seed to sale.” This means that they should provide customers with information that begins with how they source their hemp material, all the way to how it’s packaged. Binoid succeeds in this department, keeping customers well-informed about every step that goes into crafting their signature HHC formulas.

HHC
Courtesy of Binoid

What Types of HHC Products are Available at Binoid?
Binoid’s HHC products come in a variety of options, including different delivery methods, strengths, strains, and more. Let’s take a look at the various HHC products that they offer, all of which have become best-sellers among anyone who seeks out the exceptional properties of this rare cannabinoid.

HHC Vape Cartridges
Binoid’s HHC Vape Carts use Binoid’s premium 99% pure HHC distillate plus terpenes to offer an ultra-potent and fast-acting way for enjoying that HHC high. These 510-threaded vape cartridges attach easily to standard vape pen devices, arriving pre-filled with vape oil for your convenience. The formula consists strictly of hemp extracts—meaning that there are zero additives getting in between you and your beloved hemp.

The vape carts contain a full gram of vape oil (1ml), and come in top-shelf strains like Hawaiian Sunrise (Sativa), Sunset Sherbet (Indica), Gorilla Glue (Hybrid), Cali Gold (Hybrid), Lucid Blue (Hybrid) and Super Silver Haze (Sativa). This is a great choice for someone who wants a heavy-hitting serving of HHC and loves exploring different sought-after strains on the market in Indica, Sativa, and Hybrid forms.

HHC
Courtesy of Binoid

HHC Tinctures
Tincture fans will want to give Binoid’s HHC Tincture a try, offering up the ideal sublingual oil formula for fast-acting yet long-lasting results. The tincture comes in an amber glass 30ml bottle, keeping the contents fresh and safe from oxidization, with a dropper cap for easy dosing and administering.

The bottle contains a total of 1000 milligrams of pure, lab-tested HHC distillate, and MCT oil is the only other ingredient, which acts as the carrier oil to deliver the cannabinoid into the body within roughly 30-60 minutes. The high can last for 4-6 hours, letting you milk HHC’s effects to feel blissfully high for a large portion of your day.

HHC
Courtesy of Binoid

HHC Capsules
Binoid’s HHC Capsules offer a fully vegan formula, which makes it easy to incorporate the cannabinoid into your daily routine. Each capsule contains plant-based ingredients, with 25 milligrams of HHC distillate per piece. One capsule a day is plenty, but keep in mind that it can take up to 2 hours before the effects kick in, and after that, they can last for up to 8 hours at a time. Softgels are easy on the stomach, and a highly effective alternative to traditional vapes and gummies.

Courtesy of Binoid

Binoid has Your HHC Needs Covered!

For better or worse, each company that makes HHC products has their own standards when it comes to quality, which is why you have to be extra careful when choosing which brand you’re going to buy from. Fortunately, Binoid is a company that has maintained a reputation for years, as being one of the most honest and trustworthy manufacturers out there. Their commitment to dazzling customers with nothing but premium hemp is evident as soon as you try one of their formulas for yourself.

Binoid’s products cover all of your bases, whether you want a fast and potent HHC high through a vape, a long-lasting high from a capsule, or the perfect middle-ground through a tincture. All of their products have undergone strict lab-testing, and it’s easy to learn more about how their products are made through their website.

Best of all, you’ll be able to snag top-shelf HHC vapes and products at excellent prices using the code HIGHTIMES25 for 25% off while being treated to fast shipping so that you can get acquainted with this fascinating cannabinoid in no time flat.

To buy HHC Products Click Here

The post How Binoid Does HHC Right appeared first on High Times.

Can You Snort Kief?

Yup, this is going to be one of those super intellectual articles. Right on par with whether you can smoke a mushroom, which we got to the bottom of not that long ago. It’s a valid question, of course, and I think it’s necessary for readers to know. So today we attack the very-important question of, can you snort kief?

Ah, the age old question of can you snort kief… here’s what you need to know. We’re a cannabis and psychedelics news publication which reports on big stories in these exciting and growing fields. We also offer the Cannadelics Weekly Newsletter for readers to keep updated, as well as access a bunch of awesome deals on all kinds of swag from vapes and other smoking paraphernalia, to edibles and cannabinoid compounds like the uber-popular Delta 8 & HHC. Head over to our ‘best of’ lists for more info, and pick yourself up the products you feel most comfortable using.


What is kief?

If you’re smoking some low grade, twiggy, full of seeds ditch weed, you’re probably not concerning yourself with kief. But for those smoking the good stuff, the kief is the cherry on top of the cake. Some people collect it by using grinders with an entrapment on the bottom to catch the powder, or stash containers with the same collection repository. Some people like to sprinkle the kief on cannabis or tobacco, or to save it up and compress it into hash. If necessary, kief is usable in place of weed, if you run out of that first.

So, what is the stuff? Kief is the powdered trichomes that come off of the flowers of the plant, often called pollen, or resin glands. The trichomes are the chemical building structures that house the cannabinoids like THC, and terpenes like linalool; so if you have a bunch of high-quality cannabis kief, you’ve essentially got a bunch of high quality cannabinoids and terpenes too.

The kief, therefore, is a concentrated form of the cannabinoids responsible for the medical and mind-altering effects of the cannabis, as well as the terpenes which are responsible for the taste, color, and smell of the plant.

Kief

Kief is the starting point of hash. Hash is made of the compressed resin glands of the plant, AKA, trichomes, or kief. Just like kief is a concentrate because its comprised solely of trichomes, hash is a concentrated version of these trichomes, as well. Hash is made pretty simply by squeezing the kief together until it becomes a solid. This doesn’t require more than rolling kief in the hand, or smashing it in a plastic bag. For some people, the entire point of saving up the kief, is to turn it into hash.

If you’re smoking the low-grade, twiggy, full of seeds ditch weed, there won’t be kief, or not as much. The plant will still have cannabinoids, but far fewer, which is why such weed isn’t known for producing a good high. The more kief there is, the stickier the plant feels, the brighter the color, the more pungent the smell and taste, and the greater the effects. Have you ever had weed so strong that you could smell it even after wrapping it in two plastic bags and sticking it in a backpack? That’s the kief!

Kief is powdery by nature, which is why there’s confusion over how its possibly used. After all, we snort other powdery substances, like cocaine and ketamine, right? Is it that far off to ask, can you snort that kief, as well?

Realistically, kief functions similarly to cannabis flowers. It can be smoked, eaten in edibles, vaped, used in a tincture, or applied to skin creams and salves. Generally, we don’t consider snorting weed, but kief is such a concentrated part, and so powdery by nature, that the question does come up. Unfortunately, the question ‘can you snort kief’, might not come with the answer you desire.

Can you snort kief?

We’re a world of people who like to self-experiment. Maybe this is a sign of widespread boredom, or simply a constant desire to try to push the boundaries of what makes us feel good. The reason I’m writing this article today, is because the question ‘can you snort kief’ is a relatively prevalent one, and an easy-enough experiment, that many have tried. Anyone who has, likely came to the same result.

There are two things to remember about cannabinoids and your nose. The first is that the mucous membranes of your nose won’t take up cannabinoids in their natural form, since you are water-based, and they are oil-soluble. When a person uses a THC nasal spray, they’re using a form of cannabis which has been emulsified to make uptake through the nasal passage possible. This process turns something oil-soluble, into something water-soluble. This doesn’t happen naturally, though. If it did, it might be commonplace to see people with the plant shoved up a nostril, and let’s be honest, no one does that.

Can kief be snorted
Can kief be snorted

The other thing to remember? Even if you could shove it up there, it would have to be decarboxylated first in order to access any psychotropic effects. It’s still weed after all, and if the THCA isn’t transformed into THC, there’s no high to access in the first place. For anyone thinking they want to go decarb their kief to try snorting it that way…just remember the first point, that it won’t matter since marijuana isn’t water-soluble. Sorry, guys!

Plus, if you want a couple more reasons not to attempt this experiment, here are a couple more things to consider. Kief is coming off a plant, it’s going to be mixed with dirt, and other unwanted particles that might not be desired by the inside of your nose. The reason people use nostrils for medication uptake is because there are a lot of blood vessels, but this means its also easy to get bad microbes up there.

