Using Cannabinoids & Fungus For The Development Of Medicine For Cancer

*** THIS IS A PRESS RELEASE ***
Cannabotech is advancing in the development of botanical medicine for cancer: It reports obtaining a worldwide exclusive license to use a unique fungus for the development and commercialization of products for the treatment of pancreatic and colon cancers

The studied fungus was found effective in killing pancreatic cancer cells and reducing the extent of cancerous tumors in animals; Cannabotech estimates it will present a prototype of the drug as early as the first half of 2023;

Using Cannabinoids & Fungus For The Development Of Medicine For Cancer - Credit PR
Using Cannabinoids & Fungus For The Development Of Medicine For Cancer – Credit PR

Herzliya, Israel – 2 January 2022 – Cannabotech, which develops, among other things, medical cannabis-based products and fungal extracts, reports it received exclusive use of a patent for the development of drugs based on the extract of Cyathus striatus fungus. The fungus is being researched in the laboratory of Professor Fouad Fares, an expert in molecular biology and cancer research at the Faculty of Natural Sciences at the University of Haifa.

According to the agreement signed between Cannabotech and Carmel, the economic company of the University of Haifa, Cannabotech will develop a botanical drug for pancreatic and colon cancers, based on a combination of cannabinoids from the cannabis plant with the fungus extract researched in Professor Fares’ laboratory, which has shown promising results and found to be effective in killing pancreatic and colon cancer cells, and reducing the extent of cancerous tumors in animals, without damaging healthy tissues. 

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Dr. Alex Weissman, an expert in organic chemistry and former director of R&D at the Chimagis Active Ingredients Factory (API), and Dr. Isaac Angel, an expert pharmacologist with more than 15 years of experience in leading drug development processes, will assist Cannabotech in the research process.

A few days ago, Cannabotech reported the results of a study according to which its CannaboBreast product for the treatment of breast cancer, based on a unique combination of cannabinoids and terpenes from the cannabis plant, combined with standard chemotherapy, resulted in an improvement of up to 6-fold in the killing of cancer cells compared to existing treatment (from 10% to 60% cancer cell mortality). 

Cannabotech CEO Elhanan Shaked said: “Cannabotech continues to advance according to its business plan. Along with our preventative medicine products that are already available today, we are operating in the medium-long term in a variety of clinical trials, the most significant of which is the development of a botanical drug for cancer-based on a unique combination of cannabinoids with the Cyathus striatus fungus.”

 Cannabotech CEO Elhanan Shaked - Credit: PR
Cannabotech CEO Elhanan Shaked Credit: PR

Professor Fouad Fares said: “We are pleased with the results achieved so far in animals and the critical reduction in the extent of cancerous tumors and with improved cancer cells’ mortality. The collaboration with Cannabotech enables us to accelerate the research and development process.”

 About Cannabotech:  

Cannabotech is an Israeli biomedical company that develops botanical solutions for preventive medicine and integrative medicine.  These solutions are based on combinations of active agents from the cannabis plant and fungi that work on two central systems in the human body: the endocannabinoid system and the immune system.

As part of the concept of integrative medicine, in the last two years, Cannabotech has been developing a series of 8 preparations based on unique combinations of botanicals from medical cannabis and fungus-based products, designed to help patients with cancer and chronic pain.  Upon completion of their development, the company’s goal is to designate the products to be integrated into oncology patients’ existing treatment protocol.   

At the same time, Cannabotech is working to develop a defined treatment protocol made available to physicians and technology for treatment customization. 

