CBGA More Effective For Seizures Than CBD, Study of Mice Finds

Researchers in Australia say they’ve discovered the “mother of all cannabinoids,” and it isn’t THC or CBD. For the first time, a study reports that three acidic cannabinoids found in cannabis, notably cannabigerolic acid (CBGA), reduced seizures in a mouse model of Dravet syndrome, an intractable form of child epilepsy.

The three acidic cannabinoids—CBGA, cannabidivarinic acid (CBDVA) and cannabigerovarinic acid (CBGVA)—”may contribute to the effects of cannabis-based products in childhood epilepsy,” and were noted with “anticonvulsant potential.” CBGA, however, demonstrated the most potential for certain anticonvulsant effects.

“From the early nineteenth century cannabis extracts were used in Western medicine to treat seizures but cannabis prohibition got in the way of advancing the science,” said Associate Professor Jonathon Arnold from the Lambert Initiative for Cannabinoid Therapeutics and the Sydney Pharmacy School. “Now we are able to explore how the compounds in this plant can be adapted for modern therapeutic treatments.” The study was recently published in the British Journal of Pharmacology

CBGA is the precursor “granddaddy” molecule of CBDA and THCA, which eventually convert to THC and CBD, among other compounds. CBGA is part of a protective system for cannabis, produced by trichomes that triggers targeted plant cell necrosis—natural self-pruning to allow the plant to focus energy on the flower. 

“We found that CBGA was more potent than CBD in reducing seizures triggered by a febrile event in a mouse model of Dravet syndrome,” Lead author of the study, Dr Lyndsey Anderson, said. “Although higher doses of CBGA also had proconvulsant effects on other seizure types highlighting a limitation of this cannabis constituent. We also found CBGA to affect many epilepsy-relevant drug targets.”

Fight Against Dravet Syndrome with CBGA

The mission for the team at the Lambert Initiative for Cannabinoid Therapeutics is simple: develop a better cannabis-based treatment for Dravet syndrome—an intractable form of child epilepsy.

In 2015, Barry and Joy Lambert made a hefty donation to the University of Sydney to push forward scientific research on medicinal cannabis. Barry and Joy’s granddaughter Katelyn suffers from Dravet syndrome.

“After using hemp oil for treatment, we got our daughter back. Instead of fearing constant seizures we had some hope that our daughter could have a life worth living. It was like the noise cleared from her mind and she was able to wake up. Today Katelyn really enjoys her life,” said Michael Lambert, Katelyn’s father.

In order to learn more, the research needs to be continual. “Our research program is systematically testing whether the various constituents of cannabis reduce seizures in a mouse model of Dravet syndrome,” said Associate Professor Jonathan Arnold. “We started by testing the compounds individually and found several cannabis constituents with anticonvulsant effects. In this latest paper we describe the anticonvulsant effects of three rarer cannabinoids, all of which are cannabinoid acids.”

The Entourage Effect

In the meantime, anecdotal evidence from cannabis consumers abroad suggests that there is more to cannabis’ healing powers than THC and CBD, although the science is limited.

Families like the Lamberts have noticed significant drops in seizures when children facing intractable epilepsy take cannabis extracts, although the source makes huge differences.

Supporting the concept of the Entourage Effect, there are unknown benefits from lesser known cannabinoids. Many people believe that the presence of terpenes and other compounds in cannabis make it more effective.

Harvard Professor, Dr. Lester Grinspoon, said that you need more than THC and CBD if you want cannabis’ full effects. It should be called the Ensemble Effect, not the Entourage Effect, he said. Dr. Grinspoon believed THC should be taken with CBD and other phytochemicals in order to be more effective. Any chemical in isolation does not perform the same way as it is found in nature, he believed.

Dr. Raphael Mechoulam is best known for his extensive work in cannabis acids, as well as Dr. Ethan Russo. In 1996, Japanese researchers found that CBGA is a precursor to CBDA and other compounds.

The post CBGA More Effective For Seizures Than CBD, Study of Mice Finds appeared first on High Times.