Snorting something dirty and unrefined is a great way of getting an infection. The other aspect of this? It probably won’t feel good. That’s a sensitive area that doesn’t want such particles coming into it. Snorting kief will result in no high, but discomfort in your nostril. Something like cocaine numbs the inside of your nose to make it a painless experience, but kief can’t do this; if you choose to experiment in this way, expect to feel the burn.

If you REALLY want to snort weed, there might be a way…

Alright, so if you cue up that kief line, and snort your way through it, you’re probably going to irritate your sinuses, and not much more. What if you’re not snorting kief, though, but an isolate instead? There are some interesting stories about people getting pretty messed up from blowing through lines of isolate.

Well, according to Marijuana Mommy Founder, and RN, Jessie Gill, nostrils don’t provide enough bioavailability for isolates since cannabinoids are fat-soluble, not water-soluble. Since mucous membranes are comprised mostly of water, this doesn’t get around the same uptake issue previously mentioned.

Despite this, Gill notes that “it’s easy to over-consume.” And specifically about CBD, “Consuming high doses of CBD via any method can lead to overstimulation, which some people may interpret as a ‘buzz.’” While there still isn’t much backing up this method of delivery, there are a few personal stories out there. In all cases, however, what other drugs the user might have taken, wasn’t accounted for. It also can’t be ruled out that those who claim a high from this experience, were really just experiencing the placebo effect.

Marijuana pollen
Marijuana pollen

Searches in online forums turn up mixed results, but way more on the side of no effect. Once again, when looking through reddit or Quora, it’s impossible to know the specific situations, confounding factors (like other drugs), whether there was a placebo effect, or if the person just wants to spin stories. The general consensus meets the science, in that though a person can snort kief, they’re just not going to get high.

Conclusion

So, there you have it. In answer to the question, can you smoke kief, the answer is a resounding ‘well, it won’t kill you, but it won’t do anything for you either.’ If you want to make good use of that kief, sprinkle it on a bowl, smash it into hash, or use it for your edibles. But if your goal is to snort it, all you’re doing is wasting some super fine bud concentrate.

Curious about what you can smoke in life? Read on to find the answer to other popular questions, like can you smoke in space? Or, can you smoke magic mushrooms? Or, can you smoke tinctures, gummies, capsules, or oils?

Welcome all! We appreciate you joining us at Cannadelics.com, the place to go for comprehensive news on the cannabis and psychedelics spaces, all independent! Stop by daily to stay informed on changes in these industries, and sign up for the Cannadelics Weekly Newsletter, so you’re never late on getting the story.

The post Can You Snort Kief? appeared first on Cannadelics.

Lack of Research Integrity In Cannabis and Beyond – 2 Examples

Sure, cannabis is a controversial topic, as it’s a federally illegal drug which is legal in certain locations. Plus, there’s the uncomfortable fact that many large industries don’t want competition from cannabis as a medicine, or hemp as an industrial product, and these industries have financial ties to government and regulators. Together, these factors lead to major deficits in research integrity when it comes to the cannabis field, and in research in general. Here I go into two examples that come up frequently for me as a drugs writer.

Issues of research integrity abound in the field of cannabis, and well beyond, and are oftentimes not understood by the masses. If you like your news to be comprehensive and independent, you’re in the right place! We put out the Cannadelics Weekly Newsletter so you can access daily updates on important topics, as well as obtain deals on tons of cannabis products from vapes and edibles, to cannabinoid compounds like the growing-in-popularity Delta 8 & HHC. You can find deals in our ‘best of’ lists, but always remember to choose the products you’re most comfortable using.


What does research integrity mean?

Research integrity is defined by how research is done. According to the US Department of Health and Human Services, on grants and funding, research integrity has three different components:

  • For proposing, performing, and evaluating research in an honest and verifiable way
  • For adherence to rules, regulations, and guidelines when reporting research results
  • For following commonly accepted codes and norms

Technically, these are non-specific guidelines, meaning they can easily be argued by someone who wants their research considered integrity-worthy, even if its not. The most important one in my mind, is the first, because it stipulates that research should be done honestly, and with verifiable results, which is where the biggest problems lie.

In fact, even standard fields of research fall pray to this first bullet point, even as most people never realize it at all. The ideas of ‘honest’ and ‘verifiable’ are so massively important, and yet entire fields of research, for which studies are published every day, regularly ignore these principals.

One of the biggest places of violation, is when a study, or campaign, is specifically put out to affect the opinions of the general population. Think Reefer Madness, a now understood smear campaign, that goes so boldly against understood knowledge of cannabis (both at the time of release, as well as now), that its frightening this was pushed by the government, and that no formal apology has been made for using it.

Of course, Reefer Madness antics abound still, with constant baseless research attempting to sway opinion, and headlines used to misrepresent studies, or the information they do provide. Reefer Madness is an incredible example of the danger that results when research integrity in a field like cannabis study is ignored for marketing reasons. And if anyone is skeptical that so much is put into swaying their opinion, perhaps go ahead and re-watch that horror of government propaganda.

Why is research integrity important?

When looking at all kinds of policy, whether drug policy, medical policy, or legal policy, a lot of what laws are based on, comes from research meant to elucidate information on different topics. This research is often then pointed to as the backing for these policies, and to create standards for industries, which means we rely a lot on scientific studies, that – let’s be honest – most standard residents are never going to read. To be even more honest, most will never get past a headline, without ever considering all the work put into headlines to sell an idea, without expecting a person to read further.

So, it matters how this research is done. Right? We don’t want shoddy research as the basis for our laws and regulation, or to be what restricts us from something, or pushes us toward something else (or worse, which requires us to do something). Yet, for how important it is to get it right – for the general health and well being of an entire population – tons of bias exists in research, and very little of the population at large understands how this research is carried out, what goes on in particular studies, who funds them, or what limitations or conflicts of interest they carry.

For how important it is to get it right – or the general health and well being of an entire population – it becomes sad and downright scary how little research integrity exists in the field of cannabis, as well as other parts of the research world. Even if the third bullet point above stipulates adherence to norms, should those norms conflict with the ability to be honest, or verify information, the only thing those norms become, is dangerous.

Why is this an issue at all, you might ask? Why would anyone want to mess with research results, or try to persuade people to think a certain way using such results? Especially if these results are fabricated, purposefully misinterpreted, or paid-for by some other entity? Because of that whole thing where policy is set using research, and products are sold. If the idea is to set a certain policy, or sell one product over another, can we expect to see legitimate research saying the opposite from what lawmakers or major product producers want, or should we automatically expect that this is no longer possible?

Example 1 – lack of research integrity with cannabis – psychiatric diseases

There are tons of places to point out deficits in research integrity, but I chose a couple that come up the most for me. One of my favorite examples is no doubt a controversial one, but its controversial nature – much like many of these instances, is built around the idea that a concept has been proliferated to the point that its internalized without question. One of the often-used lines in cannabis research, by those seeking to keep it illegal, is that there’s a tie to increased levels of schizophrenia. In fact, this line comes out all the time.

What’s the problem with it? Schizophrenia has no medical definition – aka no medical diagnosis, meaning by definition, it can’t be verified. Ever. Like, never ever. Not that cannabis can increase incidences of it, and not that it exists at all. Any psychiatric disorder that relies on a specific therapist to use their opinion on a set of symptoms, is by nature unverifiable, and that breaks the first rule of research integrity. Every single diagnosis is no more than one person’s opinion, and regardless of how much we’re told this has value, what it actually means, is that 10 different professionals, can give 10 different diagnoses, and this happens all the time.

schizophrenia
Schizophrenia

Not only that, it means when you see a review that’s based off multiple studies, you must consider that every single diagnosis of every patient used, was merely one doctor’s opinion. Now, if you’re thinking that this doesn’t sound right, and that something like schizophrenia can actually be medically diagnosed, you’ll want to think again. While I’m saying psychiatric conditions can exist, I’m saying there’s no finite way to define them.