*** END OF PRESS RELEASE **

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Everything you should know about CBD and how it can help you

Having questions, whether you’re an old or new cannabis user, is completely normal. It’s confusing when we talk about hemp, cannabidiol, CBD, cannabis and THC, and how they can all have different effects — especially when they are all linked back to cannabis. Here, we’ll go over everything you should know about CBD, and how […]

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6 Rock Stars who Rock the Cannabis Business

Some rock stars aren’t just rocking the stage — they also rock their own cannabis business.  With the creativity and empathy-enhancing effects, it makes sense why many musicians are open about their love of Mary Jane, whether for creativity, medical reasons, or just for fun. You may have heard of brands like Leafs by Snoop, TICAL, […]

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Study Shows Cancer Patients Consume Less Cannabis Than General Public

A new study conducted in Virginia has found that the general public currently consumes more cannabis than cancer patients.

The Virginia Commonwealth University of Massey Cancer Center (VCU) published a study in the journal Cancer on August 13, entitled “Cannabis use among cancer survivors in the United States: Analysis of a nationally representative sample,” which analyzed data from 19,055 people over a four-year period.

Lead author of the study, Bernard Fuemmeler, Ph.D., M.P.H., who also holds the titles of associate director for population science and interim co-leader of the Cancer Prevention and Control research program at VCU expressed his surprise when they conclude their results. “Even when we looked at whether someone used cannabis over the four years of observation and we control for things like age and race, cancer patients are still not increasing their use over time like the general population,” he said. “I would have expected them to have at least mirrored what was happening in the general population.”

The study analyzed data collected between 2013 and 2018, which was a monumental time frame for cannabis legalization and growth of the industry. Data was collected from the Population Assessment of Tobacco and Health, which surveys Americans’ smoking habits both in the vein of tobacco and cannabis. A VCU diagram shows that only nine percent of cancer patients consume cannabis within the four-year period, whereas 14 percent of the general public stated that they consumed.

Because of the industry boom during the study’s four-year time frame, study co-author Sunny Jung Kim, Ph. D., and also Harrison Scholar at VCU Massey Cancer Center and assistant professor of health behavior and policy at the VCU School of Medicine, explains that the stigma against cannabis begins to be lifted, both with recreational consumers as well as medical patients. “Because of law enforcement changing, we expect to see changes in attitudes and perceived benefits and harms. This work gives us perspective on prevalence of cannabis use among cancer patients and how it has changed over time.”

One assertion as to why cancer patients are not consuming more cannabis today, according to Fuemmeler, is because of hesitation. “There is that element of a life-changing moment when you have cancer,” said Fuemmeler. “You have to be mindful of your health and contemplate whether something like cannabis is helpful or hurtful.” The study results revealed, unsurprisingly, that people who experience higher amounts of pain are more likely to use cannabis. On the other hand, women, the elderly and people with “higher incomes, medical insurance or better mental health” were more likely to have lower levels of pain.

As is common in cannabis studies, the VCU researchers believe that more research is necessary to achieve better results. “As with all health decisions, it’s best to talk to your doctor before making any big changes,” said another study co-author, Egidio Del Fabbro, M.D. professor of internal medicine at VCU. “Now that marijuana is becoming legal in more parts of the country, we’re expecting more questions, and although we may not have all the answers, we’re here to listen and provide our patients with the best available evidence.”

The study of the relationship of cannabis and cancer has made increasing headway over the past few years. One Canadian study published in December 2020 found that more Canadians with cancer were using cannabis than in previous years. Another more recent study from July found that 71 percent of gynecological cancer patients found relief when consuming cannabis. The American Cancer Society writes that based on small studies, cannabis has been known to help treat patients experiencing nausea and vomiting from chemotherapy, neuropathic pain, increase their appetites, reduce the need for pain medication and more.

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New Research Labels THCA as Novel Therapy for Drug Resistant Cancer

THCA, or tetrahydrocannabinolic acid, is a relatively unknown compound found in the cannabis plant. Research on this cannabinoid is quite promising, despite the fact that it’s still mostly uncharted territory. However, one of the most hopeful studies to date is a new one from Israel that suggests THCA could be beneficial in the treatment of drug resistant tumors.