Jamaican Cannabis Flower Now Available in Germany

Australia-based Cannim is partnering with Germany-based Cantourage to help bring Jamaican cannabis to German pharmacies.

Cannim is one of the leading cannabis cultivators in Jamaica, which plans to utilize Cantourage’s Fast Track Access Platform to sell its flower product, called Lumir, in Germany. The platform offers what Cantourage calls an “end-to-end solution.” While Cannim focuses on cultivating a high-quality product, Cantourage will control everything related to importation, manufacturing and pharmacy distribution abroad.

Although Jamaica is well-known for both its historical roots in cannabis, as well as its unique cannabis products, it isn’t commonly found outside of the Caribbean country. Cantourage Co-CEO Philip Schetter is proud to help bring a potent Jamaican cannabis product to medical patients abroad. “We are delighted to offer patients in Germany this unprecedented opportunity by bringing medical cannabis from Jamaica into the fast-growing European medical cannabis market for the first time,” Schetter said in a press release.

He continued, “We are excited to offer Cannim’s high-quality indica-dominant Lumir flowers in Europe and to further create access to the European market for medical cannabis from across the world through our platform. Cantourage continues to provide innovative cultivars and a safe, diverse supply for patients.” Lumir’s indica-dominant flowers are available in German pharmacies starting today, August 19.

Cantourage launched its Fast Track Access Platform in June 2021. In a press release, Schetter noted that the European market is dominated by just a few companies that have been able to clear all of the hurdles required to sell medical cannabis in that region. With Cantourage’s platform, Schetter hopes to help the pool of options for medical cannabis patients to expand—and more competition will also help make cannabis medicine more affordable for patients as well. Now, over 14 cultivators are using the Fast Track Access Platform.

Cannabis intended for patients in Germany must meet many regulations, and Lumir fits the bill. Cannim’s Chief Commercial Officer, Stuart Marsh, is equally honored to be approved to sell Lumir outside of Jamaica. “Germany represents an exciting opportunity for Cannim,” Marsh said. “Our ability to cultivate high quality, medical grade Jamaican cannabis that meets the strict standards of the German Pharmacopoeia is testament to the experience and expertise of our team in Jamaica.

“With our 500-acre plantation and over six cultivation circles per year, Cannim ensures continuous supply of medicinal cannabis all year round. Our partnership with Cantourage allows us to introduce our products to the European market and provide new therapy options for patients,” Marsh concluded.

The Lumir product line is named after Professor Lumír Ondřej Hanuš, an analytical chemist from the Czech Republic whose experience in cannabis research began nearly 50 years ago. One of his most famous contributions to the cannabis world includes isolating the endocannabinoid known as anandamide. He has also published his findings in numerous scientific studies on cannabis topics, and has written 16 cannabis-related articles as well. These research efforts have earned him multiple awards, the most recent being a Lifetime Achievement Award at CanEx in Jamaica in 2018.

The Lumir product line will consist of sending “Lumir flowers to pharmacies in Germany, giving German patients and doctors reliable and ongoing access to the natural, high-quality Jamaican product.” The press release confirms the transportation of cannabis flower, but does not verify if Cannim will eventually offer its line of three different 30mL tincture blends, which are currently available in Australia: The “10:10 Balanced” product that contains 10mg THC and 10mg CBD, “THC 27” that contains 27mg THC (and less than or equal to 1mg CBD) and “CBD 50” with 50mg CBD (and less than or equal to 1mg THC).

The post Jamaican Cannabis Flower Now Available in Germany appeared first on High Times.

Friday, January 31, 2020 Headlines | Marijuana Today Daily News

Marijuana Today Daily Headlines
Friday, January 31, 2020 | Curated by host Shea Gunther

// After hearing, THC concentrates bill stalls in Washington legislature (Leafly)

// White Weed Entrepreneurs Are Gaming Programs Meant to Help People of Color (Vice)

// USDA Got More Than 4,600 Hemp Comments Prior To This Week’s Deadline (Marijuana Moment)


These headlines are brought to you by Curaleaf, one of the leading vertically-integrated cannabis operators in the U.S. With legal medical marijuana dispensaries, cultivation sites, and processing facilities all over the United States, Curaleaf has served more than 165,000 medical cannabis patients and looks forward to helping many more long into the future. Swing over to Curaleaf.com to learn more about this very cool company!