A medical definition is the ability to define a problem with hard evidence. A cancer test looks for cancer cells, or a reaction to them. A diabetes test looks at insulin production, a flu test tells you if a virus exists in your body. These are all medically provable. They have medical definitions. But no matter how many people are called schizophrenic, not one has ever been verified in any medical way. Therefore, there is no way to say what increases or decreases the incidence of something that can’t be medically proven.

This goes well beyond research integrity of cannabis, into other topics, like how pharmaceutical companies operate; who makes up the DSM, which sets diagnostic standards for psychiatric disorders and medication prescribing (over 95% are tied to pharma companies); and why people are being medicated for something that can’t be defined (a much bigger question that can take it’s own article). To step this argument up a notch, entire studies are done on how to improve the reliability of psychiatric diagnoses, which just by their existence, should tell you this is a major problem, and something to consider when those diagnoses are all we have to go on.

In the world of cannabis, if a study is telling you that cannabis has any effect on schizophrenia numbers, or on any other psychiatric condition, the first question you should ask, is if the study, or the studies it pulls from, are based only on non-verifiable diagnoses. If they’re about something like schizophrenia, this unfortunately goes without saying. Yet even with this inability to actually diagnose people, headlines constantly abound, proving the massive deficit in research integrity in the cannabis field and beyond.

I want to take a second to say that this is not my opinion. Whether something has a medical definition or not is not up to me, and I don’t get to say what counts as a medical definition, or what conditions come with one. So regardless of what another person’s opinion is on the diagnosis of psychiatric disorders, the fact that they fundamentally have no means of definitive medical diagnosis, is not up for debate.

Lack of research integrity with cannabis – fake studies

Another place where research integrity is sadly missing, is in instances where researchers pull a study together quickly by taking unrelated information from other pieces of research, and work it through a computer to find any correlation; even if that correlation is baseless, or only applies to that one occurrence. A great example is this study, Open Access Recent cannabis use and myocardial infarction in young adults: a cross-sectional study, for which investigators used data from the 2017-2018 American Behavioral Risk Factor Surveillance System survey.

In that study, researchers could control for nothing, as they didn’t design a study. They couldn’t ask respondents questions, or modify methodology, because there wasn’t any. A study is supposed to start with a hypothesis, and then have an experiment designed around it to test that hypothesis. These fake studies do none of that, meaning they aren’t actually testing anything. The study above very erroneously tried to draw a link between recent cannabis use and heart attacks in adults aged 18-44. And in fact, their conclusion was that a correlation does exist.

So, what’s the problem? They only looked at those who smoke cannabis, and not once accounted for smoking in the study, the one thing we already know leads to a higher risk of heart attacks. Whereas there is literally nothing linking cannabis itself to heart attacks in the thousands of years its been used, this study tried to draw a link, by ignoring the actual risk factor, which was applicable to every person used in the study.

fake research studies
Fake research

It’s such a glaring oversight, that one could ask what kind of training the researchers had in order to make such a massive mistake. In fact, the study left out all kinds of useful confounding information, simply trying to focus on the one non-existing correlation that the writers wanted readers to come away with. One could also ask, was there another reason for professional researchers to put out such a bad study? While I can’t say for sure, it certainly doesn’t make me feel better that one of the main investigators accepted money from multiple pharma companies, some of which sell cannabis products.

This study highlights yet another issue with research integrity in cannabis, that your opinion is meant to be changed in order to push you toward one product or thought process, over another one. This idea of conflict of interest runs rampant in research, highlighted by one of the guys in the previous study mentioned, accepting pharmaceutical money, and then writing a study demonizing the plant. Of course pharma companies want you to be afraid if it. Because if you aren’t afraid and confused by the real thing, you probably won’t want to buy their super safe, and better-than-nature product.

Conclusion

The reality is that as long as people blindly follow what’s put in front of them, without asking questions or making connections, this will continue on. Right now, the US is weed illegal based on nothing but a smear campaign and corrupt research from nearly a hundred years ago. And while we all technically understand this, our understanding doesn’t force a legal change, and is sadly not generalized to other topics by the majority of the population. Hopefully in the future, better campaigns will come out to help the masses understand how to read their research, and what is really being sold to them.

If you want more ideas on how smear campaigns based in bad research are used to inform your opinion, check out this article on a study attempting to link cannabis to suicide, this article about how the FDA banned Juul products without banning cigarettes, this article on the disappearance of Quaaludes, this article attempting to link vaping to erectile dysfunction, and this article about how the US government continually tries to encourage the public to forego vaping in the face of massive cigarette deaths.

Should I have added a third example of breaks in research integrity, it would’ve been the buying and selling of research by large corporations (including conflicts of interest in funding), which many of these articles exemplify.

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The post Lack of Research Integrity In Cannabis and Beyond – 2 Examples appeared first on Cannadelics.

How Drug Tolerance Actually Works

One of the main reasons that drugs have such varied effects in different people, is because of drug tolerance. Some people develop a tolerance to certain drugs after long-term regular use, and others have a seemingly natural tolerance to certain substances. So how does drug tolerance actually work in the body, and how can we use this knowledge to our advantage to curate safer and more personalized drug experiences?  

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Drug Tolerance Defined  

The pharmacological meaning of drug tolerance refers to a person’s decreased response to a drug or group of drugs over an extended period of time. While this is a very useful adaptive mechanism that allows our bodies to adjust to an ever-changing environment, it’s a major issue when it comes to consistency and dosing with various substances, because it means the initial dose that a patient/consumer started on is no longer working.  

The only solution at that point would be to increase the dosage, but because that can work to speed up tolerance, there are a few issues when going this route including the rising cost of medication and other products (because higher dosed products often carry a higher price tag as well), difficulty filling prescriptions, and most importantly, an increased risk of possible overdose. 

Tolerance-related overdose can happen one of two different ways, and it can happen whether you have a low tolerance or high one. If you have a low tolerance to drugs, then of course, too much too fast will be problematic. If you have a very high tolerance, you need more and more drugs to feel their effects. But just because you can’t feel the drugs, that doesn’t mean you can’t still experience toxicity from taking too much. So yes, there is a sort-of sweet spot when it comes to substance tolerance. 

Many factors and drug-use patterns can impact tolerance such as taking a break from using the drug, changing the dosage on your own, changing the type of drug you’re on, changing how or when you take the drugs, using drugs that are less potent than what you’re used to, shortages or inconsistent access to prescriptions, and other unpredictable changes in supply and quality.   

What is Cross-Tolerance? 

Cross-tolerance happens when someone develops a tolerance to a drug or group of drugs after taking one with similar properties, because drugs from the same classes affect the same parts of the brain. For example, if a patient takes oxycontin and then ends up with a tolerance to other opiates as well. Serontogenic drugs (hallucinogens) also have the same effects.

Below are the most common drug classes for cross-tolerance: 

Sedatives: Different categories of sedative drugs like benzodiazepines, alcohol, barbiturates, and sleep aids all act on similar receptors in the brain and thus, cross-tolerance can easily develop. It’s quite common in patients taking drugs like Xanax, Klonopin, Ambien, and so on.  

Opioids: According to the Mayo Clinic, all opioids lead to cross-tolerance with other drugs within the class. This why opiate patients sometimes end up addicted to heroin, because when tolerance develops to a powerful prescription drug like Oxycontin, some believe their only option is to move on to street drugs like heroin, which obviously carries risk of arrest, overdose, and death.

Stimulants: Many stimulants are known to create cross-tolerance effects. People who use amphetamines like methamphetamine will have an increased tolerance to weaker stimulants like cocaine and ecstasy.  

Psychedelics: Less known is that people can develop cross-tolerances to different psychedelics. This is because mescaline, psilocybin, LSD, DMT, ketamine, and most other hallucinogenic drugs act by modulating the serotonin pathways in our brains.  

Genetics and Natural Drug Tolerance 

We all know that tolerance is something that can be established the more you use something… but can we be born with a high tolerance to drugs or medications? In short, yes The concept of natural drug tolerance is not something new, in either clinical or recreational settings. From a more casual standpoint, if you’re a person who uses drugs, or if you hang out with people that do, you know that a seemingly inherent tolerance to substances is a very real thing. Doctors, pharmacists, and other healthcare practitioners are also very familiar with the concept.  