Medical cannabis has come a long way. From SciCann and its new-age THCA cancer treatments, to delta-8 THC – an alternative to delta-9, which won’t cause anxiety, and leaves users with a clear-headed high, and slightly less psychoactive effect. New cannabis technology means new and improved products for consumers, and that’s good for you. If you want to try what today’s world of cannabis technology has to offer, subscribe to The CBD Flowers Weekly Newsletter for more articles, exclusive deals, and to take advantage of today’s best advancements in cannabis products.  Or you can check out the Delta 8 Weekly Newsletter for the best deals on Delta 8 THC.


What is THCA?

Everyone’s heard of THC (tetrahydrocannabinol) but most people don’t know about its precursor compound, THCA, which is found only in raw cannabis plants. As the buds dry, cure, or when heat is applied, THCA eventually turns into THC. This process – when THCA loses its carboxyl acid group – is known as decarboxylation. Contrary to popular belief, THC actually isn’t found in fresh flowers.

If you’ve ever bought cannabis from a dispensary that sends their bud out for lab-testing, you may have noticed that somewhere on the package it will have the “THC content” listed. It’s labeled this way because, presumably, the consumer is going to smoke, vape, or otherwise heat the product in some way. However, it would be more accurate to label it as “THCa content” since the flowers are raw when purchased.

For many years, this acid compound has been largely ignored and the central focus was on THC and finding ways to vilify it. Thankfully now, we’re starting to make great strides in the way of cannabis research and medical researchers are starting to look at the unique benefits of multiple cannabinoids, including THCA.

Unlike its decarbed counterpart, THCA is non-psychoactive, although very relaxing, and it does have numerous medical benefits. THCA can help with pain, inflammation, and neurological disorders like epilepsy. It has been found to contain neuroprotective qualities and can be a helpful compound in the treatment of Alzheimer’s, Parkinson’s, and Multiple Sclerosis. Also, in addition to the research I’m covering in this particular article, previous studies have suggested that THCA has some level of anti-cancer properties.

Cancer Statistics

In the United States alone, an estimated 1,806,590 new cases of cancer will be diagnosed in the coming year, and out of those cases, 606,520 will die from the disease or a related complication. The most common cancers, in descending order, are breast, lung, prostate, colon, melanoma, bladder, non-Hodgkin lymphoma, kidney/renal, endometrial, leukemia, pancreatic, thyroid, and liver cancer. In women, the most commonly diagnosed cancers are breast, lung, and colorectal, while for men the most common are prostate, lung, and colorectal. These 4 different types of cancer account for roughly 50% of all new cases.

Despite living in a nation that prides itself on having the best medical care on earth, cancer mortality rates remain high. For men, the number rate of death is higher with 190 per 100,000 – compared to 136 per 100,000 for women. There are race discrepancies as well, with cancer mortality being highest in African American men (227 per 100,000) and lowest in Asian/Pacific Islander women (86 per 100,000).

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Approximately 40 percent of American adults will be diagnosed with cancer at some point during their lives and an estimated 16,850 children and adolescents between the ages of 0 to 19 will receive a diagnosis. The cost of national cancer-related expenditures is around $160 billion. These numbers are all estimated to increase over the coming decades as a result of an aging population and exposure to environmental and dietary carcinogens.

Worldwide, cancer is among the leading causes of death. Every year around 18 million people are diagnosed with cancer, with roughly 9.5 million deaths. Generally, cancer rates are highest in countries whose populations have the highest life expectancy, education level, and standard of living, which tells us a few different things.

First, the obvious, incidence rates for cancer go up as age increases, so naturally, a population with a larger number of older citizens will have higher rates of cancer as well. Now, the less obvious, people living in more developed nations live in a more sedentary way and are exposed to many unnatural compounds over the course of their lives, many of which are carcinogenic. People living a simpler and more natural lifestyle are typically healthier overall.