// How California’s legal marijuana market wound up in crisis mode after two years (Marijuana Business Daily)

// Australia expedites review of medical cannabis product Epidiolex (Marijuana Business Daily)

// The First Historically Black College Is Launching A CBD Line (Green Market Report)

// Medical cannabis flower imported into Germany doubles again in 2019, confirming strong growth (Marijuana Business Daily)

// Missouri Activists Launch Signature Drive To Put Marijuana Legalization On 2020 Ballot (Marijuana Moment)

// Detroit bans adult-use cannabis sales through March 31 (Marijuana Business Daily)

// Bernie Sanders’s Team Includes Legalizing Marijuana In List Of Executive Orders For 2021 (Marijuana Moment)


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Friday, February 21, 2020 Headlines | Marijuana Today Daily News

Marijuana Today Daily Headlines
Friday, February 21, 2020 | Curated by host Shea Gunther

// New Hampshire House Approves Marijuana Legalization Bill (Marijuana Moment)

// Kentucky House Approves Medical Marijuana Legalization Bill (Marijuana Moment)

// USDA Approves Hemp Plans For Washington State And Wyoming (Marijuana Moment)


These headlines are brought to you by Green Worx Consults, a company specializing in project management, workflow mapping and design, and Lean & 6 Sigma process. If you could use help making your business better at business, get in touch with Green Worx Consults.


// Missouri faces complaints over how it licensed marijuana businesses. So who won? (St. Louis Today)

// NFL Would End Marijuana Suspensions In Deal Circulated By Players Union (Forbes)

// Harvest expands medical cannabis market reach by buying Arizona rival (Marijuana Business Daily)

// Peru sells out of medical cannabis (Marijuana Business Daily)

// Australia claims it has enough cannabis flower to meet demand, but industry says otherwise (Marijuana Business Daily)

// Australis ends purchase of Colorado CBD firm after lurid charges emerge (Marijuana Business Daily)

// New York Governor Will Visit Legal Marijuana States To Take Lessons Back Home (Marijuana Moment)


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Friday, April 10, 2020 Headlines | Marijuana Today Daily News

Marijuana Today Daily Headlines
Friday, April 10, 2020 | Curated by host Shea Gunther

// Budtenders Are Being Put At Risk For COVID-19 (Green Entrepreneur)

// Cannabis producers in Australia avoid ‘nonessential’ designation (Marijuana Business Daily)

// Cory Booker Says Medical Marijuana Access Should Be Prioritized Amid Coronavirus (Marijuana Moment)


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// Michigan Marijuana Market ‘Maturing Rapidly,’ But Faces Barriers To Growth, State Report Finds (Marijuana Moment)

// Oregon sets cannabis sales mark with $84.5 million in March (Marijuana Business Daily)

// New Zealand eases prescription requirement for cannabis-based medicine Sativex (Marijuana Business Daily)

// Italian medical cannabis sales grew 50% in 2019, and supply remains stable despite coronavirus (Marijuana Business Daily)

// BDS Analytical Data Details Surging Sales in Two East Coast Cannabis Markets (New Cannabis Ventures)

// BDS Analytics Data Shows Strong Cannabis Sales Growth in Western States During February (New Cannabis Ventures)

// How to disinfect cannabis packaging during the coronavirus pandemic (Leafly)


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Monday, April 27, 2020 Headlines | Marijuana Today Daily News

Marijuana Today Daily Headlines
Monday, April 27, 2020 | Curated by host Shea Gunther

// Top New York Lawmaker Wants To Pass Marijuana Legalization This Year Despite Coronavirus (Marijuana Moment)

// Marijuana Seems To Reduce Opioid Use Among Chronic Pain Patients, Meta-Study Finds (Marijuana Moment)

// Australia moves toward over-the-counter CBD sales (Marijuana Business Daily)