While tolerance is different for everyone, for some people, it’s largely caused by genetic factors. Additionally, people with low body weight and either very young people, or the elderly, may have lower drug tolerances as well. But back to those genes. Our genes influence everything about us, including the number and types of receptors in our brains, how and what those receptors react to most, how quickly our bodies metabolize drugs, and how well or poorly our bodies respond to different substances in general. Utilizing genetic, environmental, and neurobiological factors in dosing is known as precision medicine.  

Of course, this applies to recreational substances as well, ranging from the mild ones like caffeine, to all the different classes of drugs noted above. So, if you have a high tolerance to alcohol and drugs, you may have got that from one of your parents, and the trait may be passed down to your offspring too. Furthermore, these same factors can influence a person’s likelihood to become addicted to drugs.  

For example, Nora Volkow, MD, director of the National Institute on Drug Abuse explained that “the number of a certain type of dopamine receptor, known as D2, might someday be used to predict whether someone will become addicted to alcohol, cocaine and heroin.” Brain imaging indicates that people with fewer D2 receptors are more likely to become addicted to various drugs than those with more of these receptors. “Of course, environmental factors also play a role, so propensity isn’t destiny, Volkow added. “First a person has to experiment with drugs, then he or she has to repeatedly use them. At that point, genetic vulnerability helps determine who winds up addicted.” 

How This Info Can Benefit You and Your Drug Experiences  

In my years of experimenting with drugs, I discovered that I personally have a high tolerance for stimulants and psychedelics, and a low tolerance for downers; especially benzodiazepines and barbiturates, but even alcohol can be questionable for me when I’ve had too much. Now, this is just me… everyone’s body is different.  For example, a friend of mine (and one of our other writers here at Cannadelics) is the complete opposite. She does well with downers but can’t handle stimulants at all. Even some coffee or mountain dew is enough to have her wired.  

This information about how I react to both stimulants and sedatives is very beneficial for me. Knowing the specifics about your own personal drug tolerance levels can be incredibly useful for both therapeutic and recreational reasons. For example, if you know that benzodiazepines make you extremely tired (like they do me), then you’ll know that taking Xanax or Lorazepam during the day is not a viable option for treating anxiety for a long-term period. Conversely, if you can’t handle stimulants, you may want to avoid using drugs that contain them at certain times (no coffee before bed).

And the stimulant effect can apply to psychedelics as well. Because most psychedelics act on our serotonin receptors, they can make you feel awake, alert, and sometimes jittery and anxious. For someone who doesn’t do well with stimulants, mixing certain things may be an issue. Like shrooms and cocaine, for instance.

Final Thoughts  

Drug tolerance is an interesting and complex physiological mechanism that normally helps us adapt to our constantly changing environments, but can hinder us in the realm of drug use. Tolerance can be either developed or intrinsic, and knowing what class of substances your body is more likely to develop a tolerance to, can help with both medical treatment plans, as well as safer recreational drug use.

Hello readers! We appreciate you joining us at Cannadelics.com, a top choice news platform for independent coverage of the growing cannabis and psychedelics landscapes of today. Come by the site whenever possible for updates on current and world-changing events, and head over to the Cannadelics Weekly Newsletter, so you’re always up on what’s going down.

The post How Drug Tolerance Actually Works appeared first on Cannadelics.

Study Shows Real Cannabis Products More Popular Than Synthetics

Okay, so for most people this is common sense. However, in a world without real sales market data from the cannabinoid industry, and patchy info on the cannabis industry at large, we rely a lot on speculation. A new study, however, makes clear a certain point, even if it wasn’t the intended point. By measuring issues with synthetic cannabinoids, this study found that real cannabis products are more popular than synthetics. Read on to find out why.

A recent study highlights how real cannabis products are more popular than synthetics for consumers, as evidenced by rates of issues with synthetics in hospitals across states. Cannadelics is an independent publication offering coverage of the cannabis and psychedelics fields, complete with the Cannadelics Weekly Newsletter for regular updates on important events. Subscribe today and also gain access to tons of products like vapes, edibles, and cannabinoid compounds including the seemingly-everywhere Delta 8 & HHC. Head to our ‘best of’ lists for product deals, and make sure to pick the products you’re totally comfortable using.


What are cannabis synthetics?

We all know what the cannabis plant is. And most of us are aware that compounds like THC and CBD can be directly extracted from the plant. Whether thinking of the plant as a whole, or the cannabinoids directly taken from it, these constitute the natural version. The term ‘synthetic’ in the drugs industry, means a drug that’s made by a human using component parts, rather than coming from nature. A synthetic compound won’t come out of the ground, however something that does come out of the ground, can also be made synthetically. In the world of cannabis it relates to synthetic cannabinoids like HHC and delta-10, as well as Spice, K2, and every government approved cannabis medicine.

While smear campaigns throw out terms like ‘Spice’ and ‘K2’, the very same governmental agencies pushing fear in those terms, also allow the sale of pharmaceutical cannabis synthetics like dronabinol and nabiximols. As synthetics means anything not directly from the plant, the term encompasses both the pharmaceutical version, and the street version.

The thing is, the ‘street’ versions are essentially the same, or similar-enough to the pharmaceutical versions. In fact, much of what is often complained about by the government, was actually made by the government, or comes from something made by the government. This includes the compounds like spice and K2, along with much of the cannabinoid market, which also represents synthetic compounds.

Now, the thing about this cannabinoids market, is that its an illegal market, which is unregulated, and which we already know falls prey to dirty tactics like using fake labs to show safety results, to keep consumers feeling safe about their purchases. And truth be told, while this is certainly a shady industry, the rate of actual death related to it, is small at best, and so far, never related – as in NOT ONCE – to the compounds themselves, as evidenced by this Australian study looking at an entire 18 years! Which makes the idea of the fear marketing around these compounds, weird, and nonsensical.

How dangerous are cannabis synthetics

If you read the previous paragraph, not dangerous at all. Pharmaceutical companies sell them every day, even in the US where cannabis is federally illegal for both recreational and medical purposes. Interesting, right? That not only does the US government demonize cannabis in general, but it actually allows under certain circumstances, not the plant itself, but synthetic versions of it.

This doesn’t mean all synthetics sold are created equally. Just because there are some totally cool versions, doesn’t mean they all are, especially in a black sales market. Though the reality is that even the less tested compounds really aren’t hurting anyone, people do get hurt by dirty products, particularly in the following two ways:

  • Taking too much. Synthetics might be just fine, but like with cannabis in general, too much can be bad. Synthetics are often packaged like regular cannabis products, but often without the THC limits – sometimes there isn’t THC in them anyway. Especially for kids getting into edible candies, this can cause a problem. But it’s the same problem that exists with regular weed products, as well as all those household cleaners under the sink, the prescription medications in the bathroom, and even the Tylenol bought over the counter.
  • The other issue is simply one of additives. Additives are anything used in a product for whatever reason, that aren’t the main compounds of action. When it comes to vape carts this can mean chemicals used to thin or thicken the oil, for flavoring, or as preservatives. For fake cannabis as a plant, it can mean pesticides, herbicides, or anything else sprayed on the random vegetation used. Plus, considering anyone selling a synthetic is unregulated by definition, anything can be in there. Even something like fentanyl, if desired.

People like to mess with products, and that’s the real issue of cannabis synthetics. I got sick once from smoking the weed-looking stuff which is actually just crushed foliage with something sprayed on it. Besides whatever the product maker put on it to cause a high, there could also have been fertilizer, rat poison, or insecticides on that foliage, and all those things, while having no relation to the synthetic compound, can certainly make a person sick.

synthetic additives

Though it likes to spout out fear messages all the time, even the FDA technically concedes that all the 68 confirmed deaths related to vapes – like 68 from the inception of vaping until early 2020 (including 29 states and DC), were all really because of additives. This same concept was reiterated in a report by the UK, in which vaping was promoted as a way to stop people from smoking.

So yeah, there are reports of people getting hurt, but I have yet to see a death statistic specifically related to either regular cannabis, or the synthetic cannabis compounds, directly. As far as getting a little sick – well that happens with THC products, and is generally more related to ingesting too much. Something also relevant to all those prescription medications in the bathroom, and even the Tylenol which is bought over the counter. Incidentally, Tylenol causes approximately 56,000 emergency room visits, 2,600 hospitalizations, and 500 deaths a year, yet I don’t remember the last time I heard fear marketing from the government about using that product.