Multiple Drug Resistance       

Although the number of available cancer treatments is growing, long term survival rates for patients undergoing traditional chemotherapy remain suboptimal. A major factor impacting the effectiveness of chemotherapy is the development of resistance to a variety of anticancer drugs. This is referred to as Multiple Drug Resistance (MDR) and it occurs in over 50 percent of cancer patients who experience a recurrence. Recurrence, coupled with MDR, greatly increases the risk of mortality.  

According to the study, “The dominant mechanism behind Multi Drug Resistance involves active extrusion of the cytotoxic drugs from the tumor cells by dedicated efflux pump proteins, that reduces the intracellular levels of cytotoxic drugs below lethal thresholds. Blocking the flow of chemotherapeutic drugs out of MDR cells by efflux pump inhibition has been for long a highly desirable approach for tumor resistance reversal, however the first two generations of chemosensitizers, drawn from drugs approved for other indications and their derivatives, did not progress to become established clinical modalities, mainly due to adverse effects and toxicity.”  

Simply put, MDR occurs via the increased release of drugs (chemotherapy drugs in this case) outside the cells, so drug absorption is reduced within the cells. There are many different mechanisms at play here, but the main point is that MDR is responsible for over 90 percent of deaths in cancer patients on chemotherapy drugs, and a solution to this problem is of utmost importance.

About the Study

According to this study, which was completed by SciCann Therapeutics in Israel, the THCA class of cannabinoids has potential as an MDR pump inhibitor, one that’s non-toxic, non-psychoactive, and free of dangerous side effects. Research on the subject is limited, but this particular study is very informative with incredibly promising results.

According to Professor Dan Peer from Faculty of Life Sciences at Tel Aviv University, “ the goal was to discover a set of potent cannabinoid compounds that would be safe and non-toxic for clinical use, however would show high efficacy in blocking cancer cell efflux pumps.” SciCann’s aims to develop a first in class cannabinoid “chemosensitizng agent to be administered as an add-on therpay together with traditional chemotherpay, for patients who have developed a Multi Drug Resistance cancer type and thus restore tumor response levels to therapy.”

This first test was conducted on the human ovarian adenocarcinoma resistant cell line (NAR) and its non-resistant parent line (OVCAR-8). MDR is one of the most common causes of chemotherapy failure in patients with ovarian cancer as well as secondary treatment failure that can lead to devastating outcomes.

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SciCann’s research program has already discovered numerous cannabinoids that can act as MDR efflux pump inhibitors. However, the most effective was THCA, which, according to their documents, “has demonstarted a very significant effect of efflux pump inhibition and synergistic activity with traditional chemotherapies”.

This study does not peg THCA as a cure for cancer, but rather as a treatment option that, when combined with other traditional cancer therapies, could greatly increase the likely hood of treatment success and a person’s chances for survival. In short, THCA can be used to re-sensitize tumors that have been previously unresponsive to other treatments.

SciCann has filed a very broad patent application that covers “any pharmaceutical composition that contains a combination of THCA and any anti-cancer or anti-bacterial drug substance, as well as the method of using THCA as a tumor cell or pathogen cell sensitizing agent. The international PCT patent office has found no relevant prior art in the literature for the THCA – chemo or antibiotics combination, or for the use of THCA as a chemo and antibiotics sensitizing agent, and therefore declared the invention as novel and patentable.”

Main Takeaway – THCA for Drug Resistant Cancer

THCA alone doesn’t kill cancer, at least, not according to this study. It does, however, help traditional chemotherapy and other cancer immunotherapy treatments work more efficiently by bypassing any existing Multi Drug Resistance, that is common in roughly half of all cancer patients. A combination of standard cancer therapies along with THCA could allow doctors to give much smaller doses of chemotherapy drugs to their patients, minimizing the risk of dangerous side effects and making survival much more likely.

Thank you for stopping by CBD TESTERS, your source for all things cannabis-related. Remember to subscribe to The CBD Flowers Weekly Newsletter for more articles like this one and exclusive deals on flowers and other products.