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// Massachusetts marijuana store seeks medical license amid coronavirus shutdown (Mass Live)

// Ohio allowing phone orders, curbside pickup at medical cannabis stores (Marijuana Business Daily)

// State-By-State COVID-19 Announcements Impacting Marijuana Businesses (JD Supra)

// Massachusetts marijuana: In lawsuit over 2-year moratorium allowing only economic empowerment applicants to open, Appeals Court sides with Cambridge (Mass Live)

// Cannabis Has Become a Major Threat to Alcohol (Real Money)

// Arkansas medical marijuana consumers are buying in Oklahoma (Marijuana Business Daily)

// 1,700 soldiers in Alabama were drug tested a day after 4/20, but the Army says it’s ‘just a coincidence’ (Business Insider)


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Friday, May 8, 2020 Headlines | Marijuana Today Daily News

Marijuana Today Daily Headlines
Friday, May 8, 2020 | Curated by host Shea Gunther

// Montana Marijuana Activists Will Begin Signature Gathering For Legalization Measure With New Safety Protocols (Marijuana Moment)

// Massachusetts marijuana delivery license applications on track to launch in May, reserved for economic empowerment and social equity applicants (Mass Live)

// Florida high court considers marijuana vertical integration, adult-use vote (Marijuana Business Daily)


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// The Pandemic Is Disrupting the Illegal Drug Trade (Bloomberg)

// Australia medical cannabis approvals steady as COVID-19 grips country (Marijuana Business Daily)

// First ‘Call of Duty,’ and Now ‘Animal Crossing’ Is Censoring Weed Language (Merry Jane)

// Missouri Lawmakers Defeat Amendment To Require They Consume Marijuana Before Voting (Marijuana Moment)

// Few impressed with Biden’s weak new marijuana decriminalization plan (Leafly)

// Cresco Labs Triples Pennsylvania Cannabis Cultivation Capacity (New Cannabis Ventures)

// San Francisco Is Delivering Weed and Alcohol to Homeless Residents in Quarantine (Merry Jane)


Check out our other projects:Marijuana Today— Our flagship title, a weekly podcast examining the world of marijuana business and activism with some of the smartest people in the industry and movement. • Marijuana Media Connect— A service that connects industry insiders in the legal marijuana industry with journalists, bloggers, and writers in need of expert sources for their stories.

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Friday, May 8, 2020 Headlines | Marijuana Today Daily News

Marijuana Today Daily Headlines
Friday, May 8, 2020 | Curated by host Shea Gunther

// Montana Marijuana Activists Will Begin Signature Gathering For Legalization Measure With New Safety Protocols (Marijuana Moment)

// Massachusetts marijuana delivery license applications on track to launch in May, reserved for economic empowerment and social equity applicants (Mass Live)

// Florida high court considers marijuana vertical integration, adult-use vote (Marijuana Business Daily)


These headlines are brought to you by Green Worx Consults, a company specializing in project management, workflow mapping and design, and Lean & 6 Sigma process. If you could use help making your business better at business, get in touch with Green Worx Consults.


// The Pandemic Is Disrupting the Illegal Drug Trade (Bloomberg)

// Australia medical cannabis approvals steady as COVID-19 grips country (Marijuana Business Daily)

// First ‘Call of Duty,’ and Now ‘Animal Crossing’ Is Censoring Weed Language (Merry Jane)

// Missouri Lawmakers Defeat Amendment To Require They Consume Marijuana Before Voting (Marijuana Moment)

// Few impressed with Biden’s weak new marijuana decriminalization plan (Leafly)

// Cresco Labs Triples Pennsylvania Cannabis Cultivation Capacity (New Cannabis Ventures)

// San Francisco Is Delivering Weed and Alcohol to Homeless Residents in Quarantine (Merry Jane)


Check out our other projects:Marijuana Today— Our flagship title, a weekly podcast examining the world of marijuana business and activism with some of the smartest people in the industry and movement. • Marijuana Media Connect— A service that connects industry insiders in the legal marijuana industry with journalists, bloggers, and writers in need of expert sources for their stories.

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Photo: Prachatai/Flickr