What study shows real cannabis products more popular than synthetics?

The purpose of the study wasn’t to establish if real cannabis products are more popular than synthetic products, but it established this information in the point it did make. The study is called Synthetic cannabinoid poisonings and access to the legal cannabis market: findings from US national poison centre data 2016–2019, and is meant to examine “trends in synthetic cannabinoid exposures reported to United States (US) poison control centres, and their association with status of state cannabis legalisation.”

How did they do this? With “Mixed-effects Poisson regression models” which “assessed synthetic exposures associated with legal status, first among all states using annual counts, and then among states that implemented permissive law alone using quarterly counts.” For this, they pulled data from the National Poison Data System (NPDS) for the years 2016-2019.

What did the study find? 7,600 reported exposures in the time frame investigated, with an overall decline through time. 64.8% of these required medical attention, and there were 61 deaths…though we already know they were unlikely directly related to cannabis compounds – synthetic or not.

States that had implemented medical cannabis laws had 13% fewer reported issues per year, while states that adopted more permissive policies during this time period saw a 37% lowered rate. As far as states that already had a permissive policy in place, there were 22% fewer reportings. Overall, states with retail markets, clocked in with 36% fewer issues than states without such policies.

Synthetic cannabis

Investigators concluded that “Adoption of permissive cannabis law was associated with significant reductions in reported synthetic cannabinoid exposures. More permissive cannabis law may have the unintended benefit of reducing both motivation and harms associated with use of synthetic cannabis products.”

What’s the other takeaway? Simply that the cannabinoid market itself (whether we’re talking about delta-8 THC or K2) relies on states being non-permissive. Given the chance, most people will choose the real thing over a synthetic product, making real cannabis more popular than its synthetic counterparts.

Conclusion

I don’t often speak well of the cannabinoid industry, because it is a dirty, shady place. But life is about comparisons, and compared to opioids, alcohol, and cigarettes, there’s so little issue with synthetic cannabinoids, that its hardly worth mentioning. On the other hand, with compounds like fentanyl finding themselves in tons of unwanted places, the unregulated aspect of the market could certainly pose problems.

For now – let’s be honest, bigger issues exist. And at least now we know that if the desire is to have synthetics fazed out, it’ll mean legalizing the actual plant, since real cannabis is more popular than synthetic cannabis.

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What is Delta 11 THC, and How Strong Is It? 

To understand what Delta 11 THC is, you will first need to understand more about the compound 11-hydroxy-THC. So, 11-hydroxy-THC is one of our naturally occurring endocannabinoids; meaning it’s made in the body. When you eat plant-based THCs, such as delta-8 or delta-9 THC, and even synthetic ones like Delta 10, the body breaks it down and metabolizes it via the liver. 11-hydroxy-THC is a metabolite of the other tetrahydrocannabinols, and it’s much more potent. This new Delta 11 THC essentially takes 11-hydroxy, and turns it in an extract that can be vaped, so you don’t have to eat an edible and wait an hour for it to kick in. 

To stay current on everything important happening in the industry, subscribe to The Cannadelics Weekly Newsletter. Also, it’ll get you premium access to deals on cannabis flowers, vapes, edibles, and much more! We’ve also got standout offers on cannabinoids, like HHC-O, Delta 8Delta 9 THCDelta-10 THCTHCOTHCVTHCP HHC, which won’t kill your bank account. Head over to our “Best-of” lists to get these deals, and remember to enjoy responsibly!


More on 11-hydroxy-THC 

Again, 11-hydroxy-THC is a highly-potent metabolite of the other tetrahydrocannabinols. This is why delta-8 THC edibles are just as strong as delta-9 edibles, but the same can’t be said for flowers or vape products. The process by which it’s created is known as first pass metabolism, and it’s the reason why ingesting cannabis products orally has much more intense and long-lasting effects compared to smoking.  

So, if you’ve been wondering why edibles get you stoned beyond reason, this why. If you’re anything like me and many other cannabis users I’ve spoken to, edibles hit different (and more intensely) than smoking. Even though it takes a while to feel anything, once they kick in, I get a serious couch-lock effect – baked and tired. This seems to be commonplace when it comes to edibles; but why exactly do they differ so much from smoking, from a scientific standpoint? 

It can be attributed to a couple of factors: the drug-metabolizing enzymes in your GI tract, and blood flow to the liver. When you first eat a cannabis edible, various enzymes in the GI tract begin digesting the food. From that point, blood flow from the GI tract goes through the liver where all these enzymes are metabolized, then the blood continues to general circulation throughout the rest of the body. When the metabolites are formed, that’s when you get the effects of 11-hydroxy-THC. 

When you smoke cannabis, on the other hand, THC is absorbed through the lungs and distributed directly into the bloodstream. The active compounds make their way to the brain where they interact with the CB receptors that are part of the endocannabinoid system. In this scenario, you are feeling the effects of the phytocannabinoids (plant-cannabinoids) themselves, rather than the compound formed during metabolism. 

Is 11-hydroxy-THC stronger than Delta 9 THC? 

Although limited, the research we do have indicates that 11-hydroxy-THC is considerably stronger than delta-9 THC, which is the most popular of the existing THCs (delta 8, 9, 10). Some studies even claim that 11-hydroxy-THC is up to 7 times more potent than delta 9 THC, although that cannot be completely substantiated, and it can vary based on body chemistry and other factors.

Back in the 1970s is when this cannabinoid was initially noted, in radiolabled THC was utilized in labs to allow researchers to better study these compounds. Radiolabled THC (which yes, is radioactive) behaves just like regular THC but it allows scientists to see where all the metabolites go once it’s broken down within the body. This is how 11-hydroxy-THC was discovered. 

At the time, very little 11-OH-THC was available, for obvious reasons, so for a very long time only small animal studies could be conducted. Once they had the ability create this compound on a larger scale, in a lab, seminal studies were launched to characterize the effects of 11-OH-THC in humans. Numerous studies of delta 11 taken intravenously showed it was not only more potent, but onset of effects was much quicker than other forms of THC also administered the same way.   

Delta 11 THC? What is it, and is it legal?

Remember, Delta 11 THC and 11-hydroxy-THC are kind of the same thing, but not exactly. In chemistry, “delta” refers to the location of the double bond on a molecule’s carbon chain. In the case of THC, we have many different variations. With delta-9 THC, the double bond is on the 9th carbon chain. Move that bond over one spot to the 8th chain, and now we have delta-8 THC.

Keep moving that double bond and you get a variety of different delta THCs. Another way that we get variation in THCs is through differing types of side chains. Most delta THCs have alkyl side chains, but change them to hexyl or butyl and you get completely different compounds again, such as THC-P, THCV, THC-H, THC-O, THC-B, and so forth. This chain variation can be applied to other psychoactive cannabinoids like hexahydrocannabinol (HHC, also known as ‘HXC’). And we have been seeing more of this with the emergence of HHC-O/HXC-O and HHC-P/HXC-P.  

THC and all of its isomers and analogues were considered illegal for a long time in the U.S., but when the US Farm Bill was revised in 2018, it allowed for the cultivation of hemp and production of hemp-derived products.The main provision there was that products sold could not have more than 0.3% delta 9 THC, but analogues were not explicitly mentioned. This led to the assumption that products containing trace cannabinoids can be sold legally under this loophole, but things remained convoluted for quite some time.

Then in 2020, the DEA released its Interim Final Rule to clarify some points of confusion in the farm bill. One of the main topics in this document, was synthetics. The Final Rule maintained that “All synthetically derived tetrahydrocannabinols remain schedule I controlled substances.” What it did not clear up, nor did the USDA Final Rule which came out the following year in 2021, is whether human processing of a trace compound constitutes “synthetic”, or if the fact that they do appear in nature allows them to still belong to the category of “naturally occuring”. And since Delta 11 THC is basically a synthetic copy of 11-hydroxy-THC, which is metabolite that occurs naturally within our own bodies, it falls into a sort of legal grey area. So technically, by default, it is legal to buy and sell, until a law that expressly bans it is passed.