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How are Covid vaccines connected to cancer? And how can cannabis help?

Covid vaccines are in full swing around the world as people receive their jab. Unofficially, reports of reactions to the vaccine are deep including death. However, long-term reactions are only just being discovered. If we go deeper into cross-reactions and a study conducted in January 2021, (1) we can find a risk for cancer longer […]

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The facts are in: here’s how THC vapes cause lung damage

2,807 cases of e-cigarette or vaping product use associated with lung injury (EVALI) have been reported up to February 2020. EVALI, or VAPI (Vaping Associated Pulmonary Injury), is an illness related to THC (and nicotine) vapes (portable vaporizer devices) that have killed at least 68 vapers. (1) But, what is the science behind vapes, surfactants […]

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What Medical Conditions Could Benefit Most from Delta 8 THC?

Delta 8 THC is one of the most popular products in the recreational cannabis market today. It’s a legal alternative to THC that offers users a mild but fun and uplifting high. But did you know that Delta 8 also has numerous medical benefits, many of which have been studied and proven through scientific research?

To learn more about Delta 8 THC from a medical and recreational standpoint, and for exclusive deals on Delta-8 THC vapes, gummies, flowers and other products, subscribe to the Delta 8 Weekly Newsletter


What is Delta 8 THC?

Before we talk about the medical benefits of this cannabinoid, let’s talk about what exactly Delta 8 THC is, and how it’s different from the more well-known, Delta 9 THC. Delta 8 THC (tetrahydrocannabinol) is a naturally occurring, minor cannabinoid found in the cannabis plant. Although it’s structurally similar to Delta 9 THC, there are some major differences as well.

For example, Delta 9 THC is the cannabis plant’s most abundant psychoactive compound, whereas Delta 8 is only found in trace amounts. As a matter of fact, Delta 8 is not even produced by the enzymes in cannabis, rather, it is created when Delta 9 THC oxidizes and slowly degrades into Delta 8. Further degradation of Delta 9 would create the cannabinoid CBN (cannabinol).  

When it comes to the chemical difference between Delta 8 and Delta 9, it all comes down to one molecule. In chemistry, “Delta” refers to the double bond in a compound’s molecular structure. Delta compounds have more electrons and will interact with the body in a different way than single bond cannabinoids. The difference between the Delta THC analogues comes down to where the double bond is located on their chain of carbon atoms. Delta 9 has this bond on the 9th carbon chain, and Delta 8 THC has the double bond on the 8th carbon chain. It seems like a small difference, but it can be significant.

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Similar to its more dominant counterpart, Delta 8 THC is a partial agonist for both the CB1 and CB2 receptors, although it seems to have a stronger affinity for CB1. This means there are effects to be felt in numerous different parts of the body, despite having weaker psychotropic potency. The National Center for Biological Information (NCBI) describes delta-8 THC as follows: “An analogue of tetrahydrocannabinol (THC) with antiemetic, anxiolytic, appetite-stimulating, analgesic, and neuroprotective properties.”

What Medical Conditions Could Be Treated With Delta 8 THC

Insomnia

Inadequate sleep can have a profound impact on one’s health. In the short-term, it can affect mood and judgement, the ability to learn and retain information, and it can increase the possibility of an immediate accident or injury. Over a longer period of time, lack of sleep can lead to diabetes, obesity, cardiovascular disease, and even early death.

Extensive research tells us that activation of the CB1 receptor leads to better, longer, and more restful sleep, and keeping in mind that Delta 8 THC directly stimulates the CB1 receptor, one can easily come to the conclusion that Delta 8 is good for sleep. REM sleep is an important part of our circadian cycles because it stimulates parts of the brain that are essential for learning new things and forming memories.

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Anecdotal evidence leads to the same conclusion with many users claiming that Delta 8 THC helps them fall asleep more easily and stay asleep longer. They also report feeling more refreshed and well-rested when waking up.