Want to try Delta 11 THC for yourself? Then check out our product deal below, and subscribe to our weekly newsletter (sign up box at the top of the page), for more sales as they come up.

Save Big on Delta 11 Vape Carts and Disposables!

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Hello readers! We appreciate you joining us at Cannadelics.com, a top choice news platform for independent coverage of the growing cannabis and psychedelics landscapes of today. Come by the site whenever possible for updates on current and world-changing events, and head over to the Cannadelics Weekly Newsletter, so you’re always up on what’s going down.

The post What is Delta 11 THC, and How Strong Is It?  appeared first on Cannadelics.

The Hemp Doctor: The Benefits of Blending Cannabinoids

What could be better than a single cannabinoid? Blending multiple cannabinoids, of course. You may be wondering, why is this method of consumption so popular? Are there potential advantages of combining cannabinoids? The answer is yes; the benefits are numerous. Here we explain the importance of this particular strategy and how blending cannabinoids can enhance your overall experience.

First, a quick definition of what cannabis and hemp are. Cannabis and hemp plants are two different varieties of the C. sativa plant. Both contain CBD and THC along with over 540 other substances. The main difference between the two plants is the amount of each compound they contain.

CBD is non-intoxicating and comes from the hemp plant. Hemp generally contains more CBD and less THC. While cannabis plants contain more THC and less CBD. Delta 9 THC (or D9) and cannabidiol (CBD) are two of the most common cannabinoids found in the flowering cannabis plant. There are several others such as cannabigerol (CBG), cannabinol (CBN), Delta 8 THC (D8), and so on.

It’s the interaction between these substances and the body’s endocannabinoid system (ECS) which helps to regulate specific functions such as appetite, pain perception, the immune system and more. Some of the benefits of hemp-derived products include heightened sensory perception, relaxation, etc. The possible short- and long-term effects are dry mouth, drowsiness, and in some cases, paranoia, etc.

The compounds found in cannabis and hemp can be processed into many different formats, providing adult consumers with a wide selection of wellness products. The current market in the U.S. has a variety of edibles, tinctures, vapes, and more. These products can be classified into three types: isolate, broad spectrum, or full spectrum.

  • Isolate: This term refers to a form of cannabis or hemp extract which contains one single cannabinoid, typically CBD.
  • Broad spectrum: A term describing cannabis or hemp extracts which are made without THC but have all the remaining compounds.
  • Full spectrum: These cannabis or hemp extracts contain (or combine) ALL the available compounds, including THC. The concept is similar to whole plant medicine.
Courtesy of The Hemp Doctor

The Entourage Effect: What is it?

Research done in the late 1990s suggests a potential synergy may exist between compounds. This mechanism is called the Entourage Effect. Each compound can have a certain effect on its own, but when consumed together could create an enhanced experience. One example is that some experts think it might be possible for CBD to reduce the euphoria from THC, which can be ideal for some consumers.

Another is that terpenes may also play a role and are important to the overall effects. When exploring the added therapeutic benefits of cannabis and hemp, look for full or broad spectrum formulations. Each consumer’s experience will vary depending on the product’s potency and individual tolerance. 

Hemp Doctor
Courtesy of The Hemp Doctor

Cannabinoids Customized

Can Cannabinoids Be Mixed? 

Yes, you can combine cannabinoids. As we mentioned above, the compounds in these flowering Cannabaceae plants work better together. Unless you prefer not to consume full or broad spectrum products, we think this strategy is the most efficient way to consume.

Furthermore, hemp-derived products are seen as safe and effective with few health risks. When shopping for cannabis, avoid purchasing products from retailers who do not provide COAs (certificate of analysis) for each product. This analysis assures the consumer that the product has been tested and cleared of heavy metals, pesticides, residual solvents, etc. Since you can use cannabis/hemp at your own discretion, it is important to choose quality products.

There are some practical reasons for blending cannabinoids (or cultivars). The first reason is value. If you want optimal results from a hemp product, for the best price, you should look for full or broad spectrum formulations. The second reason is fairly straightforward. Consumers will sometimes blend different cultivars to adjust the taste or enhance the effects. This strategy makes customizing your experience possible!

Hemp Doctor
Courtesy of The Hemp Doctor

At this time, hemp-derived products are federally regulated and legal for sale in most states. However, cannabis products remain illegal across the country on a federal level. In order for the cannabinoid, THC to be legal it must be sourced from hemp and contain a maximum of 0.3% D9 by dry weight. Although these products are derived from hemp, many of the cannabinoids can have intoxicating effects. For this reason, it is recommended to start with lower doses, and increase as needed for desired effect.

Our Top 5 Cannabinoid Combining Concoctions Include:

  1. Delta 9 THC/Delta 8 THC full spectrum Gummies (30-piece jar) Each piece has 15mg of Delta 9 THC and 50mg of Delta 8 THC, sourced from U.S.-grown hemp. These gummies come in several classic flavors with something for everyone.

This recent online review from Nicole via Trustpilot describes how this popular product helped her at bedtime.

  1. Delta 9 THC/CBD/CBN Full Spectrum Nighttime Gummies (30 pieces per bottle) These gummies have 12.5mg of D9, 15mg of CBD and 5mg of CBN in every piece, for total relaxation. Choose from three delicious flavors.

See how much Samantha loves these gummies by reading her Trustpilot review.

  1. Delta 9 THC Infused Gummies (either 20 or 50-piece bottle) Every piece is packed with 7.5mg of D9, 1mg of CBC, 1mg of CBG and 1mg of CBN. With a tasty mix of fruit flavors! Helping you catch your Zs.
  2. Full Spectrum High Octane CBD/CBG/CBN (30 ml bottle) This premium tincture comes in two formats, with a combined total of 1500mg (25mg per 0.5ml) or 2800mg (46.7mg per 0.5ml). Available in either natural or lemon flavors.
  3. CBD + CBG Salve (2oz per jar) The jar contains 2000mg of CBD and 2000mg of CBG. Our formulation also includes a variety of essential oils to moisturize, soothe, and improve overall skin quality. This product has been designed to be used as often as necessary.

NEW! Try our 2ml D8/D10/HHC Disposable Vapes.

The Hemp Doctor has five stars! Check out what our customers are saying about these products on our website and Trustpilot. Since everyone’s needs are unique, it is important for us to educate the consumer. Formulating a self care system that works with one’s lifestyle. Selecting and customizing your cannabinoid regimen is very personal, depending on your lifestyle, budget, and more.

The Hemp Doctor is here to help. Contact us directly to reach our customer service team.

You Are in the Driver’s Seat!

Many things are better together, like macaroni and cheese or pen and paper. Why not enjoy all the benefits that hemp has to offer? Rather than restrict yourself to just one cannabinoid, embrace all 500-plus available substances.

Particularly if you are looking to achieve a certain effect, consuming full and broad spectrum products can be a great option. After all, this is the way cannabis and hemp have been used since the beginning of time. It’s only recently that cannabinoids have been isolated. Blending cannabinoids is popular for good reason. Allowing consumers to take advantage of the entourage effect, which is the ultimate in self-care. You are in control of your health and wellness, enjoy experimenting and consume responsibly.

Reach out on social media and tell us about your favorite combinations!

What makes us different from other providers? We guarantee the highest quality, offering our customers a 30-day money-back guarantee. We also offer a wide variety of products to suit everyone’s preference. Our hemp is organically grown in the USA, and is lab tested for purity. Using our proprietary hemp extraction process to preserve the beneficial compounds, further providing premium products to our customers. Getting started with CBD can be easy and affordable.

Buy compliant, high-quality cannabinoid products from The Hemp Doctor today!

The post The Hemp Doctor: The Benefits of Blending Cannabinoids appeared first on High Times.

New Cannabinoid: What is THC-B (Tetrahydrocannabutol)?

As we’ve seen over the last decade, there is always more to learn about the weed. Aside from emerging research on different potential therapeutic benefits, it seems like scientists are always uncovering new compounds within various parts of the cannabis plant, from the flowers, to the stems, to even the pollen. One of the most recent to be isolated is THC-B, or tetrahydrocannabutol, which was first noted by a group of Italian researchers in late 2019.

There are over 120 known cannabinoids at the moment, 15 of which are different types of THCs (tetrahydrocannabinols). THC-B is a phytocannabinoid, found naturally in cannabis in very minimal levels. From a chemical standpoint, it’s very closely related to Delta 9 THC (tetrahydrocannabinol), with only some slight differences in structure. Research is extremely limited on this compound, but below is what we know so far.  

To stay current on everything important happening in the industry, subscribe to The Cannadelics Weekly Newsletter. Also, it’ll get you premium access to deals on cannabis flowers, vapes, edibles, and much more! We’ve also got standout offers on cannabinoids, like HHC-O, Delta 8Delta 9 THCDelta-10 THCTHCOTHCVTHCP HHC, which won’t kill your bank account. Head over to our “Best-of” lists to get these deals, and remember to enjoy responsibly!


What makes THCs different from one another? 

By now we’re all relatively familiar with Delta-9 THC. When discussing the high caused by cannabis and tetrahydrocannabinol in general, most people are referring to Delta 9 THC. Nearly all consumers are familiar with the existence of D9 THC, but what is less common knowledge is the fact that many, many more types of THC exist.  

The latest industry trend (in the world of alternative cannabinoids, anyway) is to synthesize and isolate as many new cannabinoids as possible, both those found naturally in the cannabis plant, as well as various synthetic analogues and isomers. The possibility of different types of THC, has opened the discussion in some circles regarding how to create these compounds via differing chain lengths and types. 

In chemistry, “delta” refers to the location of the double bond on a molecule’s carbon chain. In the case of THC, we have many different variations. With delta-9 THC, the double bond is on the 9th carbon chain. Move that bond over one spot to the 8th chain, and now we have delta-8 THC. Keep moving that double bond and you get a variety of different delta THCs. Another way that we get variation in THCs is through differing types of side chains. Most delta THCs have alkyl side chains, but change them to hexyl or butyl and you get completely different compounds again, such as THC-P, THCV, THC-H, THC-O, THC-B, and so forth. 

This chain variation can be applied to other psychoactive cannabinoids like hexahydrocannabinol (HHC, also known as ‘HXC’). And we have been seeing more of this with the emergence of HHC-O/HXC-O and HHC-P/HXC-P.  

Now, keep in mind that these are all synthetic cannabinoids – but the definition of ‘synthetic cannabinoids’ can mean one of two things. First, synthetic cannabinoids are compounds that do not exist in nature and must be created in a lab, like THC-O. Also, a synthetic can be a cannabinoid that does exist in nature, but in such minimal amounts that in order to manufacture enough for it to be used in consumer products, it must still be synthesized in a lab, like Delta 8 THC. So whether the cannabinoid in question is actually found in the plant or not, you’re likely getting a synthetic version of it in the products available today. 

THCB explained  

Tetrahydrocannabutol (THCB) is a homolog of delta-9 THC with the main difference being a butyl side chain replacing the alkyl chain. There is very little information available on this cannabinoid, other than the discovery that it has an affinity for both CB receptors. 

A formalin test in vivo was performed to determine whether THC-B had any analgesic and/or anti-inflammatory properties, which it does both: help relieve pain and reduce inflammation. Additionally, the report stated that THC-B slowed reaction time and could be used to improve sleep and reduce symptoms of anxiety and related disorders such as Obsessive Compulsive Disorder.  

The butyl homologues of Delta 9 THC and CBD (cannabidiol/cannabidibutol) were both isolated from the cannabis plant, inflorescence, in trace amounts. THC-B is metabolized like all other THCs, and it also has 7 double bond isomers and 30 stereoisomers.  

Effects of THC-B

Since THC-B is new and somewhat niche, it hasn’t been tried and reviewed by a large group of consumers. That said, it’s believed that THC-B is not as potent as Delta 9 THC, and does not produce the same wide range of psychoactive effects. Those who have tried THC-B (myself not included) claim that it can produce feelings of relaxation and sleepiness, so it can be helpful for those with anxiety or insomnia.  

According to a handful of redditors, THC-B has somewhat of a “headband” effect. Headbang is a specific type of hybrid marijuana strain created by cross-breeding OG Kush and Sour Diesel. The effects of this strain are said to be relaxing but exceptionally clear-headed.  

Regardless, this was another area where information on THC-B was lacking. Because it’s so new and barely any products containing only THC-B even exist, it’s no surprise that the general public is wildly unfamiliar with how this cannabinoid feels and what exactly the effects are.  

Where to find THCB 

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Final thoughts

New cannabinoids are fun. And they don’t have to be the most potent and intoxicating to be relevant to the conversation. THC-B fits the bill here: it’s psychoactive, but not more so than Delta 9 THC, but it has it’s interesting to learn more about as it comes with its own unique effects and potential benefits. Remember to subscribe to the newsletter to learn more and get access to product deals as they become available.

Welcome all! Thanks for dropping by Cannadelics.com, a top offering for comprehensive news covering the burgeoning cannabis and psychedelics industries. Stop by daily for a dose of news on these dynamically changing fields, and sign up for The Cannadelics Weekly Newsletter, so you’re up on everything important going on.

The post New Cannabinoid: What is THC-B (Tetrahydrocannabutol)? appeared first on Cannadelics.

HXC vs HHC: Why Companies Are Choosing HXC

To stay current on everything important happening in the industry, subscribe to The Cannadelics Weekly Newsletter. Also, it’ll get you premium access to deals on cannabis flowers, vapes, edibles, and much more! We’ve also got standout offers on cannabinoids, like HHC-O, Delta 8Delta 9 THCDelta-10 THCTHCOTHCVTHCP HHC, which won’t kill your bank account. Head over to our “Best-of” lists to get these deals, and remember to enjoy responsibly!

Although still considered a somewhat less common alternative cannabinoid, HHC – or Hexahydrocannabinol – has been gaining popularity over the last year. To the point that it’s currently undergoing a rebrand, so to speak. Some companies have started referring to HHC, as HXC. Learn why the switch to HXC is happening. 


What is Hexahydrocannabinol (HHC/HXC)? 

All abbreviations aside, let’s focus on the basics here: what are hexahydrocannabinols? In short, they are another group of psychoactive cannabinoids that are very similar to tetrahydrocannabinols. HHC is basically a simplified version of Delta 9 THC. Both HHC, Delta-8 and Delta-9 THC have very similar molecular structures and comparable effects. With HHC, all the double bonds have been broken and replaced with hydrogen (AKA hydrogenation). It was discovered during research in the 1960s and 70s in which the goal was to find the most basic cannabinoid-like substances that could still bind to CB receptors.   

There is a biologically active naturally occurring (−)-hexahydrocannabinol, as well as its synthetic enantiomer (+)-hexahydrocannabinol. The synthetic HHC, which can be found in spice, has the chemical formula: 9-Nor-9β-hydroxyhexahydrocannabinol, and the natural variety, found in trace amounts in cannabis pollen, goes by the formula: 6aR,9R,10aR-Hexahydrocannabinol.    

In addition to the natural and synthetic HHCs, a couple of more potent analogues and isomers that have been created, as well as new discussion regarding the possibility of more chain lengths and combinations like HHCV, HHCB, HHCH and so on. These are the same chain length variations we see in all the different THCs.  

Now, keep in mind that these are all synthetic cannabinoids – but in cannabis, the definition of “synthetic” can mean one of two things. First, synthetic cannabinoids are compounds that do not exist in nature and must be created in a lab, like THC-O. Also, a synthetic can be a cannabinoid that does exist in nature, but in such minimal amounts that in order to manufacture enough for it to be used in consumer products, it must still be synthesized in a lab, like Delta 8 THC. HHC-O falls into the first category, while HHC belongs to the second. In cannabis plants, HHC is found in trace amounts in the pollen. Then we have HHC-O, which is the acetate version of HHC, and HHC-P which is the carbon version.  

We’re seeing a small influx of new, HHC-P products, hitting the store shelves, but it’s close to impossible to find any information about this cannabinoid that comes from a neutral, fact-based party rather than from the companies who are selling it. It’s likely because, the companies selling the compounds are also the ones who are creating them in the first place, and no one else really knows about these compounds or has had the opportunity to study them yet. 