It’s believed that Delta 8 THC’s analgesic and anti-inflammatory properties play a major role in its ability to function as a sleep aid. There is a strong connection between pain and sleep. Obviously, someone who is experiencing a lot of pain will have trouble getting comfortable and thus, have difficulty falling asleep. But the relationship goes even deeper – as lack of sleep increases the perception of pain. Breaking the pain/lack of sleep cycle is incredibly difficult, and having a good night’s sleep with both REM and deep sleep stages is key to making improvements.  

Cancer

While I’m not saying that smoking some delta 8 flowers or popping a few gummies will cure cancer, studies have proven that pharmaceutical products with highly concentrated doses of certain cannabinoids will do the trick.

This was first observed in 1974, in none other than Israel, where a study meant to focus on the immune system inadvertently found that Delta 8 THC alone significantly slowed tumor growth in mice. When combined with CBN (cannabinol), tumors actually began to shrink in as little as 3 weeks.

“Mice treated for 20 consecutive days with delta8-THC and CBN had reduced primary tumor size. CBD showed no inhibitory effect on tumor growth at 14, 21, or 28 days. Delta9-THC, delta8-THC, and CBN increased the mean survival time.” Antineoplastic activity of cannabinoids – PubMed (nih.gov)

Another study in 1995 on children with leukemia, showed a high rate of efficacy for treating the cancer, while also controlling side effects like nausea and vomiting caused by more conventional forms of treatment. The study was conducted at Shaare Zedek Hospital, Bikur Holim Hospital and the Hebrew University located in Jerusalem. The creators of the study, led by Raphael Mechulam, noted that “at the same this research was occurring, there had been 480 successful treatments of cancer with delta-8 THC.”

Anxiety

If you’re prone to anxiety, the mild and uplifting high you get from Delta 8 THC might be just what you need. Delta 8 THC offers all the medicinal effects of THC, and even some minor psychoactive effects, without the paranoia that often comes with Delta 9. The carefree high that comes with weed is often dampened by the anxious, nervous high some people experience.

Studies show that the endocannabinoid system, mainly the CB1 receptor, is centrally involved in regulating anxiety and depression. When the CB1 receptor is blocked, increased anxiety often occurs. Many people successfully utilize CBD (cannabidiol) to relieve their anxiety, but for many others it’s just not strong enough.

According to the National Cancer Institute, “this phytocannabinoid displays anxiolytic (anti-anxiety) qualities similar to delta-9 THC.” There is little in the way clinical research investing delta-8 THC’s potential to reduce anxiety, however, anecdotal evidence suggests that delta 8 products provide a nice, calm, focused, and stress-free high.

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Final thoughts

There are many more medical ailments that Delta 8 THC can be used for, but these are some of the more studied and most frequently cited uses for this cannabinoid. If you want to learn more about Delta 8, make sure to subscribe to the Delta 8 Weekly Newsletter where you will find more interesting articles and exclusive deals on flowers and other products.

The post What Medical Conditions Could Benefit Most from Delta 8 THC? appeared first on CBD Testers.

Answer to a century-old cancer mystery supports cannabis use for cancer

New research by the Sloan Kettering Institute has finally answered how cancerous cells consume and use up energy from glucose. Interestingly though, their answer to a century-old cancer mystery supports cannabis use and medicinal cannabinoid therapy to treat cancer. How does cancer consume fuel? Cells efficiently eat sugar (glucose) but cancer cells strangely avoid this […]

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Goodbye to Marijuana Man – Greg Williams Passes Away

The cannabis community is grieving the loss of Greg Williams, aka Marijuana Man as he passed away from cancer today. Well known and well-liked, Greg Williams was a grassroots cannabis activist. If you have smoked bud in Canada, there is a possibility that it’s linked to genetics he distributed. Bought mail-order seeds from Cannabis Culture? […]

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