What’s in a name? HXC vs HHC 

Just to make It perfectly clear, HXC and HHC are the same thing. Simply put, HHC is undergoing a rebrand, with a few select companies now selling HXC, HXC-O, and HXC- P… instead of HHC, HHC-O, and HHC-P. It’s hard to tell how many companies will begin doing this, but because a couple of the bigger industry brands like Delta Extrax and Cake are doing it, it’s likely to catch on.  

According to our friends over at Delta Extrax, “As cannabinoids gain popularity, so does the misinformation about them. You can look at this slight change in abbreviation as an upgrade and those who don’t adapt get left behind. Another big reason why the name upgrade occurred is that HXC is the abbreviated word for Hexahydrocannabinol (HHC).” 

It’s a simply but straightforward reason. I personally cannot think of any other cannabinoids getting a new name or rebranding, as there is usually some scientific basis to their names and acronyms. But it’s possible that we may see more of this in the future, and perhaps this is signaling a time when consumer products start to veer away from their chemical descriptions and start using more marketable names.  

For the latest deals on HXC / HHC products subscribe to the THC Weekly newsletter!

HHC/HXC and drug testing

When it comes to cannabis, standard urine tests are used to detect use ranging from roughly 1 to 45 days. Occasional users will typically be clean after 1-5 days, regular light users will take about 1-3 weeks, and for heavy daily users, expect 4 to 6 weeks to get clean. Contrary to popular belief, standard urine tests don’t screen for the THC (tetrahydrocannabinol) in cannabis, but rather, they detect the metabolites created by the human body when we are exposed to THC.

This class of metabolites is known as THC-COOH. These metabolites are inactive, so drug testing only measures exposure, NOT impairment.THC-COOH, or “carboxy THC” is the most common name for this metabolite. It’s the second THC-metabolite formed in our bodies, following hydroxy-THC, immediately after exposure. THC-COOH is lipid-soluble, meaning it’s stored in our fat cells making it detectable in our systems for much longer than other substances, those that are water soluble for example.

One of the more interesting and appealing attributes about HHC/HXC, is that it is believed to not show up on a drug test, because it does not trigger the same metabolites in the body as tetrahydrocannabinols. Now, this is where things get a bit sketchy… it’s quite difficult to find products that are pure HHC/HXC. Even when advertised as such, many of these products contain trace amounts of Delta 8, Delta 9, and other THCs, in which case, the user would fail their drug test. To be safe, all cannabis products should be avoided if you have an important drug test coming up.

Companies that have switched to HXC – and what consumers are saying about it

So far, I’ve only discovered two major companies and one smaller brand that are selling HHC products as HXC. The two household names are Cake and Delta Extrax, and the lesser known company is Medusa Delta 8 – all of which are selling some HXC vape devices.

Examples of some HXC products you can find at Delta Extrax: SFV OG HXC + HXC-P 2 Gram Disposable, Space Candy HXC + HXC-P 2 Gram Cartridge, and Tropical Zkittlez HXC + HXC-P 2 Gram Cartridge. At cake, you can check out HXC disposables in a variety of different strains and flavors including: Animal Cookies, Banana Runtz, Blue Dream, Kush Mints, Pineapple Express, Gelato 41, Dragonfruit Rosin, and many more.

The Delta Extrax products are new, so reviews aren’t out yet, but the Cake HXC products have been around for a few months, and the reviews are mixed. As with most alternative cannabinoid products, some people love them and some don’t. Some say they have little effect, while others believe they’re stronger than THC. Case in point, everyone has different body chemistry and tolerances, and may react differently to the same compound or product.

Conclusion

Once again, HXC and HHC are the same thing. HXC is the new name/acronym given to hexahydrocannabinol by a small number of companies who sell alternative cannabinoid products. Whether you’re looking for products or information on HXC, your best bet is to check back here or subscribe to our weekly newsletter for all the latest industry updates.

Welcome all! Thanks for dropping by Cannadelics.com, a top offering for comprehensive news covering the burgeoning cannabis and psychedelics industries. Stop by daily for a dose of news on these dynamically changing fields, and sign up for The Cannadelics Weekly Newsletter, so you’re up on everything important going on.

The post HXC vs HHC: Why Companies Are Choosing HXC appeared first on Cannadelics.

Learn All About High-Potency Cannabinoids and the Products Containing Them  

In today’s cannabis market – at the very least, in states that don’t have legal recreational weed – high-potency products containing blends of extra strong cannabinoids and gaining popularity. But what exactly are these new compounds? Are they natural or synthetic? What makes them different from one another? And what kind of products contain them? Scroll down to learn all about high-potency products.

To stay current on everything important happening in the industry, subscribe to The Cannadelics Weekly Newsletter. Also, it’ll get you premium access to deals on cannabis flowers, vapes, edibles, and much more! We’ve also got standout offers on cannabinoids, like HHC-O, Delta 8Delta 9 THCDelta-10 THCTHCOTHCVTHCP HHC, which won’t kill your bank account. Head over to our “Best-of” lists to get these deals, and remember to enjoy responsibly!


What are high-potency cannabis products? 

High-potency cannabis products are just that, consumer weed products that contain the more psychoactive compounds found in the cannabis plant, as well as some new, synthetic variations. The two categories of cannabinoids that actually produce these type of effects are THCs (tetrahydrocannabinols) and HHCs (hexahydrocannabinols).  

When it comes to high-potency cannabis products, they can fall into one of three categories: products that contain only one high-potency cannabinoid, such as THC-P only products. You can also have products with a blend of high-potency cannabinoids, like THC-O, Delta 10, THCjd, and THCh mixed together. Or, you can have a product with very high concentrations of any psychoactive cannabinoid, like edibles with 100mg or more of delta 9 per serving.  

Typically, high-potency products consist of vapes, edibles, and concentrates. Flower products can be infused with stronger cannabinoids, but they still are not usually considered high-potency, because there really is a limit to how high one can get on smokables.  

More about THCs and HHCs 

First, let’s quickly review THCs. There are a total of at least 15 that we know of. There are 4 major types of THC that are naturally occurring in the plant: THCA, THCV, Delta 8 THC and Delta 9 THC. Then, we have a few synthetics like THC-O and Delta 10. And we also have some very trace cannabinoids (those that show up in very low amounts) like THCP. And then we have a whole slew of new THCs that very little remains known about, and these include THCjd and THCh.

We also have one, naturally occurring endocannabinoid that is in the family of THCs, and that’s 11-hydroxy THC. This is not a cannabinoid per se, but a metabolite that our body creates when we digest different types of THC. So, if you’re eating naturally occurring THCs, like Delta 8 or Delta 9, the effects in our bodies will be the same, because they are all converted to 11-hydroxy THC. Synthetic THCs may have different effects, this has not been thoroughly studied.  

Now, on to HHCs. There are way less HHCs than THCs, so at least it doesn’t get very confusing here. With hexahydrocannabinols we have HHC, HHC-O, and HHC-P. There is a biologically active naturally occurring (−)-hexahydrocannabinol, as well as its synthetic enantiomer (+)-hexahydrocannabinol. The synthetic HHC, which can be found in spice, has the chemical formula: 9-Nor-9β-hydroxyhexahydrocannabinol, and the natural variety, found in trace amounts in cannabis pollen, goes by the formula: 6aR,9R,10aR-Hexahydrocannabinol. 

Both HHC-O and HHC-P are synthetic. HHC-O is the acetate version of HHC. HHC-P has the same alkaline chain as HHC but with two extra carbons included. The addition of these extra carbons is believed to enhance its ability to bind to cannabinoid receptors in the human body – but again, much of this research is extremely new and limited.  

Deals on High-Potency Cannabis Products  

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Welcome all! Thanks for dropping by Cannadelics.com, a top offering for comprehensive news covering the burgeoning cannabis and psychedelics industries. Stop by daily for a dose of news on these dynamically changing fields, and sign up for The Cannadelics Weekly Newsletter, so you’re up on everything important going on.

The post Learn All About High-Potency Cannabinoids and the Products Containing Them   appeared first on Cannadelics.